Profibro Injection|Smart Skin Clinic (Jimbocho, Tokyo)

*Number of cases|From September 1, 2023 to March 31, 2024

What is profilo and what kind of effect can I expect from it?"

I'm looking at clinics for a profilo and want to compare prices."

Do you have any of these questions or concerns?

Smart Skin Clinic, a cosmetic dermatology clinic, will explain in an easy-to-understand manner from a professional standpoint.

*If you would like to know specific items such as fees, you can jump to the table of contents below.


What is the next-generation hyaluronic acid "Profibro"?

PROFHILO injection

Profibro is an injectable formulation containing a high concentration of two types of hyaluronic acid, high molecular weight and low molecular weight. Because these two types of hyaluronic acid are not cross-linked, Profibro is called a non-cross-linked hyaluronic acid product.

Hyaluronic acid has the following properties

  • Moisturizing effect
  • Promotes tissue repair and regeneration
  • Support for cell movement
  • Regulation of cell proliferation and differentiation

Due to these properties of hyaluronic acid, Profibro is expected to improve skin elasticity and firmness, improve skin texture, and rejuvenate the overall skin

Differences from General Hyaluronic Acid

What is conventional hyaluronic acid (cross-linked type)?

In general hyaluronic acid injections, bone and fat volume loss due to aging was "filled in" with hyaluronic acid to improve facial contours, wrinkles, and lines.

Areas such as the eye area, laugh lines, and marionette lines are individually targeted, and the injected hyaluronic acid stays in the treatment area, filling in reduced fat and lifting ligaments.

What is cross-linking? Difference between non-crosslinked and crosslinked

First, hyaluronic acid is a substance that is distributed not only in the skin but also in many other parts of the body.

There are two types of hyaluronic acid: cross-linked hyaluronic acid and non-cross-linked hyaluronic acid.

The hyaluronic acid found in the body is "non-cross-linked hyaluronic acid," while the hyaluronic acid preparations conventionally used in the cosmetic field are "cross-linked hyaluronic acid.
Cross-linking" refers to the binding of hyaluronic acid to each other so that they do not separate.

In other words, the difference between cross-linked and non-cross-linked is whether the hyaluronic acids are "bound" to each other or not.

Conventional hyaluronic acid preparations are used for volume enhancement and contouring. The manufacturing technique of cross-linking was developed based on the fact that hyaluronic acid is a naturally occurring substance in the body that is less likely to cause adverse reactions. Cross-linked hyaluronic acid is less likely to be degraded by the body and retains its shape, allowing conventional hyaluronic acid formulations to be used for volume enhancement and contouring. Due to its solid nature, it carries the risk of vascular embolization.

In contrast, non-cross-linked hyaluronic acid has the same properties as hyaluronic acid in its natural state in the body and diffuses widely when injected. In other words, non-cross-linked hyaluronic acid improves skin quality by spreading the effects of hyaluronic acid, including moisturizing and cell activation, throughout the skin.

Various awards received

Profilo Award

Profibro is an award-winning cosmetic treatment product worldwide.

Recommended for the following problems

  • I want to do something about wrinkles and sagging skin.
  • not feeling bouncy
  • I need more volume in the cheeks.
  • Wrinkles not only on the face but also on the neck and hands
  • I want it to look natural so people don't think I did anything to it.
  • I'm concerned about my laugh lines.

Effect|Profilo has a skin rejuvenation effect.

Profilo has the following benefits

z Improvement of wrinkles and sagging skin
0 Effect of improving firmness and elasticity (increased freshness)
0 Lifting effect
0 Natural volume increase


These effects are achieved by the following properties of hyaluronic acid

  • Moisturizing effect
  • Promotes tissue repair and regeneration
  • Support for cell movement
  • Regulation of cell proliferation and differentiation

These properties will be explained based on the following cross-sectional view of the skin.

The skin consists of three layers, each with its own role

  • Epidermis|Barrier function
  • Dermis|Regulates elasticity and firmness
  • Subcutaneous tissue|Insulation and heat retention functions
  1. Moisturizing effect
    Hyaluronic acid has the ability to attract and retain large amounts of moisture in the skin. After being injected into the skin, hyaluronic acid absorbs the surrounding moisture and brings moisture into the skin. This plumps the skin from the inside out, smoothing the surface and improving the appearance of fine wrinkles and roughness caused by dryness.

