{"id":3462,"date":"2024-02-18T00:41:52","date_gmt":"2024-02-17T15:41:52","guid":{"rendered":"https:\/\/smartskin-clinic.com\/?page_id=3462"},"modified":"2026-10-07T11:22:17","modified_gmt":"2026-10-07T02:22:17","slug":"exosoma-spray-nasal","status":"publish","type":"page","link":"https:\/\/smartskin-clinic.com\/es\/menu\/exosome-nasalspray\/","title":{"rendered":"Terapia de goteo nasal con exosomas"},"content":{"rendered":"<div class=\"swell-block-fullWide pc-py-0 sp-py-0 alignfull\" style=\"background-color:#f7f7f7\"><div class=\"swell-block-fullWide__inner\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"614\" height=\"1024\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/11\/\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u85ac\u30a2\u30a4\u30ad\u30e3\u30c3\u30c1-6747dab683b0b-614x1024.jpg\" alt=\"Gotas nasales Exosome Eye Catch.\" class=\"wp-image-6730\" style=\"width:480px\" srcset=\"\" sizes=\"auto, (max-width: 614px) 100vw, 614px\" data-srcset=\"\" \/><\/figure>\n<\/div><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><span class=\"swl-fz u-fz-s\"><span style=\"color:#777777\" class=\"swl-inline-color\">*El precio de la primera vez se aplica a quienes adquieren este producto por primera vez en nuestra cl\u00ednica.<\/span><\/span><\/p>\n\n\n\n<div class=\"swell-block-button blue_ -size-l is-style-btn_solid\"><a href=\"https:\/\/smartskin-clinic.com\/es\/reserva-exosome-nasalspray\/\" class=\"swell-block-button__link\"><span>Reserve en l\u00ednea o solicite una consulta gratuita aqu\u00ed<\/span><\/a><\/div>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container\">\n<p class=\"wp-block-paragraph\"><strong>\u00abConozco el goteo IV de exosomas, pero \u00bfqu\u00e9 es el spray nasal? \u00bfEn qu\u00e9 se diferencian?\u00bb<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00abMe gustar\u00eda recibir el spray nasal de exosomas, pero no s\u00e9 por qu\u00e9 cl\u00ednica decidirme\u00bb.<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u00bfTiene usted alguna de estas dudas o preocupaciones?<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Los exosomas son un tratamiento antienvejecimiento muy conocido, y existen diversas formas de administraci\u00f3n, como las infusiones intravenosas o las inyecciones faciales. Entre ellas, nuestra cl\u00ednica de dermatolog\u00eda est\u00e9tica, <strong><span class=\"swl-marker mark_blue\">centro acreditado por el Ministerio de Salud, Trabajo y Bienestar en el Plan de Prestaci\u00f3n de Medicina Regenerativa<\/span><\/strong>, le ofrece una explicaci\u00f3n clara y desde un punto de vista especializado sobre el m\u00e9todo de \"administraci\u00f3n nasal\". <br><span class=\"swl-fz u-fz-s\">(\u203bN\u00famero de acreditaci\u00f3n del Plan de Prestaci\u00f3n de Medicina Regenerativa, Tipos II y III: NA8230001)<\/span><br><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">*Si est\u00e1 comparando cl\u00ednicas y le preocupa el precio, puede ahorrar tiempo accediendo directamente desde el \u00edndice que figura a continuaci\u00f3n.<\/p>\n\n\n\n<!-- ======================================\n     \u76e3\u4fee\u8005\u60c5\u5831 \u2013 Smart Skin Clinic\n     Brand Colors: #ffffff #000000 #f5f5f5 #a3e3fc\n====================================== -->\n<section class=\"ssc-supervisor\">\n\n  <!-- \u76e3\u4fee\u8005\u60c5\u5831\u30bf\u30a4\u30c8\u30eb -->\n  <div class=\"ssc-supervisor-title-wrapper\">\n    <span class=\"ssc-supervisor-title\">Informaci\u00f3n del supervisor<\/span>\n  <\/div>\n\n  <div class=\"ssc-supervisor-inner\">\n\n    <!-- \u76e3\u4fee\u533b\u5e2b \u9854\u5199\u771f -->\n    <div class=\"ssc-supervisor-photo\">\n      <img decoding=\"async\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg\" alt=\"Kota Ishii, director general del Grupo Smart Skin Clinic\" loading=\"lazy\" \/>\n    <\/div>\n\n    <!-- \u30c6\u30ad\u30b9\u30c8\u60c5\u5831 -->\n    <div class=\"ssc-supervisor-text\">\n\n      <p class=\"ssc-supervisor-role\">Director m\u00e9dico general del Grupo Smart Skin Clinic<\/p>\n      <p class=\"ssc-supervisor-name translation-block\">Kota Ishii<\/p>\n\n      <div class=\"ssc-supervisor-block\">\n        <h4>Trayectoria<\/h4>\n        <p>Licenciado por la Facultad de Medicina de la Universidad de Juntendo<\/p>\n        <p>Trabaj\u00f3 en el Hospital de la Universidad M\u00e9dica de Mujeres de Tokio y centros afiliados<\/p>\n        <p>Trabaj\u00f3 en una importante cl\u00ednica est\u00e9tica de Tokio<\/p>\n      <\/div>\n\n      <div class=\"ssc-supervisor-block\">\n        <h4>Afiliaciones \/ Titulaciones<\/h4>\n        <p>Especialista de la Sociedad Japonesa de Cirug\u00eda<\/p>\n        <p>Especialista de la Sociedad Japonesa de Medicina Antienvejecimiento<\/p>\n      <\/div>\n\n    <\/div><!-- \/.text -->\n  <\/div><!