![[Official] Smart Skin Clinic Group](https://smartskin-clinic.com/wp-content/uploads/2023/05/Smart-skin-clinic-ロゴ500-×-100-px.png)
Exosome IV Drip | First Session: 250 mg, 18,400 yen; 15–30 minutes for whole-body anti-aging care
Fatigue, skin firmness,
Light sleep.
Changes Due to Age
An IV drip lasting 15 to 30 minutesde (particle)
This treatment focuses on caring for the entire body.
What You Can Expect from Exosome Infusions
Since it's delivered throughout the body via an IV,
You can take care of your body from the inside out
not just a matter ofFirmness and Luster
Research has shown that exosomes act on fibroblasts deep within the skin, promoting the production of collagen and elastin.
Resistance to Fatigue and Physical Condition
By delivering exosomes throughout the body via an IV drip, where they repair cells and reduce inflammation, this treatment is expected to help alleviate persistent fatigue.
Sleep Quality
It is believed that the effects of promoting cell repair and reducing inflammation also have a positive impact on the brain, and can help improve the ability to fall asleep and the quality of sleep.
HairBody and Bounce
Since hair is made up of cells, exosomes may have an effect on it, potentially leading to improved hair elasticity and strength.
Full-Body Anti-Aging Care
Since it is carried by the bloodstream to every part of the body, it can comprehensively address age-related changes throughout the entire body—not just in certain areas of the face.
You can take it even just once, but,
8 to 12 times every 1 to 2 weeksBy continuing to...
It's a treatment that makes you feel the results right away.
*Results may vary from person to person. This is a description of the expected effects and does not guarantee specific results.
Exosome IV Therapy Fees
The first dose is 18,400 yen (250 mg) and
You can try it out
Compared to other clinics in Tokyo
Price for a single exosome infusion
Average of 7 clinics in Tokyo57,543 yen
Our Clinic: 1 dose (250 mg)23,000 yen
Our Clinic: First Dose (250 mg)18,400 yen
Per visit, compared to the Tokyo average
34,543–39,143 yen Great Deal
*Average price (including tax) for a single session of the most basic exosome IV treatment at seven cosmetic clinics in Tokyo. Calculated based on the standard prices listed on each clinic’s website and other sources (as of October 2026, according to our clinic’s survey). Dosage and concentration vary by clinic.
| 250mg | Regular Price | Our Clinic's Prices |
|---|---|---|
| Initial Price | 18,400 yen | |
| Once | 23,000 yen | |
| 5 sessions | 99,800 yen19,960 yen per session | |
| 10 sessions | 179,800 yen17,980 yen per session |
*All prices include tax. Since our clinic provides private medical care, insurance does not apply.
*The introductory price is valid only for the first purchase and cannot be combined with other promotions.
*Please check the "Pricing" section below for the prices of the 500 mg, 1,000 mg, and 2,000 mg options.
- Consultation fees, acupuncture fees, etc.All-inclusive priceThat's right. There are no additional fees or upsells on the day of the event.
- The more you continue, the lower the price per session becomes.For a 10-session course, each session costs 17,980 yen.
Patient Reviews and Ratings
On an external review site, patients who have actually visited our clinic
Here are the ratings and reviews I posted.
"I'm glad I was able to try it out at such a great price."
I was interested in exosome IV therapy, but I was hesitant because of the high cost—until I discovered this special introductory price plan.
The therapist explained everything very kindly and clearly, so I decided to go ahead and get the treatment right then and there. I’m glad I was able to try it out at such a great price.
Excerpt from reviews posted on Hot Pepper Beauty
View the full review
Tap the image to enlarge it.Screenshot of the Hot Pepper Beauty listing (captured on October 19, 2026)
https://clinic.beauty.hotpepper.jp/H000659471/reviews/CR00044248/
"I wanted to keep doing this, so I asked them again."
Since I felt that my skin condition and fatigue had improved after my last treatment, I decided to continue with the treatments and made another appointment.
It's very convenient to visit because it's easy to make appointments and there's little waiting time. I'd like to keep going about once or twice a month.
Excerpt from reviews posted on Hot Pepper Beauty
View the full review
Tap the image to enlarge it.Screenshot of the Hot Pepper Beauty listing (captured on October 19, 2026)
https://clinic.beauty.hotpepper.jp/H000659471/reviews/CR00024345/
"Like when they prepare the medication right in front of you"
I could tell that you were responding to my questions and concerns with sincerity, which put me at ease.
I’m very grateful that they prepared the medication right in front of me and checked in with me at appropriate intervals to see if I was in any pain or feeling okay.
