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What Is Juvelook Volume (Renisna)? | A Doctor Explains Its Effects and Costs
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What Is Juvelook Volume (Lenisna)?
Juvelook Volume (Renisna) is an injectable formulation that combines non-crosslinked hyaluronic acid with “poly-DL-lactic acid (PDLLA)” , and is classified as a “skin booster.”
Known in Japanese as poly-lactic acid, it is extracted from starches such as corn, potato, and sugarcane as raw materials and produced through a scientific process.
- A polymer created by polymerizing lactic acid
- A substance with excellent compatibility with the body, whose safety for the human body is approved by the U.S. FDA
- Gradually broken down into water and carbon dioxide over about one to two years
- Also used as surgical sutures, as grafting material in orthopedic surgery, and as vascular grafting material, among other uses
After injection, it is slowly absorbed by the body over one to two years, during which it stimulates fibroblasts to naturally increase collagen and elastin, so a lasting effect can be expected.
Because it is made from lactic acid, a substance that also occurs naturally in the human body, it is unlikely to trigger allergies and offers a high level of safety.
"Lenisna" is written as "Lenisna" in Romanized form.
This is a coined word combining "Lenis" (Latin for "smooth, soft") and "na" (Korean for "I").
"The me who became special with soft skin"
The name was chosen to convey the idea that it gives me smooth, soft, and supple skin.
Juvelook is used to create natural facial contours or add volume by injecting it. When injected into areas of the face lacking volume (such as nasolabial folds, cheeks, temples, and forehead), the solution stimulates the production of the body’s own collagen, and over time, it creates natural, plump volume and roundness.
Areas and Concerns Where Juvelook Volume (Lenisna) Is Effective
Juvelook Volume (Lenisna) is effective for a variety of facial areas. Areas and concerns for which it may be particularly effective include the following:
- Nasolabial folds
- Marionette lines (lines from the corners of the mouth to the chin)
- Tear-trough (Golgo) lines (lines from the outer corners of the eyes to the cheeks)
- Loss of cheek volume
- Hollows in the temples
- Wrinkles and hollows on the forehead
These areas are prone to volume loss and wrinkle formation due to aging and repeated facial expressions. When Juvelook Volume is injected into these areas, it simultaneously provides natural volume enhancement and improves skin texture.
Effect on Nasolabial Folds and Mechanism of Action
Nasolabial folds are one of the facial concerns that many people worry about. We’ll explain in detail the effects of Juvelook Volume (Renisna) on nasolabial folds and its mechanism of action.
Effect on nasolabial folds
- Adding volume: Adds volume to the subcutaneous tissue around the nasolabial folds, making the hollows less noticeable.
- Improvement of skin quality: Improves the skin's firmness and elasticity by promoting collagen production.
- Wrinkle reduction: By supporting the skin from within, it makes the wrinkles of the nasolabial folds less noticeable.
- Natural finish: Because collagen increases gradually, you can expect a natural improvement rather than an abrupt change.
Mechanism of action
- Immediate volume effect: Immediately after injection, a temporary increase in volume can be seen thanks to the non-cross-linked hyaluronic acid.
- Sustained collagen production:
- As poly-DL-lactic acid (PDLLA) is gradually broken down within the body, it stimulates the surrounding fibroblasts.
- The stimulated fibroblasts increase their production of collagen and elastin.
- Tissue remodeling:
- The newly generated collagen and elastin support the skin's structure from within.
- This gradually strengthens the tissue around the nasolabial folds, making the hollows less noticeable.
- Long-term effects:
- Collagen production advances gradually over one to two years after injection.
- During this time, continuous improvement of skin quality and increased volume can be expected.
Juvelook Volume (Renisna) is a treatment that simultaneously provides immediate volume enhancement for nasolabial folds and long-term skin texture improvement. Unlike conventional hyaluronic acid fillers, this treatment uses the body’s own tissue to create volume, resulting in more natural and long-lasting results.
Case photos (before/after)
Nasolabial folds
Treatment name Juvelook Volume (Lenisna): Before = before treatment, After = after completing 3 treatments
Treatment details Juvelook Volume (Lenisna) is a procedure that injects ingredients which hydrate and add volume to the skin into the dermal layer. It plumps and improves deep wrinkles that appear in specific areas, such as the nasolabial folds and marionette lines, for a natural rejuvenating effect. The treatment is performed area by area according to each patient's concerns, with the aim of reducing the appearance of prominent wrinkles.
Treatment period and number of sessions Usually one course is three sessions at one-month intervals.
Main risks and side effects Mild swelling, redness, and bruising may be seen after injection, but these usually subside within a few days. Temporary discomfort or a sense of lumpiness may be felt at the injection site, but it eases with proper care. Allergic reactions may occur in rare cases. Results vary from person to person, and how the outcome is perceived may differ.
Treatment price 29,800 to 99,800 yen (per session) *The price range reflects the availability of multiple dosage plans tailored to your concerns.