-- \/.inner -->\n<\/section>\n\n<style>\n\/* =========================================================\n  Smart Skin Clinic \u2013 Supervisor Component (Monotone + Water)\n========================================================= *\/\n\n\/* \u25c7 \u30d1\u30ec\u30c3\u30c8 *\/\n:root{\n  --ssc-black:#000000;\n  --ssc-white:#ffffff;\n  --ssc-gray:#f5f5f5;\n  --ssc-water:#a3e3fc;   \/* \u30a2\u30af\u30bb\u30f3\u30c8\u6c34\u8272 *\/\n}\n\n\/* \u30bb\u30af\u30b7\u30e7\u30f3 *\/\n.ssc-supervisor{\n  background:var(--ssc-gray);\n  padding:40px 5%;\n  border:1px solid #e0e0e0;\n  border-radius:8px;\n  margin:40px 0;\n  color:var(--ssc-black);\n  font-family:\"Noto Sans JP\",\"Hiragino Sans\",\"Helvetica Neue\",Arial,sans-serif;\n}\n\n\/* \u30bf\u30a4\u30c8\u30eb *\/\n.ssc-supervisor-title-wrapper {\n  font-size: 1.5rem;\n  font-weight: 700;\n  margin: 0 0 24px;\n  display: flex;\n  align-items: flex-end;\n  gap: 8px;\n  color: var(--ssc-black);\n}\n\n.ssc-supervisor-title {\n  font-size: 1.5rem;\n  font-weight: 700;\n  color: var(--ssc-black); \/* \u6587\u5b57\u8272\u3092\u9ed2\u306b *\/\n}\n\n\/* \u30ec\u30a4\u30a2\u30a6\u30c8 *\/\n.ssc-supervisor-inner{\n  display:flex;\n  gap:28px;\n  flex-wrap:wrap;\n}\n\n\/* \u30c6\u30ad\u30b9\u30c8 *\/\n.ssc-supervisor-text{\n  flex:1 1 260px;\n  min-width:260px;\n}\n.ssc-supervisor-role{\n  font-size:0.9rem;\n  color:var(--ssc-black);  \/* \u9ed2\u6587\u5b57\u306b\u4fee\u6b63 *\/\n  margin:0 0 4px;\n}\n.ssc-supervisor-name{\n  font-size:1.25rem;\n  font-weight:700;\n  margin:0 0 16px;\n  background-color:transparent;  \/* \u80cc\u666f\u306e\u8272\u3092\u900f\u660e\u306b\u8a2d\u5b9a *\/\n  color:var(--ssc-black); \/* \u6587\u5b57\u8272\u3092\u9ed2\u306b *\/\n}\n\n\/* \u30d6\u30ed\u30c3\u30af *\/\n.ssc-supervisor-block{\n  margin-bottom:18px;\n}\n.ssc-supervisor-block h4{\n  font-size:1rem;\n  font-weight:600;\n  margin:0 0 6px;\n  color:var(--ssc-black);\n  border-left:4px solid var(--ssc-water);\n  padding-left:8px;\n}\n\n\/* \u30c6\u30ad\u30b9\u30c8\u8868\u793a\u306e\u5909\u66f4\uff08\u7b87\u6761\u66f8\u304d\u306f\u4f7f\u7528\u305b\u305a\u3001\u30b7\u30f3\u30d7\u30eb\u306b\u8868\u793a\uff09 *\/\n.ssc-supervisor-block p{\n  font-size:1rem;\n  margin: 0 0 10px;\n  color: var(--ssc-black);\n  line-height: 1.6;\n}\n\n\/* \u76e3\u4fee\u533b\u5e2b \u9854\u5199\u771f *\/\n.ssc-supervisor-photo{\n  flex:0 0 190px;\n  max-width:190px;\n}\n.ssc-supervisor-photo img{\n  width:100%;\n  height:auto;\n  display:block;\n  border-radius:8px;\n}\n\n\/* \u30b9\u30de\u30db *\/\n@media(max-width:600px){\n  .ssc-supervisor-inner{\n    flex-direction:column;\n    gap:20px;\n  }\n  .ssc-supervisor-photo{\n    flex:0 0 auto;\n    max-width:150px;\n    margin:0 auto;\n  }\n}\n<\/style>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u00bfQu\u00e9 es el spray nasal de exosomas?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Es un tratamiento que consiste en la \u00abadministraci\u00f3n por la nariz\u00bb de exosomas con propiedades antienvejecimiento.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Como m\u00e9todos de administraci\u00f3n de exosomas, quiz\u00e1 sean m\u00e1s conocidos el goteo IV o el Dermapen.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La administraci\u00f3n por v\u00eda nasal permite hacer llegar los exosomas al cerebro, lo que puede contribuir a la prevenci\u00f3n de la demencia, a mejorar la concentraci\u00f3n y a aliviar la fatiga cerebral.<\/p>\n\n\n\n<div style=\"height:54px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u00bfQu\u00e9 son los exosomas?<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"650\" height=\"500\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/HP\u7528-1.jpg\" alt=\"Exosomas\" class=\"wp-image-3497\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/HP\u7528-1.jpg 650w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/HP\u7528-1-300x231.jpg 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/HP\u7528-1-16x12.jpg 16w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Los exosomas son sustancias que existen de forma natural en el organismo. En t\u00e9rminos m\u00e9dicos, son peque\u00f1as ves\u00edculas celulares envueltas en una membrana lip\u00eddica de doble capa; se secretan de forma activa por diversas c\u00e9lulas y desempe\u00f1an un papel fundamental en la comunicaci\u00f3n intercelular.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A trav\u00e9s de esta funci\u00f3n de comunicaci\u00f3n intercelular, los exosomas ejercen efectos muy diversos, como acciones antiapopt\u00f3tica, antiinflamatoria, neurog\u00e9nica y angiog\u00e9nica. Gracias a estos efectos, contribuyen a lo que se conoce como acci\u00f3n antienvejecimiento.<\/p>\n\n\n\n<div style=\"height:37px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Variantes de los m\u00e9todos de administraci\u00f3n de exosomas<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Los m\u00e9todos de administraci\u00f3n de exosomas se dividen a grandes rasgos en dos: administraci\u00f3n sist\u00e9mica y administraci\u00f3n local.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Administraci\u00f3n sist\u00e9mica<\/h3>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container\">\n<ul class=\"wp-block-list is-style-num_circle\">\n<li>Goteo intravenoso<\/li>\n\n\n\n<li>Inyecci\u00f3n<\/li>\n\n\n\n<li>Spray nasal<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">M\u00e1s informaci\u00f3n sobre la administraci\u00f3n por goteo IV aqu\u00ed.<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -external -noimg\" data-type=\"type3\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">[Oficial] Smart Skin Clinic&#8230;<\/span>\n\t\t\t\t\t\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/smartskin-clinic.com\/es\/menu\/inyeccion-infusion\/infusion-de-exosomas\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00bfQu\u00e9 es la infusi\u00f3n de exosomas? | Un m\u00e9dico explica los efectos, el precio y el n\u00famero de sesiones | [Oficial] Grupo Smart Skin Clinic<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">La infusi\u00f3n de exosomas es un tratamiento antienvejecimiento que mejora el estado general del organismo. En Smart Skin Clinic utilizamos preparados de alta pureza, y nuestros m\u00e9dicos ofrecen asesoramiento personalizado a cada paciente. Tokio (Jimbocho, \u2026<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n<div style=\"height:38px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Administraci\u00f3n local<\/h3>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container\">\n<ul class=\"wp-block-list is-style-num_circle\">\n<li>Inyecci\u00f3n Water Light<\/li>\n\n\n\n<li>Dermapen<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">M\u00e1s informaci\u00f3n sobre la administraci\u00f3n con Dermapen aqu\u00ed.