Profhilo 59,800yen, most affordable price in Japan | Smart Skin Clinic (Jimbocho, Tokyo)

*Number of cases | For the period from September 1, 2023 to March 31, 2024

At our clinic, free consultations are provided directly by specialized doctors, not by beauty counselors like at major clinics. For this reason, there is absolutely no high-pressure sales pitch during the free consultation. This approach has been very well-received by our clients, including those who are new to cosmetic procedures. Please feel free to book an appointment with peace of mind.


What is Profhilo?


Profhilo injection is a treatment called an “injectable moisturizer” or “next-generation hyaluronic acid.” The official product name is “Profhilo®.”

It has been on the market since 2015 and is a hyaluronic acid product created using IBSA’s patented NAHYCO™ technology from Italy.

It is attracting attention in the cosmetic medicine industry as the latest treatment that can simultaneously achieve skin tightening and skin quality improvement.

Profhilo injections are highly effective for various concerns

  • Want to improve sagging and wrinkles on the entire face (under eyes, corners of eyes, cheeks, neck) all at once, while also enhancing skin quality
  • Concerned about dark circles under the eyes
  • Bothered by hollowness under the eyes
  • Worried about fine lines around the corners of the eyes
  • Troubled by sunken and sagging cheeksDesire to improve neck wrinkles
  • Concerned about visible veins and wrinkles on the back of hands
  • Wish to naturally rejuvenate the entire face

Effects | Profhilo has skin rejuvenating benefits

〇 Wrinkle and sagging improvement
〇 Improved firmness and elasticity (enhanced hydration)
〇 Lifting effect
〇 Natural volume enhancement

When can the effects be felt after the treatment?

When can the effects be felt after the treatment?

Dr. Smartskin

While the perception of effects may vary from person to person, many individuals gradually start to notice improvements within a few days to a few weeks after the injection. The maximum effects are typically felt around one month post-treatment.

How long do the effects last?

How long do the effects last?

Dr. Smartskin

The effects of Profhilo are said to last for about 6 months to 1 year. To maintain the results and ensure continuous improvement, regular injections as maintenance treatments are recommended.

Profhilo at Smart Skin Clinic

We use “Profhilo®,” a hyaluronic acid treatment with a proven track record that has been introduced in over 80 countries as of 2020.

More than 500,000 cases have been reported worldwide, and it has also received the AMEC & AESTHETICS award, making it a globally recognized hyaluronic acid treatment for its safety and effectiveness.

Profhilo is the only treatment that can remodel the skin without the use of devices.

Anti-aging medicine specialists with over 1,000 Profhilo treatment cases perform the procedure

At Smart Skin Clinic, anti-aging medicine specialists with extensive experience in over 1,000 Profhilo treatment cases and high technical skills are always in charge of the procedure.

This ensures not only high-quality results but also minimizes swelling during downtime and pain during the procedure.

Below are actual quotes from our customers.

“I was worried about injection marks (bruising) on my face, but the doctor’s skill was excellent, and there were zero marks… I got the injection after work, and I was careful to wash my face gently during my bath.

When I woke up the next day, any marks that looked like mosquito bites had completely disappeared. There was no unnecessary face washing before the procedure, and the treatment itself was completed swiftly in 15-20 minutes.

I’m looking forward to my second session on 1/11.

The doctor’s ability to instantly grasp the situation is high, and their skill in understanding my requests is exceptional.

I have had many consultations at cosmetic surgery clinics, and this is a clinic I would recommend!!!!! “

Excerpt from a review of Smart Skin Clinic on Hot Pepper Beauty

Safety of Profhilo

Profhilo has a high safety profile because it does not contain any chemical substances or biologics, including cross-linking agents.

Specifically, this means that it is less likely to cause allergic reactions.

The reason for this is that Profhilo does not contain “cross-linking agents.” Cross-linking agents may cause allergic reactions, immune responses, and inflammation.

Although very rare, allergic reactions have been reported.

Conventional hyaluronic acid injectables contain a substance called a cross-linking agent.

Furthermore, the high safety of Profhilo has been mentioned in several research papers.

Based on three years of post-marketing experience, the safety profile of the medical device in this study is good

Daniel Cassuto, et al. (2020)Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.

Smart Skin Clinic consistently receives high ratings in reviews on multiple sites such as Google

We, Smart Skin Clinic, have achieved both “low cost,” “high quality,” and “high satisfaction” by thoroughly considering what is truly necessary for our customers and eliminating unnecessary costs.

This has earned us high ratings on all of the various review sites, including Google, Hot Pepper Beauty, etc.

As a result, approximately 80% of those who come once are repeat customers.

