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Jalpro (Milan Injection) [Smart Skin Clinic] Yahoo!
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What is Jalupro?
An injectable preparation made of non-cross-linked hyaluronic acid + amino acids + peptides
By blending high concentrations of both low- and high-molecular-weight hyaluronic acid, the low-molecular-weight hyaluronic acid boosts immediate action and hydration, while the high-molecular-weight hyaluronic acid enhances the scaffold for the moisturizing effect and its long-term retention. In this way, by strengthening the ligaments, density is increased and the skin's elasticity is restored.
Through the action of amino acids, it activates fibroblasts and promotes the production of collagen and elastin, remodeling the skin to improve natural firmness and fine lines. In particular, Jalupro contains a high concentration—50%—of "glycine," which supports collagen production.
Peptides contain growth factors and moisturizing factors. Through their "growth factors," they actively generate new skin cells, which may help improve or prevent wrinkles and support wound healing.
An ECM preparation—a type of injectable known as a collagen booster
ECM preparations are drugs that act on the ECM (Extracellular Matrix) to improve the condition of the skin. In addition to Jalupro, ECM preparations include Profhilo and Sunekos. Even among ECM preparations, the ingredients differ, so the effects you can expect differ as well.
Milan Injection
It is also called the "Milan Injection" because its manufacturing plant is located in Milan, Italy.
It is a hyaluronic acid–based collagen booster developed by the Swiss biotechnology company "Professional Derma." Three types of Jalupro are currently available.
Three types of Jalupro
- Classic
- HMW
- Superhydro
1. Classic
- Ingredients:
Low-molecular-weight hyaluronic acid + 4 amino acids - Injection site:
Fine lines at the corners of the eyes, dark circles under the eyes, around the eyes, forehead, neck - Expected effects:
Dark circles around the eyes, wrinkles at the corners of the eyes, improvement of acne scars, improvement of pigmentation, strong antioxidant action, fine wrinkles, wrinkle prevention, skin maintenance, improvement of scars after surgery - Recommended number of sessions:
4 sessions in total, spaced 1 to 2 weeks apart. After that, once every 6 to 9 months.
②HMV (High Molecular Volume)
- Ingredients:
High-molecular-weight hyaluronic acid + 4 amino acids. HMV (High Molecular Volume) means high molecular weight. - Expected effects:
Deeply etched wrinkles. Natural aging care, especially for those with thin skin or little subcutaneous fat. High-molecular-weight hyaluronic acid can hold more water, moisturizing the skin and providing long-lasting hydration. It is often used to form a film on the skin's surface to protect it from dryness. - Injection site:
Mid-face to lower face. As a guide, injecting 9 spots on one side—18 spots on both sides combined—allows it to penetrate over several hours to a day, taking effect across the entire area from the eyes downward.
Superhydro
- Overview:
An injectable preparation designed to regenerate the retinacula cutis (RC)—that is, the ligaments. For this reason, it is also"a tightening injection."as it is also called. Ligaments, like the branches of a tree, spread in all directions through the layers of subcutaneous tissue and support the skin. - Ingredients:
It contains "7 amino acids," "3 peptides," and "80mg/2.5ml of low-/high-molecular-weight hyaluronic acid." Hyaluronic acid of different sizes—from low to medium to high molecular weight—is combined. Low-molecular-weight hyaluronic acid penetrates easily into the deeper layers of the skin, while high-molecular-weight hyaluronic acid is effective at retaining moisture on the surface. This combination of hyaluronic acids is designed to provide a multifaceted moisturizing and therapeutic effect on the skin.- [7 amino acids] Glycine, proline, lysine, leucine, alanine, valine, arginine
- [3 peptides] Acetyl decapeptide-3, oligopeptide-24, acetyl tetrapeptide
- [Hyaluronic acid of two molecular weights] Low molecular weight: 200kDa, high molecular weight: 2000kDa
- Expected effects:
Strengthening the ligaments, lifting, remodeling the subcutaneous tissue, moisturizing, and tightening the skin—especially in the midface. - Injection site:
Predetermined. One side of the face: 6 to 7 spots, one side of the neck: 6 spots - Recommended number of sessions:
It is best to do a set of 2 sessions within one month. Once the skin is in good condition, we recommend a treatment about once every 6 months for maintenance. - Other:
Launched in 2021
Recommended if you have any of these concerns
- I want to aim for a natural improvement
- dark circles under the eyes
- Wrinkles at the corners of the eyes, crepe-like fine lines
- I want firmness and radiance
- Hollow cheeks
- I want firmness and radiance in my cheeks
- neck wrinkles
- Sagging of the face and cheeks
- I want to lift and firm
- Nasolabial folds
Expected Effects and Benefits
[Expected effects]
Within the skin, Jaluproremodeling of the extracellular matrix (ECM)By encouraging this, a variety of effects may be achieved.
Remodeling of the extracellular matrix refers to the action of reactivating the collagen and elastin in aged skin.
Young skin has many fibroblasts, and as these fibroblasts work actively, collagen and elastin are metabolized smoothly, keeping the skin healthy, firm, and elastic. In aging skin, on the other hand, fibroblasts decrease and collagen and elastin decline, leading to wrinkles and sagging.
By replenishing fibroblasts with amino acids, Jalupro stimulates fibroblast activity, boosts the production of collagen and elastin, and promotes remodeling of the extracellular matrix (ECM).
After injection, the effect of the hyaluronic acid appears within a few days, while the effect of the amino acids appears gradually over 6 months, starting about 1 month later.
[Expected benefits]
・Improved skin hydration:
Jalupro enhances the skin's ability to retain moisture, leaving it hydrated and plump.
・Reduced fine lines:
By promoting collagen production and refining skin texture, it makes wrinkles and fine lines less noticeable.
