Jubelook Volume (Renisna) Yahoo!

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Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What Is Juvelook Volume (Lenisna)?
Juvelook Volume (Renisna) is an injectable formulation that combines non-crosslinked hyaluronic acid with “poly-DL-lactic acid (PDLLA)” , and is classified as a “skin booster.”
Known in Japanese as poly-lactic acid, it is extracted from starches such as corn, potato, and sugarcane as raw materials and produced through a scientific process.
- A polymer created by polymerizing lactic acid
- A substance with excellent compatibility with the body, whose safety for the human body is approved by the U.S. FDA
- Gradually broken down into water and carbon dioxide over about one to two years
- Also used as surgical sutures, as grafting material in orthopedic surgery, and as vascular grafting material, among other uses
After injection, it is slowly absorbed by the body over one to two years, during which it stimulates fibroblasts to naturally increase collagen and elastin, so a lasting effect can be expected.
"Lenisna" is written as "Lenisna" in Romanized form.
This is a coined word combining "Lenis" (Latin for "smooth, soft") and "na" (Korean for "I").
"The me who became special with soft skin"
It was named with the meaning of giving me smooth, supple, soft skin.
Juvelook Volume is used to create a natural facial contour and to add volume. By injecting it into areas of the face where volume is lacking (nasolabial folds, cheeks, temples, forehead, etc.), the drug promotes the production of your own collagen, so that over timeYou can expect it to create volume and roundness.
Juvelook Volume (Lenisna) case photos (before/after)
Nasolabial folds

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[Detailed Explanation of Case Photos]
Treatment Name: Jubelook Volume (Renisna) Injection (Nasolabial Folds)
This treatment is provided on a private basis and is not covered by insurance.
Cost (tax and anesthesia included): 2 cc (both sides) per session: 54,800 yen / 3-session package: 149,400 yen
Number of Treatments and Duration: We recommend three treatments at two-month intervals (results may vary from person to person).
Major Risks and Side Effects: Redness, swelling, pain, edema, bruising, temporary swelling, and nodules at the injection site (Estimated downtime: approximately 24 hours)
Cheeks, tear-trough (Golgo) lines, marionette lines

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[Detailed Explanation of Case Photos]
Treatment Name: Jubelook Volume (Renisna) Injection (Cheeks, Gorgon Lines, Marionette Lines)
This treatment is provided on a private basis and is not covered by insurance.
Cost (tax included, anesthesia fee included): 1 cc (marionette lines) 29,800 yen to 6 cc (cheeks) 99,800 yen (varies depending on the injection site and volume)
Number of Treatments and Duration: We recommend three treatments at two-month intervals (results may vary from person to person).
Major Risks and Side Effects: Redness, swelling, pain, edema, bruising, temporary swelling, and nodules at the injection site (Estimated downtime: approximately 24 hours)
Forehead


[Detailed Explanation of Case Photos]
Treatment Name: Jubelook Volume (Renisna) Injection (Forehead)
This treatment is provided on a private basis and is not covered by insurance.
Cost (tax included, anesthesia fee included): 4 cc per session: 74,980 yen / 3-session package: 209,400 yen
Number of Treatments and Duration: We recommend three treatments at two-month intervals (results may vary from person to person).
Major Risks and Side Effects: Redness, swelling, pain, edema, bruising, temporary swelling, and nodules at the injection site (Estimated downtime: approximately 24 hours)
Eye area