Hot Pepper Beauty Rating 4.57/5.00

Beauty passport Ratng 4.30/5.00

Kumapon Rating 4.71/5.00

gangnamunni Rating 9.3/10.0

Japan’s most affordable Profhilo prices

Once(2cc)129,000 yen → 59,800 yen
2 Times(2cc×2)258,000 yen → 109,600 yen
(1st syringe 59,800 yen)
(2nd syringe 49,800 yen)
3 Times(2cc×3)258,000 yen → 149,400 yen
(1st syringe 59,800 yen)
(2nd syringe 49,800 yen)
(3rd syringe 39,800 yen)
*All prices include tax
*Our clinic provides elective medical treatments, and insurance is not applicable
*Profhilo uses the BAP (Bio Aesthetic Points) technique, which involves injecting into specific predetermined areas. Basically, in any clinic, 2cc of Profhilo is used for the above-mentioned treatment areas.

The prices include consultation fees, needle costs, and all other expenses.

There will be no additional upselling on the day of the treatment.

Need for anesthesia | Low

We generally consider this procedure to not require anesthesia. As we wish to maintain our current pricing, if you request cream anesthesia, there will be an additional charge of [5,500 yen (tax included) / 1 session].
(This is because the use of anesthesia will add approximately 20 minutes to the treatment time.)

Market price comparison

In beauty clinics in the Kanto region, the market price for Profhilo injections on the face ranges from 65,000 to 80,000 yen per session. A set of two sessions typically costs between 130,000 to 170,000 yen, and three sessions would cost around 200,000 yen.

*Based on research conducted in February 2024

Those who are not suitable for the treatment

Those who are pregnant or breastfeeding

Those who have abnormal immune function or a history of such, and those undergoing immunosuppressive therapy

Those who are prone to keloid formation, hypertrophic scarring, or pigmentation disorders

Those with bleeding tendencies or those using non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin

Those with excessive sunburn, eczema, dermatitis, severe inflammatory acne, or scabs at the Profhilo injection site

Risks and Side Effects

At the needle puncture site:

  • Redness, swelling, pain, and edema
  • Bruising
  • Temporary bumps or nodules


Redness and bumps may occur at the injection site, but in most cases, they will resolve within about 24 hours.

Due to the nature of the treatment, there is a possibility of subcutaneous hemorrhage (bruising) at the needle puncture site, although this does not always occur. If bruising does appear, it will gradually fade over the course of 10 to 14 days.

Flow of treatment


You can easily make reservations with your mobile phone


This is a “smart” and easy receptionist service that requires only that you give us your name

Counseling and medical examination

Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales

Profhilo Injection

After completing the markings, we will proceed with the injections while communicating with you throughout the process.

After-care services

We will explain in detail about the care of the treated area and precautions for daily life.

Returning home

More Information

Treatment TimeAround 15min (Not including Counceling)
Recommended number and frequency of treatmentsIt is recommended to perform a set of 2 treatments, with an interval of at least 6 weeks between each session
After the initial set of treatments, maintenance sessions are recommended approximately once every six months
Down timeAround 24 hours
Treatment on the day of counselingPossible
MakeupPossible immediately after the treatment
SkincarePossible immediately after the treatment
ShoweringPossible on the same day
PainThere is a slight pricking sensation when the needle is inserted
※*There are differences among individuals


How often and how many times should I receive the treatment for the best results?
Dr. Smartskin

Although you can see effects even after a single treatment, we recommend one of the following methods for optimal results:

1. Perform the first and second treatments with a 1-month interval, and then continue the same pattern every year.

2. Perform the first and second treatments with a 1-month interval, and then continue with treatments every 6 months.

*The skin remodeling effect of Profhilo increases the extracellular matrix, leading to skin rejuvenation. If maintenance treatments are not performed, the extracellular matrix will gradually decrease due to aging after reaching the peak of the treatment effect. For this reason, we recommend the above methods.

Will I feel any pain?
Dr. Smartskin

While individual experiences may vary, we use a fine needle, but you may feel a slight pricking sensation. It is also said that the central part of the face is more sensitive to pain.

How long is the downtime?
Dr. Smartskin

Redness typically subsides within about 24 hours.

Can I see results after just one treatment?
Dr. Smartskin

You can achieve results with just one treatment. In fact, you can feel the lifting effect immediately after the treatment. However, many people start to notice the effects 3-4 weeks later, as the skin remodeling (reconstruction) process progresses.

Legal Notices

Profhilo treatment includes the use of drugs or medical devices that are not approved in Japan. The drugs and devices used in the treatment have been personally imported under the judgment of our clinic’s doctor.

For information on drugs and devices that require caution when personally importing, please refer to the following: Ministry of Health, Labour and Welfare “Drugs and devices that require caution when personally importing.”

Smart Skin Clinic

The concept of the clinic is to “Make cosmetic medicine more accessible and smart”

Costs are reduced by eliminating ornate interior decorations, cutting down on interior expenses, and carefully selecting necessary equipment.

Our goal is to “make cosmetic medicine more accessible to as many people as possible.”


Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo

Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo

About the physician supervision of this site

About the physician supervision of this site

This site is operated under the supervision of the Smart Skin Clinic supervising physicians.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.