{"id":6173,"date":"2024-09-29T13:31:31","date_gmt":"2024-09-29T04:31:31","guid":{"rendered":"https:\/\/smartskin-clinic.com\/?p=6173"},"modified":"2026-07-14T17:48:34","modified_gmt":"2026-07-14T08:48:34","slug":"innate-handswrinkles","status":"publish","type":"post","link":"https:\/\/smartskin-clinic.com\/en\/innate-handswrinkles\/","title":{"rendered":"Doctor's Commentary: For those who have a complex about their hands being \"born with many wrinkles\" - Suggestions on how to improve them."},"content":{"rendered":"<p class=\"wp-block-paragraph\">Some people are born with many wrinkles on their hands,<\/p>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><strong>'I've had dark wrinkles on my hands since I was a child, and I'm embarrassed when people look at them.'<br>I've tried hand creams and massages, but they just don't seem to work.\"<br>'If I was born with a lot of wrinkles on my hands, can they be faded with care?'<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Some of you may feel this way.<\/p>\n\n\n\n<div style=\"height:8px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Hello, I am a doctor at Smart Skin Clinic, an aesthetic dermatology clinic.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wrinkles generally begin to appear around the age of 30s or 40s, but if you are born with many wrinkles, you may feel complex about them and suffer from them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Just having wrinkles makes you look older than you actually are, especially if you are in your teens, twenties, or other young age group, and you want to \"do something about it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Small improvements that can be made to prevent further wrinkle growth as a way to reduce wrinkles<strong><span class=\"swl-marker mark_blue\">Self-Care.\"<\/span><\/strong>and improve the cause of wrinkles from the root.<strong><span class=\"swl-marker mark_blue\">Cosmetology.\"<\/span><\/strong>are available.<\/p>\n\n\n\n<div style=\"height:5px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In this article, a cosmetic dermatology clinic explains in simple terms the characteristics of people who are born with many wrinkles on their hands and how to improve them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you were born with many wrinkles on your hands, please refer to this page.<\/p>\n\n\n\n<!-- ======================================\n     \u76e3\u4fee\u8005\u60c5\u5831 \u2013 Smart Skin Clinic\n     Brand Colors: #ffffff #000000 #f5f5f5 #a3e3fc\n====================================== -->\n<section class=\"ssc-supervisor\">\n\n  <!-- \u76e3\u4fee\u8005\u60c5\u5831\u30bf\u30a4\u30c8\u30eb -->\n  <div class=\"ssc-supervisor-title-wrapper\">\n    <span class=\"ssc-supervisor-title\">Supervisor Information<\/span>\n  <\/div>\n\n  <div class=\"ssc-supervisor-inner\">\n\n    <!-- \u76e3\u4fee\u533b\u5e2b \u9854\u5199\u771f -->\n    <div class=\"ssc-supervisor-photo\">\n      <img decoding=\"async\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg\" alt=\"Kota Ishii, Chief Medical Director, Smart Skin Clinic Group\" loading=\"lazy\" \/>\n    <\/div>\n\n    <!-- \u30c6\u30ad\u30b9\u30c8\u60c5\u5831 -->\n    <div class=\"ssc-supervisor-text\">\n\n      <p class=\"ssc-supervisor-role\">Group Chief Director, Smart Skin Clinic Group<\/p>\n      <p class=\"ssc-supervisor-name translation-block\"><ruby>Ishii<rt>Ishii<\/rt><\/ruby> <ruby>Kota<rt>Kota<\/rt><\/ruby><\/p>\n\n      <div class=\"ssc-supervisor-block\">\n        <h4>Career<\/h4>\n        <p>Graduated from Juntendo University School of Medicine<\/p>\n        <p>Worked at Tokyo Women's Medical University Hospital and affiliated facilities<\/p>\n        <p>Worked at a major aesthetic clinic in Tokyo<\/p>\n      <\/div>\n\n      <div class=\"ssc-supervisor-block\">\n        <h4>Affiliations \/ Qualifications<\/h4>\n        <p>Board-certified specialist, Japan Surgical Society<\/p>\n        <p>Board-certified specialist, Japanese Society of Anti-Aging Medicine<\/p>\n      <\/div>\n\n    <\/div><!-- \/.text -->\n  <\/div><!