[Detailed Explanation of Case Photos]
Treatment Name: Jubelook Volume (Renisna) Injection (Eye Area)
This treatment is provided on a private basis and is not covered by insurance.
Cost (tax and anesthesia included): Starting at 29,800 yen (varies depending on the injection site and volume. Please refer to the “Pricing” table on this page for details)
Number of Treatments and Duration: We recommend three treatments at two-month intervals (results may vary from person to person).
Major Risks and Side Effects: Redness, swelling, pain, edema, bruising, temporary swelling, and nodules at the injection site (Estimated downtime: approximately 24 hours)
A board-certified anti-aging specialist with over 1,000 procedures* performed using skin-rejuvenating injections, including Jubelook Volumeperforms the treatment
At Smart Skin Clinic,A board-certified anti-aging specialist with a proven track record of over 1,000 procedures* using skin rejuvenation injections alonewill always be in charge of the treatment.
Having a doctor experienced in injections perform the procedure can help minimize the discomfort associated with post-treatment swelling and pain during the procedure.
*Number of treatments performed based on our clinic's records
Areas and Concerns Where Juvelook Volume (Lenisna) Is Effective
Juvelook Volume (Lenisna) can offer benefits for various areas of the face. The areas and concerns for which it is especially effective include the following:
- Nasolabial folds
- Marionette lines (lines from the corners of the mouth to the chin)
- Tear-trough (Golgo) lines (lines from the outer corners of the eyes to the cheeks)
- Loss of cheek volume
- Hollows in the temples
- Wrinkles and hollows on the forehead
These areas are prone to volume loss and wrinkle formation due to aging and repeated facial expressions. By injecting Juvelook Volume into these areas,You can expect added volume and improved skin quality.
Effect on Nasolabial Folds and Mechanism of Action
Nasolabial folds are one of the most common facial concerns.Expected Effects and Mechanism of Action of Juvelook Volume (Lenisna) on Nasolabial Foldsare explained in detail here.
Expected Effects on Nasolabial Folds
- Adding volume: Adds volume to the subcutaneous tissue around the nasolabial folds, making the hollows less noticeable.
- Improvement of skin quality: Improves the skin's firmness and elasticity by promoting collagen production.
- Wrinkle reduction: By supporting the skin from within, it makes the wrinkles of the nasolabial folds less noticeable.
- Natural finish: Because collagen increases gradually, you can expect a natural improvement rather than an abrupt change.
Mechanism of action
- Volume effect: After injection, you can expect a temporary boost in volume from the non-crosslinked hyaluronic acid.
- Sustained collagen production:
- As poly-DL-lactic acid (PDLLA) is gradually broken down within the body, it stimulates the surrounding fibroblasts.
- The stimulated fibroblasts increase their production of collagen and elastin.
- Tissue remodeling:
- The newly generated collagen and elastin support the skin's structure from within.
- This gradually strengthens the tissue around the nasolabial folds, making the hollows less noticeable.
- Long-term effects:
- Collagen production advances gradually over one to two years after injection.
- During this time, continuous improvement of skin quality and increased volume can be expected.
Juvelook Volume (Lenisna) isFor nasolabial folds, it offers both a volume effect and improved skin quality at the same time.This is a treatment method. Unlike conventional hyaluronic acid fillers, it uses your own tissue to create volume, so you can expect a more natural and longer-lasting effect.
Expected Effects of the Treatment
- Improvement of skin quality
- Softens the skin
- Adds firmness and radiance
- Pore reduction
- Wrinkle improvement
- Brightens skin tone
- Improvement of flushing
- Repair of acne scars and other scars
The Difference Between Juvelook Volume (Lenisna) and Juvelook
Because the particle size and concentration differ, the purpose and treatment areas differ as well.
Because Juvelook has finer particles and a lower concentration than Lenisna, it is suited to improving the more superficial layers of the skin, and can help restore firmness and elasticity, reduce fine lines, and improve the appearance of scars.
Because Lenisna has large particles and a high concentration, it can add volume from the deep subcutaneous layer. It is used on the temples, hollows below the cheeks, nasolabial folds, and similar areas.
Juvelook Volume (Lenisna)
Deep wrinkles (nasolabial folds, marionette lines, tear-trough/Golgo lines, etc.), and indentations of the forehead and temples
Juvelook
Fine lines (under the eyes, neck, forehead, etc.), sagging skin, open pores, acne scars and other scars, etc.

Who Is Suited to Juvelook Volume / Who Is Suited to Juvelook
Who is suited to Juvelook Volume
- Those concerned about nasolabial folds
- Those concerned about marionette lines
- Those concerned about tear-trough (Golgo) lines
Who is suited to Juvelook
- Those concerned about fine lines
- Those concerned about sagging skin
- Those concerned about open pores
- Those concerned about acne scars and other scars
The Difference Between Juvelook Volume and Hyaluronic Acid Fillers
In Europe and South Korea, there is already growing demand for skin rejuvenation and volume enhancement through the body’s own collagen production using PDLLA formulations such as Renisna, rather than filler treatments that use hyaluronic acid to add volume. In South Korea, more and more people are switching from hyaluronic acid fillers to Juvelook Volume.

Juvelook by Smart Skin Clinic
We use the official Juvelook Volume (Lenisna) formulation, approved by the FDA and KFDA.

