{"id":3029,"date":"2024-01-28T11:35:02","date_gmt":"2024-01-28T02:35:02","guid":{"rendered":"https:\/\/smartskin-clinic.com\/?p=3029"},"modified":"2026-08-02T16:52:10","modified_gmt":"2026-08-02T07:52:10","slug":"rejuran-effect-undertheeyes","status":"publish","type":"post","link":"https:\/\/smartskin-clinic.com\/en\/rejuran-effect-undertheeyes\/","title":{"rendered":"What are the expected effects of Rejuran for dark circles and fine wrinkles under the eyes?"},"content":{"rendered":"<p class=\"has-border -border01 wp-block-paragraph\">Does Rejuran work under the eyes?\"<br>When can I expect to see the benefits of Rejuran for dark circles under my eyes?\"<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Do you have these questions about Rejuran?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hello. I am a doctor at Smart Skin Clinic.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rejuran is effective for a variety of skin problems, but it is also a treatment for under-eye problems.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this issue, our cosmetic dermatology clinic will explain the effects that Rejuran can have on the under-eye area, when the effects appear, how long the effects last, suitable formulations and treatments, and how to receive effective treatment.<\/p>\n\n\n\n<!-- ======================================\n     \u76e3\u4fee\u8005\u60c5\u5831 \u2013 Smart Skin Clinic\n     Brand Colors: #ffffff #000000 #f5f5f5 #a3e3fc\n====================================== -->\n<section class=\"ssc-supervisor\">\n\n  <!-- \u76e3\u4fee\u8005\u60c5\u5831\u30bf\u30a4\u30c8\u30eb -->\n  <div class=\"ssc-supervisor-title-wrapper\">\n    <span class=\"ssc-supervisor-title\">Supervisor Information<\/span>\n  <\/div>\n\n  <div class=\"ssc-supervisor-inner\">\n\n    <!-- \u76e3\u4fee\u533b\u5e2b \u9854\u5199\u771f -->\n    <div class=\"ssc-supervisor-photo\">\n      <img decoding=\"async\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg\" alt=\"Kota Ishii, Chief Medical Director, Smart Skin Clinic Group\" loading=\"lazy\" \/>\n    <\/div>\n\n    <!-- \u30c6\u30ad\u30b9\u30c8\u60c5\u5831 -->\n    <div class=\"ssc-supervisor-text\">\n\n      <p class=\"ssc-supervisor-role\">Group Chief Director, Smart Skin Clinic Group<\/p>\n      <p class=\"ssc-supervisor-name translation-block\"><ruby>Ishii<rt>Ishii<\/rt><\/ruby> <ruby>Kota<rt>Kota<\/rt><\/ruby><\/p>\n\n      <div class=\"ssc-supervisor-block\">\n        <h4>Career<\/h4>\n        <p>Graduated from Juntendo University School of Medicine<\/p>\n        <p>Worked at Tokyo Women's Medical University Hospital and affiliated facilities<\/p>\n        <p>Worked at a major aesthetic clinic in Tokyo<\/p>\n      <\/div>\n\n      <div class=\"ssc-supervisor-block\">\n        <h4>Affiliations \/ Qualifications<\/h4>\n        <p>Board-certified specialist, Japan Surgical Society<\/p>\n        <p>Board-certified specialist, Japanese Society of Anti-Aging Medicine<\/p>\n      <\/div>\n\n    <\/div><!-- \/.text -->\n  <\/div><!-- \/.inner -->\n<\/section>\n\n<style>\n\/* =========================================================\n  Smart Skin Clinic \u2013 Supervisor Component (Monotone + Water)\n========================================================= *\/\n\n\/* \u25c7 \u30d1\u30ec\u30c3\u30c8 *\/\n:root{\n  --ssc-black:#000000;\n  --ssc-white:#ffffff;\n  --ssc-gray:#f5f5f5;\n  --ssc-water:#a3e3fc;   \/* \u30a2\u30af\u30bb\u30f3\u30c8\u6c34\u8272 *\/\n}\n\n\/* \u30bb\u30af\u30b7\u30e7\u30f3 *\/\n.ssc-supervisor{\n  background:var(--ssc-gray);\n  padding:40px 5%;\n  border:1px solid #e0e0e0;\n  border-radius:8px;\n  margin:40px 0;\n  color:var(--ssc-black);\n  font-family:\"Noto Sans JP\",\"Hiragino Sans\",\"Helvetica Neue\",Arial,sans-serif;\n}\n\n\/* \u30bf\u30a4\u30c8\u30eb *\/\n.ssc-supervisor-title-wrapper {\n  font-size: 1.5rem;\n  font-weight: 700;\n  margin: 0 0 24px;\n  display: flex;\n  align-items: flex-end;\n  gap: 8px;\n  color: var(--ssc-black);\n}\n\n.ssc-supervisor-title {\n  font-size: 1.5rem;\n  font-weight: 700;\n  color: var(--ssc-black); \/* \u6587\u5b57\u8272\u3092\u9ed2\u306b *\/\n}\n\n\/* \u30ec\u30a4\u30a2\u30a6\u30c8 *\/\n.ssc-supervisor-inner{\n  display:flex;\n  gap:28px;\n  flex-wrap:wrap;\n}\n\n\/* \u30c6\u30ad\u30b9\u30c8 *\/\n.ssc-supervisor-text{\n  