-- \/.inner -->\n<\/section>\n\n<style>\n\/* =========================================================\n  Smart Skin Clinic \u2013 Supervisor Component (Monotone + Water)\n========================================================= *\/\n\n\/* \u25c7 \u30d1\u30ec\u30c3\u30c8 *\/\n:root{\n  --ssc-black:#000000;\n  --ssc-white:#ffffff;\n  --ssc-gray:#f5f5f5;\n  --ssc-water:#a3e3fc;   \/* \u30a2\u30af\u30bb\u30f3\u30c8\u6c34\u8272 *\/\n}\n\n\/* \u30bb\u30af\u30b7\u30e7\u30f3 *\/\n.ssc-supervisor{\n  background:var(--ssc-gray);\n  padding:40px 5%;\n  border:1px solid #e0e0e0;\n  border-radius:8px;\n  margin:40px 0;\n  color:var(--ssc-black);\n  font-family:\"Noto Sans JP\",\"Hiragino Sans\",\"Helvetica Neue\",Arial,sans-serif;\n}\n\n\/* \u30bf\u30a4\u30c8\u30eb *\/\n.ssc-supervisor-title-wrapper {\n  font-size: 1.5rem;\n  font-weight: 700;\n  margin: 0 0 24px;\n  display: flex;\n  align-items: flex-end;\n  gap: 8px;\n  color: var(--ssc-black);\n}\n\n.ssc-supervisor-title {\n  font-size: 1.5rem;\n  font-weight: 700;\n  color: var(--ssc-black); \/* \u6587\u5b57\u8272\u3092\u9ed2\u306b *\/\n}\n\n\/* \u30ec\u30a4\u30a2\u30a6\u30c8 *\/\n.ssc-supervisor-inner{\n  display:flex;\n  gap:28px;\n  flex-wrap:wrap;\n}\n\n\/* \u30c6\u30ad\u30b9\u30c8 *\/\n.ssc-supervisor-text{\n  flex:1 1 260px;\n  min-width:260px;\n}\n.ssc-supervisor-role{\n  font-size:0.9rem;\n  color:var(--ssc-black);  \/* \u9ed2\u6587\u5b57\u306b\u4fee\u6b63 *\/\n  margin:0 0 4px;\n}\n.ssc-supervisor-name{\n  font-size:1.25rem;\n  font-weight:700;\n  margin:0 0 16px;\n  background-color:transparent;  \/* \u80cc\u666f\u306e\u8272\u3092\u900f\u660e\u306b\u8a2d\u5b9a *\/\n  color:var(--ssc-black); \/* \u6587\u5b57\u8272\u3092\u9ed2\u306b *\/\n}\n\n\/* \u30d6\u30ed\u30c3\u30af *\/\n.ssc-supervisor-block{\n  margin-bottom:18px;\n}\n.ssc-supervisor-block h4{\n  font-size:1rem;\n  font-weight:600;\n  margin:0 0 6px;\n  color:var(--ssc-black);\n  border-left:4px solid var(--ssc-water);\n  padding-left:8px;\n}\n\n\/* \u30c6\u30ad\u30b9\u30c8\u8868\u793a\u306e\u5909\u66f4\uff08\u7b87\u6761\u66f8\u304d\u306f\u4f7f\u7528\u305b\u305a\u3001\u30b7\u30f3\u30d7\u30eb\u306b\u8868\u793a\uff09 *\/\n.ssc-supervisor-block p{\n  font-size:1rem;\n  margin: 0 0 10px;\n  color: var(--ssc-black);\n  line-height: 1.6;\n}\n\n\/* \u76e3\u4fee\u533b\u5e2b \u9854\u5199\u771f *\/\n.ssc-supervisor-photo{\n  flex:0 0 190px;\n  max-width:190px;\n}\n.ssc-supervisor-photo img{\n  width:100%;\n  height:auto;\n  display:block;\n  border-radius:8px;\n}\n\n\/* \u30b9\u30de\u30db *\/\n@media(max-width:600px){\n  .ssc-supervisor-inner{\n    flex-direction:column;\n    gap:20px;\n  }\n  .ssc-supervisor-photo{\n    flex:0 0 auto;\n    max-width:150px;\n    margin:0 auto;\n  }\n}\n<\/style>\n\n\n\n<h2 class=\"wp-block-heading\">Why are we born with so many wrinkles in our hands?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The age at which wrinkles begin to appear varies from person to person, but it is often said that the elasticity and firmness of the skin gradually begins to decline and wrinkles become more noticeable. So what are the differences between people who are born with wrinkles?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>The following three are the main differences<\/p>\n\n\n\n<ol class=\"wp-block-list is-style-index\">\n<li>genetic factor<\/li>\n\n\n\n<li>Dryness<\/li>\n\n\n\n<li>Nutritionally imbalanced diets<\/li>\n<\/ol>\n\n\n\n<div style=\"height:6px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">We will explain each of them.<\/p>\n\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:47px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\">(1) Genetic factors<\/span><\/strong><br>If the skin is naturally thin, it is considered a type of skin that is more prone to wrinkles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Skin thickness is determined by the components in the dermis layer that control skin elasticity, such as collagen and elastin. Generally, these components decrease with age, causing the skin to become thinner, but people born with thin skin may be born with fewer of these components.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There are several points to consider in determining skin thickness.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group has-border -border04\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline;\"><span class=\"swl-fz u-fz-l\">feeling of having one's skin pinched<\/span><\/span><br>You can lightly pinch the skin to see if it feels thinner or thicker. Thin skin tends to feel soft and thin.