With manual injection by a physician, the physician identifies the areas of concern and injects them precisely.
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees. This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Special Prices Available Only at the Hatchobori and Yokohama LocationsAn additional 20%OFF off the discounted price
HydraFacial | Rituo 1 vial (full face)
Sessions
Through September 30 Special Prices Available Only at the Hatchobori and Yokohama Locations
Once
¥65,800 52,640 yen
3 times
184,000 yen 147,200 yen(49,066 yen per session)
HydraFacial | 1 vial of Rituo + 1 vial of Chiara Reju (Full Face)
Sessions
Through September 30 Special Prices Available Only at the Hatchobori and Yokohama Locations
Once
89,800 yen 71,840 yen
3 times
248,000 yen 198,400 yen(66,133 yen per session)
*The special prices available exclusively at the Hatchobori and Yokohama locations apply only to HydraFacial treatments (excluding treatments administered manually by a physician). *All prices include tax. *We offer self-pay (non-insured) treatments only; insurance does not apply. *Limited to treatments at the Hatchobori and Yokohama locations (This offer is valid only at the location where you signed your contract.)
Over 24,000 cases treated annually, more than 600 Google 5-star reviews, and a satisfaction rate of 92.6%. Board-certified anti-aging specialists handle everything from consultation to treatment.
Reasons to Undergo Re2O Treatment at Our Clinic
One of the lowest prices in the country. A 3-session set of HydraFacial treatments costs 184,000 yen (61,333 yen per session), and this price is consistent across all our clinics.
The total price includes anesthesia, consultation, and needle fees. There are no additional charges on the day of the procedure.
A board-certified specialist in anti-aging medicine will provide comprehensive care, from consultation through treatment.
★★★★★
Koyuki (from Hot Pepper Beauty)
Lately, I've grown increasingly concerned about the changes that come with age. I felt I'd reached the limits of self-care when it came to sagging around my mouth, hollow cheeks, nasolabial folds, sunken temples, and the wrinkles and hollows under my eyes. I found Smart Skin Clinic through an online search,and it had extremely high reviews,so I decided to come here. I chose Profhilo because I wanted minimal downtime, safety, and rejuvenation of my whole face. Treatment began right after the consultation, with injections at five points on each side of my face, ten in total. The moment of the needle is just a slight prick, but the discomfort builds as the solution goes in. Still, it's not painful enough to require anesthesia. After the procedure, the injection sites swell a little like mosquito bites, but it's mild enough to hide with a mask and doesn't interfere with heading home. In my case, one spot under my eye bruised, and I'm still covering it with a mask for work. I expect the bruise to fade in about 10 days. On day 1 after the procedure, my cheeks felt fuller. It's now day 5, andthe results far exceed what I imagined,and I couldn't be happier.
★★★★★
Jumomaro (from Hot Pepper Beauty)
I'd long wanted to improve the sagging and wrinkles under my eyes, and since this site had good reviews, I made an appointment.The staff and the doctor were all very pleasant,so I felt at ease receiving my first treatment. I wanted to improve the sagging and wrinkles under my eyes, and I was interested in injections like hyaluronic acid. After the consultation, I went with Sunekos injections. It was relativelydowntime-free,and while I'd been anxious beforehand about how I'd look the next day, I was relieved to be back to normal about 30 minutes after the treatment. After consulting with the doctor and hearing about the treatments I was considering and other details, I chose what best suited me at this point. I then went straight to the treatment room, and it was over in about 15 minutes. I was told that four sessions every two weeks would help maintain the results for about a year, so I decided to do the four-session course.
★★★★★
Ms. B (from Hot Pepper Beauty)
I was concerned about sagging around my mouth and jawline as well as my nasolabial folds, and I was looking for a treatment that could lift and firm these areas. I'd had a similar treatment at this clinic before and could feel its effects, so I keep coming back.The doctor's knowledge and skill are outstanding,and since I've settled on this clinic for my anti-aging care,I can entrust it with complete peace of mind..More affordable than other clinics and easier to keep upso even if you're not well-versed in beauty treatments, I think you'll find it easy to consult with them. I had the Shopping Lift performed on the areas I was concerned about—my jawline, mouth area, and nasolabial folds. My nasolabial folds seemed to improve almost immediately the next day. Within about a week to ten days,I could feel firmer, more radiant skin and a natural lift.It was done. They always answer questions so carefully, and not only are the prices reasonable,there are absolutely no markups or excessive recommendations,so I feel at ease. The reception staff are all approachable too, creating an atmosphere that's easy to visit even for those who find beauty clinics intimidating.
