Lately, I've grown increasingly concerned about the changes that come with age. I felt I'd reached the limits of self-care when it came to sagging around my mouth, hollow cheeks, nasolabial folds, sunken temples, and the wrinkles and hollows under my eyes. I found Smart Skin Clinic through an online search,and it had extremely high reviews,so I decided to come here. I chose Profhilo because I wanted minimal downtime, safety, and rejuvenation of my whole face. Treatment began right after the consultation, with injections at five points on each side of my face, ten in total. The moment of the needle is just a slight prick, but the discomfort builds as the solution goes in. Still, it's not painful enough to require anesthesia. After the procedure, the injection sites swell a little like mosquito bites, but it's mild enough to hide with a mask and doesn't interfere with heading home. In my case, one spot under my eye bruised, and I'm still covering it with a mask for work. I expect the bruise to fade in about 10 days. On day 1 after the procedure, my cheeks felt fuller. It's now day 5, andthe results far exceed what I imagined,and I couldn't be happier.
One of the Lowest Prices in Japan: Plural—1cc for 13,300 yen (anesthesia included) | [Official] Smart Skin Clinic Group, Tokyo and Yokohama

| 2cc | Price | Per 1 cc Price |
| Once | 44,800 yen | 22,400 yen |
| 3 times | 119,400 yen (per session 39,800 yen) | 19,900 yen |
| 4 sessions | 155,200 yen (per session 38,800 yen) | 19,400 yen |
| 1 bottle (2cc) | Limited discount price (Through September 30) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | 44,820 yen | ¥22,410 |
| 3 times (20% off) | ¥117,120 (per session ¥39,040) | ¥19,520 |
| 5 sessions (20% off) | 187,200 yen (per session ¥37,440) | ¥18,720 |
| 10 sessions (20% off) | 342,400 yen (per session 34,¥240) | ¥17,120 |
| 2 bottles (4cc) | Limited discount price (Through September 30) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥71,820 | ¥17,950 |
| 3 times (20% off) | ¥189,120 (per session 63,040 yen) | ¥15,760 |
| 5 sessions (20% off) | 307,200 yen (per session 61,¥440) | ¥15,360 |
| 10 sessions (20% off) | 582,400 yen (per session 58,¥240) | ¥14,560 |
| 3 bottles (6cc) | Limited discount price (Through September 30) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥98,820 | ¥16,470 |
| 3 times (20% off) | ¥258,720 (per session ¥86,240) | ¥14,380 |
| 5 sessions (20% off) | 419,200 yen (per session ¥83,840) | 14,000 yen |
| 10 sessions (20% off) | 798,400 yen (per session ¥79,840) | 13,300 yen |
Over 24,000 cases treated annually, more than 600 Google 5-star reviews, and a satisfaction rate of 92.6%. Board-certified anti-aging specialists handle everything from consultation to treatment.
Reasons to Get Plural at Our Clinic
- One of the lowest prices in Japan. Densify/Hair Density: 3 vials × 10-session set for 13,300 yen per 1 cc
- Prices are listed as total amounts, including anesthesia fees and all other costs. There are no additional charges on the day of the procedure.
- From Silk Densify Hair Density, a doctor will compare and recommend options based on your specific concerns.
Google Reviews 4.5/5.0

Hot Pepper Beauty 4.57/5.00

KireiPass rating4.30/5.00

Kumapon rating4.71/5.00

Gangnam Unni rating9.3/10.0

Kota Ishii
Chairman, Smart Skin Clinic
What is the Pluryal (PLURYAL) Densifier series?
The Pluryal (PLURYAL) Densifier series is a new injectable formulation using biostimulator technology.
Developed by MD Skin Solutions of Luxembourg,it is used in more than 20 countries, primarily across Europe,and is a product drawing considerable attention.
Pluryal comes in the following four types:
- Pluryal Silk (PLURYAL SILK)
- Pluryal Densify (PLURYAL DENSIFY)
- Biosculpture (PLURYAL BIOSCULPTURE)
- Pluryal Hair Density (PLURYAL HAIR DENSITY)
These products provide comprehensive solutions for a wide range of needs, from eye care to full-face rejuvenation and even hair growth.
Main ingredient of the Pluryal (PLURYAL) Densifier series
This series'main ingredient of the flagship products is polynucleotide (PN),a highly purified DNA fragment derived from salmon.
PN offers the following effects:
- Increased skin hydration
- antioxidant action
- anti-inflammatory action
- Promotes fibroblast proliferation
- DNA repair and regeneration
- Promotion of angiogenesis
Thanks to these effects, the Pluryal (PLURYAL) Densifier series delivers more than just temporary improvement; it revitalizes the natural functions of the skin and hair for long-term improvement in quality.