<\/li>\n\n\n\n<li><span style=\"text-decoration: underline;\"><span class=\"swl-fz u-fz-l\">Ease of scarring and redness<\/span><\/span><br>Thin skin is more sensitive to irritation and tends to redden easily with light scratching or friction. Conversely, thicker skin is more resistant to irritation and less likely to show redness and scarring.<\/li>\n\n\n\n<li><span style=\"text-decoration: underline;\"><span class=\"swl-fz u-fz-l\">Visibility of blood vessels<\/span><\/span><br>Thin skin is characterized by easily visible blood vessels, especially on the back of the hands, neck, and around the eyes.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:11px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Through these sensations and observations, it is possible to determine if one's skin is thin.<\/p>\n\n\n\n<div style=\"height:91px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\">(2) Dryness<\/span><\/strong><br>Dry skin is a factor that increases wrinkles regardless of age. So, if you are born with a skin type that is prone to dryness, you are more likely to develop wrinkles from a young age.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The back of the hands, in particular, have no sebaceous glands and are easily exposed to irritation, making them prone to dryness if not moisturized enough.<\/p>\n\n\n\n<div style=\"height:101px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\">(iii) Eating habits with imbalanced nutritional balance<\/span><\/strong><br>An unbalanced diet can affect wrinkle formation. This is because a lack of nutrients necessary for the production of collagen, elastin, and other components that support skin elasticity and firmness prevents these components from being adequately produced. Specifically, these include protein, vitamin C, and zinc.<\/p>\n\n\n\n<div style=\"height:4px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list is-style-check_list\">\n<li>Excessive dieting<\/li>\n\n\n\n<li>A carbohydrate-centered diet<\/li>\n\n\n\n<li>Frequent consumption of fast food and instant meals<\/li>\n<\/ul>\n\n\n\n<div style=\"height:4px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Let's look back and see if we are eating like this.<\/p>\n\n\n\n<div style=\"height:117px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">How can I improve wrinkles on my hands that I was born with?<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">There are several ways.<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">To improve wrinkles on the hands, it is first important to find the right care for your lifestyle and skin type.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There are several ways to improve wrinkles in the hands, listed below.<\/p>\n\n\n\n<div class=\"wp-block-group has-border -border04\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<ul class=\"wp-block-list is-style-check_list\">\n<li>Moisturizing Care<\/li>\n\n\n\n<li>UV protection<\/li>\n\n\n\n<li>Reviewing your dietary habits<\/li>\n\n\n\n<li>Review of self-treatment methods for unwanted hair<\/li>\n\n\n\n<li>Massage and stretching<\/li>\n\n\n\n<li>Cosmetic medicine, etc.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:8px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In this issue, we will discuss two of these in detail: \"review of self-care\" as a small improvement and \"cosmetic medicine\" as a fundamental solution.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Change the way you do small improvements \"self-care\".<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Daily self-care is important in terms of improving and preventing wrinkles on the hands. Particularly, continuing proper care from a young age can help prevent the progression of wrinkles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is generally said,<strong><span class=\"swl-marker mark_blue\">Moisturizer.\"<\/span><\/strong>and<strong><span class=\"swl-marker mark_blue\">UV protection.\"<\/span><\/strong>is especially important for self-care.<\/p>\n\n\n\n<div style=\"height:27px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\"><span style=\"text-decoration: underline;\">1. Thorough moisturizing care<\/span><\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The back of the hand is an area that tends to dry out easily, so it is important to moisturize frequently. Choose a moisturizing cream containing hyaluronic acid or ceramide and apply it thoroughly before going out or after washing hands. In addition, do not leave your hands wet, and if you work with water, make sure to wear gloves, and take care to both moisturize and keep hands dry at the same time.