<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -external -noimg\" data-type=\"type3\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">[Oficial] Smart Skin Clinic&#8230;<\/span>\n\t\t\t\t\t\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/smartskin-clinic.com\/es\/dermapen-exosoma\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00bfQu\u00e9 es el Dermapen 4 \u00d7 Exosomas? | Un m\u00e9dico explica los efectos, los precios y el tiempo de recuperaci\u00f3n | [Oficial] Smart Skin Clinic\u2026<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">La soluci\u00f3n de introducci\u00f3n Dermapen + Exosomas contribuye a mejorar la calidad de la piel y los poros. La soluci\u00f3n de introducci\u00f3n de exosomas tambi\u00e9n ayuda a reducir el tiempo de recuperaci\u00f3n. Smart Skin Clinic, que ha incorporado la f\u00f3rmula oficial de exosomas de Dermapen&#8230;<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Efecto<\/h2>\n\n\n\n<div class=\"wp-block-group has-border -border01\"><div class=\"wp-block-group__inner-container\">\n<ul class=\"wp-block-list is-style-check_list\">\n<li>prevenci\u00f3n de la demencia<\/li>\n\n\n\n<li>Alivio de la fatiga cerebral<\/li>\n\n\n\n<li>Mejora del insomnio<\/li>\n\n\n\n<li>Mejora de la concentraci\u00f3n<\/li>\n\n\n\n<li>Rinitis al\u00e9rgica<\/li>\n\n\n\n<li>Mejora de las secuelas del COVID-19<\/li>\n<\/ul>\n\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">*Efectos que cabe esperar<br>*Los resultados var\u00edan seg\u00fan cada persona<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Para que determinadas sustancias lleguen al cerebro, deben atravesar una barrera denominada BBB.<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl2\"><div class=\"cap_box_ttl\"><span>\u00bfQu\u00e9 es la BBB?<\/span><\/div><div class=\"cap_box_content\">\n<p class=\"wp-block-paragraph\">BBB es un t\u00e9rmino m\u00e9dico, siglas de Blood Brain Barrier (barrera hematoencef\u00e1lica); en japon\u00e9s se denomina \u8133\u8840\u7ba1\u95a2\u9580.<\/p>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Para superar este obst\u00e1culo o barrera, la administraci\u00f3n nasal ha atra\u00eddo la atenci\u00f3n como una v\u00eda no invasiva (sin da\u00f1os) y eficaz para hacer llegar f\u00e1rmacos al sistema nervioso central (el cerebro).<br><br>Numerosos estudios han confirmado que la administraci\u00f3n nasal (intranasal) puede sortear la BBB y hacer llegar al sistema nervioso central (el cerebro) tanto sustancias de bajo peso molecular como prote\u00ednas de alto peso molecular.<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl2\"><div class=\"cap_box_ttl\"><span>Referencias<\/span><\/div><div class=\"cap_box_content\">\n<ul class=\"wp-block-list is-style-note_list\">\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014480015000192?via%3Dihub\">Li YH, Feng L, Zhang GX, Ma CG. Intranasal delivery of stem cells as therapy for central nervous system disease. Exp Mol Pathol. 2015;98(2):145\u201351.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0169409X11002997?via%3Dihub\">Banks WA. Drug delivery to the brain in Alzheimer's disease: consideration of the blood-brain barrier. Adv Drug Deliv Rev. 2012;64(7):629\u201339.<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">La administraci\u00f3n nasal tiene las ventajas de ser no invasiva y de gran utilidad pr\u00e1ctica. Facilita que todo tipo de mol\u00e9culas de f\u00e1rmacos y c\u00e9lulas madre sorteen la BBB y lleguen al sistema nervioso central, y ofrece un m\u00e9todo no invasivo y eficaz para la terapia con c\u00e9lulas madre en enfermedades del sistema nervioso central.<\/p>\n<cite><a href=\"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-021-02274-0\">Yu-Ting Zhang, et al. Advances in intranasal application of stem cells in the treatment of central nervous system diseases. Stem Cell Research &amp; Therapy volume 12, Article number: 210 (2021).<\/a><\/cite><\/blockquote>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"swell-block-capbox cap_box\"><div class=\"cap_box_ttl\"><span>Ilustraci\u00f3n de la administraci\u00f3n de exosomas por spray nasal en un estudio cl\u00ednico en ratones.<\/span><\/div><div class=\"cap_box_content\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"829\" height=\"586\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u70b9\u9f3b\u306b\u3088\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u6295\u4e0e.jpeg\" alt=\"Administraci\u00f3n de exosomas por goteo nasal\" class=\"wp-image-3467\" style=\"width:600px\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u70b9\u9f3b\u306b\u3088\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u6295\u4e0e.jpeg 829w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u70b9\u9f3b\u306b\u3088\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u6295\u4e0e-300x212.jpeg 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u70b9\u9f3b\u306b\u3088\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u6295\u4e0e-768x543.jpeg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u70b9\u9f3b\u306b\u3088\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u6295\u4e0e-18x12.jpeg 18w\" sizes=\"auto, (max-width: 829px) 100vw, 829px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">(Fuente)<a href=\"https:\/\/journals.lww.com\/nrronline\/fulltext\/2024\/06000\/intranasal_administration_of_stem_cell_derived.26.aspx\">Gotoh, Shuho, et al. Intranasal administration of stem cell-derived exosomes for central nervous system diseases. Neural Regeneration Research 19(6):p 1249-1255, June 2024.