★★★★★
Mika (from Hot Pepper Beauty)
You always take such good care of me,and I can feel my skin getting so much better.Andthe prices are also more reasonable than at other clinics.This time I had Jalupro for the fifth time. I chose Jalupro because it has given me the most visibly noticeable results so far, and because other clinics kept recommending things unrelated to my concerns,so I went to the director I trust.There is pain. But I take deep breaths and get through it, telling myself my skin will be beautiful again. On the day, my face looks a little puffy. The next day it settles into just the right amount of swelling that makes me look younger, which I actually like. I'm thrilled at this point. The director kindly and thoroughly explains everything. I've been taking my own before-and-after photos since getting Jalupro injections, andI'm visibly getting more beautiful.At another clinic I had a skin analysis done, and although my actual age is 39,my skin age was 32.That was the result.I truly, sincerely feel it was the right thing to do.
★★★★★
Pi (from Hot Pepper Beauty)
The reason I chose this clinic is thatit's more affordable than other clinics,and yetit had high reviews.During the consultation I learned about the clinic and heard the doctor's explanation, then decided to go ahead with the treatment—and I'm so glad I chose this clinic for my procedure.
With no waiting time, thereception and the guidance to the exam room were smooth,and the doctor gave precise advice and explanations.I was anxious about the pain, but since it was my first time, they reassured me they could reduce the planned 60 threads to 40 if needed,and they even suggested lower-cost treatment options, which gave me great confidence in them.
Right after the treatment, my nasolabial folds looked so much less noticeable I wondered if they'd already faded. I felt a firm tautness in the lower part of my face, and my makeup went on beautifully. This Shopping Lift is so easy and quick. Next time I'd like to try it again with a few more threads. It was my first time at a beauty clinic and I hesitated over what to do, butI'm satisfied with the treatment I received.This clinicdoesn't push unnecessary recommendations, and considering the price, it's very reasonable.
★★★★★
e e (from Google)
This is my second visit. Last time I had Jalupro treatment for my nasolabial folds, andthe results were quite significant compared with any nasolabial-fold treatment I'd tried before,so this time I came hoping to improve the fine lines on my forehead. Since it's the most affordable formulation in the Jalupro range, I was honestly a little worried they might steer me toward a pricier option, butthere was no hard selling at all,and they went ahead with the Classic just as I'd wanted. Jalupro Classic was quite painful. I'll admit I have a low pain tolerance, but topical anesthesia alone wasn't enough, so I asked for block anesthesia partway through. Even then,they handled it without so much as a frown,for which I'm very grateful. I plan to come back next month for treatment of my nasolabial folds and hollow cheeks.This is a clinic I want to keep visiting.
★★★★★
MI YO (from Google)
The explanation, the speed, the treatment, the price—
everything was highly satisfying.I asked all sorts of questions about things I didn't understand or wanted to know, and every one of themwas answered thoughtfully and thoroughly.Also,I was impressed that they gave honest answers.That's why—though I don't usually make on-the-spot decisions—I was glad I could decide right there today.
With hardly any waiting,everything from counseling to the completed treatment and payment was done within an hour. The sense of efficiency was great. The treatment was careful, too, and I felt less pain than usual, which made me think, "Maybe a skilled doctor causes less discomfort."
The price was also lower than the place I used to go to.For someone like me who values speed, quality of treatment, and price, this is a clinic I feel very satisfied visiting.I think it's a clinic in Tokyo with really great value for money.I feel I can keep coming here with peace of mind.