<\/p>\n\n\n\n<div style=\"height:75px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\"><span style=\"text-decoration: underline;\">2. take measures to protect against ultraviolet rays<\/span><\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hands are exposed to the same UV rays as the face. UV rays reach deep into the skin and destroy collagen and elastin (photoaging). As the skin loses elasticity due to UV rays, it becomes thinner and more prone to wrinkles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">UV protection, such as wearing sunscreen and using UV-protective gloves on a daily basis, will help prevent wrinkles.<\/p>\n\n\n\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Although not covered here, it is also important to actively consume foods containing protein, vitamins C and E, and zinc, to review a well-balanced diet, and to maintain a regular lifestyle that does not cause lack of sleep or stress.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Also, review the method of self-treatment of unwanted hair. This is because self-treatment methods such as razors and waxes may cause strong friction and irritation and weaken the skin's barrier function.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Treatment by \"cosmetic medicine\" to improve the root of the problem<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">I mentioned the innate thinness of the skin as a characteristic of people who are born with many wrinkles on their hands.<br>The thickness and thinness of the skin depends on the components of collagen and elastin in the dermis layer of the skin, and there are procedures in cosmetic medicine that can be expected to increase this collagen and elastin.<br>Such procedures are ECM preparations and PRP injections. These procedures are an approach to growing the skin in the area of concern from the inside out.<\/p>\n\n\n\n<div style=\"height:148px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">How cosmetic medicine improves wrinkles in hands that were born with them<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">ECM formulations and PRP injections are recommended for people who are born with many wrinkles on their hands. These procedures take the approach of nurturing the skin from the inside out, and are sometimes referred to on social networking sites as \"skin growth treatments\" that prepare the skin from the foundation.<\/p>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">What is ECM formulation?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">ECM preparations are cosmetic treatments that primarily use non-cross-linked hyaluronic acid to regenerate and rejuvenate the skin. Specific preparations that can be injected into the back of the hand include,<strong><span class=\"swl-marker mark_blue\">Profhilo,\" \"Sunekos,\" and \"Jalupro Classic.\"<\/span><\/strong>and more.<\/p>\n\n\n\n<div style=\"height:4px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Non-cross-linked hyaluronic acid can be described as hyaluronic acid with spreadable properties, allowing the moisturizing and cell activating effects of hyaluronic acid to spread to every corner of the skin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The reason why ECM formulations are referred to as \"skin growth therapy\" or \"skin regeneration and rejuvenation\" that adjusts the skin from its foundation is that they are expected to increase collagen and elastin in the dermal layer. The increase in these components is expected to restore elasticity to the skin, making it firmer, fresher, and plumper.<\/p>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><strong><span style=\"text-decoration: underline;\"><span class=\"swl-fz u-fz-l\">Specific effects of ECM formulations<\/span><\/span><\/strong><\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl\"><div class=\"cap_box_ttl\"><span><span class=\"swl-fz u-fz-xl\">Moisturizing effect<\/span><\/span><\/div><div class=\"cap_box_content\">\n<p class=\"wp-block-paragraph\">Hyaluronic acid has the property of attracting and holding large amounts of water.