Excerpt from reviews posted on Hot Pepper Beauty
View the full review
Tap the image to enlarge it.Screenshot of the Hot Pepper Beauty listing (captured on October 19, 2026)
https://clinic.beauty.hotpepper.jp/H000659471/reviews/CR00033934/
Swipe to the side to see other reviews (3 in total)
*Reviews reflect the personal opinions of the reviewers. Results may vary from person to person.
*Rating scores and review counts are based on the information displayed on each website as of October 19, 2026, for Hot Pepper Beauty, and October 5, 2026, for Kumapon and Kirei Pass.
For those with these concerns
- Even after sleeping, I still feel tiredIt's getting harder to take off...
- Skin firmness and radianceI feel like I fell...
- Trouble falling asleep・I've been having more days when I don't sleep well...
- Even if you keep using cosmetics and supplements...I don't feel any response...
- It's not a procedure that changes your face, but rather,I want to take care of myself from the inside out
For those of you who are facing these kinds of challenges,Our clinic's exosome IV therapyIt has been selected.
What Is an Exosome Infusion?
Exosomes are,Secreted by cellsThese are tiny particles with diameters ranging from 50 to 150 nm.
It facilitates the exchange of information between cells, andPromotes cell repair and reduces inflammationIt has a function.
The Effects of Exosomes
With effects that reach throughout the entire body,
You can expect the following changes:
| What to Expect | The Functions of Exosomes |
|---|---|
| Skin Firmness and Radiance | It acts on the fibroblasts deep within the skin to promote the production of collagen and elastin |
| Skin Irritation and Acne | Helps soothe inflammation and restore balance to the skin |
| Hair Body and Strength | Acts on the cells of the hair follicles |
| Resistance to fatigue | Helps promote the repair of cells throughout the body |
| Sleep Quality | It is believed that the effects of cell repair and inflammation suppression also have a positive impact on the brain. |
| Reduced downtime | Reduces inflammation and promotes recovery after other treatments |
| Full-Body Anti-Aging Care | It travels through the bloodstream and acts on cells throughout the body |
*Results may vary from person to person. This description is based on effects reported or suggested by research and does not guarantee specific results.
Why Our Exosomes Are the Best Choice
Umbilical cord-derived exosomes,
With quality that meets international standards
Umbilical cord-derivedUsing exosomes from
Active Ingredients14More than double
There are three types of exosomes: umbilical cord-derived, adipose tissue-derived, and dental pulp/bone marrow-derived. At our clinic, we use umbilical cord-derived exosomes. Compared to adipose tissue- and bone marrow-derived exosomes, umbilical cord-derived exosomes contain more than 14 times the amount of active ingredients.
Works on the skinRich in growth factors
Effective skin growth factors: approx.3More than double
Exosomes have various anti-aging effects, one of which is their effect on the skin. Umbilical cord-derived exosomes contain higher levels of growth factors that act on the skin (such as EGF and VEGF) than those derived from adipose tissue or bone marrow.
Proteins Associated with Youth
"GDF-11"abundant
GDF-11 is a growth and differentiation factor believed to be associated with youthfulness. It is thought to promote skin firmness by increasing the number of fibroblasts and boosting collagen and elastin production. Umbilical cord-derived exosomes contain high levels of this GDF-11.
International Guidelines
Compliant with "MISEV2018"
Exosomes vary by preparation in terms of extraction methods, size, and storage methods. For this reason, the International Society for Extracellular Vesicles (ISEV) has established the “MISEV 2018” guidelines for standardization. At our clinic, we use exosomes that have been extracted and purified in a cell culture processing facility in accordance with MISEV2018. Treatment is conducted in accordance with the “Guidance on the Clinical Application of Extracellular Vesicles, etc.” issued by the Japanese Society for Regenerative Medicine, and the formulations are selected and managed by specialists in anti-aging medicine.
View the Quality Checklist
Scroll horizontally to view the entire page.
*All comparisons are with exosomes derived from adipose tissue and bone marrow stem cells (based on data from the manufacturer). Results may vary from person to person.
Differences Between NMN IV Therapy and Placenta Therapy
| Comparison point | ＼ Our Treatments ／Exosome IV drip | NMN IV drip |
|---|---|---|
| Main ingredient | Umbilical cord-derivedExosomeSubstances that transmit information between cells | NMNComponents that serve as precursors to NAD⁺ |
| Main Purpose | Throughout the body's Anti-Aging CareSkin, Fatigue, Sleep, Hair | Energy MetabolismFrom the Perspective of Fatigue and Vitality |
| Like this to | My overall physical condition and I want to maintain my youthful appearance | In terms of vitality I want to tidy up |
| Treatment Time | 15 to 30 minutes | 15 to 30 minutes |
*Placenta (placental extract) is an IV treatment used for general health maintenance. This comparison is intended to help you organize your thoughts when choosing a treatment. Results may vary from person to person, and a doctor will determine suitability following a medical examination.