★★★★☆
S T (from Google)
I'd been hoping to fix the dark circles under my eyes and searched online for good treatments, which led me here. With so many types of injections available, I was unsure, but the doctor told me about a newer product called NEOFOUND rather than Sunekos injections, so I went with that. There was a value course for a set of four sessions, but I wanted to try it once for now, so I did a single session. At 34,500 yen,with no initial or examination fee charged, it was very reasonable.It was my first time getting an injection around my eyes, so I was really scared, but the female doctoradministered it so gently and carefully that there was almost no pain,and it went smoothly. Topical anesthesia does cost a little extra, but there was no pressure—she suggested, "Let's try it without anesthesia first, and if it hurts we can add it next time." I tried without it and felt almost no pain, so I'm glad I followed her advice. When I looked in the mirror afterward, I was surprised by the puffiness under my eyes, but it seems to have absorbed quickly—by day two today it looks completely natural, and with makeup you can't even see the tiny needle marks.The blue dark circles that troubled me for years are gone, too.It's amazing. Next time I think I'll sign up for the course.
★★★★★
Ms. Mihoko Sato (from Google)
I recently had a Water Light Injection. As others have written,there was no sales pressure at all,,
and the reception staff and the doctor all give a great impression!
I've been to several other clinics, but I'd grown tired of fending off upsells during counseling and uneasy about assembly-line treatments... Here,nothing of the sort happened,so I could focus solely on the treatment! I look forward to coming again next month 🙇
★★★★★
Yuka T (from Google)
A few years ago I had treatment for under-eye sagging and dark circles, but it left me with wrinkles that made me look older, which troubled me. Deciding to look into another treatment, I compared several clinics, and since Smart Skin Clinic offered a variety of products and methods, I went in for a consultation hoping to find one that suited me. I shared my concerns, had my condition assessed, and received Sunekos Performa.
They injected it carefully and precisely into the areas I was concerned about.With no bruising,I'm now in the downtime period and things are settling a little, but I'm looking forward to the final result. From booking through treatment, both the doctor and staff came across as genuinely sincere,with no hard selling and no unnecessary upselling or cross-selling, and I found the whole experience very pleasant.
They also avoid spending on unnecessary things, and overallthe prices are kept low,I think.
I'm grateful it's so easy to keep visiting.
★★★★★
IRO code (from Google)
Since childhood I've had atopic dermatitis and sensitive skin, and I'd bruise every time I got an injection. Given the downtime, I couldn't just casually go in. But when I told the doctor at Smart Skin Clinic about my concerns with bruising,they injected very carefully, taking their time to go slowly,which they were able to do for me.
There was no bruising on my face, neck, or under my eyes‼︎This was a first for me, and I was so happy. The bumpy areas from the evening treatment gradually flattened out by night,and I could tell it wouldn't affect my work the next day,which made me truly glad I went through with it. While some clinics keep you waiting even with an appointment, at Smart Skin Clinic everything—from reception to the doctor's consultation, the treatment, and payment—was smooth, a truly "smart" flow just as the name suggests.That was my experience.Profhilo here is also more affordable than at any other clinic, making it easy to keep up,and I'm very satisfied.
★★★★★
Raran (from Hot Pepper Beauty)
While researching Rejuran prices, I learned there's a Rejuran generic, and the place offering it was Smart Skin Clinic. When I checked the cost, compared to the other clinic I'd been going to, it wasconsiderably cheaper,so I booked right away. At other clinics they push other or add-on treatments and it's a hassle to decline, but Smart Skin Clinichad no such sales pitch at all,and I really appreciated that they only recommended the treatment I was there for. The doctor gave me a consultation and, since my goal is nurturing my skin,answered my questions so clearly that I was fully convinced,so I had the treatment that same day. This time it was the mechanical (machine) method, sothere was no bruising.
The receptionist's courteous service left a good impression, and the nurse and the treatment itself were done efficiently and quickly. The interior is very clean and simply designed, and since they don't spend on unnecessary things,the treatment fees are lower than at other clinics,or so I felt.
I was thoroughly satisfied with everything.
Google Reviews 4.5/5.0
Hot Pepper Beauty 4.57/5.00
KireiPass rating4.30/5.00
Kumapon rating4.71/5.00
Gangnam Unni rating9.3/10.0
Kota Ishii
Chairman, Smart Skin Clinic
Board-certified specialist, Japanese Society of Anti-Aging Medicine
"Cosmetic medicine doesn't have to be expensive." It's an answer I arrived at precisely because I was once a patient myself.