  2. Promotes tissue repair and regeneration
    In the skin, hyaluronic acid activates fibroblasts in the dermis. As a result, the production of new collagen and elastin is stimulated, assisting in the recovery of damaged skin and skin regeneration. This treatment in which damaged skin undergoes tissue repair and recovery is called ECM remodeling treatment.
What is ECM Remodeling Treatment?

First, ECM stands for "Extracellular Matrix," which refers to the outer crevice of the cell.

ECM remodeling treatment means remodeling (restructuring) the outer part of these cells, in other words, creating new ones. The cells referred to here are fibroblasts, and the gaps outside the fibroblasts are collagen, elastin, hyaluronic acid, etc.

It is difficult to describe in abstract terms, so I will explain in concrete terms to make it easier to understand.

First, skin firmness, elasticity, and flexibility are produced by collagen and elastin, which are fibrous tissues in the dermis layer, and hyaluronic acid, a gel-like substance that fills in the gaps. And it is fibroblasts that produce these three tissues.

Elastic fibrous tissue that serves as the skin's foundation as a three-dimensional mesh-like framework

It is responsible for providing elasticity to the skin and keeping it flexible enough to return to its original shape even when the skin stretches and contracts with the movement of facial expressions. Also plays a role in holding collagen fibers together so that they do not fall apart, helping to maintain the three-dimensional framework of collagen

hyaluronic acid
A substance that fills in the gaps between collagen, elastin, and other fibrous tissues. It has a strong ability to attract water, and when bound to water, it swells to a gel-like state and plays a central role in maintaining the elasticity and moisture of the skin.

They produce collagen, elastin, and hyaluronic acid. Fibroblasts themselves also self-differentiate and proliferate

In other words, the more fibroblasts, collagen, elastin, and hyaluronic acid, the younger and healthier the skin.

Skin sags due to aging and UV rays. Aging causes a decrease in the number of cells (fibroblasts) that produce skin and their function declines. UV rays also destroy collagen, elastin, and other fibrous tissue.

When hyaluronic acid stimulates fibroblast activity, collagen, elastin, and hyaluronic acid are increased and destroyed tissues are repaired. The proliferation of fibroblasts themselves is also stimulated. As a result, the skin regains elasticity and firmness from the inside out and becomes healthier.

This treatment, in which the diminished dermal layer is rebuilt by activating fibroblasts, is called ECM remodeling treatment.

  1. Support for cell movement
    Hyaluronic acid is an important component of the ECM: the extracellular matrix (the interstitial space between cells inside the skin). When the skin's interior is enriched by hyaluronic acid, it facilitates the migration and movement of immune cells and other cells. It also helps deliver nutrients and oxygen to cells in the dermis and supports the elimination of waste products. This effect promotes skin recovery and restores a more even and healthy skin texture.

  2. Regulation of cell proliferation and differentiation
    Hyaluronic acid has a regulatory effect on cell proliferation and differentiation. The specific mechanism is too complex and technical to discuss here, but hyaluronic acid provides signals that promote skin cell proliferation and differentiation in the correct direction. This stimulates the production of new skin cells and assists in skin rejuvenation.

When can the effects be felt after the treatment?

When can the effects be felt after the treatment?

Dr. Smaski.

The feeling of the effect varies from person to person, but it is often felt gradually from a few days to a few weeks after injection. The maximum effect is usually felt around one month after injection.

How long do the effects last?

How long do the effects last?

Dr. Smaski.

It is estimated to last from 6 months to 1 year. For continued effectiveness, we recommend regular injections as maintenance.

Characteristics of PROFILO|Deep and wide penetration in multiple directions

We have discussed the properties of hyaluronic acid. Here, we will explain the characteristics of PROFILO, including the properties of hyaluronic acid.

Penetrating power to penetrate deeply and widely in multiple directions"

This is what makes Profilo unique.

PROFILO is a special formulation of two types of hyaluronic acid, using the NAHYCO™ technology patented internationally by IBSA of Italy.

High molecular weight hyaluronic acid moisturizes the superficial layers of the skin, while low molecular weight hyaluronic acid penetrates deeper into the skin and exerts its effects. These different hyaluronic acid molecules allow Profibro to penetrate more widely and deeply into the epidermis, dermis, and subcutaneous tissue.

This penetration is stronger than that of other non-cross-linked hyaluronic acids and penetrates deeper into the skin.

It is believed that this permeability allows the action of hyaluronic acid to reach the subcutaneous fat in the subcutaneous tissue, making the skin healthier and plumper.