Who cannot receive this treatment
Those who are pregnant or breastfeeding
Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders
Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin
- Those who have excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Juvelook Volume (Lenisna) injection site
Risks and Side Effects
At the needle puncture site:
Redness, swelling, pain, edema
Bruising
Temporary raised bumps
At the injection site
- Nodules
Downtime
Redness and raised bumps may occur at the injection site, but in most cases they return to normal in about 24 hours.
Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, though not always. If bruising occurs, it gradually fades over 10 to 14 days.
Injection site / Injection volume (cc)

- For all areas except the forehead, the cc figures represent the combined total for the left and right sides.
- The above are only guideline amounts for each area. Because there are individual differences, a physician experienced in injections will propose the optimal volume for you after counseling.
Pricing
| 1cc (Marionette lines) | |
|---|---|
| Once | 29,800 yen |
| 3 sets | 89,400 yen |
| 2cc (Left and rightNasolabial folds, temples) | |
|---|---|
| Once | 54,800 yen |
| 3 sets | 149,400 yen |
| 4cc (Forehead) | |
|---|---|
| Once | 74,980 yen |
| 3 sets | 209,400 yen |
| 6cc (Cheeks) | |
|---|---|
| Once | 99,800 yen |
| 3 sets | 278,400 yen |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Anesthesia|Includes topical anesthetic cream
This procedure is performed after applying a topical anesthetic cream. The price listed includes the cost of the topical anesthetic cream.
We open a brand-new package right there on the spot to show you.
To ensure that even those who are concerned about whether the medication is genuine can receive treatment with peace of mind, our clinicWe open a brand-new product right in front of our customers before performing the treatment.

Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to discuss anything that’s on your mind.
After marking is done, we perform the injection while checking in with you as we go.
We will provide detailed instructions on how to care for the treated area and what to keep in mind in your daily life.
In addition, with a focus on prevention and maintenance, we recommend appropriate home care products—such as oral medications and skincare products—that can help alleviate your concerns.
FAQ
- When will I see results?
Dr. IshiiMany people feel the effect after two to three weeks.
You can expect results even after just one session, but noticeable changes tend to be easier to feel after completing a set of three sessions.
We also recommend the following as an effective approach.
- A set of three sessions at two-month intervals, followed by maintenance every six months to one year
※Juvelook Volume promotes sustained collagen production, so long-term effects can be expected.- How is it different from hyaluronic acid treatment?
Dr. IshiiHyaluronic acid treatment injects cross-linked hyaluronic acid, a firmer form of hyaluronic acid, which physically adds volume to improve wrinkles and similar concerns. Juvelook, on the other hand, achieves a natural increase in volume by boosting the collagen your own body produces.
- What are the advantages of using Juvelook Volume (Lenisna) for nasolabial folds?
-
Juvelook Volume (Lenisna) combines an immediate volumizing effect with a long-term effect that promotes collagen production. As a result, you can expect improvement of the nasolabial folds together with an improvement in skin quality, for a more natural and lasting result.
- Is Jubelook Volume (Renisna) an approved medication?
-
Jubelook Volume (Renisna), which we use at our clinic, is an officially approved formulation by the U.S. FDA and the South Korean KFDA. Please note that it is an unapproved drug in Japan. For details, please refer to the “Legal Disclosures” section on this page.
Details
| Treatment Time | About 30 to 40 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | ・It is recommended to undergo a series of three treatments at two-month intervals. ・After that, maintenance treatments are recommended approximately once every six months to one year. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | A sharp, stinging pain when the needle is inserted A dull, pressing pain during the injection |
Legal Notices
Juvelook Volume (Lenisna) treatment includes procedures using drugs or medical devices that are not approved in Japan. The drugs and devices used in treatment have been imported through personal importation at the discretion of our physicians.
Disclosure of the approval status of the drug in Japan: Juvelook Volume is an unapproved drug in Japan.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Physician Who Supervised This Page

Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
Hatchobori Clinic
104-0032
2nd Floor, Tokyo NS Building, 2-29-4 Hatchobori, Chuo-ku, Tokyo
Hours: 10:00 a.m.–7:00 p.m. (Closed from 1:00 p.m. to 2:00 p.m.) / Closed: Mondays and Thursdays
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of Smart Skin Clinic's supervising physicians.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
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