Hello, I'm Ishii, the Chairman. As a physician, I have also received a variety of cosmetic treatments as a patient myself. Through that experience, I came to hold a strong conviction: I want to offer genuinely effective treatments at prices everyone can comfortably continue.
Smart Skin Clinic thoroughly cuts costs that have nothing to do with treatment quality—such as lavish interiors and excessive advertising—and passes those savings back to you in our prices. Beyond affordability, we invite you to discover our commitment to putting patient satisfaction first.
Our commitment: promising value that goes beyond the price
✓
The same physician cares for you throughout
Rather than leaving things to counselors, a physician takes responsibility for everything from your examination to aftercare.
✓
Products opened in front of you
To remove any worry about "what's in this product," we always open a new, unused product in front of you for your confirmation.
✓
Ultra-fine needles to reduce pain
We use ultra-fine needles (34G) personally selected by the director. Our advanced technique helps keep discomfort during treatment to a minimum.
✓
No upselling whatsoever
The listed price is the all-inclusive total, covering the examination fee, needle costs, and everything else. There's no need to worry about the price going up later.
Rituo (product name: Elravie Re2O in the Korean version, BNAJU in the Japanese version) is a skin booster formulation developed by Humedix in Korea.
It is characterized by a novel approach and main ingredient never seen before.
[Features of Rituo]
An approach that supplements the skin's structure
The main ingredient is hADM
How does it differ from conventional skin boosters? The concept of "directly supplementing"
If you have tried conventional skin boosters but find it hard to feel results, your skin's structure and regenerative capacity may have weakened.
Conventional skin boosters took the approach of injecting PDRN, PDLLA, porcine collagen, and the like to "activate cells and promote the synthesis of the substances that make up the skin."
On the other hand, Rituo is characterized by “an approach that directly replenishes the extracellular matrix (ECM)—the very structure that provides the foundation for lost firmness and elasticity—into the dermis” . Think of it as installing new pillars in a house whose foundation has collapsed. By “rebuilding” the skin’s foundation, the fibroblasts that produce collagen and elastin are activated.
ECM (extracellular matrix) and aging
Our bodies are made up of "cells" and "non-cellular components."
The collective term for components found on the “outside” of cells (i.e., the extracellular space) is “ECM (Extracellular Matrix)” . The term “matrix” refers to a “structure” or “foundation.”
The ECM includes, for example, collagen, elastin, hyaluronic acid, and growth factors; it plays a role in signal transmission between cells and provides the foundation for cells to interact with the surrounding tissue.
When the ECM is healthy, the skin can more easily maintain its firmness and elasticity. Young skin is rich in ECM . Through interaction with fibroblasts, collagen is constantly produced and maintained.
Conversely, it is known that when the ECM becomes disrupted due to aging or UV exposure, collagen fragmentation progresses and fibroblast function tends to decline.
What is the main ingredient "hADM"? A collagen structure derived from human skin
Rituo contains 150 mg of human acellular dermal matrix (hADM) as its main ingredient .
hADM is derived from human skin tissue from which cells and lipids that trigger immune responses have been completely removed, leaving only the ECM structure. Although it is “human-derived,” it contains absolutely no “cells themselves”; it consists solely of collagen structures , and is therefore considered unlikely to cause a foreign body reaction or rejection.
Because it retains the three-dimensional structure of the ECM intact, after injection your own fibroblasts can readily use this scaffold, creating an environment in which they can easily produce collagen.
Rituo is a treatment designed to improve skin texture while reinforcing the foundation that supports the skin's structure.
Comparison|Rituo, Rejuran, and Juvelook
We have compared the differences with representative skin boosters in a table.
Item
Lituo
Rejuran
Juvelook
Main ingredient
hADM (human-derived acellular dermis)
PN (salmon-derived polynucleotide)
PDLLA (polylactic acid derivative)
Approach
Replenishes the ECM scaffold to reinforce the foundation and activate fibroblasts
DNA fragments promote skin regeneration
Stimulates and increases collagen production
Duration
6–12 months
More than 12 months
12–24 months
Main indications
Pores, dark spots and dullness, texture
Sagging, fine lines around the eyes, dark circles
Acne scars, pores
It is also possible to combine multiple formulations. For details, please consult us during your counseling.