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hyaluronic acid delivered to every corner of the skin will moisturize and soften the skin from deep within, while at the same time attracting more moisture and volume. Moisturized, resilient, and elastic skin reduces the appearance of wrinkles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The return of elasticity to the skin also reduces the likelihood of wrinkles settling due to the repetitive motions of the hands.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl\"><div class=\"cap_box_ttl\"><span><span class=\"swl-fz u-fz-xl\">Cell activation effect<\/span><\/span><\/div><div class=\"cap_box_content\">\n<div class=\"wp-block-group is-stack is-vertical is-layout-flex wp-container-core-group-is-layout-4fc3f8e1 wp-block-group-is-layout-flex\">\n<div class=\"wp-block-group is-stack\"><div class=\"wp-block-group is-stack__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group is-stack is-row is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<p class=\"wp-block-paragraph\">Hyaluronic acid has the property of activating cells.<br>The dermis layer is also responsible for skin firmness and elasticity, and is composed of collagen, elastin, hyaluronic acid, and fibroblasts.<br><br>The cell-activating effect of hyaluronic acid also works to activate the fibroblasts themselves, which produce the constituent components and the components in the first place, so that the dermal layer, which is the foundation of the skin, can be expected to become more complete and the dermis layer, the foundation of the skin, can be expected to become more organized.<\/p>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group is-stack\"><div class=\"wp-block-group is-stack__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/12\/\u771f\u76ae\u306e\u65ad\u9762\u56f3.png\" alt=\"Cross-sectional view of skin\" class=\"wp-image-2717\"\/><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Incidentally,<strong><span class=\"swl-marker mark_blue\">Hyaluronic acid acts on cells in the dermal layer in this way to restore skin firmness and elasticity, which is called ECM remodeling.<\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are born with many wrinkles, the original thinness of the skin may be the cause. For such individuals, ECM formulations can be an effective means.<\/p>\n\n\n\n<div style=\"height:124px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Profhilo<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Profhilo is a formulation containing two types of non-cross-linked hyaluronic acid (high molecular weight and low molecular weight) in high concentrations, and its major characteristic is its \"ability to penetrate deeply and widely in multiple directions. Compared to other non-cross-linked hyaluronic acids, its penetration is extremely high, and it is believed to be able to deliver its effects to the deeper layers of the skin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This penetration allows hyaluronic acid to penetrate well into the subcutaneous tissue for plump, supple skin. Profhilo is expected to maintain the healthy appearance of the skin by promoting rejuvenation from within, rather than merely moisturizing the surface.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To learn more about Profhilo, click here.<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -external -noimg\" data-type=\"type3\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">[Official] Smart Skin Clinic&#8230;<\/span>\n\t\t\t\t\t\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/profhilo\/\" target=\"_blank\" rel=\"noopener noreferrer\">What Is Profhilo? | A Doctor Explains the Effects, Costs, and Downtime | [Official] Smart Skin Clinic Group<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">Profhilo is an injectable treatment that promotes skin firmness and elasticity. At Smart Skin Clinic, our doctors tailor their recommendations to each patient\u2019s skin condition, and treatments are available in Tokyo (Jimbocho and Hatchobori), Yokohama, and Omiya. Fees\u2026<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n<div style=\"height:112px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Sunekos<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Sunekos is a formulation composed mainly of low molecular weight non-cross-linked hyaluronic acid and six amino acids. It is widely used, especially in procedures aimed at improving skin elasticity and firmness, and is often applied over a wide area, such as the entire face and neck.