Jalpro (Milano injection) [Smart Skin Clinic Tokyo Jimbocho] Yahoo!

JalPro Classic Product Images

What is JALPRO?

Injectable formulation made of non-cross-linked hyaluronic acid + amino acids + peptides

The high concentration of both low molecular weight and high molecular weight hyaluronic acid in the formulation increases the immediate effect and moisturizing power of low molecular weight hyaluronic acid, while high molecular weight hyaluronic acid improves the scaffolding of the moisturizing effect and the long-term maintenance of the effect. In this way, the ligament is strengthened to increase density and restore skin elasticity.

The amino acids activate fibroblasts and promote the production of collagen and elastin, thereby remodeling and improving natural firmness and fine lines and wrinkles. In particular, Jalpro contains a high concentration of "glycine" (50%), which helps collagen production.

Peptides contain growth and moisturizing factors. Growth factors actively generate new skin cells, which may improve or prevent wrinkles and wound healing.

ECM formulations, a type of injection called a collagen booster

ECM preparations are drugs that improve skin conditions by acting on the ECM (Extracellular Matrix). Even though they are the same ECM preparation, they contain different ingredients and therefore have different effects.

Milan injection

It is also called "Milan Injection" because the production plant is located in Milan, Italy.

It is a hyaluronic acid-based collagen booster developed by the Swiss biotechnology company ProfessionalDerma. Three types of JalPro are currently available.

Three types of Jalpro

  1. Classic
  2. HMW
  3. Superhydro

(1) Classic

JalPro Classic Product Images
  • Ingredients:
    Low molecular weight hyaluronic acid + 4 types of amino acids
  • Injection site:
    Fine lines at the corners of the eyes, dark circles under the eyes, around the eyes, forehead, and neck
  • Expected Effects:
    Dark circles around the eyes, wrinkles at the corner of the eyes, improvement of acne scars, improvement of pigmentation, strong antioxidant effect, fine wrinkles, wrinkle prevention, skin maintenance, improvement of scars after surgery
  • Recommended number of times:
    A total of four times, spaced one to two weeks apart. Then every six to nine months.

(2)HMV (High Molecular Volume)

Jalpro HMV product images
  • Ingredients:
    High Molecular Volume (HMV) means high molecular weight.
  • Expected Effects:
    Deeply etched wrinkles. Natural aging care, especially for those with thin skin and little subcutaneous fat. High molecular weight hyaluronic acid can hold more water, moisturizing the skin and providing long-lasting hydration. It is often used to form a film on the skin's surface to protect it from dryness
  • Injection site:
    Mid-face to lower face. A total of 9 injections on one side and 18 injections on the left and right sides together will penetrate over several hours to a day to effect the entire area from the eyes down.


JalPro Super Hydro product image
  • Overview:
    Retinacular Cutis (RC) is an injectable formulation designed to regenerate ligaments. ThereforeTightening injections."It is also called a Ligaments, like the branches of a tree, spread across the layers of subcutaneous tissue and support the skin.
  • Ingredients:
    The formula contains 7 kinds of amino acids, 3 kinds of peptides, and 80mg/2.5ml of low/high molecular weight hyaluronic acid. Hyaluronic acid of different sizes from low molecular weight to medium and high molecular weight are combined. Low molecular weight hyaluronic acid easily penetrates into the deeper layers of the skin, while high molecular weight hyaluronic acid is effective in retaining moisture on the surface. This combination of hyaluronic acids is intended to provide a complex moisturizing and therapeutic effect on the skin.
    • glycine, proline, lysine, leucine, alanine, valine, arginine
    • Acetyldecapeptide 3, Oligopeptide 24, Acetyltetrapeptide
    • Low molecular weight: 200kDa, High molecular weight: 2000kDa
  • Expected Effects:
    Ligament strengthening, lifting, subcutaneous tissue remodeling, moisturizing effects, skin tightening especially in the midface (midface)
  • Injection site:
    Determined by. One side of the face: 6-7 places, one side of the neck: 6 places
  • Recommended number of times:
    A set of two sessions should be performed in one month. After the skin is in good condition, we recommend a treatment once every 6 months as maintenance
  • Other:
    Launched in 2021
Jalpro case photo (1)
Jalpro case photo (2)

Recommended for the following problems

Jal Pro Classic
  • I want to aim for natural improvement.
  • dark circles under the eyes
  • Wrinkles at the corners of the eyes, crepe lines
  • I want to have elasticity and luster.
Jalpro HMV
  • Moss on cheeks
  • I want firmness and luster in my cheeks.
  • Neck wrinkles
JalPro Super Hydro
  • Sagging face and cheeks
  • I want to lift up.
  • laugh lines

Expected Effects and Benefits

Expected effects

Jalpro in the skin,Extracellular matrix (ECM) remodelingThere are a variety of benefits that can be achieved by encouraging the

Remodeling of the extracellular matrix is the process of activating collagen and elastin in aging skin.

Young skin has many fibroblasts, which work actively to maintain healthy skin with elasticity and firmness by smoothly metabolizing collagen and elastin. On the other hand, aging skin has fewer fibroblasts, resulting in a decrease in collagen and elastin, which leads to wrinkles and sagging skin.

