{"id":2594,"date":"2023-12-24T19:42:58","date_gmt":"2023-12-24T10:42:58","guid":{"rendered":"https:\/\/smartskin-clinic.com\/?page_id=2594"},"modified":"2026-09-06T15:09:39","modified_gmt":"2026-09-06T06:09:39","slug":"yahoo_profillo","status":"publish","type":"page","link":"https:\/\/smartskin-clinic.com\/en\/yahoo_profillo\/","title":{"rendered":"Profhilo Injections Yahoo!"},"content":{"rendered":"<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"444\" height=\"1024\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated1-444x1024.jpg\" alt=\"\" class=\"wp-image-5182\" style=\"width:675px;height:auto\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated1-444x1024.jpg 444w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated1-130x300.jpg 130w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated1-768x1772.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated1-666x1536.jpg 666w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated1-5x12.jpg 5w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated1.jpg 780w\" sizes=\"auto, (max-width: 444px) 100vw, 444px\" \/><\/figure>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"444\" height=\"1024\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated2-444x1024.jpg\" alt=\"\" class=\"wp-image-5183\" style=\"width:656px;height:auto\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated2-444x1024.jpg 444w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated2-130x300.jpg 130w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated2-768x1772.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated2-666x1536.jpg 666w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated2-5x12.jpg 5w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/06\/LP\u7528_updated2.jpg 780w\" sizes=\"auto, (max-width: 444px) 100vw, 444px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">Profhilo pricing at Smart Skin Clinic<\/h2>\n\n\n\n<figure class=\"wp-block-table is-all-centered\"><table><tbody><tr><td>1 session (2cc)<\/td><td>49,800 yen<\/td><\/tr><tr><td>Set of 2 (2cc x 2)<\/td><td>95,600 yen<br>(47,800 yen per vial)<\/td><\/tr><tr><td>Set of 3 (2cc x 3)<\/td><td>137,400 yen<br>(45,800 yen per vial)<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">*All prices include tax.<br>*We offer self-pay (non-insured) treatments only; insurance does not apply.<br>*Profhilo uses a set of designated injection points known as the BAP technique (treatment at bio-aesthetic points), so at essentially any clinic 2cc covers the treatment area described above.<\/figcaption><\/figure>\n\n\n\n<div class=\"swell-block-button blue_ -size-l is-style-btn_shiny\" id=\"nayami\"><a href=\"https:\/\/smartskin-clinic.com\/en\/reservation-profhilo\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"swell-block-button__link\"><span>Book a web appointment or free consultation here<\/span><\/a><\/div>\n\n\n\n<div class=\"ssc-tw-btn\" style=\"text-align:center;margin:22px auto 6px;\"><a href=\"https:\/\/smartskin-clinic.com\/en\/profhilo-tw\/\" style=\"display:inline-flex;align-items:stretch;width:694px;max-width:100%;border-radius:80px;overflow:hidden;text-decoration:none;border:1px solid #000095;\"><span style=\"display:flex;align-items:center;justify-content:center;background:#000095;padding:0 15px;flex:0 0 auto;\"><svg width=\"26\" height=\"26\" viewbox=\"0 0 100 100\" aria-hidden=\"true\"><path d=\"M97.0,50.0 L68.6,46.0 L68.6,54.0 Z M90.7,73.5 L68.1,55.9 L64.1,62.7 Z M73.5,90.7 L62.7,64.1 L55.9,68.1 Z M50.0,97.0 L54.0,68.6 L46.0,68.6 Z M26.5,90.7 L44.1,68.1 L37.3,64.1 Z M9.3,73.5 L35.9,62.7 L31.9,55.9 Z M3.0,50.0 L31.4,54.0 L31.4,46.0 Z M9.3,26.5 L31.9,44.1 L35.9,37.3 Z M26.5,9.3 L37.3,35.9 L44.1,31.9 Z M50.0,3.0 L46.0,31.4 L54.0,31.4 Z M73.5,9.3 L55.9,31.9 L62.7,35.9 Z M90.7,26.5 L64.1,37.3 L68.1,44.1 Z\" fill=\"#FFFFFF\"\/><circle cx=\"50\" cy=\"50\" r=\"19\" fill=\"#FFFFFF\"\/><\/svg><\/span><span style=\"display:flex;align-items:center;justify-content:center;background:#FE0000;color:#FFFFFF;font-weight:700;font-size:17px;line-height:1.45;padding:16px 20px;flex:1 1 auto;text-align:center;\">Click here for the page exclusively for customers in Taiwan \u2192<\/span><\/a><\/div>\n\n\n<div class=\"p-blogParts post_content\" data-partsid=\"10904\">\n<div class=\"swell-block-button -size-l is-style-btn_solid\"><a href=\"tel:050-1720-6230\" class=\"swell-block-button__link\"><span>Book by phone here<br>050-1720-6230<\/span><\/a><\/div>\n<\/div>\n\n\n<!