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sunekos is offered at a relatively low price point among ECM formulations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To learn more about Sunekos, click here.<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -external -noimg\" data-type=\"type3\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">[Official] Smart Skin Clinic&#8230;<\/span>\n\t\t\t\t\t\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/sunekos\/?__lt__cid=b885de58-c509-4ff4-98ad-fc066491dfd6\" target=\"_blank\" rel=\"noopener noreferrer\">What Is a Sunekos Injection? | A Doctor Explains the Effects, Cost, and Downtime | [Official] Smart Skin Clinic Group<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">Sunekos is an injectable treatment that replenishes ingredients that support skin firmness and elasticity, offering the potential to improve skin texture itself. The doctors at Smart Skin Clinic will recommend a treatment plan tailored to each patient\u2019s skin condition. Tokyo (Kami\u2026<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n<div style=\"height:103px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Jalupro Classic<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Jalupro Classic is a formulation containing low molecular weight non-cross-linked hyaluronic acid and four types of amino acids as its main ingredients. It is primarily expected to promote collagen production and improve skin texture. It is also suitable for anti-aging treatments, such as reducing the appearance of fine lines and wrinkles, as well as improving skin firmness and elasticity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To learn more about the Jalupro Classic, click here.<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -external -noimg\" data-type=\"type3\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">[Official] Smart Skin Clinic&#8230;<\/span>\n\t\t\t\t\t\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/smartskin-clinic.com\/en\/menu\/jalupro-classic\/\" target=\"_blank\" rel=\"noopener noreferrer\">What Is Jalupro Classic? | A Doctor Explains the Effects, Costs, and Downtime | [Official] Smart Skin Clinic...<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">Click here to book online or schedule a free consultation. Click here for phone consultation &amp; booking: 050-1720-6230. \"I'm curious about Jalupro Classic, but what kind of treatment is it?\" \"What's the price of Jalupro Classic?&#8230;<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n<div style=\"height:112px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">What is the difference between Sunekos and Jalupro Classic?<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Both Sunekos and Jalupro Classic are formulations containing low molecular weight non-cross-linked hyaluronic acid and amino acids. Amino acids act as materials necessary for the synthesis of collagen and elastin, and have the effect of activating cells inside the skin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Both formulations are expected to improve skin elasticity and firmness, but each has different ingredients.<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl2\"><div class=\"cap_box_ttl\"><span><span class=\"swl-fz u-fz-l\">Sunekos<\/span><\/span><\/div><div class=\"cap_box_content\">\n<p class=\"wp-block-paragraph\">Ingredients: Low molecular weight non-cross-linked hyaluronic acid and 6 amino acids (glycine, L-proline, L-lysine, L-alanine, L-valine, L-leucine)<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl2\"><div class=\"cap_box_ttl\"><span><span class=\"swl-fz u-fz-l\">Jalupro Classic<\/span><\/span><\/div><div class=\"cap_box_content\">\n<p class=\"wp-block-paragraph\">Ingredients: Low molecular weight non-cross-linked hyaluronic acid and 4 amino acids (glycine, L-proline, L-lysine, L-leucine).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It features a different ratio of amino acids than Sunekos.