prurial densify aqueous light injections
*Number of cases｜From September 1, 2023 to March 31, 2024
Yokohama Clinic Opening Discount Campaign
Pull Real Densify and Jalpro Super Hydro will be discounted for a limited time.
Period] June 19, 2025 - July 31, 2025
Note: Prices differ at Yokohama and Jimbocho clinics.
What's a pull real densify?"
I'm looking for a clinic where I can get pull real densify at a reasonable price."
'I'm concerned about fine lines and pores all over my face.'
I wonder if there is a full-face treatment that would have a natural rejuvenating effect."
Hello, I am a doctor at Smart Skin Clinic, a cosmetic dermatology clinic.
Do you have any of these concerns or questions?
In this article, our cosmetic dermatology clinic, which performs more than 10,000 injections per year, will provide an easy-to-understand explanation from a professional standpoint of "Pulreal Densify," one of the four types in the Pulreal Densifiers series.
*If you are interested in the fees, you can quickly jump to the appropriate section from the table of contents below.
What is Pluridensify?
Basic Information: What kind of treatment? What kind of problems does it help?
Plurial Densify is a CE certified injectable made by MD Skin Solutions from Luxembourg.
The fine needles are delivered to the dermis, stimulating collagen production and raising the skin's natural regenerative power. It can simultaneously treat multiple signs of aging, such as loss of firmness, fine lines and wrinkles, and pores, and is popular for its "nurturing" approach rather than immediate, unnatural expansion. At our clinic, it is widely used for the entire face and neck, and is popular among women in their 30s to 60s who seek natural rejuvenation.
Ingredients and Mechanism｜PN, non-cross-linked hyaluronic acid, mannitol
PullReal Densify contains (1) polynucleotide (PN) 10 mg/ml, (2) non-cross-linked hyaluronic acid 10 mg/ml, and (3) mannitol 40 mg/ml in a unique ratio: PN activates fibroblasts, hyaluronic acid creates a high water retention environment, and mannitol inhibits active oxygen and delays ingredient degradation. This trinity of "regeneration + moisturizing + anti-oxidation" results in an increase in luster and elasticity from the inside out several weeks after the treatment.
Polynucleotide (PN) regeneration mechanism
Salmon DNA-derived PN is a nucleic acid fragment that promotes repair of damaged cells, increases expression of fibroblast growth factor and accelerates collagen and elastin synthesis.
Moisture retention and elasticity support by hyaluronic acid
Non-cross-linked hyaluronic acid has a high molecular weight but no mesh structure, diffuses evenly in the dermis, and retains moisture up to 1,000 times, allowing the new collagen produced by PN to hold moisture and provide long-term support for plumpness and elasticity.
Antioxidant and persistence played by mannitol
Mannitol is a type of sugar alcohol that has a strong free radical scavenging ability and blocks active oxygen that promotes hyaluronic acid degradation. This has been confirmed to have a moisturizing effect and prolong the PN regeneration cycle.
What are the effects of Pulreal Densify｜5 changes you can feel
(1) Draw out skin moisture and elasticity from the inside
The non-cross-linked hyaluronic acid in PullRealDensify spreads evenly throughout the dermis and forms a "cushion" that holds moisture in place. In addition, polynucleotides (PN) stimulate fibroblasts and boost the production of collagen and elastin. This dual action is the reason why many patients feel a "moist feeling and increased elasticity" two to three weeks after the treatment (effects may vary from person to person).
(2) Smoothing and tightening fine lines and sagging skin
PN repairs damaged dermis and plumps and pushes up the skin's surface as hyaluronic acid stores moisture inside. As a result, shallow expression lines and mild sagging of the cheeks are gently diminished.
(3) Toning of uneven skin such as pores and acne scars
Pore openings and shallow acne scars are caused by a lack of collagen and disturbed turnover; PN promotes repair and hyaluronic acid creates a moisture environment that smoothes out unevenness and helps improve foundation application. Pore tightening" is also introduced as a major benefit in the manufacturer's case studies.
