Profhilo, most affordable price in Japan | Smart Skin Clinic (Jimbocho, Tokyo)
| Sessions | Regular Price | Special Price | Per Session |
|---|---|---|---|
| 1 session (2cc) | ¥52,800 | ¥49,800 | ¥49,800 |
| 2 session set (2cc x 2) | ¥99,600 | ¥95,600 | ¥47,800 |
| 3 session set (2cc x 3) | ¥139,800 | ¥137,400 | ¥45,800 |
At our clinic, free consultations are provided directly by specialist doctors, not by beauty counselors as at major clinics. For this reason, there is absolutely no high-pressure sales during the free consultation. This approach has been very well received by our clients, including those new to cosmetic procedures. Please feel free to book with complete peace of mind.
Profhilo before/after


What is Profhilo?

Profhilo injection is a treatment known as an "injectable moisturizer" or "next-generation hyaluronic acid." The official product name is "Profhilo®."
It has been on the market since 2015 and is a hyaluronic acid product created using IBSA's patented NAHYCO™ technology from Italy.
It is drawing attention in the aesthetic medicine field as a cutting-edge treatment that may simultaneously support skin tightening and skin quality improvement.
Profhilo injections may help with a wide range of concerns
- Want to improve sagging and wrinkles across the whole face (under the eyes, corners of the eyes, cheeks, neck) all at once, while also enhancing skin quality
- Concerned about dark circles under the eyes
- Bothered by hollowness under the eyes
- Worried about fine lines at the corners of the eyes
- Troubled by sunken, sagging cheeksWish to improve neck wrinkles
- Concerned about visible veins and wrinkles on the backs of the hands
- Wish to naturally rejuvenate the whole face
Effects | Profhilo offers skin-rejuvenating benefits
〇 Improvement of wrinkles and sagging
〇 Improved firmness and elasticity (enhanced hydration)
〇 Lifting effect
〇 Natural volume enhancement
When can the effects be felt after treatment?

When can the effects be felt after treatment?
Dr. IshiiWhile the perception of results may vary from person to person, many people gradually begin to notice improvements within a few days to a few weeks after the injection. Peak results are typically felt around one month after treatment.
How long do the effects last?

How long do the effects last?
Dr. IshiiThe effects of Profhilo are said to last about 6 months to 1 year. To help maintain the results and support continued improvement, regular injections as maintenance treatments are recommended.
Profhilo at Smart Skin Clinic
We use "Profhilo®," a hyaluronic acid treatment with a proven track record that has been adopted in over 80 countries as of 2020.
More than 500,000 cases have been reported worldwide, and it has also received the AMEC & AESTHETICS award, making it a globally recognized hyaluronic acid treatment for its safety and effectiveness.
Profhilo is the only treatment that can remodel the skin without the use of devices.
Anti-aging medicine specialists with experience in over 1,000 Profhilo treatments perform the procedure
At Smart Skin Clinic, anti-aging medicine specialists with extensive experience in over 1,000 Profhilo treatments and advanced technical skills always perform the procedure.
This helps ensure not only high-quality results but also minimal swelling during downtime and reduced discomfort during the procedure.
Below are actual comments from our patients.
"I was worried about injection marks (bruising) on my face, but the doctor's skill was excellent, and there were zero marks. I had the injection after work, and I was careful to wash my face gently in the bath.
When I woke up the next day, any marks that had looked like mosquito bites had completely disappeared. There was no unnecessary face-washing before the procedure, and the treatment itself was done swiftly in 15-20 minutes.
I'm looking forward to my second session on 1/11.
The doctor's ability to instantly grasp the situation is impressive, and their skill in understanding my requests is exceptional.
I've had many consultations at cosmetic clinics, and this is one I would recommend!!!!! "
Excerpt from a review of Smart Skin Clinic on Hot Pepper Beauty
Safety of Profhilo
Profhilo has a high safety profile because it contains no chemical substances or biologics, including cross-linking agents.
Specifically, this means that it is less likely to cause allergic reactions.
The reason is that Profhilo does not contain "cross-linking agents." Cross-linking agents may cause allergic reactions, immune responses, and inflammation.
Although very rare, allergic reactions have been reported.
Conventional hyaluronic acid injectables contain a substance called a cross-linking agent.
Furthermore, the high safety of Profhilo has been noted in several research papers.
Based on three years of post-marketing experience, the safety profile of the medical device in this study is good
Daniel Cassuto, et al. (2020) Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.
Smart Skin Clinic consistently receives high ratings in reviews on multiple sites, such as Google
At Smart Skin Clinic, we have achieved low cost, high quality, and high satisfaction all at once by carefully considering what is truly necessary for our clients and eliminating unnecessary costs.
This has earned us high ratings across the various review sites, including Google, Hot Pepper Beauty, and others.
As a result, about 80% of first-time visitors become repeat clients.