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:9px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Both formulations have similar ingredients and claim to be effective in \"improving firmness and elasticity\" and \"reducing fine wrinkles. In particular, they are expected to improve skin texture and restore skin elasticity, but there is no conclusive data on which is superior, and it is important to choose the right one for your skin condition and individual needs.<\/p>\n\n\n\n<div style=\"height:104px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">PRP injection<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">PRP injections are a type of regenerative medicine that utilizes growth factors extracted from autologous blood; they are different from ECM preparations, but share a commonality in that they promote skin regeneration and repair.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In PRP injections, the patient's own blood is first collected by blood sampling, and from the collected blood, platelet-rich plasma (PRP) is extracted. The PRP is then mixed with fibroblast growth factor (FGF) to create an original preparation, which is injected into the back of the hand or other parts of the body.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FGF is a type of growth factor (growth factor) that aids cell growth and tissue regeneration. When it works deep into the skin and promotes the production of collagen and elastin, the skin on the back of the hands looks healthier and wrinkles are expected to be less noticeable.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While ECM preparations activate fibroblasts through hyaluronic acid, PRP injections activate fibroblasts through growth factors (especially FGF).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition, PRP injections are particularly safe as a natural regenerative medicine because they use autologous blood and can be applied to the skin of the face and neck as well as the back of the hands.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Please refer to the table below for a summary so that the four treatments can be compared.<\/p>\n\n\n\n<figure class=\"wp-block-table is-all-centered\"><table class=\"has-fixed-layout\"><tbody><tr><td>&nbsp;<\/td><td>Profhilo<\/td><td>Sunekos<\/td><td>Jalupro<br>Classic<\/td><td>PRP injection<\/td><\/tr><tr><td>Hyaluronic acid<br>Molecular weight<\/td><td>Polymer Low Molecular<\/td><td>Low molecular weight<\/td><td>Low molecular weight<\/td><td>-<\/td><\/tr><tr><td>Amino acids<\/td><td>-<\/td><td>6 types<\/td><td>4 types<\/td><td>&nbsp;<\/td><\/tr><tr><td>Other<\/td><td>-<\/td><td>-<\/td><td>-<\/td><td>Growth factors<\/td><\/tr><tr><td>Price<\/td><td>60,000&#8211;160,000 yen<\/td><td>30,000&#8211;60,000 yen<\/td><td>40,000&#8211;90,000 yen<\/td><td>140,000&#8211;500,000 yen<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">Comparison of 4 treatments<\/figcaption><\/figure>\n\n\n\n<div style=\"height:93px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">If you want to improve wrinkles on your hands that you were born with, go to Smart Skin Clinic.<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">We have discussed the skin characteristics of people who are born with wrinkled hands and how to improve wrinkles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hands are parts that are often seen by people, so if you have many wrinkles, you may feel embarrassed. In addition, you may feel that living your life with your hands hidden makes you feel self-conscious and unsure of yourself.<\/p>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">The quickest way to improve wrinkles on the hands may be to prevent them through self-care while relying on cosmetic medicine to correct them at the root of the problem.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Once you have undergone the treatment, you will notice the changes.<\/p>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Smart Skin Clinic has a large number of cases of ECM products, and one and the same doctor consistently performs counseling, treatment, and aftercare.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We offer free counseling, so please talk to us at the clinic first.