-- ======================================\n     \u76e3\u4fee\u8005\u60c5\u5831 \u2013 Smart Skin Clinic\n     Brand Colors: #ffffff #000000 #f5f5f5 #a3e3fc\n====================================== -->\n<section class=\"ssc-supervisor\">\n\n  <!-- \u76e3\u4fee\u8005\u60c5\u5831\u30bf\u30a4\u30c8\u30eb -->\n  <div class=\"ssc-supervisor-title-wrapper\">\n    <span class=\"ssc-supervisor-title\">Supervisor Information<\/span>\n  <\/div>\n\n  <div class=\"ssc-supervisor-inner\">\n\n    <!-- \u76e3\u4fee\u533b\u5e2b \u9854\u5199\u771f -->\n    <div class=\"ssc-supervisor-photo\">\n      <img decoding=\"async\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg\" alt=\"Kota Ishii, Chief Medical Director, Smart Skin Clinic Group\" loading=\"lazy\" \/>\n    <\/div>\n\n    <!-- \u30c6\u30ad\u30b9\u30c8\u60c5\u5831 -->\n    <div class=\"ssc-supervisor-text\">\n\n      <p class=\"ssc-supervisor-role\">Group Chief Director, Smart Skin Clinic Group<\/p>\n      <p class=\"ssc-supervisor-name translation-block\"><ruby>Ishii<rt>Ishii<\/rt><\/ruby> <ruby>Kota<rt>Kota<\/rt><\/ruby><\/p>\n\n      <div class=\"ssc-supervisor-block\">\n        <h4>Career<\/h4>\n        <p>Graduated from Juntendo University School of Medicine<\/p>\n        <p>Worked at Tokyo Women's Medical University Hospital and affiliated facilities<\/p>\n        <p>Worked at a major aesthetic clinic in Tokyo<\/p>\n      <\/div>\n\n      <div class=\"ssc-supervisor-block\">\n        <h4>Affiliations \/ Qualifications<\/h4>\n        <p>Board-certified specialist, Japan Surgical Society<\/p>\n        <p>Board-certified specialist, Japanese Society of Anti-Aging Medicine<\/p>\n      <\/div>\n\n    <\/div><!-- \/.text -->\n  <\/div><!-- \/.inner -->\n<\/section>\n\n<style>\n\/* =========================================================\n  Smart Skin Clinic \u2013 Supervisor Component (Monotone + Water)\n========================================================= *\/\n\n\/* \u25c7 \u30d1\u30ec\u30c3\u30c8 *\/\n:root{\n  --ssc-black:#000000;\n  --ssc-white:#ffffff;\n  --ssc-gray:#f5f5f5;\n  --ssc-water:#a3e3fc;   \/* \u30a2\u30af\u30bb\u30f3\u30c8\u6c34\u8272 *\/\n}\n\n\/* \u30bb\u30af\u30b7\u30e7\u30f3 *\/\n.ssc-supervisor{\n  background:var(--ssc-gray);\n  padding:40px 5%;\n  border:1px solid #e0e0e0;\n  border-radius:8px;\n  margin:40px 0;\n  color:var(--ssc-black);\n  font-family:\"Noto Sans JP\",\"Hiragino Sans\",\"Helvetica Neue\",Arial,sans-serif;\n}\n\n\/* \u30bf\u30a4\u30c8\u30eb *\/\n.ssc-supervisor-title-wrapper {\n  font-size: 1.5rem;\n  font-weight: 700;\n  margin: 0 0 24px;\n  display: flex;\n  align-items: flex-end;\n  gap: 8px;\n  color: var(--ssc-black);\n}\n\n.ssc-supervisor-title {\n  font-size: 1.5rem;\n  font-weight: 700;\n  color: var(--ssc-black); \/* \u6587\u5b57\u8272\u3092\u9ed2\u306b *\/\n}\n\n\/* \u30ec\u30a4\u30a2\u30a6\u30c8 *\/\n.ssc-supervisor-inner{\n  display:flex;\n  gap:28px;\n  flex-wrap:wrap;\n}\n\n\/* \u30c6\u30ad\u30b9\u30c8 *\/\n.ssc-supervisor-text{\n  flex:1 1 260px;\n  min-width:260px;\n}\n.ssc-supervisor-role{\n  font-size:0.9rem;\n  color:var(--ssc-black);  \/* \u9ed2\u6587\u5b57\u306b\u4fee\u6b63 *\/\n  margin:0 0 4px;\n}\n.ssc-supervisor-name{\n  font-size:1.25rem;\n  font-weight:700;\n  margin:0 0 16px;\n  background-color:transparent;  \/* \u80cc\u666f\u306e\u8272\u3092\u900f\u660e\u306b\u8a2d\u5b9a *\/\n  color:var(--ssc-black); \/* \u6587\u5b57\u8272\u3092\u9ed2\u306b *\/\n}\n\n\/* \u30d6\u30ed\u30c3\u30af *\/\n.ssc-supervisor-block{\n  margin-bottom:18px;\n}\n.ssc-supervisor-block h4{\n  