<\/a><\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:31px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Eficacia de la terapia por spray nasal en pacientes con demencia tipo Alzheimer<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Existen datos sobre la aplicaci\u00f3n de la terapia por spray nasal en pacientes con demencia tipo Alzheimer.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"909\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u3078\u306e\u52b9\u679c.png\" alt=\"Efectos del goteo nasal de exosomas en la enfermedad de Alzheimer.\" class=\"wp-image-3469\" style=\"width:600px\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u3078\u306e\u52b9\u679c.png 1000w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u3078\u306e\u52b9\u679c-300x273.png 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u3078\u306e\u52b9\u679c-768x698.png 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u3078\u306e\u52b9\u679c-13x12.png 13w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n<\/div>\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">El uso de exosomas ha mostrado una mejora notable en enfermedades de dif\u00edcil tratamiento como la demencia tipo Alzheimer, el infarto cerebral, la dermatitis at\u00f3pica, la artritis reumatoide y la alergia al polen.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sin necesidad de costosas intervenciones de \u00abtrasplante\u00bb,<strong>el tratamiento es posible \u00fanicamente mediante goteo IV, aplicaci\u00f3n t\u00f3pica o inhalaci\u00f3n por la nariz.<\/strong>\u3000\u3000\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Desde 2019 se ha iniciado un amplio estudio cl\u00ednico conjunto sobre esta innovadora tecnolog\u00eda con la Universidad de Bergen (Noruega).<\/p>\n<cite>Minoru Ueda, \u00abLa sorprendente medicina regenerativa: \u00bfqu\u00e9 es el sobrenadante de cultivo?\u00bb<\/cite><\/blockquote>\n\n\n\n<div style=\"height:53px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Ventajas e inconvenientes del spray nasal<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Ventajas<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La administraci\u00f3n por la nariz permite hacer llegar los exosomas hasta el cerebro.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los vasos sangu\u00edneos que llegan al cerebro cuentan con una barrera denominada BBB (barrera hematoencef\u00e1lica), que hace que solo determinados componentes puedan llegar al interior del cerebro. Por ello, con m\u00e9todos como el goteo IV no es posible hacerlos llegar de forma eficaz hasta el cerebro.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En cambio, como se ha mencionado antes, la administraci\u00f3n de exosomas por la nariz (administraci\u00f3n intranasal) permite que estos lleguen directamente al cerebro sorteando la barrera hematoencef\u00e1lica.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Inconvenientes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Como inconveniente, cabe se\u00f1alar que \u00abpuede resultar costoso\u00bb.<\/p>\n\n\n\n<div style=\"height:53px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Riesgos y efectos secundarios<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Es b\u00e1sicamente igual que el goteo IV de exosomas. A diferencia del goteo IV, no se introduce una aguja, por lo que no se producen efectos secundarios derivados de la punci\u00f3n.<\/p>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Compromiso con la seguridad \uff5c Cumplimiento de la gu\u00eda de la Sociedad de Medicina Regenerativa<\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Nuestro tratamiento de goteo IV de exosomas se realiza <strong><span class=\"swl-marker mark_blue\">conforme a la \u00abGu\u00eda sobre la aplicaci\u00f3n cl\u00ednica de ves\u00edculas extracelulares (1.\u00aa edici\u00f3n)\u00bb, publicada por la Sociedad Japonesa de Medicina Regenerativa el 30 de abril de 2024.<\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Esta gu\u00eda constituye una referencia fundamental para garantizar la seguridad y la eficacia del tratamiento con exosomas, y en nuestra cl\u00ednica aplicamos <strong><span class=\"swl-marker mark_blue\">un riguroso control de calidad y medidas de seguridad basadas en dicha gu\u00eda<\/span><\/strong>.<\/p>\n\n\n\n<div style=\"height:34px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Nuestras medidas concretas para garantizar la seguridad<\/h3>\n\n\n\n<ol class=\"wp-block-list is-style-num_circle\">\n<li><strong>Elaboraci\u00f3n de un perfil de riesgo<\/strong>\n<ul class=\"wp-block-list\">\n<li>Identificamos los riesgos potenciales asociados al tratamiento y adoptamos las medidas adecuadas.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Procesos de preparaci\u00f3n y control de calidad rigurosos<\/strong>\n<ul class=\"wp-block-list\">\n<li>Aplicamos procesos de fabricaci\u00f3n y controles de calidad basados en los conocimientos cient\u00edficos m\u00e1s recientes.