At our clinic, we combine both approaches
We also offer the “Exosome + NMN IV Set.”
Pricing
Fees by Dosage
| Dosage | Initial Price | Once | 10-Session Course |
|---|---|---|---|
| 250mg | 18,400 yen | 23,000 yen | 179,800 yen17,980 yen per session |
| 500mg | 29,440 yen | 36,800 yen | 289,800 yen28,980 yen per session |
| 1,000mg | 58,880 yen | 73,600 yen | 579,600 yen57,960 yen per session |
| 2,000 mg | 99,800 yen | 119,800 yen | 978,000 yen97,800 yen per session |
*All prices include tax. Since our clinic provides private medical care, insurance does not apply.
*The introductory price is valid only for the first purchase and cannot be combined with other promotions.
*We also offer 3-, 5-, and 7-session courses, as well as a package combining exosome and NMN IV therapy. The dosage will be determined by a doctor following a consultation.
- Consultation fees, acupuncture fees, etc.All-inclusive priceThat's right. There are no additional fees or upsells on the day of the event.
First of all,You're welcome to just come in for a free consultation.
"I'm nervous about deciding on a treatment right away..."That's what most people say.
Counseling at our clinic is,This is not intended to be a treatment.
- Sales and Upselling areNone at all
- "Just listen to what I have to say,We also welcome you to “take your time to consider it at home.”
- Includes a doctor's consultation.Whether you're eligible or not, andUntil the appropriate dosage and frequency are determinedI can confirm that
- All-inclusive, covering consultation fees and other costsTransparent pricing.There are no additional charges on the day of the event.
Reception Hours: Weekdays 11:00 a.m.–8:00 p.m. / Saturdays and Sundays 10:00 a.m.–7:00 p.m.
Treatment Flow
Regarding your concerns and requests,Please feel free to ask us about anything.Sales and Upselling areNone whatsoever.
Check your medical history, current medications, and health checkup status, andCan I receive an exosome infusion,Your doctor will determine the appropriate dosage and frequency.
If you have any questions, please consult directly with a physician
To help ease any concerns as much as possible, at our clinic
During a free consultation, a doctor will speak with you directlyHere is my answer.
Whether or not to undergo the treatment depends on,
Please take your time to consider it after that.
There is absolutely no sales or upselling.
Treatment details
・Those who are pregnant or breastfeeding
・People with infectious diseases or those who are immunocompromised
・People with blood clotting disorders or those currently taking anticoagulant medications
・People with autoimmune diseases
・Anyone who has experienced an allergic reaction to an exosome-related treatment in the past
・For those who wish to donate blood or receive a blood transfusion in the future
*If it has been a long time since you had a health checkup and you are unsure of your current health status, please consult with us.
A doctor must always examine you before the procedure, and
We will determine whether you are eligible.
FAQ
How many times should I take it?
You can receive this treatment even just once, but you’ll likely notice the results more clearly with repeated sessions. We generally recommend about 8 to 12 sessions, spaced approximately 1 to 2 weeks apart. Your doctor will recommend the dosage and number of sessions after your consultation.
Is there any pain?
Just like a regular IV, you'll feel only a slight prick when the needle goes in.
Can I go back to work or do housework right after the treatment?
Yes, you can go home. There is virtually no downtime from the procedure itself, and you can apply makeup and take a bath on the same day. In rare cases, bruising may occur at the injection sites, but it usually fades within a few days.
Could it affect one's genes or similar?
Based on the results of research to date, there is no data indicating that genetic information has been altered.
Is there any chance I might get cancer?
It is generally believed that exosomes themselves do not cause cancer. However, if cancer is present in the body, they may promote its growth; therefore, we do not perform this procedure on patients with a history of cancer.
Are allergic reactions a concern?
If allergies have been identified in advance, the risks are generally considered to be no different from those of a standard IV drip. If an allergic reaction occurs, the doctor will take appropriate action.
What is the difference between this and an NMN IV drip?
Exosome IV therapy is a systemic anti-aging treatment that uses exosomes—substances that transmit information between cells—while NMN IV therapy focuses on energy metabolism; thus, their purposes differ. There is also a package that combines both treatments.
Can I use my insurance?
Since exosome infusions are considered elective treatment, they are not covered by public health insurance.
Please feel free to reach out first
We welcome your questions and inquiries regarding exosome IV therapy, and we are happy to schedule a free consultation for you.
Your doctor will advise you on whether you are eligible for the treatment and recommend the appropriate dosage and frequency.
There is never any high-pressure sales, so please consult with us with confidence.
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last Reviewed: August 1, 2026