font-size:1rem;\n  font-weight:600;\n  margin:0 0 6px;\n  color:var(--ssc-black);\n  border-left:4px solid var(--ssc-water);\n  padding-left:8px;\n}\n\n\/* \u30c6\u30ad\u30b9\u30c8\u8868\u793a\u306e\u5909\u66f4\uff08\u7b87\u6761\u66f8\u304d\u306f\u4f7f\u7528\u305b\u305a\u3001\u30b7\u30f3\u30d7\u30eb\u306b\u8868\u793a\uff09 *\/\n.ssc-supervisor-block p{\n  font-size:1rem;\n  margin: 0 0 10px;\n  color: var(--ssc-black);\n  line-height: 1.6;\n}\n\n\/* \u76e3\u4fee\u533b\u5e2b \u9854\u5199\u771f *\/\n.ssc-supervisor-photo{\n  flex:0 0 190px;\n  max-width:190px;\n}\n.ssc-supervisor-photo img{\n  width:100%;\n  height:auto;\n  display:block;\n  border-radius:8px;\n}\n\n\/* \u30b9\u30de\u30db *\/\n@media(max-width:600px){\n  .ssc-supervisor-inner{\n    flex-direction:column;\n    gap:20px;\n  }\n  .ssc-supervisor-photo{\n    flex:0 0 auto;\n    max-width:150px;\n    margin:0 auto;\n  }\n}\n<\/style>\n\n\n\n<h2 class=\"wp-block-heading\">What is Profhilo?<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"500\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/10\/\u30d7\u30ed\u30d5\u30a1\u30a4\u30ed\u5546\u54c1\u753b\u50cf.png\" alt=\"Profhilo Product Images\" class=\"wp-image-1798\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/10\/\u30d7\u30ed\u30d5\u30a1\u30a4\u30ed\u5546\u54c1\u753b\u50cf.png 600w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/10\/\u30d7\u30ed\u30d5\u30a1\u30a4\u30ed\u5546\u54c1\u753b\u50cf-300x250.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Its official product name is \"Profhilo&reg;.\" On the market since 2015, it is a hyaluronic acid product from the Italian company IBSA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To explain it in technical terms,<\/p>\n\n\n\n<div class=\"wp-block-group has-border -border04 has-swl-pale-02-background-color has-background\"><div class=\"wp-block-group__inner-container\">\n<p class=\"wp-block-paragraph\">it is a hybrid complex of low- and high-molecular-weight hyaluronic acid (hybrid hyaluronic acid), combining two types of hyaluronic acid \u2014 high- and low-molecular-weight \u2014 through NAHYCO Hybrid Technology.<\/p>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><br>The conventional hyaluronic acid that most people are familiar with<strong>\"cross-linked\"<\/strong>hyaluronic acid.<strong><mark>Profhilo is a \"non-cross-linked\" hyaluronic acid.<\/mark><\/strong>That is the key distinction.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The major difference between cross-linked and non-cross-linked lies in whether it spreads. Profhilo, a non-cross-linked hyaluronic acid, spreads out from the injection site to deliver its effects over a wide area.<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-shadow\"><div class=\"cap_box_ttl\"><span>Conventional hyaluronic acid<\/span><\/div><div class=\"cap_box_content\">\n<p class=\"wp-block-paragraph\">With conventional hyaluronic acid injections, bone and fat volume lost with age was \"filled in\" with hyaluronic acid to refine facial contours and improve wrinkles and nasolabial folds.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It targets specific areas such as the under-eyes, nasolabial folds, and marionette lines; the injected hyaluronic acid stays within the treatment area, filling in lost fat and lifting ligaments.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:38px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Recommended if you have any of these concerns<\/h2>\n\n\n\n<div class=\"wp-block-group is-style-kakko_box\"><div class=\"wp-block-group__inner-container\">\n<ul class=\"wp-block-list is-style-check_list\">\n<li><strong>Sagging under the eyes<\/strong><\/li>\n\n\n\n<li><strong>Dark circles under the eyes<\/strong><\/li>\n\n\n\n<li><strong>Hollows under the eyes<\/strong><\/li>\n\n\n\n<li><strong>Fine lines at the corners of the eyes<\/strong><\/li>\n\n\n\n<li><strong>Gaunt or sagging cheeks<\/strong><\/li>\n\n\n\n<li><strong>Wanting to improve neck wrinkles<\/strong><\/li>\n\n\n\n<li><strong>Prominent tendons and wrinkles on the backs of the hands<\/strong><\/li>\n\n\n\n<li>Wanting fast-acting results from skin treatment<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:42px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Effects and how they work<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In a nutshell,<strong><mark>it \"rebuilds the skin's cells.