4) Evening out redness, dullness, and unevenness of color
Mannitol, with its strong antioxidant capacity, eliminates active oxygen species and calms inflammation; its synergistic effect with PN controls microinflammation and gently soothes red faces and yellow tints caused by UV damage.
(5) Approximate timing and duration of effect
The moisturizing effect of hyaluronic acid can be experienced on the same day, while collagen reconstruction by PN progresses in 2 to 4 weeks. Internationally, maintenance is recommended 2-3 times every 3-4 weeks, then once every 6 months, and the feeling of hydration and firmness lasts an average of 6-9 months. The fact that mannitol slows hyaluronic acid degradation is another reason for its longevity.
Who is Plurial Densify suitable for?
(1) Adaptation according to age and skin problems
PulleReal Densify is a treatment suitable for women who want to naturally improve the appearance of fine lines and wrinkles that begin to bother them in their 20s. It is especially suitable for women in their 30s to 60s who do not need as much volume as hyaluronic acid fillers, but want to improve the quality of their skin from the root.
It is also effective for men who want to reduce shine and pores, and is suitable for a wide range of age groups, from preventive beauty care to full-fledged anti-aging care. Since makeup can be applied the day after the treatment, the treatment is also popular among those who find it difficult to take time off for work or childcare.
Applicable areas: Whole face, eyes, mouth, neck, back of hands, etc.
While the basic treatment is aqueous light injections or manual injections to the entire face, Plurial Densify can also be used for partial applications. It can be applied to thin-skinned areas such as dry wrinkles around the eyes, fine lines around the mouth, pores on the cheeks, horizontal wrinkles on the neck, and lack of firmness on the backs of the hands, with natural-looking results. It can also be applied to dull and rough skin on the body, such as elbows and knees, and can be combined with multiple areas on the same day to bring out a total youthful look with less swelling. Another major advantage is that the active ingredients can be delivered directly to the dermal layer, which cannot be reached by esthetic treatments.
*Smart Skin Clinic recommends "Plurial Silk" for the eye area. Pullreal Silk is a drug developed specifically for the eye area. Please see the following page for details.
(3) Persons who should avoid the procedure and cases requiring caution
Although Plurial Densify is designed to be hypoallergenic, it is not suitable for everyone. Avoid it if you are pregnant or nursing, have a severe autoimmune disease, have a tendency to bleed, or have infection or severe inflammation at the treatment site. If you have keloids or are taking anticoagulants, be sure to inform your doctor in advance as internal bleeding and redness may be prolonged. Also, if you have undergone laser or peeling immediately prior to the procedure, it is safe to allow sufficient recovery time as the skin is more sensitive.
The process and the day of the Plurial Densify procedure
On the day of the procedure, we will first carefully listen to your concerns in a counseling session. We will also check your skin condition and discuss the indications for PulReal Densify and the areas to be treated. After washing your face, we will apply a surface anesthetic cream over a wide area to minimize pain and allow it to penetrate for about 20 minutes.
At Smart Skin Clinic, Pluridensify is basically administered by water-light injections. Our water-light injection is a stamp-type device, which allows us to administer an even dose to an even layer, without any leakage. Please be assured that there is no significant difference in effectiveness unless you have a special preference.
The procedure itself takes 15 to 20 minutes for the entire face. The anesthesia is effective and the pain is tolerable. The redness of the needle scars will settle down in a few hours. Makeup is recommended from the next day. Bathing, exercise, and alcohol consumption should be avoided on the same day, and sufficient moisturizing and UV care will reduce skin damage.
What is the downtime and side effects? For your peace of mind
progress
Immediately after the Plurial Densify procedure, the needle holes will be dotted with light redness and a bulge that looks like a mosquito bite. Most will subside within a few hours to 24 hours and can be covered with makeup the next day. Small internal bleeding may occur if small blood vessels are hit, but this can be covered with concealer and will be absorbed naturally in 1-2 weeks.
Risk of side effects and our safety measures
Plurial Densify uses PN derived from salmon DNA, and the incidence of allergy is considered to be extremely low. Nevertheless, persistent swelling and tenderness may occur depending on the patient's constitution and medications, so we check the patient's medical history and medications in detail before the procedure. If you experience any abnormalities within 48 hours after the procedure, our doctors and staff will respond to you on line or by phone.