flex:1 1 260px;\n  min-width:260px;\n}\n.ssc-supervisor-role{\n  font-size:0.9rem;\n  color:var(--ssc-black);  \/* \u9ed2\u6587\u5b57\u306b\u4fee\u6b63 *\/\n  margin:0 0 4px;\n}\n.ssc-supervisor-name{\n  font-size:1.25rem;\n  font-weight:700;\n  margin:0 0 16px;\n  background-color:transparent;  \/* \u80cc\u666f\u306e\u8272\u3092\u900f\u660e\u306b\u8a2d\u5b9a *\/\n  color:var(--ssc-black); \/* \u6587\u5b57\u8272\u3092\u9ed2\u306b *\/\n}\n\n\/* \u30d6\u30ed\u30c3\u30af *\/\n.ssc-supervisor-block{\n  margin-bottom:18px;\n}\n.ssc-supervisor-block h4{\n  font-size:1rem;\n  font-weight:600;\n  margin:0 0 6px;\n  color:var(--ssc-black);\n  border-left:4px solid var(--ssc-water);\n  padding-left:8px;\n}\n\n\/* \u30c6\u30ad\u30b9\u30c8\u8868\u793a\u306e\u5909\u66f4\uff08\u7b87\u6761\u66f8\u304d\u306f\u4f7f\u7528\u305b\u305a\u3001\u30b7\u30f3\u30d7\u30eb\u306b\u8868\u793a\uff09 *\/\n.ssc-supervisor-block p{\n  font-size:1rem;\n  margin: 0 0 10px;\n  color: var(--ssc-black);\n  line-height: 1.6;\n}\n\n\/* \u76e3\u4fee\u533b\u5e2b \u9854\u5199\u771f *\/\n.ssc-supervisor-photo{\n  flex:0 0 190px;\n  max-width:190px;\n}\n.ssc-supervisor-photo img{\n  width:100%;\n  height:auto;\n  display:block;\n  border-radius:8px;\n}\n\n\/* \u30b9\u30de\u30db *\/\n@media(max-width:600px){\n  .ssc-supervisor-inner{\n    flex-direction:column;\n    gap:20px;\n  }\n  .ssc-supervisor-photo{\n    flex:0 0 auto;\n    max-width:150px;\n    margin:0 auto;\n  }\n}\n<\/style>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/lizne\/\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"350\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc.png\" alt=\"Rizne Banner\" class=\"wp-image-5340\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc.png 1000w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-300x105.png 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-768x269.png 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-18x6.png 18w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><\/figure>\n<\/div>\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">What is Rejuran?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">What is Rejuran, and how does it work and show its effects on under-eye concerns?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rejuran is an injectable treatment, and the formulation is based on \"polynucleotides\" extracted from salmon. Polynucleotides act on the dermis layer deep in the skin to activate fibroblasts. Fibroblasts are cells that produce collagen and hyaluronic acid, which are the source of firmness and moisture. By injecting Rejelan, it is expected to bring firmness and moisture to the skin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rejuran also contains astaxanthin, an antioxidant 1,000 times more potent than vitamin E. Oxidation of the skin causes aging, leading to spots, wrinkles, and sagging. Its antioxidant effect can be expected to improve these symptoms.<\/p>\n\n\n\n<div style=\"height:47px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>How Rejuran works under the eyes<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Rejelan can be expected to improve various problems under the eyes, such as fine lines and wrinkles, dryness, dark circles, and dark circles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The skin under the eyes is thinner than any other part of the face and moves around a lot, exposing it to an environment where fine lines and wrinkles can easily form due to dryness and fatigue. In addition, the area is prone to skin problems such as blue circles due to poor blood circulation, pigmentation and brown circles due to rubbing the eye area, and black circles caused by sagging.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rejuran can be expected to gradually restore firmness, moisture retention, and elasticity around the eyes by increasing hyaluronic acid and collagen, reduce the appearance of dark circles caused by sagging and fine lines caused by dryness, and improve blue circles by promoting capillary circulation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The effectiveness of Rejuran injections into the periorbital area for rejuvenation, including firmness, hydration, and pore improvement, is described in the following research paper, \"Comparison of polynucleotide-containing products (\u2252 Rejuran) and hyaluronic acid injected into the periorbital area in 27 subjects\".