\"<\/mark><\/strong>.<br><br>As a result, you can gain the following three main effects.<\/p>\n\n\n\n<div class=\"wp-block-group has-border -border04 has-swl-pale-02-background-color has-background\"><div class=\"wp-block-group__inner-container\">\n<ol class=\"wp-block-list\">\n<li><strong>Improvement of wrinkles<\/strong><\/li>\n\n\n\n<li><strong>Improvement of firmness and elasticity (enhanced, dewy skin)<\/strong><\/li>\n\n\n\n<li><strong>Lifting effect<\/strong><\/li>\n<\/ol>\n<\/div><\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">To give a more technical explanation,<br>hyaluronic acid comes in low- and high-molecular-weight forms. (Different molecular weights have different biological actions.) The \"NAHYCO Hybrid Technology\" used in Profhilo makes it possible to loosely bond low- and high-molecular-weight hyaluronic acid. In the dermal layer of the skin, this combined complex of low- plus high-molecular-weight hyaluronic acid (hybrid hyaluronic acid)<strong><mark>stimulates fibroblasts to produce extracellular matrix.<\/mark><\/strong>At the same time, it also increases fat cells in the subcutaneous tissue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Through these actions, it can improve wrinkles and sagging and plump up the skin.<\/p>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-small_ttl\"><div class=\"cap_box_ttl\"><span>What is the extracellular matrix?<\/span><\/div><div class=\"cap_box_content\">\n<p class=\"wp-block-paragraph\">The extracellular matrix is the collective term for the substances surrounding cells in the body. In the dermis,<strong><mark>the extracellular matrix refers to collagen, elastin, and ground substance (such as hyaluronic acid).<\/mark><\/strong>This dermal extracellular matrix is responsible for maintaining skin elasticity and retaining moisture.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">With age, the extracellular matrix degenerates and deteriorates. This degeneration causes the skin to lose elasticity, become thinner, and lose moisture. As a result, the skin loses firmness and shows signs such as sagging and fine lines.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"swell-block-button blue_ -size-l is-style-btn_shiny\" id=\"nayami\"><a href=\"https:\/\/smartskin-clinic.com\/en\/reservation-profhilo\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"swell-block-button__link\"><span>Book a web appointment or free consultation here<\/span><\/a><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">efficacy<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Profhilo contains no chemicals or biological agents whatsoever.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Therefore,<strong>it is less likely to cause allergic reactions and the like.<\/strong>This is one of its characteristics.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Also,<strong>The efficacy of Profhilo has also been noted in several published papers.<\/strong><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Based on three years of post-market experience, the efficacy profile of the medical device in this study is favorable<\/p>\n<cite><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7327616\/\">Daniel Cassuto, et al. (2020) Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo\u00ae) as Derived from Worldwide Postmarketing Data. Biomed Res Int.<\/a><\/cite><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Profhilo at Smart Skin Clinic<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">We use \"Profhilo\u00ae.