Cheeks, tear-trough (Golgo) lines, marionette lines
Treatment name Juvelook Volume (Lenisna): Before = before treatment, After = after completing 3 treatments
Treatment details Juvelook Volume (Lenisna) is a procedure that injects ingredients which hydrate and add volume to the skin into the dermal layer. It plumps and improves deep wrinkles that appear in specific areas, such as the nasolabial folds and marionette lines, for a natural rejuvenating effect. The treatment is performed area by area according to each patient's concerns, with the aim of reducing the appearance of prominent wrinkles.
Treatment period and number of sessions Usually one course is three sessions at one-month intervals.
Main risks and side effects Mild swelling, redness, and bruising may be seen after injection, but these usually subside within a few days. Temporary discomfort or a sense of lumpiness may be felt at the injection site, but it eases with proper care. Allergic reactions may occur in rare cases. Results vary from person to person, and how the outcome is perceived may differ.
Treatment price 29,800 to 99,800 yen (per session) *The price range reflects the availability of multiple dosage plans tailored to your concerns.
Forehead
Treatment name Juvelook Volume (Lenisna): Before = before treatment, After = after completing 3 treatments
Treatment details Juvelook Volume (Lenisna) is a procedure that injects ingredients which hydrate and add volume to the skin into the dermal layer. It plumps and improves deep wrinkles that appear in specific areas, such as the nasolabial folds and marionette lines, for a natural rejuvenating effect. The treatment is performed area by area according to each patient's concerns, with the aim of reducing the appearance of prominent wrinkles.
Treatment period and number of sessions Usually one course is three sessions at one-month intervals.
Main risks and side effects Mild swelling, redness, and bruising may be seen after injection, but these usually subside within a few days. Temporary discomfort or a sense of lumpiness may be felt at the injection site, but it eases with proper care. Allergic reactions may occur in rare cases. Results vary from person to person, and how the outcome is perceived may differ.
Treatment price 29,800 to 99,800 yen (per session) *The price range reflects the availability of multiple dosage plans tailored to your concerns.
Eye area
Treatment name Juvelook Volume (Lenisna): Before = before treatment, After = after completing 3 treatments
Treatment details Juvelook Volume (Lenisna) is a procedure that injects ingredients which hydrate and add volume to the skin into the dermal layer. It plumps and improves deep wrinkles that appear in specific areas, such as the nasolabial folds and marionette lines, for a natural rejuvenating effect. The treatment is performed area by area according to each patient's concerns, with the aim of reducing the appearance of prominent wrinkles.
Treatment period and number of sessions Usually one course is three sessions at one-month intervals.
Main risks and side effects Mild swelling, redness, and bruising may be seen after injection, but these usually subside within a few days. Temporary discomfort or a sense of lumpiness may be felt at the injection site, but it eases with proper care. Allergic reactions may occur in rare cases. Results vary from person to person, and how the outcome is perceived may differ.
Treatment price 29,800 to 99,800 yen (per session) *The price range reflects the availability of multiple dosage plans tailored to your concerns.
Effects of the Treatment
- Improvement of skin quality
- Softens the skin
- Adds firmness and radiance
- Pore reduction
- Wrinkle improvement
- Brightens skin tone
- Improvement of flushing
- Repair of acne scars and other scars
The Difference Between Juvelook Volume (Lenisna) and Juvelook
Because the particle size and concentration differ, the purpose and treatment areas differ as well.
Because Juvelook has smaller particles and a lower concentration than Lenisna, it is better suited to improving the shallow layers of the skin, and is used to restore skin firmness and elasticity and to improve fine lines and scarring.
Because Lenisna has large particles and a high concentration, it can add volume from the deep subcutaneous layer. It is used on the temples, hollows below the cheeks, nasolabial folds, and similar areas.
Juvelook Volume (Lenisna)
Deep wrinkles (nasolabial folds, marionette lines, tear-trough/Golgo lines, etc.), and indentations of the forehead and temples
Juvelook
Fine lines (under the eyes, neck, forehead, etc.), sagging skin, open pores, acne scars and other scars, etc.
Who Is Suited to Juvelook Volume / Who Is Suited to Juvelook
Who is suited to Juvelook Volume
- Those concerned about nasolabial folds
- Those concerned about marionette lines
- Those concerned about tear-trough (Golgo) lines
Who is suited to Juvelook
- Those concerned about fine lines
- Those concerned about sagging skin
- Those concerned about open pores
- Those concerned about acne scars and other scars
The Difference Between Juvelook Volume and Hyaluronic Acid Fillers
In Europe and South Korea, there is already growing demand for skin rejuvenation and volume enhancement through the body’s own collagen production using PDLLA formulations such as Renisna, rather than filler treatments that use hyaluronic acid to add volume. In South Korea, more and more people are switching from hyaluronic acid fillers to Juvelook Volume.