<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">PATIENTS\/METHODS: A total of 27 subjects were enrolled in this randomized, paired-matched, active-control study. Each subject received three PN filler injections on one side and non-cross-linked hyaluronic acid (HA) filler injections on the contralateral periorbital area, 2 weeks apart. RESULTS. Improvements in visual analog scale and global esthetic improvement scale scores were not significantly different between the PN and HA groups. The rate of improvement in skin elasticity and hydration decreased over time in both groups, with a higher rate of improvement in the PN group. The improvement rate of skin roughness and pore volume was higher in the PN group than in the HA group. There was no significant difference in the improvement rate of dermal density between the two groups.<\/p>\n<cite><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/09546634.2020.1748857\">Ye Jin Lee, Hak Tae Kim, You Jin Lee, Seung Hwan Paik, Young Seon Moon, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Joon Min Jung, Chong Hyun Won. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. The Journal of dermatological treatment. 2022 Feb;33(1);254-260. doi: 10.1080\/09546634.2020.1748857.<\/a><\/cite><\/blockquote>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">When will Rejuran be effective under the eyes?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The effects of Rejuran will be difficult to feel after just one treatment. Repeated treatments will make it easier to feel the effects. The recommended number of treatments is three to four, spaced about three weeks apart.<\/p>\n\n\n\n<div style=\"height:29px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Duration of effect of Rejuran under the eyes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The effects of Rejuran on the under-eye area will essentially last for a year or more.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Injection stimulates fibroblasts to produce collagen, elastin, and hyaluronic acid on their own. Even the best treatment will be less effective if lifestyle habits and aftercare are neglected.<\/p>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">I recommend \"Rejuran i (Rejuran Eye)\" for under eyes.<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Rejuran has a formulation called \"Rejuran i\" suitable for under the eyes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There are four different formulations of Rejuran for different purposes, each with different amounts of ingredients, hardness, effectiveness, and degree of pain. The formulations called \"Rejuran (Healer)\" and \"Rejuran HB\" can be used for the entire face.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, if you are particularly concerned about the area around the eyes, we recommend that you choose Rejuran i, which is not as painful as Rejuran (Healer) and whose hardness and absorption rate are suitable for the eye area. Since it is soft and stretchy, a smooth and natural finish without discomfort can be expected even when injected into the thin skin around the eyes.<\/p>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/lizne\/\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"350\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc.png\" alt=\"Rizne Banner\" class=\"wp-image-5340\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc.png 1000w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-300x105.png 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-768x269.png 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-18x6.png 18w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">How to treat under eyes with Rejuran<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The flow of Rejuran treatment is as follows<\/p>\n\n\n\n<ul class=\"wp-block-list is-style-num_circle\">\n<li>Cleanse and wash face to clean the treatment area.<\/li>\n\n\n\n<li>Cooling and surface anesthesia to alleviate needle pain<\/li>\n\n\n\n<li>Injection while checking for pain<\/li>\n<\/ul>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">I recommend \"doctor's hand\" for rejuran under the eyes.