Home care and lifestyle precautions to minimize downtime
Avoid long baths, saunas, strenuous exercise, and alcohol consumption on the same day to avoid increased swelling due to increased body temperature. Wash your face gently with lukewarm water and use a hypoallergenic moisturizer. Since UV rays can prolong inflammation, be sure to use a sunscreen with SPF 30 or higher the next morning, and implement shading. Antioxidant supplements containing vitamins C and E and adequate sleep will help smooth the recovery process of prurial dermatitis.
What's the difference from other skin growth injections? How to choose by comparison
1) Difference between Plurial Densify and Plurial Silk
PullReal Silk is a formulation that is easy to understand if you remember that it is a "special model for the eye area. It is designed with a low concentration of ingredients to prevent swelling even in thin skin, and is good at pinpointing dark circles and wrinkles. On the other hand, PURURIAL DENSIFY has a high concentration of PN and hyaluronic acid, and can improve the firmness and hydration of the entire face and neck. The basic concept is to use Silk if you want to take care of the eye area in detail, and use Densify if you want to brighten the entire face.
(2) Plurial Densify vs. Ridgerun Healer
Rejelan, known as "Salmon Injection," excels at creating a fine texture and shine through the action of PN. The transparency of the skin, which is called "ceramic skin finish" in Korea, can be attributed to the lightness of PN alone. However, it does not contain water retention and antioxidants, so if you want to improve dryness and dullness at the same time, Pulreal Densify is a better match. Densify's strength is that it supplements moisture with hyaluronic acid and suppresses active oxygen with mannitol, making it easy to maintain a long-lasting "moist and shiny" feeling.
(3) Plurialdensify vs Snecos
SUNECOS is a popular injection for intensive care around the eyes for "blue dark circles, dry fine lines and wrinkles. The combination of low molecular weight hyaluronic acid and amino acids creates the image of fluffing up the shallow layer. If you want to improve even complex problems such as pores and sagging, PullRealDensify, in which PN and moisturizing ingredients work simultaneously, has a wider coverage and can approach aging signs on the cheeks and face line.
(4) Pluridensify vs. Profilo
PROFILO is a "volumizing" skin revitalizing injection in which highly concentrated hyaluronic acid is diffused into the subcutaneous fat to plump up the cheeks and contour sharpness. It is more suited for those who want to restore a three-dimensional appearance to their cheeks rather than improve skin texture, such as those with "hollowed cheeks" or "lost flesh. The most obvious choice is PulleReal Densify if you want a smooth texture and natural moisture, or Profibro if you want volume and a light lift.
5) Recommended pattern of combination treatment
- The entire face is injected with PullReal Densify to raise the firmness and moisture of the foundation.
- On the same day, silk and snekos were added only around the eyes for intensive care of blue dark circles and crepe wrinkles.
- If cheek moss or contour volume is a concern, add profilo or other points at a later date.
With this process, "skin texture, detail, and 3D effect" can be prepared in stages, maximizing the finished product while minimizing downtime.
Smart Skin Clinic's "specialties" of hydroxyapatite injections ".
Smart Skin Clinic Fees
Yokohama Clinic Opening Discount Campaign
Pull Real Densify and Jalpro Super Hydro will be discounted for a limited time.
Period] June 19, 2025 - July 31, 2025
Note: Prices differ at Yokohama and Jimbocho clinics.
Jimbocho Clinic Fees
| 1 bottle (2cc) | |
|---|---|
| Once | 48,800 yen |
| 3 sets | 140,400 yen (per time)46,800 yen) |
| 4 sets | 179,200 yen (per time)44,800 yen) |
| 2 bottles (4cc) | |
|---|---|
| Once | 69,800 yen |
| 3 sets | 194,400 yen (per time)64,800 yen) |
| 4 sets | 255,200 yen (per time)63,800 yen) |
| 3 bottles (6cc) | |
|---|---|
| Once | 96,800 yen |
| 3 sets | 278,400 yen (per time)92,800 yen) |
| 4 sets | 359,200 yen (per time)89,800 yen) |
Need for anesthesia｜High
Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.