<\/p>\n\n\n\n<div class=\"wp-block-group ssc-eeat\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n\n<h2 class=\"wp-block-heading\">Physician Who Supervised This Page<\/h2>\n\n\n\n<div class=\"wp-block-media-text profile is-stacked-on-mobile\" style=\"grid-template-columns:28% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1280\" height=\"1920\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg\" alt=\"Kota Ishii, Chief Medical Director, Smart Skin Clinic\" class=\"wp-image-12584 size-full\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg 1280w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-200x300.jpg 200w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-768x1152.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-1024x1536.jpg 1024w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-8x12.jpg 8w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"u-mb-0 wp-block-paragraph\"><span class=\"swl-fz u-fz-s\"><strong>Smart Skin Clinic, Chief Medical Director \/ Physician<\/strong><\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\">Kota Ishii<\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.<\/p>\n\n\n\n<div class=\"swell-block-button is-style-btn_normal\"><a href=\"https:\/\/smartskin-clinic.com\/en\/concept\/\" class=\"swell-block-button__link\"><span>See the Philosophy of Our Doctors and Clinics<\/span><\/a><\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Interview with Director Kota Ishii<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"A number of repeat customers for skin growth injections: \u2049\ufe0fAttack on the handsome general director of a popular clinic: \ud83e\uddd1\u200d\u2695\ufe0f\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/u6cP6jPmfwU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n<\/div><\/div>\n\n\n\n\n\n<!-- ssc-schema:MedicalWebPage -->\n<script type=\"application\/ld+json\">{\n    \"@context\": \"https:\\\/\\\/schema.org\",\n    \"@type\": \"MedicalWebPage\",\n    \"url\": \"https:\\\/\\\/smartskin-clinic.com\\\/innate-handswrinkles\\\/\",\n    \"reviewedBy\": {\n        \"@type\": \"Physician\",\n        \"name\": \"\\u77f3\\u4e95\\u6643\\u592a\",\n        \"jobTitle\": \"\\u7d71\\u62ec\\u9662\\u9577\",\n        \"url\": \"https:\\\/\\\/smartskin-clinic.com\\\/concept\\\/\",\n        \"worksFor\": {\n            \"@type\": \"MedicalBusiness\",\n            \"name\": \"\\u30b9\\u30de\\u30fc\\u30c8\\u30b9\\u30ad\\u30f3\\u30af\\u30ea\\u30cb\\u30c3\\u30af\",\n            \"url\": \"https:\\\/\\\/smartskin-clinic.com\"\n        }\n    },\n    \"publisher\": {\n        \"@type\": \"Organization\",\n        \"name\": \"\\u30b9\\u30de\\u30fc\\u30c8\\u30b9\\u30ad\\u30f3\\u30af\\u30ea\\u30cb\\u30c3\\u30af\",\n        \"url\": \"https:\\\/\\\/smartskin-clinic.com\"\n    },\n    \"about\": {\n        \"@type\": \"MedicalCondition\",\n        \"name\": \"\\u624b\\u306e\\u3057\\u308f\"\n    }\n}<\/script>\n\n\n\n<div class=\"wp-block-group ssc-related-tx\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n\n<h3 class=\"wp-block-heading\">Treatments Related to This Article<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li><a href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/profhilo\/\">Profhilo<\/a><\/li>\n\n\n<li><a href=\"https:\/\/smartskin-clinic.com\/en\/menu\/injection-infusion\/sunekos\/\">SUNEKOS injection<\/a><\/li>\n\n<\/ul>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u751f\u307e\u308c\u3064\u304d\u624b\u306b\u30b7\u30ef\u304c\u591a\u304f\u3066\u60a9\u3093\u3067\u3044\u308b\u65b9\u306e\u4e2d\u306b\u306f\u3001 \u300c\u5b50\u3069\u3082\u306e\u9803\u304b\u3089\u624b\u306e\u30b7\u30ef\u304c\u6fc3\u304f\u3066\u4eba\u306b\u898b\u3089\u308c\u308b\u306e\u304c\u6065\u305a\u304b\u3057\u3044\u300d [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"swell_btn_cv_data":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-6173","post","type-post","status-publish","format-standard","hentry","category-column"],"_links":{"self":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/posts\/6173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/comments?post=6173"}],"version-history":[{"count":6,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/posts\/6173\/revisions"}],"predecessor-version":[{"id":15547,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/posts\/6173\/revisions\/15547"}],"wp:attachment":[{"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/media?parent=6173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/categories?post=6173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/smartskin-clinic.com\/en\/wp-json\/wp\/v2\/tags?post=6173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}