<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">There are three treatment methods for Rejuran: (1) manual injection by a doctor, (2) water light injection, and (3) dermapen.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Manual injection by a physician\" is recommended for treating a narrow area under the eyes. Manual injection allows for fine adjustment of \"injection depth,\" \"injection volume,\" and \"injection density,\" and thus has the advantage of allowing for a more personalized approach for each patient. In this case, it is important to choose a clinic with a high level of skill. Check the results with case photos in advance.<\/p>\n\n\n\n<div style=\"height:36px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Downtime, side effects, and risks of Rejuran under the eyes<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Rejuran is a treatment with relatively few side effects and risks.<\/p>\n\n\n\n<div style=\"height:42px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Downtime of Rejuran under the eyes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Downtime for Rejuran is relatively mild, lasting only a few days.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pain and swelling will subside in a few days. If internal bleeding appears, it will take 10 to 14 days to disappear, but it can be covered with makeup such as foundation and concealer for daily life. Makeup can be applied after 24 hours.<\/p>\n\n\n\n<div style=\"height:38px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Risk of fish allergy.<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Since Rejuran uses ingredients extracted from salmon, people who are allergic to fish should be careful. The risk of allergic reactions to Rejuran also makes it inadvisable for them to undergo treatment.<\/p>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Pain during injection can be alleviated with anesthesia.<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Because Rejuran is an injectable treatment, it causes a prickling pain when the needle pricks the skin. Rejuran is said to be more painful than other injectable products. However, it is \"Rejuran (Healer)\" that is more painful, and the pain of \"Rejuran i\" is about the same as other injection treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cooling and surface anesthesia prior to the procedure will alleviate pain during injection.<\/p>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">If swelling and pain increase, infection is possible.<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Downtime symptoms of Rejuran will gradually subside over time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If it takes time for the pain and swelling to resolve, you may have an infection. Please contact the clinic immediately. If you have any other symptoms of concern, please consult the clinic.<\/p>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Maximize effectiveness with regular treatment intervals.<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Rejuran will be more effective with repeated treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Regardless of the area, the recommended number and frequency of treatments is 3 to 4 sessions, spaced about 3 weeks apart. After that, maintenance is recommended once every six months to a year.<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Difference from hyaluronic acid injections<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Hyaluronic acid injections are a treatment that physically increases volume. Although the effects can be felt immediately, the preparation is gradually absorbed into the body. In addition, hyaluronic acid suitable for the eye area is particularly easily absorbed, so the effect lasts only about six months.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On the other hand, Rejelan is a treatment that improves the patient's own skin through its own regenerative power. Although the effect is not immediate, it is gradual, and the natural look lasts longer.<\/p>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Go to Smart Skin Clinic for under eye rejurant.