\"<br><br>As of 2020,<strong><mark>it has been introduced in more than 80 countries<\/mark><\/strong>It is a hyaluronic acid with over 500,000 cases reported worldwide, and it has also won AMEC &amp; AESTHETICS awards.<\/p>\n\n\n\n<div class=\"swell-block-button blue_ -size-l is-style-btn_shiny\" id=\"nayami\"><a href=\"https:\/\/smartskin-clinic.com\/en\/reservation-profhilo\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"swell-block-button__link\"><span>Book a web appointment or free consultation here<\/span><\/a><\/div>\n\n\n<div class=\"p-blogParts post_content\" data-partsid=\"10904\">\n<div class=\"swell-block-button -size-l is-style-btn_solid\"><a href=\"tel:050-1720-6230\" class=\"swell-block-button__link\"><span>Book by phone here<br>050-1720-6230<\/span><\/a><\/div>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><strong>Who cannot receive this treatment<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container\">\n<p class=\"wp-block-paragraph\">Those who are pregnant or breastfeeding<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Profhilo injection site<\/p>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Risks and Side Effects<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container\">\n<p class=\"wp-block-paragraph\">At the needle puncture site:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Redness, swelling, pain, edema<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bruising<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Temporary raised bumps<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:38px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Downtime<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container\">\n<p class=\"wp-block-paragraph\">Redness and raised bumps may occur at the injection site, but in most cases they return to normal in about 24 hours.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, though not always. If bruising occurs, it gradually fades over 10 to 14 days.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Treatment Flow<\/strong><\/h2>\n\n\n\n<div class=\"swell-block-step\" data-num-style=\"circle\">\n<div class=\"swell-block-step__item\"><div class=\"swell-block-step__number u-bg-main\"><span class=\"__label\">STEP<\/span><\/div><div class=\"swell-block-step__title u-fz-l\">Booking<\/div><div class=\"swell-block-step__body\">\n<p class=\"wp-block-paragraph\">You can book from your smartphone.<\/p>\n\n\n\n<div class=\"swell-block-button blue_ -size-l is-style-btn_solid\" data-align=\"left\" data-id=\"ab461b08\"><a href=\"https:\/\/smartskin-clinic.com\/en\/reservation-profhilo\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"swell-block-button__link\"><span>Book a web appointment here<\/span><\/a><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"swell-block-step__item\"><div class=\"swell-block-step__number u-bg-main\"><span class=\"__label\">STEP<\/span><\/div><div class=\"swell-block-step__title u-fz-l\">Reception<\/div><div class=\"swell-block-step__body\">\n<p class=\"wp-block-paragraph\">A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"swell-block-step__item\"><div class=\"swell-block-step__number u-bg-main\"><span class=\"__label\">STEP<\/span><\/div><div class=\"swell-block-step__title u-fz-l\">Counseling &amp; Examination<\/div><div class=\"swell-block-step__body\">\n<p class=\"wp-block-paragraph\">During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"swell-block-step__item\"><div class=\"swell-block-step__number u-bg-main\"><span class=\"__label\">STEP<\/span><\/div><div class=\"swell-block-step__title u-fz-l\">Profhilo injection<\/div><div class=\"swell-block-step__body\">\n<p class=\"wp-block-paragraph\">After marking is done, we perform the injection while checking in with you as we go.