Jalpro stimulates fibroblast activity by replenishing fibroblasts with amino acids, increasing collagen and elastin production and promoting remodeling of the extracellular matrix (ECM).

After injection, the effect of hyaluronic acid appears within a few days, while the effect of amino acids appears gradually over 6 months, starting after 1 month.

[Expected benefits

Improved skin hydration:
JalPro improves the skin's ability to retain moisture, leaving it hydrated and plump.

Decrease in fine lines and wrinkles:
It reduces the appearance of wrinkles and fine lines by stimulating collagen production and improving skin texture.

Improved skin tone and texture:
Improves overall skin texture and even skin tone, making skin appear smoother and brighter.

Less downtime:
Non-invasive JalPro treatment requires little to no downtime, allowing patients to resume their daily activities immediately.

JalPro can be used on various parts of the body as well as the face, making it ideal for addressing multiple areas of concern.

Natural impression:
It provides a natural appearance without giving the impression of artificiality.

Risks of JALPRO

Jalpro does not contain a cross-linking agent,Allergic reactions and embolisms.It is unlikely.

The reason for this is that Jalpro does not contain a "cross-linking agent".

Cross-linking agents can cause allergic reactions, immune reactions, and inflammation. Allergic reactions have been reported to occur, although they are very infrequent. Conventional hyaluronic acid injectables contain a substance called a cross-linker.

What is cross-linking?

It is the creation of new chemical bonds that bridge the chain-like structure of hyaluronic acid. As a result of cross-linking, hyaluronic acid becomes a three-dimensional structure. The three-dimensional structure created by cross-linking slows the absorption and degradation of hyaluronic acid at the injection site and prolongs its duration.

Those who cannot be treated

Pregnant or nursing mothers

Those with abnormal immune function or a history of such abnormality, and those undergoing immunosuppressive therapy.

Those prone to keloid formation, hypertrophic scars and hyperpigmentation

Those with bleeding tendency or using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin

Excessive sunburn, eczema, dermatitis, acne with severe inflammation, or scabs at the site of Jalpro injection

Risks and Side Effects

of the needle puncture site.

Redness, swelling, pain, edema

Intravascular hemorrhage

Temporary protuberance

Down time

Redness and bumps at the injection site may occur, but often return to normal in about 24 hours.

Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, although not always. If subcutaneous bleeding spots occur, they will gradually disappear over a period of 10-14 days.

Flow of treatment


You can easily make reservations with your mobile phone.

Reception (desk)

This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.

Counseling and medical examination

Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.

JalPro injection

After the marking is carried out, the injection is carried out while talking to the patient.

After-sales service

We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.

Returning home

More Information

Treatment Time20~30 minutes (not including counseling)
Recommended number and frequency of treatmentsClassic/HMV
It is recommended to do a set of 4 sessions, spaced 1~2 weeks apart.
After that, maintenance is recommended every six to nine months.
Super Hydro
It is recommended that two sets of two times be performed two weeks apart.
After that, maintenance is recommended every six to nine months.
Down timeAbout 24 hours
Treatment on the day of counselingPossible
MakePossible immediately after the treatment
Skin carePossible immediately after the treatment
ShowerPossible from the same day
PainIf a surface anesthesia is applied, the stinging pain of the prick will be reduced.
There is not that much pain while the drug is being injected.
*There are individual differences.


1 bottle (3cc)39,800 yen
4 sets
(3cc x 4)
139,200 yen
(34,800 yen per session)
1 bottle (3cc)79,800 yen
4 sets
(3cc x 4)
279,800 yen
(69,950 yen per session)
Face or neck 1 time
99,800 yen
Face + neck 1 time
(3cc x 2)
179,800 yen
Face or Neck 2 times
(3cc x 2)
179,800 yen
(89,900 yen per session)
Face + Neck 2 times
(3cc x 2 x 2)
298,000 yen
(149,000 yen per session)
Anesthesia (cream)
Once5,500 yen
All prices include tax.
We are a free clinic and not covered by insurance.


How often and how many times should I take the course?
Dr. Smaski.

Although a single dose may be effective, we recommend one of the following for each formulation as the most effective method

Set 4 times, 1~2 weeks apart.
After that, maintenance is performed every six to nine months.
Super Hydro
Two sets, 2 weeks apart
After that, maintenance is performed every six to nine months.

Do you feel pain?
Dr. Smaski.

Although it depends on the individual, we use a thin needle, but you may feel a slight stinging pain. It is also said that the center of the face is more sensitive to pain.

How long is the downtime?
Dr. Smaski.

Redness often disappears in about 24 hours.

Legal description

JalPro treatment includes the use of drugs or medical devices that are not approved in Japan. The drugs and devices used in the treatment have been imported on a private import basis based on the judgment of our physicians.

Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".

Smart Skin Clinic

Smart Skin Clinic

The concept of the clinic is to "make cosmetic medicine more accessible and smart. is the concept of the clinic.

Instead of eliminating ornate interiors to reduce interior design costs and installing equipment in the dark, we carefully select the equipment we need and reduce the cost of the equipment.

We aim to "make cosmetic medicine more accessible" for you.

Clinic Reception

Address:EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo

Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo

About the physician supervision of this site

About the physician supervision of this site

This site is operated under the supervision of the Smart Skin Clinic supervising physicians.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.