<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Have your questions been answered about Rejuran under the eyes?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rejelan is a formulation suitable for various problems around the eyes, such as wrinkles, sagging and dark circles under the eyes. In particular, Rejuran i is specially designed for the eye area and offers natural-looking results. When undergoing treatment, choose a clinic you can trust and have the procedure performed at appropriate intervals.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Smart Skin Clinic offers free consultations. If you suffer from dark circles, sagging skin under the eyes, or wrinkles, please feel free to contact us for a consultation.<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -external -noimg\" data-type=\"type3\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">[Official] Smart Skin Clinic&#8230;<\/span>\n\t\t\t\t\t\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/rejuran\/\" target=\"_blank\" rel=\"noopener noreferrer\">What Are Rejuran Injections (Salmon Injections)? | A Doctor Explains the Effects, Costs, and Number of Sessions | [Official] Smart Skin Clinic\u2026<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">Book online or reserve a free consultation here. For phone consultation &amp; booking, call 080-9683-3508. Rejuran Injection (also known as Salmon Injection) is a treatment in which a preparation containing an ingredient called polynucleotide (Rejuran&#8230;<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/lizne\/\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"350\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc.png\" alt=\"Rizne Banner\" class=\"wp-image-5340\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc.png 1000w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-300x105.png 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-768x269.png 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/01\/\u30ea\u30ba\u30cd\u30d0\u30ca\u30fc-18x6.png 18w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">In addition, our clinic has the following \"particulars\" in injections of Rejuran and other products.<\/p>\n\n\n\n<blockquote class=\"instagram-media\" data-instgrm-captioned data-instgrm-permalink=\"https:\/\/www.instagram.com\/p\/C1gskFoSzuV\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"14\" style=\" background:#FFF; border:0; border-radius:3px; box-shadow:0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width:540px; min-width:326px; padding:0; width:99.375%; width:-webkit-calc(100% - 2px); width:calc(100% - 2px);\"><div style=\"padding:16px;\"> <a href=\"https:\/\/www.instagram.com\/p\/C1gskFoSzuV\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" background:#FFFFFF; line-height:0; padding:0 0; text-align:center; text-decoration:none; width:100%;\" target=\"_blank\" rel=\"noopener\"> <div style=\" display: flex; flex-direction: row; align-items: center;\"> <div style=\"background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;\"><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;\"><\/div><\/div><\/div><div style=\"padding: 19% 0;\"><\/div> <div style=\"display:block; height:50px; margin:0 auto 12px; width:50px;\"><svg width=\"50px\" height=\"50px\" viewbox=\"0 0 60 60\" version=\"1.1\" xmlns=\"https:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"https:\/\/www.w3.org\/1999\/xlink\"><g stroke=\"none\" stroke-width=\"1\" fill=\"none\" fill-rule=\"evenodd\"><g transform=\"translate(-511.000000, -20.000000)\" fill=\"#000000\"><g><path d=\"M556.869,30.41 C554.814,30.41 553.148,32.076 553.148,34.131 C553.148,36.186 554.814,37.852 556.869,37.852 C558.924,37.852 560.59,36.186 560.59,34.131 C560.59,32.076 558.924,30.41 556.869,30.41 M541,60.657 C535.114,60.657 530.342,55.887 530.342,50 C530.342,44.114 535.114,39.342 541,39.342 C546.887,39.342 551.658,44.114 551.658,50 C551.658,55.887 546.887,60.657 541,60.657 M541,33.886 C532.1,33.886 524.886,41.1 524.886,50 C524.886,58.899 532.1,66.113 541,66.113 C549.9,66.113 557.115,58.899 557.115,50 C557.115,41.1 549.9,33.886 541,33.886 M565.378,62.101 C565.244,65.022 564.756,66.606 564.346,67.663 C563.803,69.06 563.154,70.057 562.106,71.106 C561.058,72.155 560.06,72.803 558.662,73.347 C557.607,73.757 556.021,74.244 553.102,74.378 