Spreading Features

What is the difference between Profilo and Borite?

What is the difference between Profilo and Borite?

Dr. Smaski.

Borite is also a type of hyaluronic acid, but the major difference is the presence or absence of cross-linking. Borite is a cross-linked hyaluronic acid. Although it is cross-linked hyaluronic acid, it is designed through a special manufacturing process to achieve natural spreading and uniform distribution.
Some of the characteristics of borites include the following
Effective for fine expression lines on the face and wrinkles around the eyes and mouth
Provides elasticity and moisture to the skin, contributing to a more youthful appearance
Long-lasting effect and natural finish
No ECM remodeling effect, so no improvement in skin elasticity or skin growth
Cross-linked hyaluronic acid has risks and side effects such as vascular embolization.

Case photos (before/after)

Profilo case photo (2)
Profilo case photo

Risks/side effects

PROFHILO contains no cross-linking agents or other chemicals or biological agents.Highly safeIt can be said that

Specifically,Less likely to cause allergic reactions, etc.This is the case.

The reason for this is that PROFHILO does not contain a "cross-linking agent".

Cross-linking agents can cause allergic reactions, immune reactions, and inflammation. Allergic reactions have been reported to occur, although they are very infrequent. Conventional hyaluronic acid injectables contain a substance called a cross-linker.

What is cross-linking?

It is the creation of new chemical bonds that bridge the chain-like structure of hyaluronic acid. As a result of cross-linking, hyaluronic acid becomes a three-dimensional structure. The three-dimensional structure created by cross-linking slows the absorption and degradation of hyaluronic acid at the injection site and prolongs its duration.

Also,The high safety profile of PROFHILO has been mentioned in several papers.

Based on 3 years of post-market experience, the safety profile of the medical devices in this study is good

Daniel Cassuto, et al. (2020)Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.

Possible side effects include the following

of the needle puncture site.

Redness, swelling, pain, edema, temporary elevation

Intravascular hemorrhage


There are no major disadvantages to be noted for Profilo. The minor disadvantages are listed below.

  • Effects are not permanent, so repeated treatments are necessary to continue to obtain results.
  • Profilo's effectiveness varies from person to person.
  •  Temporary redness and swelling may occur after injection. These usually resolve in a few days, but may affect the immediate appearance of the procedure
  • Cost is high. Profibro itself is an expensive preparation, so the general market price is: 1 time: 80,000-150,000, 2 times: 150,000-300,000.

For more information on the disadvantages of Profilo, see this article.

Treatment area/method

PROFHILO is,BAP method (bioesthetic point method)It is decided that the injection is to be done by a method called
It is believed that standardizing the areas to be injected will provide effective and uniform results.

Injection site of BAP method

10 locations each on the face OR neck.
These 10 points are centered on the lower 1/3 of the face, which is prone to skin atrophy due to aging, and are considered anatomically safe areas without large blood vessels or nerves.

*Supplemental Explanation
Since PROFHILO has "spreading properties," it does not matter if the injection is made at 10 different sites. Specifically, when injected, the effect is spread over a 2 cm square from the injection site, and the above injection method has been proven to be sufficient to achieve the desired effect.

of the BAP method.Injection Method

Inject a small, shallow amount of 0.2 cc per site. 1 bottle (2 cc) is used per treatment.

Facial injection sites

Facial Treatment Points

Neck injection point

Neck Treatment Points

Injection site on the back of the hand

Back of the hand treatment points

Profilo "Profilo Body" dedicated to body

Profilo Body Kit

A body-specific formulation of Profilo was introduced in Japan around mid-2023.

Profilo was also able to hit the body, but Profilo Body is a formulation optimized for the body, as it is designed specifically for the body.

Any part of the body can be addressed, with the most recommended areas being the décolleté, back of the hands, and stomach.

If you are interested in more details, please refer to the following articles.

Recommended number/frequency of treatments|Schedule of treatments

The recommended number of treatments and the timing of the third session are as follows

  • After the first injection,About 4~6 weeksIt is recommended that two sets of two sessions be performed at a time.
  • As for the subsequent third injections, it is recommended that the same pattern of injections be performed every year or every six months for maintenance.
Profilo treatment interval

Smart Skin Clinic PROFHILOCharacteristics of the "Kao Group's" commitment to injectable formulations

Our director's policy is to implement the following "particulars" in injections.

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Those who cannot be treated

Pregnant or nursing mothers

Those with abnormal immune function or a history of such abnormality, and those undergoing immunosuppressive therapy.