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Verificaci\u00f3n adecuada de la eficacia<\/strong>\n<ul class=\"wp-block-list\">\n<li>Evaluamos de forma continua la eficacia del tratamiento para ofrecer a cada paciente la opci\u00f3n m\u00e1s adecuada.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Su seguridad es nuestra m\u00e1xima prioridad; nos comprometemos a ofrecerle un tratamiento basado en los conocimientos cient\u00edficos m\u00e1s recientes.<\/p>\n\n\n\n<div style=\"height:55px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Modo de empleo del spray nasal (instrucciones de uso)<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"614\" height=\"1024\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/1-2-614x1024.jpg\" alt=\"C\u00f3mo hacer preparados l\u00edquidos\" class=\"wp-image-3478\" style=\"width:400px\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/1-2-614x1024.jpg 614w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/1-2-180x300.jpg 180w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/1-2-768x1280.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/1-2-7x12.jpg 7w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/1-2.jpg 780w\" sizes=\"auto, (max-width: 614px) 100vw, 614px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"614\" height=\"1024\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/2-2-614x1024.jpg\" alt=\"C\u00f3mo pulverizar\" class=\"wp-image-3479\" style=\"width:400px\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/2-2-614x1024.jpg 614w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/2-2-180x300.jpg 180w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/2-2-768x1280.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/2-2-7x12.jpg 7w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/2-2.jpg 780w\" sizes=\"auto, (max-width: 614px) 100vw, 614px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">Caracter\u00edsticas de la terapia con spray nasal de exosomas de Smart Skin Clinic<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"1000\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_exosome_2_0.png\" alt=\"juego de goteo nasal\" class=\"wp-image-3492\" style=\"width:500px\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_exosome_2_0.png 1000w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_exosome_2_0-300x300.png 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_exosome_2_0-150x150.png 150w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_exosome_2_0-768x768.png 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_exosome_2_0-12x12.png 12w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\">Utilizamos exosomas derivados del cord\u00f3n umbilical<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">En Smart Skin Clinic utilizamos exosomas \u00ab\u2460 derivados del cord\u00f3n umbilical\u00bb, uno de los tres grandes tipos existentes: \u2460 derivados del cord\u00f3n umbilical, \u2461 derivados del tejido adiposo y \u2462 derivados de la pulpa dental y la m\u00e9dula \u00f3sea.<br><br>En comparaci\u00f3n con otros exosomas, los derivados del cord\u00f3n umbilical contienen m\u00e1s de 14 veces la cantidad de componentes activos, tal como se muestra en el siguiente diagrama.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"614\" height=\"495\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0.png\" alt=\"Diferencias entre los exosomas derivados de la sangre del cord\u00f3n umbilical y otras fuentes Introducci\u00f3n 1).\" class=\"wp-image-1668\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0.png 614w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0-300x242.png 300w\" sizes=\"auto, (max-width: 614px) 100vw, 614px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">A continuaci\u00f3n le presentamos dos de estos \u00abprincipios activos\u00bb, acompa\u00f1ados de datos concretos.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u2460 Rico en principios activos para la piel<\/h4>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">El primero son los datos sobre los principios activos que act\u00faan sobre la \u00abpiel\u00bb.<br><br>Los exosomas ofrecen diversos efectos antienvejecimiento, y uno de ellos es su acci\u00f3n sobre la piel. Como muestra el siguiente diagrama, los exosomas derivados del cord\u00f3n umbilical contienen una mayor concentraci\u00f3n de principios activos para la piel que otros tipos de exosomas.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"444\" height=\"487\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u2461.png\" alt=\"Diferencias entre los exosomas derivados de la sangre del cord\u00f3n umbilical y otras fuentes de exosomas (2).\" class=\"wp-image-1669\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u2461.png 444w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u2461-274x300.png 274w\" sizes=\"auto, (max-width: 444px) 100vw, 444px\" \/><\/figure>\n<\/div>\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">\u2461 Rico en la prote\u00edna rejuvenecedora \u00abGDF-11\u00bb<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">El segundo se refiere a los datos sobre los componentes implicados en el \u00abrejuvenecimiento\u00bb.<br><br>Existe un componente denominado GDF-11, implicado en el rejuvenecimiento, que se encuentra en abundancia en los exosomas derivados del cord\u00f3n umbilical, tal como muestran los siguientes datos.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"569\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/GDF-1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0.jpg\" alt=\"Exosomas derivados de sangre de cord\u00f3n umbilical con alta actividad GDF-1.