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"swell-block-step__item\"><div class=\"swell-block-step__number u-bg-main\"><span class=\"__label\">STEP<\/span><\/div><div class=\"swell-block-step__title u-fz-l\">Aftercare<\/div><div class=\"swell-block-step__body\">\n<p class=\"wp-block-paragraph translation-block\">We will provide detailed instructions on how to care for the treated area and what to keep in mind in your daily life. <br> In addition, with a focus on prevention and maintenance, we recommend appropriate home care products\u2014such as oral medications and skincare products\u2014that can help alleviate your concerns.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"swell-block-step__item\"><div class=\"swell-block-step__number u-bg-main\"><span class=\"__label\">STEP<\/span><\/div><div class=\"swell-block-step__title u-fz-l\">Going Home<\/div><div class=\"swell-block-step__body\">\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Details<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-table is-all-centered\"><table><tbody><tr><td>Treatment Time<\/td><td>About 15 minutes (not including counseling)<\/td><\/tr><tr><td>Recommended Number &amp; Frequency of Treatments<\/td><td class=\"translation-block\">\u30fbIt is recommended to wait at least 6 weeks and undergo the treatment as a two-session set. <br>\u30fbAfter that, maintenance treatment is recommended about once every six months.<\/td><\/tr><tr><td>Downtime<\/td><td>About 24 hours<\/td><\/tr><tr><td>Treatment on the day of counseling<\/td><td>Available<\/td><\/tr><tr><td>Makeup<\/td><td>Possible right after the treatment<\/td><\/tr><tr><td>Skincare<\/td><td>Possible right after the treatment<\/td><\/tr><tr><td>Shower<\/td><td>Possible from the same day<\/td><\/tr><tr><td>Pain<\/td><td>A slight pricking sensation when the needle is inserted.<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">*Results vary from person to person.<\/figcaption><\/figure>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">FAQ<\/h2>\n\n\n\n<dl class=\"swell-block-faq\" data-q=\"col-text\" data-a=\"col-text\">\n<div class=\"swell-block-faq__item\"><dt class=\"faq_q\">How often and how many times should I receive it?<\/dt><dd class=\"faq_a\"><div class=\"swell-block-balloon\"><div class=\"c-balloon -bln-left\" data-col=\"blue\"><div class=\"c-balloon__icon -circle\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2025\/09\/1-1-150x150.jpg\" alt=\"\" class=\"c-balloon__iconImg\" width=\"80px\" height=\"80px\"><span class=\"c-balloon__iconName\">Dr. Ishii<\/span><\/div><div class=\"c-balloon__body -speaking -border-none\"><div class=\"c-balloon__text\">\n<p>A single session may be effective, but as more effective approaches we recommend one of the following.<br>\u2460 Have the first and second sessions one month apart, then continue the same pattern once a year thereafter.<br>\u2461 Have the first and second sessions one month apart, then continue every six months thereafter.<br><br>*Through Profhilo's skin-remodeling effect, the extracellular matrix increases and skin recovery is encouraged. Without maintenance, once treatment reaches its peak, the extracellular matrix gradually declines \"with aging.\" For this reason, we recommend the approach above.<\/p>\n<span class=\"c-balloon__shapes\"><span class=\"c-balloon__before\"><\/span><span class=\"c-balloon__after\"><\/span><\/span><\/div><\/div><\/div><\/div><\/dd><\/div>\n\n\n\n<div class=\"swell-block-faq__item\"><dt class=\"faq_q\">Does it hurt?<\/dt><dd class=\"faq_a\"><div class=\"swell-block-balloon\"><div class=\"c-balloon -bln-left\" data-col=\"blue\"><div class=\"c-balloon__icon -circle\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2025\/09\/1-1-150x150.jpg\" alt=\"\" class=\"c-balloon__iconImg\" width=\"80px\" height=\"80px\"><span class=\"c-balloon__iconName\">Dr. Ishii<\/span><\/div><div class=\"c-balloon__body -speaking -border-none\"><div class=\"c-balloon__text\">\n<p>It varies from person to person. We use a fine needle, but you may feel a slight pricking sensation. The center of the face is also said to be more sensitive to pain.