Juvelook by Smart Skin Clinic
We use the official Juvelook Volume (Lenisna) formulation, approved by the FDA and KFDA.
Who cannot receive this treatment
Those who are pregnant or breastfeeding
Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders
Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin
- Those who have excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Juvelook Volume (Lenisna) injection site
Risks and Side Effects
At the needle puncture site:
Redness, swelling, pain, edema
Bruising
Temporary raised bumps
At the injection site
- Nodules
Downtime
Redness and raised bumps may occur at the injection site, but in most cases they return to normal in about 24 hours.
Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, though not always. If bruising occurs, it gradually fades over 10 to 14 days.
Injection site / Injection volume (cc)
- For all areas except the forehead, the cc figures represent the combined total for the left and right sides.
- The above are only guideline amounts for each area. Because there are individual differences, a physician experienced in injections will propose the optimal volume for you after counseling.
Which layer is it injected into?
Injectable formulations vary in both their ingredients and intended purposes.
Therefore, it is extremely important to administer each formulation at the appropriate “depth” and “volume” to ensure optimal results.
With Juvelook Volume, the main injection layer is "from the deep dermis to the subcutaneous fat layer."
The skin is structured in layers, starting from the surface: the "epidermis," the "dermis" (comprising the superficial, middle, and deep layers), the "subcutaneous fat layer," and the "muscle layer," each of which plays a distinct role. The area extending from the deep dermis to the subcutaneous fat layer serves as the structural foundation and provides volume deep within the skin.
The area where Juvelook Volume's ingredients and intended effects are most effective is the deep dermis and subcutaneous fat layer; this is the medical rationale behind our clinic's practice of injecting this product into this specific area.
Pricing
| 1cc (Marionette lines) | Price |
|---|---|
| Once | 29,800 yen |
| 3 times | 89,400 yen (per session 29,800 yen) |
| Trial Price (3 sessions) | 82,400 yen (per session 27,500 yen) |
| 2cc (laugh lines, temples) | Price | Per 1 cc Price |
|---|---|---|
| Once | 54,800 yen | 27,400 yen |
| 3 times | 149,400 yen (per session 49,800 yen) | 24,900 yen |
| Trial Price (3 sessions) | 142,400 yen (per session 47,500 yen) | 23,700 yen |
| 4cc (Forehead) | Price | Per 1 cc Price |
|---|---|---|
| Once | 74,980 yen | 18,750 yen |
| 3 times | 209,400 yen (per session 69,800 yen) | 17,450 yen |
| Trial Price (3 sessions) | 198,800 yen (per session 66,300 yen) | 16,600 yen |
| 6cc (Cheeks) | Price | Per 1 cc Price |
|---|---|---|
| Once | 99,800 yen | 16,600 yen |
| 3 times | 278,400 yen (per session 92,800 yen) | 15,500 yen |
| Trial Price (3 sessions) | 268,400 yen (per session 89,500 yen) | 14,900 yen |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
After marking is done, we perform the injection while checking in with you as we go.
We will provide detailed instructions on how to care for the treated area and what to keep in mind in your daily life.
In addition, with a focus on prevention and maintenance, we recommend appropriate home care products—such as oral medications and skincare products—that can help alleviate your concerns.
FAQ
- When will I see results?
Dr. IshiiMany people feel the effect after two to three weeks.
You can see an effect even with a single session, but it is easier to notice a significant change after receiving a set of three sessions.
We also recommend the following as an effective approach.
- A set of three sessions at two-month intervals, followed by maintenance every six months to one year
*With Juvelook Volume, collagen is produced continuously, so the effect lasts for a long time.- Is it safe?
- Dr. Ishii
Juvelook Volume (Lenisna) is approved by the U.S. FDA and Korea's KFDA and can be considered highly safe.
- How is it different from hyaluronic acid treatment?
- Dr. Ishii
Hyaluronic acid treatment injects cross-linked hyaluronic acid, a firmer form of hyaluronic acid, which physically adds volume to improve wrinkles and similar concerns. Juvelook, on the other hand, achieves a natural increase in volume by boosting the collagen your own body produces.
- What are the advantages of using Juvelook Volume (Lenisna) for nasolabial folds?
-
Juvelook Volume (Lenisna) combines an immediate volumizing effect with a long-term effect that promotes collagen production. As a result, you can expect improvement of the nasolabial folds together with an improvement in skin quality, for a more natural and lasting result.
Details
| Treatment Time | About 30 to 40 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | ・It is recommended to undergo a series of three treatments at two-month intervals. ・After that, maintenance treatments are recommended approximately once every six months to one year. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | A sharp, stinging pain when the needle is inserted A dull, pressing pain during the injection |
Legal Notices
Juvelook Volume (Lenisna) treatment includes procedures using drugs or medical devices that are not approved in Japan. The drugs and devices used in treatment have been imported through personal importation at the discretion of our physicians.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of Smart Skin Clinic's supervising physicians.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.