C549.944,74.521 548.997,74.552 541,74.552 C533.003,74.552 532.056,74.521 528.898,74.378 C525.979,74.244 524.393,73.757 523.338,73.347 C521.94,72.803 520.942,72.155 519.894,71.106 C518.846,70.057 518.197,69.06 517.654,67.663 C517.244,66.606 516.755,65.022 516.623,62.101 C516.479,58.943 516.448,57.996 516.448,50 C516.448,42.003 516.479,41.056 516.623,37.899 C516.755,34.978 517.244,33.391 517.654,32.338 C518.197,30.938 518.846,29.942 519.894,28.894 C520.942,27.846 521.94,27.196 523.338,26.654 C524.393,26.244 525.979,25.756 528.898,25.623 C532.057,25.479 533.004,25.448 541,25.448 C548.997,25.448 549.943,25.479 553.102,25.623 C556.021,25.756 557.607,26.244 558.662,26.654 C560.06,27.196 561.058,27.846 562.106,28.894 C563.154,29.942 563.803,30.938 564.346,32.338 C564.756,33.391 565.244,34.978 565.378,37.899 C565.522,41.056 565.552,42.003 565.552,50 C565.552,57.996 565.522,58.943 565.378,62.101 M570.82,37.631 C570.674,34.438 570.167,32.258 569.425,30.349 C568.659,28.377 567.633,26.702 565.965,25.035 C564.297,23.368 562.623,22.342 560.652,21.575 C558.743,20.834 556.562,20.326 553.369,20.18 C550.169,20.033 549.148,20 541,20 C532.853,20 531.831,20.033 528.631,20.18 C525.438,20.326 523.257,20.834 521.349,21.575 C519.376,22.342 517.703,23.368 516.035,25.035 C514.368,26.702 513.342,28.377 512.574,30.349 C511.834,32.258 511.326,34.438 511.181,37.631 C511.035,40.831 511,41.851 511,50 C511,58.147 511.035,59.17 511.181,62.369 C511.326,65.562 511.834,67.743 512.574,69.651 C513.342,71.625 514.368,73.296 516.035,74.965 C517.703,76.634 519.376,77.658 521.349,78.425 C523.257,79.167 525.438,79.673 528.631,79.82 C531.831,79.965 532.853,80.001 541,80.001 C549.148,80.001 550.169,79.965 553.369,79.82 C556.562,79.673 558.743,79.167 560.652,78.425 C562.623,77.658 564.297,76.634 565.965,74.965 C567.633,73.296 568.659,71.625 569.425,69.651 C570.167,67.743 570.674,65.562 570.82,62.369 C570.966,59.17 571,58.147 571,50 C571,41.851 570.966,40.831 570.82,37.631\"><\/path><\/g><\/g><\/g><\/svg><\/div><div style=\"padding-top: 8px;\"> <div style=\" color:#3897f0; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:550; line-height:18px;\">View this post on Instagram<\/div><\/div><div style=\"padding: 12.5% 0;\"><\/div> <div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\"><div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div> <div style=\"background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div><\/div><div style=\"margin-left: 8px;\"> <div style=\" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div> <div style=\" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)\"><\/div><\/div><div style=\"margin-left: auto;\"> <div style=\" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div> <div style=\" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div> <div style=\" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div><\/div><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;\"><\/div><\/div><\/a><p style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; line-height:17px; margin-bottom:0; margin-top:8px; overflow:hidden; padding:8px 0 7px; text-align:center; text-overflow:ellipsis; white-space:nowrap;\"><a href=\"https:\/\/www.instagram.com\/p\/C1gskFoSzuV\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none;\" target=\"_blank\" rel=\"noopener\">A post shared by Smart Skin Clinic [Aesthetic Dermatology] Jimbocho Juvelook &amp; Profhilo &amp; Sunekos (@smartskin_clinic)<\/a><\/p><\/div><\/blockquote> <script async src=\"\/\/www.instagram.com\/embed.js\"><\/script>\n\n\n\n<div style=\"height:51px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Reference<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/09546634.2020.1748857\">Ye Jin Lee, Hak Tae Kim, You Jin Lee, Seung Hwan Paik, Young Seon Moon, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Joon Min Jung, Chong Hyun Won. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. The Journal of dermatological treatment. 2022 Feb;33(1);254-260. doi: 10.1080\/09546634.2020.1748857.<\/a><\/p>\n\n\n\n\n\n<p class=\"ssc-hublink-a wp-block-paragraph\">Guidelines and precautions for use around the eyes are as follows:<a href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/rejuran\/\">Our Clinic's Rejuran Injection Page<\/a>We provide information on this page.