\" class=\"wp-image-1672\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/GDF-1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0.jpg 1000w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/GDF-1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0-300x171.jpg 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2023\/09\/GDF-1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u81cd\u5e2f\u8840\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0-768x437.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Nuestro \u00abcompromiso\u00bb con el precio y la calidad<\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"1000\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_1_0.jpg\" alt=\"caja de narices\" class=\"wp-image-3490\" style=\"width:400px\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_1_0.jpg 1000w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_1_0-300x300.jpg 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_1_0-150x150.jpg 150w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_1_0-768x768.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/02\/PS_nasal_1_0-12x12.jpg 12w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">En nuestra cl\u00ednica tenemos un firme compromiso con el precio y la calidad. Para hacer realidad ese compromiso, llevamos a cabo diversas iniciativas. Aplicamos distintas medidas de reducci\u00f3n de costes (por ejemplo, prescindir de una decoraci\u00f3n interior lujosa y eliminar la recepci\u00f3n para reducir los costes de personal), entre otras.<br><br>Consulte aqu\u00ed para m\u00e1s informaci\u00f3n.<\/p>\n\n\n\n<blockquote class=\"instagram-media\" data-instgrm-permalink=\"https:\/\/www.instagram.com\/p\/C0lhfufycQM\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"14\" style=\" background:#FFF; border:0; border-radius:3px; box-shadow:0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width:540px; min-width:326px; padding:0; width:99.375%; width:-webkit-calc(100% - 2px); width:calc(100% - 2px);\"><div style=\"padding:16px;\"> <a href=\"https:\/\/www.instagram.com\/p\/C0lhfufycQM\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" background:#FFFFFF; line-height:0; padding:0 0; text-align:center; text-decoration:none; width:100%;\" target=\"_blank\" rel=\"noopener\"> <div style=\" display: flex; flex-direction: row; align-items: center;\"> <div style=\"background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;\"><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;\"><\/div><\/div><\/div><div style=\"padding: 19% 0;\"><\/div> <div style=\"display:block; height:50px; margin:0 auto 12px; width:50px;\"><svg width=\"50px\" height=\"50px\" viewbox=\"0 0 60 60\" version=\"1.1\" xmlns=\"https:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"https:\/\/www.w3.org\/1999\/xlink\"><g stroke=\"none\" stroke-width=\"1\" fill=\"none\" fill-rule=\"evenodd\"><g transform=\"translate(-511.000000, -20.000000)\" fill=\"#000000\"><g><path d=\"M556.869,30.41 C554.814,30.41 553.148,32.076 553.148,34.131 C553.148,36.186 554.814,37.852 556.869,37.852 C558.924,37.852 560.59,36.186 560.59,34.131 C560.59,32.076 558.924,30.41 556.869,30.41 M541,60.657 C535.114,60.657 530.342,55.887 530.342,50 C530.342,44.114 535.114,39.342 541,39.342 C546.887,39.342 551.658,44.114 551.658,50 C551.658,55.887 546.887,60.657 541,60.657 M541,33.886 C532.1,33.886 524.886,41.1 524.886,50 C524.886,58.899 532.1,66.113 541,66.113 C549.9,66.113 557.115,58.899 557.115,50 C557.115,41.1 549.9,33.886 541,33.886 M565.378,62.101 C565.244,65.022 564.756,66.606 564.346,67.663 C563.803,69.06 563.154,70.057 562.106,71.106 C561.058,72.155 560.06,72.803 558.662,73.347 C557.607,73.757 556.021,74.244 553.102,74.378 C549.944,74.521 548.997,74.552 541,74.552 C533.003,74.552 532.056,74.521 528.898,74.378 C525.979,74.244 524.393,73.757 523.338,73.347 C521.94,72.803 520.942,72.155 519.894,71.106 C518.846,70.057 518.197,69.06 517.654,67.663 C517.244,66.606 516.755,65.022 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0;\"><\/div> <div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\"><div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div> <div style=\"background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div><\/div><div style=\"margin-left: 8px;\"> <div style=\" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div> <div style=\" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)\"><\/div><\/div><div style=\"margin-left: auto;\"> <div style=\" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div> <div style=\" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div> <div style=\" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div><\/div><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;\"><\/div><\/div><\/a><p style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; line-height:17px; margin-bottom:0; margin-top:8px; overflow:hidden; padding:8px 0 7px; text-align:center; text-overflow:ellipsis; white-space:nowrap;\"><a href=\"https:\/\/www.instagram.com\/p\/C0lhfufycQM\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none;\" target=\"_blank\" rel=\"noopener\">Publicaci\u00f3n compartida por Smart Skin Clinic [Dermatolog\u00eda Est\u00e9tica] Jimbocho Juvelook &amp; Profhilo &amp; Sunekos (@smartskin_clinic)<\/a><\/p><\/div><\/blockquote> <script async src=\"\/\/www.instagram.com\/embed.js\"><\/script>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Conforme a MISEV2018, \u00abMinimal