Which layer is it injected into?
Injectable formulations vary in both their ingredients and intended purposes. Therefore, it is extremely important to administer each formulation at the appropriate “depth” and “volume” to ensure optimal results.
In the case of Rituo, the main injection layer is "from the superficial to the deep dermis (the full thickness of the dermis)."
The skin is structured in layers, starting from the surface: the "epidermis," the "dermis" (comprising the superficial, middle, and deep layers), the "subcutaneous fat layer," and the "muscle layer," each of which plays a distinct role. From the superficial to the deep dermis is the region responsible for the skin's various functions, from the texture and firmness of the skin's surface to structural support deep within.
The full thickness of the dermis is the range where Rituo's ingredients and intended effects can be most effectively drawn out, and this is the medical rationale behind our clinic's practice of injecting this formulation into this range.
When do the effects start? How many sessions are needed? How long do they last?
Immediately after: a certain degree of firmness
2 to 4 weeks after the procedure: collagen production from ECM reconstruction
Peak: 1 to 2 months after completing one course (3 sessions)
Duration: approximately 6 to 12 months
Maintenance interval: every 3 to 6 months
Risks and Side Effects
Redness, swelling, pain, and edema at the needle insertion site
Bruising
Temporary raised bumps
Results and downtime may vary from person to person.
Those who are not eligible for the treatment
Women who are pregnant or breastfeeding
People with impaired immune function or those undergoing immunosuppressive therapy
People who are prone to keloids, hypertrophic scars, or pigmentary disorders
People with a tendency to bleed or those taking anticoagulants or similar medications
People with sunburn, eczema, dermatitis, or severe inflammation at the injection site
With manual injection by a physician, the physician identifies the areas of concern and injects them precisely.
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees. This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Special Prices Available Only at the Hatchobori and Yokohama LocationsAn additional 20%OFF off the discounted price
HydraFacial | Rituo 1 vial (full face)
Sessions
Through September 30 Special Prices Available Only at the Hatchobori and Yokohama Locations
Once
¥65,800 52,640 yen
3 times
184,000 yen 147,200 yen(49,066 yen per session)
HydraFacial | 1 vial of Rituo + 1 vial of Chiara Reju (Full Face)
Sessions
Through September 30 Special Prices Available Only at the Hatchobori and Yokohama Locations
Once
89,800 yen 71,840 yen
3 times
248,000 yen 198,400 yen(66,133 yen per session)
*The special prices available exclusively at the Hatchobori and Yokohama locations apply only to HydraFacial treatments (excluding treatments administered manually by a physician). *All prices include tax. *We offer self-pay (non-insured) treatments only; insurance does not apply. *Limited to treatments at the Hatchobori and Yokohama locations (This offer is valid only at the location where you signed your contract.)
Final Call to Action
🙏 Thank you for reading all the way to the end!
Through September 30The limited-time special price is almost gone!
If you miss this opportunity, the regular price will apply.
The benefits of booking now
This limited-time special price may end without notice. Now is your chance to receive it at the lowest price level in Japan.
Treatments are performed by a board-certified anti-aging specialist with a track record of over 24,000 skin rejuvenation injections.
A free consultation with a physician (normally valued at 10,000 yen)
Minimal downtime, with natural improvements and changes that others won't notice
Trusted with a 90%-plus satisfaction rating across various reviews and ratings
Even a consultation-only visit is more than welcome!
At our clinic, consultations are conducted directly by a physician, not a beauty counselor. There is no hard selling whatsoever, so please feel free to consult with us.
*Please feel free to visit us even just for a free consultation. There is no high-pressure selling whatsoever.
The treatments described on this page involve the use of drugs or medical devices that have not been approved in Japan. The drugs and devices used for treatment have been imported through personal import procedures based on the judgment of our clinic’s physicians. Please refer to the Ministry of Health, Labor and Welfare’s website for information on drugs and other items requiring caution when imported through personal import.