<\/p>\n<span class=\"c-balloon__shapes\"><span class=\"c-balloon__before\"><\/span><span class=\"c-balloon__after\"><\/span><\/span><\/div><\/div><\/div><\/div><\/dd><\/div>\n\n\n\n<div class=\"swell-block-faq__item\"><dt class=\"faq_q\">How long is the downtime?<\/dt><dd class=\"faq_a\"><div class=\"swell-block-balloon\"><div class=\"c-balloon -bln-left\" data-col=\"blue\"><div class=\"c-balloon__icon -circle\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2025\/09\/1-1-150x150.jpg\" alt=\"\" class=\"c-balloon__iconImg\" width=\"80px\" height=\"80px\"><span class=\"c-balloon__iconName\">Dr. Ishii<\/span><\/div><div class=\"c-balloon__body -speaking -border-none\"><div class=\"c-balloon__text\">\n<p>Redness often subsides within about 24 hours.<\/p>\n<span class=\"c-balloon__shapes\"><span class=\"c-balloon__before\"><\/span><span class=\"c-balloon__after\"><\/span><\/span><\/div><\/div><\/div><\/div><\/dd><\/div>\n<\/dl>\n\n\n\n<div style=\"height:59px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Legal Notices<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In Japan, Profhilo is a pharmaceutical not approved by the Ministry of Health, Labour and Welfare. The pharmaceuticals and devices used in Profhilo treatment are personally imported at the discretion of our physicians. There is also no other domestically approved product with the same performance available for this treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition, because Profhilo is an unapproved product in Japan, it is not covered by the Adverse Drug Reaction Relief System.<br><br>Please refer to this page for information on medications and similar items that require caution in personal importation.<br><a href=\"https:\/\/www.mhlw.go.jp\/topics\/bukyoku\/iyaku\/kojinyunyu\/050609-1.html\">Ministry of Health, Labour and Welfare, \"Medications and Similar Items That Require Caution in Personal Importation.\"<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Launched in Italy in 2015, the Profhilo procedure has been recognized for its wide-ranging effects and is now offered in more than 80 countries worldwide.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition, more than 500,000 cases have been reported to date, and it has also received the AMEC &amp; AESTHETICS award (a prominent international award).<\/p>\n\n\n\n<div class=\"swell-block-button blue_ -size-l is-style-btn_shiny\" id=\"nayami\"><a href=\"https:\/\/smartskin-clinic.com\/en\/reservation-profhilo\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"swell-block-button__link\"><span>Book a web appointment or free consultation here<\/span><\/a><\/div>\n\n\n<div class=\"p-blogParts post_content\" data-partsid=\"10904\">\n<div class=\"swell-block-button -size-l is-style-btn_solid\"><a href=\"tel:050-1720-6230\" class=\"swell-block-button__link\"><span>Book by phone here<br>050-1720-6230<\/span><\/a><\/div>\n<\/div>\n\n\n<p class=\"has-text-align-center sp_only wp-block-paragraph\"><span style=\"font-size:18px\" class=\"swl-fz\"><strong>Smart Skin Clinic<\/strong><\/span><\/p>\n\n\n\n<p class=\"has-text-align-center pc_only wp-block-paragraph\"><span style=\"font-size:30px\" class=\"swl-fz\">Smart Skin Clinic<\/span><\/p>\n\n\n\n<div style=\"height:3px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A clinic built on the concept of \"making aesthetic medicine more accessible and smart.\"<br><br>Rather than spending on ornate interiors, we keep fit-out costs down, and rather than adding equipment indiscriminately, we carefully select only the devices we need to keep equipment costs down.<br><br>We aim to \"make aesthetic medicine more accessible\" for you.