Hot Pepper Beauty Rating 4.57/5.00

Beauty Passport Rating 4.30/5.00

Kumapon Rating 4.71/5.00

Gangnamunni Rating 9.3/10.0

Japan's most affordable Profhilo prices
| Sessions | Regular Price | Special Price | Per Session |
|---|---|---|---|
| 1 session (2cc) | ¥52,800 | ¥49,800 | ¥49,800 |
| 2 session set (2cc x 2) | ¥99,600 | ¥95,600 | ¥47,800 |
| 3 session set (2cc x 3) | ¥139,800 | ¥137,400 | ¥45,800 |
The prices include consultation fees, needle costs, and all other expenses.
There will be no additional upselling on the day of the treatment.
Need for anesthesia | Low
We generally consider that this procedure does not require anesthesia. As we wish to maintain our current pricing, if you request cream anesthesia, there will be an additional charge of [5,500 yen (tax included) / 1 session].
(This is because using anesthesia adds approximately 20 minutes to the treatment time.)
Market price comparison
At aesthetic clinics in the Kanto region, the market price for Profhilo injections on the face ranges from 65,000 to 80,000 yen per session. A set of two sessions typically costs between 130,000 and 170,000 yen, and three sessions cost around 200,000 yen.
*Based on research conducted in February 2024
Those who are not suitable for the treatment
Those who are pregnant or breastfeeding
Those who have abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those who are prone to keloid formation, hypertrophic scarring, or pigmentation disorders
Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin
Those with excessive sunburn, eczema, dermatitis, severe inflammatory acne, or scabs at the Profhilo injection site
Risks and Side Effects
At the needle puncture site:
- Redness, swelling, pain, and edema
- Bruising
- Temporary bumps or nodules
Downtime
Redness and bumps may occur at the injection site, but in most cases they resolve within about 24 hours.
Due to the nature of the treatment, subcutaneous bleeding (bruising) may occur at the needle puncture site, although this does not always happen. If bruising does appear, it will gradually fade over the course of 10 to 14 days.
Flow of treatment
You can easily make a reservation from your mobile phone
This is a “smart,” easy reception process that requires only that you give us your name
Please feel free to discuss any concerns during the counseling session. Rest assured, there is no pushy sales pressure
After completing the markings, we proceed with the injections while communicating with you throughout the process.
We will explain in detail how to care for the treated area and what to keep in mind in daily life.
More Information
| Treatment Time | Around 15 min (not including counseling) |
| Recommended number and frequency of treatments | We recommend a set of 2 treatments, with an interval of at least 6 weeks between each session After the initial set of treatments, maintenance sessions are recommended approximately once every six months |
| Downtime | Around 24 hours |
| Treatment on the day of counseling | Possible |
| Makeup | Possible immediately after the treatment |
| Skincare | Possible immediately after the treatment |
| Showering | Possible on the same day |
| Pain | There is a slight pricking sensation when the needle is inserted |
FAQ
- How often and how many times should I have the treatment for the best results?
Dr. IshiiAlthough you can see effects even after a single treatment, we recommend one of the following approaches for optimal results:
1. Have the first and second treatments one month apart, then repeat the same pattern each year.
2. Have the first and second treatments one month apart, then continue with treatments every 6 months.
*The skin-remodeling effect of Profhilo increases the extracellular matrix, leading to skin rejuvenation. If maintenance treatments are not performed, the extracellular matrix will gradually decline with aging after the treatment effect reaches its peak. For this reason, we recommend the approaches above.- Will I feel any pain?
Dr. IshiiWhile individual experiences may vary, we use a fine needle, though you may feel a slight pricking sensation. The central part of the face is also said to be more sensitive to pain.
- How long is the downtime?
Dr. IshiiRedness typically subsides within about 24 hours.
- Can I see results after just one treatment?
Dr. IshiiYou can achieve results with just one treatment. In fact, you may feel the lifting effect immediately afterward. However, many people begin to notice the effects 3-4 weeks later, as the skin-remodeling (reconstruction) process progresses.
Legal Notices
Profhilo treatment involves the use of drugs or medical devices that are not approved in Japan. The drugs and devices used in the treatment have been personally imported under the judgment of our clinic's doctor.
For information on drugs and devices that require caution when personally imported, please refer to the following: Ministry of Health, Labour and Welfare, "Drugs and devices that require caution when personally imported."
Smart Skin Clinic
The clinic's concept is to “make cosmetic medicine more accessible and smart.”
Costs are reduced by doing away with ornate interior decoration, cutting back on interior expenses, and carefully selecting only the necessary equipment.
Our goal is to “make cosmetic medicine accessible to as many people as possible.”

Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
About the medical supervision of this site
About the medical supervision of this site
This site is operated under the supervision of the Smart Skin Clinic supervising physicians.
This page is produced under the supervision of our supervising physician, who operates the website as a medical institution in accordance with the Medical Advertising Guidelines revised and enforced in June 2018.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.
Medical Supervision of This Page

Group Director, Smart Skin Clinic / Physician
Kota Ishii
Dr. Kota Ishii oversees the treatment policy across the entire Smart Skin Clinic group, tailored to each patient's skin condition. This page is supervised in accordance with our clinical policy.
Interview with Group Director Kota Ishii
Dr. Kota Ishii shares our approach to treatment. (Interview in Japanese.)
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