<\/p>\n\n\n\n<div class=\"wp-block-group ssc-eeat\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n\n<h2 class=\"wp-block-heading\">Physician Who Supervised This Page<\/h2>\n\n\n\n<div class=\"wp-block-media-text profile is-stacked-on-mobile\" style=\"grid-template-columns:28% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1280\" height=\"1920\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg\" alt=\"Kota Ishii, Chief Medical Director, Smart Skin Clinic\" class=\"wp-image-12584 size-full\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg 1280w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-200x300.jpg 200w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-768x1152.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-1024x1536.jpg 1024w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-8x12.jpg 8w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"u-mb-0 wp-block-paragraph\"><span class=\"swl-fz u-fz-s\"><strong>Smart Skin Clinic, Chief Medical Director \/ Physician<\/strong><\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\">Kota Ishii<\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.<\/p>\n\n\n\n<div class=\"swell-block-button is-style-btn_normal\"><a href=\"https:\/\/smartskin-clinic.com\/en\/concept\/\" class=\"swell-block-button__link\"><span>See the Philosophy of Our Doctors and Clinics<\/span><\/a><\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Interview with Director Kota Ishii<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"A number of repeat customers for skin growth injections: \u2049\ufe0fAttack on the handsome general director of a popular clinic: \ud83e\uddd1\u200d\u2695\ufe0f\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/u6cP6jPmfwU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n<\/div><\/div>\n\n\n\n\n\n<!-- ssc-schema:MedicalWebPage -->\n<script type=\"application\/ld+json\">{\n    \"@context\": \"https:\\\/\\\/schema.org\",\n    \"@type\": \"MedicalWebPage\",\n    \"url\": \"https:\\\/\\\/smartskin-clinic.com\\\/rejuran-effect-undertheeyes\\\/\",\n    \"reviewedBy\": {\n        \"@type\": \"Physician\",\n        \"name\": \"\\u77f3\\u4e95\\u6643\\u592a\",\n        \"jobTitle\": \"\\u7d71\\u62ec\\u9662\\u9577\",\n        \"url\": \"https:\\\/\\\/smartskin-clinic.com\\\/concept\\\/\",\n        \"worksFor\": {\n            \"@type\": \"MedicalBusiness\",\n            \"name\": \"\\u30b9\\u30de\\u30fc\\u30c8\\u30b9\\u30ad\\u30f3\\u30af\\u30ea\\u30cb\\u30c3\\u30af\",\n            \"url\": \"https:\\\/\\\/smartskin-clinic.com\"\n        }\n    },\n    \"publisher\": {\n        \"@type\": \"Organization\",\n        \"name\": \"\\u30b9\\u30de\\u30fc\\u30c8\\u30b9\\u30ad\\u30f3\\u30af\\u30ea\\u30cb\\u30c3\\u30af\",\n        \"url\": \"https:\\\/\\\/smartskin-clinic.com\"\n    },\n    \"about\": {\n        \"@type\": \"MedicalCondition\",\n        \"name\": \"\\u76ee\\u306e\\u4e0b\\u306e\\u30af\\u30de\\u30fb\\u5c0f\\u3058\\u308f\"\n    }\n}<\/script>","protected":false},"excerpt":{"rendered":"<p>\u300c\u30ea\u30b8\u30e5\u30e9\u30f3\u306f\u76ee\u306e\u4e0b\u306b\u52b9\u679c\u304c\u3042\u308b\uff1f\u300d\u300c\u30ea\u30b8\u30e5\u30e9\u30f3\u3092\u76ee\u306e\u4e0b\u306e\u30af\u30de\u306b\u671f\u5f85\u3067\u304d\u308b\u52b9\u679c\u306f\u3044\u3064\u304b\u3089\uff1f\u300d \u30ea\u30b8\u30e5\u30e9\u30f3\u306b\u3064\u3044 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"swell_btn_cv_data":"","footnotes":""},"categories":[6],"tags":[32,34,33],"class_list":["post-3029","post","type-post","status-publish","format-standard","hentry","category-column","tag-32","tag-34","tag-33"],"_links":{"self":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/posts\/3029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/comments?post=3029"}],"version-history":[{"count":25,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/posts\/3029\/revisions"}],"predecessor-version":[{"id":16160,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/posts\/3029\/revisions\/16160"}],"wp:attachment":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/media?parent=3029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/categories?post=3029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/tags?post=3029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}