<\/p>\n\n\n<div class=\"wp-block-image is-style-shadow\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"690\" height=\"520\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/07\/26-1.jpg\" alt=\"Clinic Reception\" class=\"wp-image-1179\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/07\/26-1.jpg 690w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/07\/26-1-300x226.jpg 300w\" sizes=\"auto, (max-width: 690px) 100vw, 690px\" \/><\/figure>\n<\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide animated fadeInUp\"\/>\n\n\n\n<p class=\"sp_only wp-block-paragraph\">Address:<span style=\"font-size:16px\" class=\"swl-fz\">EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo<\/span><\/p>\n\n\n\n<p class=\"pc_only wp-block-paragraph\"><span style=\"font-size:22px\" class=\"swl-fz\">Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo<\/span><\/p>\n\n\n\n<div style=\"height:76px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center sp_only wp-block-paragraph\">About the physician supervision of this site<\/p>\n\n\n\n<p class=\"has-text-align-center pc_only wp-block-paragraph\"><span style=\"font-size:26px\" class=\"swl-fz\">About the physician supervision of this site<\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span style=\"font-size:20px\" class=\"swl-fz\">This site is operated under the supervision of Smart Skin Clinic's supervising physicians.<\/span><\/strong><\/p>\n\n\n\n<p class=\"sp_only wp-block-paragraph\">This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.<\/p>\n\n\n\n<p class=\"pc_only wp-block-paragraph\"><span style=\"font-size:18px\" class=\"swl-fz\">This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.<\/span><\/p>\n\n\n\n<div style=\"height:67px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group ssc-eeat\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n\n<h2 class=\"wp-block-heading\">Physician Who Supervised This Page<\/h2>\n\n\n\n<div class=\"wp-block-media-text profile is-stacked-on-mobile\" style=\"grid-template-columns:28% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1280\" height=\"1920\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg\" alt=\"Kota Ishii, Chief Medical Director, Smart Skin Clinic\" class=\"wp-image-12584 size-full\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg 1280w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-200x300.jpg 200w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-768x1152.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-1024x1536.jpg 1024w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-8x12.jpg 8w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"u-mb-0 wp-block-paragraph\"><span class=\"swl-fz u-fz-s\"><strong>Smart Skin Clinic, Chief Medical Director \/ Physician<\/strong><\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\">Kota Ishii<\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.<\/p>\n\n\n\n<div class=\"swell-block-button is-style-btn_normal\"><a href=\"https:\/\/smartskin-clinic.com\/en\/concept\/\" class=\"swell-block-button__link\"><span>See the Philosophy of Our Doctors and Clinics<\/span><\/a><\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Interview with Director Kota Ishii<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"A number of repeat customers for skin growth injections: \u2049\ufe0fAttack on the handsome general director of a popular clinic: \ud83e\uddd1\u200d\u2695\ufe0f\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/u6cP6jPmfwU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u30b9\u30de\u30fc\u30c8\u30b9\u30ad\u30f3\u30af\u30ea\u30cb\u30c3\u30af\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30ed\u306e\u4fa1\u683c 1\u56de\uff082cc\uff09 49,800\u5186 2\u56de\u30bb\u30c3\u30c8\uff082cc\u00d72\uff09 95, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"swell_btn_cv_data":"{\"ab461b08\":{\"pv\":11202,\"imp\":2841,\"click\":20}}","footnotes":""},"class_list":["post-2594","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/pages\/2594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/comments?post=2594"}],"version-history":[{"count":20,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/pages\/2594\/revisions"}],"predecessor-version":[{"id":16869,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/pages\/2594\/revisions\/16869"}],"wp:attachment":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/media?parent=2594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}