Information for Studies of Extracellular Vesicles (MISEV), edici\u00f3n de 2018\u00bb<\/h3>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">En el caso de los exosomas, var\u00edan los m\u00e9todos de extracci\u00f3n, el tama\u00f1o de los exosomas, los m\u00e9todos de conservaci\u00f3n y su forma, entre otros aspectos. <br><br>Por ello, la Sociedad Internacional de Ves\u00edculas Extracelulares (ISEV) ha establecido unas directrices para la estandarizaci\u00f3n de los protocolos relativos a los exosomas. <br><br>Las directrices propuestas por la ISEV se denominan \"Minimal Information for Studies of Extracellular Vesicles (MISEV) \u2014 Edici\u00f3n de 2018\". <br><br><strong><span class=\"swl-marker mark_blue\">En nuestro centro, nos ajustamos a esta norma MISEV 2018 y llevamos a cabo la extracci\u00f3n y purificaci\u00f3n en instalaciones de procesamiento de cultivos celulares, y utilizamos el resultado en nuestro centro<\/span><\/strong>.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"760\" height=\"586\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/09\/misev2018.png\" alt=\"\" class=\"wp-image-5848\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/09\/misev2018.png 760w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/09\/misev2018-300x231.png 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2024\/09\/misev2018-16x12.png 16w\" sizes=\"auto, (max-width: 760px) 100vw, 760px\" \/><\/figure>\n<\/div>\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"swell-block-button blue_ -size-l is-style-btn_solid\"><a href=\"https:\/\/smartskin-clinic.com\/es\/reserva-exosome-nasalspray\/\" class=\"swell-block-button__link\"><span>Reserve en l\u00ednea o solicite una consulta gratuita aqu\u00ed<\/span><\/a><\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Tarifas<\/h2>\n\n\n<div class=\"p-blogParts post_content\" data-partsid=\"10708\">\n<figure class=\"wp-block-table is-all-centered\"><table><thead style=\"--thead-color--bg:var(--color_gray);--thead-color--txt:var(--swl-text_color--black)\"><tr><th>1 frasco de 5 cc [suministro para 1 semana]<\/th><th><\/th><\/tr><\/thead><tbody><tr><td>Precio de primera visita<\/td><td>29.440 yen<\/td><\/tr><tr><td>1 frasco<\/td><td>36.800 yen<\/td><\/tr><tr><td>2 frascos (suministro para 2 semanas)<\/td><td>71.600 yen<br><span style=\"color:#929292\" class=\"swl-inline-color\">(35.800 yen por frasco<\/span>)<\/td><\/tr><tr><td>4 frascos (suministro para 1 mes)<\/td><td class=\"translation-block\">131 200 yenes<br><span style=\"color:#929292\" class=\"swl-inline-color\">(1 unidad <\/span> <span class=\"swl-inline-color has-swl-main-color\">32 800 yenes <\/span>)<\/td><\/tr><tr><td>12 frascos (suministro para 3 meses)<\/td><td class=\"translation-block\">345 600 yenes<br><span style=\"color:#929292\" class=\"swl-inline-color\">(1 unidad <\/span> <span class=\"swl-inline-color has-swl-main-color\">28 800 yenes <\/span>)<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">\u203bUn frasco tiene una capacidad aproximada para una semana seg\u00fan el modo de uso recomendado.<\/figcaption><\/figure>\n<\/div>\n\n\n<div class=\"swell-block-button blue_ -size-l is-style-btn_solid\"><a href=\"https:\/\/smartskin-clinic.com\/es\/reserva-exosome-nasalspray\/\" class=\"swell-block-button__link\"><span>Reserve en l\u00ednea o solicite una consulta gratuita aqu\u00ed<\/span><\/a><\/div>\n\n\n<div class=\"p-blogParts post_content\" data-partsid=\"14253\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"2000\" height=\"650\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/10\/\uff06DR.\u30d0\u30ca\u30fcA.jpg\" alt=\"\" class=\"wp-image-18918\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/10\/\uff06DR.\u30d0\u30ca\u30fcA.jpg 2000w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/10\/\uff06DR.\u30d0\u30ca\u30fcA-300x98.jpg 300w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/10\/\uff06DR.\u30d0\u30ca\u30fcA-768x250.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/10\/\uff06DR.\u30d0\u30ca\u30fcA-1536x499.jpg 1536w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/10\/\uff06DR.\u30d0\u30ca\u30fcA-18x6.jpg 18w\" sizes=\"auto, (max-width: 2000px) 100vw, 2000px\" \/><\/figure>\n<\/div>\n\n\n<div style=\"height:113px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n\n\n<div class=\"wp-block-group ssc-eeat\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n\n<h2 class=\"wp-block-heading\">M\u00e9dico responsable de la supervisi\u00f3n de esta p\u00e1gina<\/h2>\n\n\n\n<div class=\"wp-block-media-text profile is-stacked-on-mobile\" style=\"grid-template-columns:28% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1280\" height=\"1920\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg\" alt=\"Kota Ishii, director general de Smart Skin Clinic\" class=\"wp-image-12584 size-full\" srcset=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f.jpg 1280w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-200x300.jpg 200w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-768x1152.jpg 768w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-1024x1536.jpg 1024w, https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/03\/\u77f3\u4e95\u7d71\u62ec\u9662\u9577\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u5199\u771f-8x12.jpg 8w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"u-mb-0 wp-block-paragraph\"><span class=\"swl-fz u-fz-s\"><strong>Director general de Smart Skin Clinic \/ M\u00e9dico<\/strong><\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span class=\"swl-fz u-fz-l\">Kota Ishii<\/span><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Coordinamos, en el conjunto del grupo, un enfoque cl\u00ednico adaptado al estado de la piel de cada paciente. El contenido de esta p\u00e1gina ha sido supervisado conforme a los criterios cl\u00ednicos de nuestra cl\u00ednica.