Those prone to keloid formation, hypertrophic scars and hyperpigmentation

Those with bleeding tendency or using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin

Excessive sunburn, eczema, dermatitis, acne, or scabs at the site of PROFHILO injection

Down time

Basically, you should expect swelling, redness, and swelling of the treatment injection site for about 1 to 2 days (basically within 24 hours, up to 48 hours).

Non-cross-linked hyaluronic acid is said to be slightly swollen immediately after injection, and the swelling is said to be absorbed within 48 hours.

Basically, the above assumptions are fine, but there is a few percent chance that "internal bleeding" may occur.

What is internal bleeding?

When you hit your body hard somewhere, you may have a bruise. This is internal bleeding. The medical mechanism is that blood vessels in the skin break and blood flows out and hardens in the skin.

Please understand that it is difficult to say that 100% does not occur, since whether or not this occurs is affected by the following two factors.

  • Physician's skill
  • Personal physical characteristics

If internal bleeding occurs, it will gradually fade over a week or two.

Dr. Smaski.

There is relatively little reaction after the injection, and makeup can be applied immediately after the procedure, so if you wear a mask, you can spend time without worrying about being seen.


The injection site and amount of Profibro is standardized as the BAP method*, and one bottle (2 cc) is used per treatment. This means that the amount of Profibro used in one treatment is basically the same at all clinics, making it simple to compare treatment details and prices.

*Some individual differences may occur in customized treatment.

Our fees (profilo)

New Price: Profhilo has been significantly reduced. (December 20, 2023)

1 time (2cc)59,800 yen
2 sets (2cc x 2)109,600 yen
(59,800 yen for the first bottle)
(Second bottle 49,800 yen)
3 sets (2cc x 3)149,400 yen
(59,800 yen for the first bottle)
(49,800 yen for the second bottle)
(39,800 yen for the third bottle)
Monitor price: 2 sets (2cc x 2)99,800 yen
(49,900 yen per bottle)
All prices include tax.
We are a free clinic and not covered by insurance.

The price is indicated as all-inclusive, including consultation and needle fees.
There is no separate upsell on the day of the event.

Need for anesthesia|Low

This procedure is basically considered anesthesia-free.
We would like to maintain this price, so if you would like cream anesthesia5,500 yen (tax included) / 1 time(*This is because anesthesia will increase the time by about 20 minutes. (*This is because anesthesia will increase the time by about 20 minutes.)

Monitoring Requirements

(i)Usage|We may post the photos on our website, Instagram, etc. with the eye area hidden, or show them to other customers as examples of treatment [please think of them as general case photos].
(2)implementation method|We will refund the difference (between the regular price and the monitor's price) at the time of the monitor's photo shoot (3 to 7 days after the second treatment).

Price quotes

At beauty clinics in the Kanto area, the market price is 65,000-80,000 yen per treatment to inject Profibro into the face, 130,000-170,000 yen for a set of two treatments, and approximately 200,000 yen for three treatments.

*Surveyed in February 2024.

profilo body

Areas to be treated

Anywhere on the body except the face
e.g.) Decollete, back of hands, stomach (upper and lower abdomen), above elbows, fingers, above knees, thighs, etc.

*Required dosage

3 cc per part is the standard. When administering left and right, or both upper and lower portions of the abdomen, a total of 6 cc per dose is recommended.

1 time (3cc)59,800 yen
2 sets (3cc x 2)
[Includes a bottle of special body cream.]
109,600 yen
(59,800 yen for the first bottle)
(Second bottle 49,800 yen)
Set of 4 times (3cc x 4)
[Includes two bottles of special body cream.]
194,200 yen
(59,800 yen for the first bottle)
(49,800 yen for the second bottle)
(3rd bottle 44,800 yen)
(39,800 yen for the 4th bottle)
Monitor price] 2 sets (3cc x 2)
[Includes a bottle of special body cream.]
99,600 yen
Monitor price] 4 times set (3cc x 4)
[Includes two bottles of special body cream.]
184,200 yen
All prices include tax.
We are a free clinic and not covered by insurance.

Flow of treatment


You can easily make reservations with your mobile phone.

Reception (desk)

This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.

Counseling and medical examination

Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.

PROFHILO injection

After the marking is carried out, the injection is carried out while talking to the patient.

After-sales service

We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.