1. Pluryal Silk (PLURYAL SILK)
PLURYAL SILK is a product developed specifically for the eye area.CE approved exclusively for use around the eyesso it does.
Key features:
- Effective for fine wrinkles around the eyes and mouth
- High expectations for improving dark circles
- A formulation designed to suit delicate areas
For more details, please see the article on Plural Silk (PLURYAL SILK).
2. Pluryal Densify (PLURYAL DENSIFY)
Plural Densify (PLURYAL DENSIFY) is,Specialized in improving the skin quality of the entire facea product that is
Key features:
- Non-cross-linked hyaluronic acid added to PN andMannitolblended in a proprietary way
- Whole-face skin-quality improvement is possible
- Effective for improving firmness and radiance
For more details, see the article on Plural Densify (PLURYAL DENSIFY).
4. Pluryal Hair Density (PLURYAL HAIR DENSITY)
Plural Hair Density (PLURYAL HAIR DENSITY) is,Specialized in hair growtha product that is
Key features:
- Can be used on the scalp, eyebrows, and beard
- Effective for male pattern hair loss (AGA) and female pattern hair loss (FAGA)
- Supports hair growth and increases hair thickness
For more information, check out the article on Plural Hair Density (PLURYAL HAIR DENSITY).

Which layer is it injected into?

A hydrafacial is a procedure in which a solution is injected directly into the superficial layer of the skin, known as the “dermis.” Prural’s Densify and Hair Density are administered via this hydrafacial procedure. Prural Silk also primarily targets the superficial layer of the dermis.
The skin has a layered structure, consisting from the surface of the “epidermis,” “dermis (superficial, middle, and deep layers),” “subcutaneous fat layer,” and “muscle layer,” each of which plays a distinct role. Injecting each formulation into the appropriate layer and in the appropriate amount is crucial for achieving the desired results.
The difference between Pluryal and Rejuran: an accurate comparison and how to choose
A question we receive from many people"the difference between Pluryal and Rejuran"is what we'll explain here.
1. The difference in main ingredient and purity
Both formulationshave polynucleotide (PN) as their main ingredient,but there is a significant difference.
- Pluryal:
- Proteins are completely removed, making the PN purity extremely high.
- The allergy risk is very low.
- Rejuran:
- A certain amount of protein remains.
- The allergy risk is slightly higher compared with Pluryal.
3. The difference in effect
- Pluryal:
- Good balance of immediate and lasting effects
- Strong three-dimensional rejuvenation effect
- In addition to improving skin quality, improvement of the contours can also be expected
- Rejuran:
- The effect emerges gradually
- Highly effective at improving skin quality
- Particularly effective at improving acne scars
*However, since there are four types of each, the characteristics and effects differ for each formulation.
Risks and Side Effects
- Redness, swelling, pain, and edema at the needle insertion site
- Bruising
- Temporary raised bumps
- Results and downtime may vary from person to person.
Those who are not eligible for the treatment
- Women who are pregnant or breastfeeding
- People with impaired immune function or those undergoing immunosuppressive therapy
- People who are prone to keloids, hypertrophic scars, or pigmentary disorders
- People with a tendency to bleed or those taking anticoagulants or similar medications
- People with sunburn, eczema, dermatitis, or severe inflammation at the injection site
Pricing
| 2cc | Price | Per 1 cc Price |
| Once | 44,800 yen | 22,400 yen |
| 3 times | 119,400 yen (per session 39,800 yen) | 19,900 yen |
| 4 sessions | 155,200 yen (per session 38,800 yen) | 19,400 yen |
| 1 bottle (2cc) | Limited discount price (Through September 30) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | 44,820 yen | ¥22,410 |
| 3 times (20% off) | ¥117,120 (per session ¥39,040) | ¥19,520 |
| 5 sessions (20% off) | 187,200 yen (per session ¥37,440) | ¥18,720 |
| 10 sessions (20% off) | 342,400 yen (per session 34,¥240) | ¥17,120 |
| 2 bottles (4cc) | Limited discount price (Through September 30) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥71,820 | ¥17,950 |
| 3 times (20% off) | ¥189,120 (per session 63,040 yen) | ¥15,760 |
| 5 sessions (20% off) | 307,200 yen (per session 61,¥440) | ¥15,360 |
| 10 sessions (20% off) | 582,400 yen (per session 58,¥240) | ¥14,560 |
| 3 bottles (6cc) | Limited discount price (Through September 30) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥98,820 | ¥16,470 |
| 3 times (20% off) | ¥258,720 (per session ¥86,240) | ¥14,380 |
| 5 sessions (20% off) | 419,200 yen (per session ¥83,840) | 14,000 yen |
| 10 sessions (20% off) | 798,400 yen (per session ¥79,840) | 13,300 yen |
- This limited-time special price may end without notice. Now is your chance to receive it at the lowest price level in Japan.
- Treatments are performed by a board-certified anti-aging specialist with a track record of over 24,000 skin rejuvenation injections.
- A free consultation with a physician (normally valued at 10,000 yen)
- Minimal downtime, with natural improvements and changes that others won't notice
- Trusted with a 90%-plus satisfaction rating across various reviews and ratings
At our clinic, consultations are conducted directly by a physician, not a beauty counselor. There is no hard selling whatsoever, so please feel free to consult with us.
Legal Notices
The treatments described on this page involve the use of drugs or medical devices that have not been approved in Japan. The drugs and devices used for treatment have been imported through personal import procedures based on the judgment of our clinic’s physicians. Please refer to the Ministry of Health, Labor and Welfare’s website for information on drugs and other items requiring caution when imported through personal import.
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