<\/p>\n\n\n\n<div class=\"swell-block-button is-style-btn_normal\"><a href=\"https:\/\/smartskin-clinic.com\/es\/concepto\/\" class=\"swell-block-button__link\"><span>Ver la filosof\u00eda de los m\u00e9dicos y las cl\u00ednicas<\/span><\/a><\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Entrevista al director general, Kota Ishii<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kota Ishii, director general, nos habla de la filosof\u00eda con la que abordamos los tratamientos en nuestra cl\u00ednica.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Una serie de clientes habituales de inyecciones para el crecimiento de la piel. \u2049\ufe0f Una entrevista exclusiva con el apuesto director general de una popular cl\u00ednica. \ud83e\uddd1\u200d\u2695\ufe0f\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/u6cP6jPmfwU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n<\/div><\/div>\n\n\n\n<!-- \u25bc\u25bc Clinic List \u5171\u901a\u30d1\u30fc\u30c4 \u25bc\u25bc -->\n<section>\n  <!-- \u30bf\u30a4\u30c8\u30eb -->\n  <div class=\"ssc-shoplist-title\">\n    <small>LISTA DE CL\u00cdNICAS<\/small>\n    <h2>Lista de Cl\u00ednicas<\/h2>\n  <\/div>\n  <!-- \u30ab\u30fc\u30c9\u4e00\u89a7 -->\n  <div class=\"ssc-shoplist-grid\">\n    <!-- \u795e\u4fdd\u753a\u9662 -->\n    <a href=\"https:\/\/smartskin-clinic.com\/es\/clinicas-2\/jimbocho\/\" class=\"ssc-shopcard\" target=\"_blank\" rel=\"noopener\">\n      <img decoding=\"async\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2025\/06\/smart-skin-clinic-jimbocho-reception-waiting-area-.webp\" alt=\"Cl\u00ednica Smart Skin Cl\u00ednica Jimbocho Recepci\u00f3n y sala de espera Vista general\">\n      <div class=\"ssc-shopcard-inner\">\n        <p class=\"ssc-shopcard__name\">Cl\u00ednica Jimbocho<\/p>\n        <p>\u3012101-0054<br>EX Kanda Nishikicho Building, 8.\u00aa planta (recepci\u00f3n general) \/ 7.\u00aa planta, 3-16-1 Kanda Nishikicho, Chiyoda-ku, Tokio<\/p>\n        <p>Horario: lunes a viernes 11:00-20:00 \/ s\u00e1bados y domingos 10:00-19:00<\/p>\n      <\/div>\n    <\/a>\n    <!-- \u6a2a\u6d5c\u9662 -->\n    <a href=\"https:\/\/smartskin-clinic.com\/es\/clinicas-2\/yokohama\/\" class=\"ssc-shopcard\" target=\"_blank\" rel=\"noopener\">\n      <img decoding=\"async\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2025\/06\/smartskin-clinic-yokohama-lobby-overview.webp\" alt=\"Smart Skin Clinic Yokohama Cl\u00ednica Recepci\u00f3n y sala de espera Vista general\">\n      <div class=\"ssc-shopcard-inner\">\n        <p class=\"ssc-shopcard__name\">Cl\u00ednica Yokohama<\/p>\n        <p>\u3012221-0835<br>TS Plaza Building, 2.\u00aa planta, 2-23-2 Tsuruyacho, Kanagawa-ku, Yokohama, Kanagawa<\/p>\n        <p>Horario: 10:00-19:00<\/p>\n      <\/div>\n    <\/a>\n    <!-- \u516b\u4e01\u5800\u9662 -->\n    <a href=\"https:\/\/smartskin-clinic.com\/es\/clinicas-2\/hatchobori\/\" class=\"ssc-shopcard\" target=\"_blank\" rel=\"noopener\">\n      <img decoding=\"async\" src=\"https:\/\/smartskin-clinic.com\/wp-content\/uploads\/2026\/08\/\u516b\u4e01\u5800\u9662_\u53d7\u4ed8\u5f85\u5408.jpg\" alt=\"Smart Skin Clinic, centro de Hatchobori: vista general de la recepci\u00f3n y la sala de espera\">\n      <div class=\"ssc-shopcard-inner\">\n        <p class=\"ssc-shopcard__name\">Centro de Hatchobori<\/p>\n        <p>C\u00f3digo postal: 104-0032<br>2.\u00aa planta, Edificio Tokyo NS, 2-29-4 Hatchobori, Chuo-ku, Tokio<\/p>\n        <p>Horario: 10:00-19:00 (cerrado de 13:00 a 14:00) \/ D\u00edas de cierre: lunes y jueves<\/p>\n      <\/div>\n    <\/a>\n    <!-- \u8ffd\u52a0\u9662\u7528\u30c6\u30f3\u30d7\u30ec -->\n    <!--\n    <a href=\"\u30ea\u30f3\u30af\" class=\"ssc-shopcard\" target=\"_blank\" rel=\"noopener\">\n      <img decoding=\"async\" src=\"\u753b\u50cfURL\" alt=\"\u4ee3\u66ff\u30c6\u30ad\u30b9\u30c8\">\n      <div class=\"ssc-shopcard-inner\">\n        <p class=\"ssc-shopcard__name\">\u25ef\u25ef\u9662<\/p>\n        <p>\u4f4f\u6240<\/p>\n        <p>\u55b6\u696d\u6642\u9593<\/p>\n      <\/div>\n    <\/a>\n    -->\n  <\/div>\n<\/section>\n<!-- \u25b2\u25b2 \u3053\u3053\u307e\u3067\u5171\u901a\u30d1\u30fc\u30c4 \u25b2\u25b2 -->\n\n\n\n<!-- \u25bc\u25bc \u533b\u5e2b\u76e3\u4fee\u30d6\u30ed\u30c3\u30af v4 \u25bc\u25bc -->\n<section class=\"ssc-audit-bg\">\n  <div class=\"ssc-audit-box\">\n\n    <h2 class=\"ssc-audit-title\">Sobre la supervisi\u00f3n m\u00e9dica de este sitio web<\/h2>\n\n    <p>Este sitio web se gestiona bajo la supervisi\u00f3n de un m\u00e9dico supervisor de Smart Skin Clinic.<\/p>\n\n    <p>Esta p\u00e1gina fue revisada y entr\u00f3 en vigor en junio de 2018.\n      <a href=\"https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/kenkou_iryou\/iryou\/kokokukisei\/index.html\" target=\"_blank\" rel=\"noopener\">Directrices de Publicidad M\u00e9dica<\/a> Se elabora y ofrece informaci\u00f3n conforme a<\/p>\n\n    <ul>\n      <li>\u00c1mbito de supervisi\u00f3n: descripci\u00f3n de los tratamientos, riesgos y efectos secundarios, indicaci\u00f3n de precios<\/li>\n      <li>\u00daltima revisi\u00f3n: 1 de agosto de 2026<\/li>\n    <\/ul>\n\n    <small>\u203bLos efectos del tratamiento var\u00edan seg\u00fan cada persona. 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