Returning home

More Information

Treatment Time15-30 minutes (not including counseling)
Recommended number and frequency of treatmentsIt is recommended that two sets of two sessions be performed at least 6 weeks apart.
After that, maintenance is recommended about once every six months.
Down timeAbout 24 hours
Treatment on the day of counselingPossible
MakePossible immediately after the treatment
Skin carePossible immediately after the treatment
ShowerPossible from the same day
PainThere is a stinging pain when the needle is inserted.
*There are individual differences.

We also recommend the following treatments

At Smart Skin Clinic, we focus on skin growth injection procedures. We currently offer 11 formulations, from which we can suggest a treatment that fits your concerns and budget.

If you are not sure what kind of treatment is best for you, please feel free to just come in for a consultation first.

The following is a brief summary of the characteristics of other injectable formulations, which you may consider if you are interested.

Skin growth injection products other than PROFILO (Jalpro, SUNECOS, REDURAN, JUVELUX, GOURI injections)

I'll tell you in conclusion first.

For overall skin moisturizing, luster improvement, and overall skin rejuvenation: JUVELUX, PROFILO, and JalPro Super Hydro.

Sagging Improvement] GOURI, JUVELUX Volume (RENISNA), JalPro Super Hydro, Profibro

Improvement of deep wrinkles and lines] GOURI, JUVELUX VOLUME (RENISNA), Jalpro HMW

Improvement of problems around the eyes (fine lines, sagging, firmness)] SUNECOS, Rejelan i, Jalpro Classic

Improvement of post-acne and scar indentations] JUVELUX, Rejelan, Rejelan HB

There are many types of skin growth system injectable preparations, so it is best to make a comprehensive decision based on your concerns, expected effects, budget, and whether your local clinic offers the product.

It is important to remember that the effects of injectable procedures vary from person to person. Although the effects can be felt after a single treatment, it is important to remember that they must be continued in order to be sustained.

To learn more about each of the injection formulations, please read the following articles.

Laser-based and surgical procedures (hyphae, thread lift) to improve sagging

Laser-based and surgical procedures are effective in improving sagging skin.

This treatment is a different approach from Profibro and aims to tighten and lift the skin.

Even in surgical procedures, there are individual differences in effectiveness. In addition, in order to maintain the effect of sagging improvement, even this procedure needs to be continued.

HIFU is not available at our clinic.

Frequently Asked Questions about Profilo

Q: Is there anything I should be aware of after Profibro injections?

A:The injected area may swell after injection, and it is recommended to avoid excessive touching or pressure on the area. After the procedure, please avoid strenuous exercise, prolonged bathing (prolonged activity in direct sunlight or sauna), and excessive alcohol consumption.

Q: How often do I have to have Profibro injections, maintenance after the second injection?

A:It is recommended that a second set of injections be performed at least 6 weeks after the first injection.
As for the subsequent third injections, it is recommended that the same pattern of injections be performed every year or every six months for maintenance.

Q: When can I expect to feel the effects of Profibro, even after just one session?

A:Effects vary from person to person, but for some people, an improvement in skin texture is felt immediately after the first treatment. Most people can feel it as an effect after 4 weeks.

Q: Can Profibro be used in combination with other cosmetic dermatology treatments?

A:Basically, it is possible to use other cosmetic procedures in combination. If you are considering other procedures as well, please consult your doctor during the consultation.

Q: Can I receive Profibro while pregnant or nursing?

A:Pregnant and lactating women are not eligible to receive this service.

Q: Can it be done under the eyes?

A:Profibro cannot be injected under the eyes because the injection site is determined. However, since the drug diffuses and permeates widely after injection, it can be expected to be effective for problems around the eyes, including under the eyes.

[Legal description

Prophylotherapy includes procedures using drugs or medical devices that are not approved in Japan. The medicines and devices used in the treatment have been imported on a personal import basis under the judgment of our physicians.

Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".

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Smart Skin Clinic

Smart Skin Clinic

The concept of the clinic is to "make cosmetic medicine more accessible and smart. is the concept of the clinic.

Instead of eliminating ornate interiors to reduce interior design costs and installing equipment in the dark, we carefully select the equipment we need and reduce the cost of the equipment.

We aim to "make cosmetic medicine more accessible" for you.

Clinic Reception

Address:EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic dermatology (cosmetic dermatology, medical hair removal, medical slimming)

Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic dermatology (cosmetic dermatology, medical hair removal, medical slimming)

About the physician supervision of this site

About the physician supervision of this site

This site is operated under the supervision of the Smart Skin Clinic supervising physicians.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.