・Improved skin tone and texture:
It improves overall skin texture and evens out skin tone, making the skin look smoother and brighter.
・Minimal downtime:
Non-invasive Jalupro treatment involves little to no downtime, so you can resume daily life right away.
・Versatility:
Jalupro can be used not only on the face but also on various parts of the body, making it well suited to addressing concerns in multiple areas.
・A natural impression:
It provides a natural appearance without looking artificial.
Risks of Jalupro
Because Jalupro contains no cross-linking agent,the likelihood of causing allergic reactions or embolismsis low.
The reason for this is that Jalupro does not contain a "cross-linking agent."
Cross-linking agents may cause allergic reactions, immune reactions, and inflammation. Although very infrequent, allergic reactions have been reported. Conventional hyaluronic acid injectables contain a substance called a cross-linking agent.
It is the creation of new chemical bonds that bridge chain-like strands of hyaluronic acid together. As a result of cross-linking, hyaluronic acid takes on a three-dimensional structure. This three-dimensional structure slows the absorption and breakdown of hyaluronic acid at the injection site, giving it a longer-lasting effect.
Who cannot receive this treatment
Those who are pregnant or breastfeeding
Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders
Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin
・Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Jalupro injection site
Risks and Side Effects
At the needle puncture site:
Redness, swelling, pain, edema
Bruising
Temporary raised bumps
Downtime
Redness and raised bumps may appear at the injection site, but they often return to normal within about 24 hours.
Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, though not always. If bruising occurs, it gradually fades over 10 to 14 days.
Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
After marking is done, we perform the injection while checking in with you as we go.
We explain in detail how to care for the treated area and what to keep in mind in daily life. From a prevention and maintenance standpoint, we also suggest suitable home care, such as oral medications and skincare products that can support improvement of your concerns.
Details
| Treatment Time | About 20 to 30 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | [Classic / HMV] ・A set of 4 sessions, spaced 1 to 2 weeks apart, is recommended. ・After that, maintenance about once every 6 to 9 months is recommended. [Super Hydro] ・A set of 2 sessions, spaced 2 weeks apart, is recommended. ・After that, maintenance about once every 6 to 9 months is recommended. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | If topical anesthesia is applied, the stinging pain of the needle prick is reduced. There is little pain while the drug is being injected. |
Fees (tax included; private treatment)
Manual injection by a physician
| Classic | |
|---|---|
| 1 bottle (3cc) | 39,800 yen |
| 4 sets (3cc x 4) | 139,200 yen (34,800 yen per session) |
| HMW | |
|---|---|
| 1 bottle (3cc) | 59,800 yen |
| 3-session course (3cc x 3) | 173,400 yen (per session57,800 yen) |
| 4 sets (3cc x 4) | 227,200 yen (per session56,800 yen) |
| Jalupro (Super Hydro) | |
|---|---|
| 1 session (2.5cc) | 59,800 yen |
| Set of 2 | 109,600 yen (per session54,800 yen) |
| 3 sets | 149,400 yen (per session49,800 yen) |
Water Light Injection (mechanical)
JALUPRO (Classic)
| 1 vial (3cc) | |
|---|---|
| Once | 29,800 yen (approx. 9,900 yen per cc) |
| 4 sets | 107,200 yen (26,800 yen per session) |
| 2 vials (4cc) | |
|---|---|
| Once | 35,200 yen (8,800 yen per cc) |
| 4 sets | 128,800 yen (32,200 yen per session) |
| 3 vials (6cc) | |
|---|---|
| Once | 47,880 yen (7,980 yen per cc) |
| 4 sets | 179,520 yen (44,880 yen per session) |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Market pricing
The typical price range for Jalupro at aesthetic clinics in the Kanto region is as follows (*surveyed February 2024).
| Classic | Per session: 40,000–80,000 yen; 4 sessions: 130,000–160,000 yen |
| HMW | Per session: 70,000–150,000 yen |
| Superhydro | Per session: 100,000–160,000 yen; 2 sessions: 170,000–300,000 yen |
FAQ
- How often and how many times should I receive it?
Dr. IshiiA single session may be effective, but as the most effective approach we recommend one of the following for each formulation.
[Classic / HMV]
・A set of 4 sessions, spaced 1 to 2 weeks apart
・After that, maintenance about once every 6 to 9 months
[Super Hydro]
・A set of 2 sessions, spaced 2 weeks apart
・After that, maintenance about once every 6 to 9 months- Does it hurt?
- Dr. Ishii
It varies from person to person. We use a fine needle, but you may feel a slight pricking sensation. The center of the face is also said to be more sensitive to pain.
- How long is the downtime?
- Dr. Ishii
Redness often subsides within about 24 hours.
Legal Notices
Jalupro treatment involves the use of drugs or medical devices not approved in Japan. The drugs and devices used in the treatment are personally imported under the judgment of our clinic's physicians.
Jalupro treatment involves a pharmaceutical not approved in Japan.
Information on safety and related matters in other countries: Jalupro has obtained approval as a pharmaceutical from Korea's MFDS (Ministry of Food and Drug Safety), certifying that it meets the most stringent standards for ensuring safety, efficacy, and quality in Korea.
In Japan, it is not eligible for relief under the Adverse Drug Reaction Relief System or similar programs.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Smart Skin Clinic
Smart Skin Clinic
A clinic built on the concept of "making aesthetic medicine more accessible and smart."
Rather than spending on ornate interiors, we keep fit-out costs down, and rather than adding equipment indiscriminately, we carefully select only the devices we need to keep equipment costs down.
We aim to "make aesthetic medicine more accessible" for you.
Address:EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of Smart Skin Clinic's supervising physicians.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.