Yokohama Hospital Fees
| 1 bottle (2cc) | |
|---|---|
| Once | 46,800 yen |
| 3 sets | 128,400 yen (per time)42,800 yen) |
| 4 sets | 159,200 yen (per time)39,800 yen) |
| 2 bottles (4cc) | |
|---|---|
| Once | 66,800 yen |
| 3 sets | 194,400 yen (per time)62,800 yen) |
| 4 sets | 239,200 yen (per time)59,800 yen) |
| 3 bottles (6cc) | |
|---|---|
| Once | 91,800 yen |
| 3 sets | 263,400 yen (per time)87,800 yen) |
| 4 sets | 339,200 yen (per time)84,800 yen) |
Need for anesthesia｜High
Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.
Reasons to Choose Our Hospital｜10,000 injections per year and technical expertise
Injection techniques backed by the number of cases
Smart Skin Clinic performs over 10,000 injection procedures annually.
With our skilled diagnosis and injection techniques, we carefully conduct custom-made procedures to determine the point, in the right layer, and with the appropriate dosage. We minimize swelling and internal bleeding with our carefully procured "medical injection needles" and injection techniques.
TOP class number of formulations handled in Japan
We have more than 20 different injectables on hand, including PN formulations, skin growth formulations, Botox, and collagen boosters. We can meet the needs of those who are unsure of which formulation to choose or those who would like a diagnosis tailored to their concerns.
Internal bleeding incidence less than 0.51 TP3T
The incidence of internal bleeding has been less than 0.51 TP3T due to our "special needle" and "injection technology".
Frequently Asked Questions (FAQ)
- When will I start to feel the effects of Plurial Densify?
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Although it varies from person to person, the moisturizing power of hyaluronic acid is easily felt on the same day, while collagen production by polynucleotides appears slowly after 2 to 3 weeks. Please take your time to observe the process of skin luster and elasticity being raised.
- How many times is best to take?
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The recommended schedule is 3~4 times every 4 weeks. After that, maintenance once every 6 months will help maintain firmness and hydration for 6 to 9 months.
- How painful is the procedure and how much downtime is involved?
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Most patients find the pain to be tolerable due to the use of surface anesthesia cream. Redness and needle marks will subside within a few hours to a day, and the rare internal bleeding can be concealed with concealer and absorbed naturally within one to two weeks.
- Can Plurial Densify be used with other injections?
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They can be used in combination. For example, a popular combination is to perform Pluridensify on the entire face, followed by intensive care around the eyes with Snekos or Silk, and supplementing the contour with Profilo or other products. The doctor will suggest the best sequence and interval according to the purpose of treatment.
- Is it safe?
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PullReal Densify is European CE certified, and its main ingredient, PN, is a regenerative medicine-based material with very few reported allergies.
- When can I start wearing makeup and exercising after the treatment?
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Makeup is recommended from the next day. Wash your face gently with lukewarm water on the same day, and moisturize and protect against UV rays. Bathing, strenuous exercise, and alcohol consumption should be avoided for 24 hours, as they increase blood flow and may prolong swelling and internal bleeding.
Summary｜Purreal Densify for naturally beautiful skin
PullReal Densify is the latest skin-enhancing injection that simultaneously satisfies the regenerative power of "skin nurturing" with polynucleotides and the moisture and antioxidant properties of hyaluronic acid and mannitol. The main attraction of this treatment is that it can naturally raise the level of complex signs of aging such as fine lines, sagging, pores, and dullness without cutting. The downtime is short, making it easy to continue even for those who are busy with work or child-rearing.
Smart Skin Clinic has a track record of over 10,000 injections per year. We can also offer custom-made proposals ranging from a full face harry up to intensive care for the eye area.
We have a policy of not doing any sales or up-selling in our counseling sessions, and we do not have counselors. If you are anxious because you have never had injections before, or if you would like to know more about the difference from other formulations, please feel free to consult with us.