Personalized PRP Injection for Nasolabial Folds

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Personalized PRP Injection 20% OFF Now On

We are currently running a campaign in which all areas are 20% OFF the regular price.

Campaign Period: December 1, 2025 – August 31, 2026

MenuRegular PriceLimited-time discount through 8/31
(20%Off)
Once208,000 yen166,400 yen
Monitor 1 session178,000 yen142,400 yen
Second area (face)166,400 yen¥133,120
Monitor
Second Area (Face)
136,400 yen¥109,120
*All prices include tax.
*We offer self-pay (non-insured) treatments only; insurance does not apply.

Nasolabial foldsAre you curious about this?

It deepens with ageNasolabial folds.With hyaluronic acid and thread lifts,I'm worried it might look unnatural...
No cutting, and it feels completely natural,Reduce nasolabial folds naturallyThere is a way to improve this.

  • Without using a scalpel,Natural finish
  • It's completed in a single session, andoffering long-lasting results of 4 to 5 years
  • Virtually no downtime,Makeup on the day of the event is also OK
  • Since we make use of the eigencomponents,No feeling of a foreign object—peace of mind

In this article,Ministry of Health, Labour and Welfare – Accredited Facility for Regenerative Medicine Provision PlanisSmart Skin Clinic, a cosmetic dermatology clinic,From a professional standpointI'll explain it in simple terms.
(*Type II and Type III Regenerative Medicine Provision Plans) Certification Number: NA8230001)

From someone who had the same concern,Three months later.

Personalized PRP Injection Case Study: Nasolabial Folds—3 Months Post-Treatment: Before/After

Treatment Name: Personalized PRP Injection (A treatment that involves injecting PRP and growth factors derived from the patient’s own blood to improve nasolabial folds and other concerns) / Price: 136,400–208,000 yen (tax included) / Major Risks and Side Effects: Redness, swelling, bruising, mild pain, or a sensation of a lump after the injection (these typically subside within a few days). Results may vary from person to person.

See More Case Photos
Supervisor Information
Kota Ishii, Chief Medical Director, Smart Skin Clinic Group

Group Chief Director, Smart Skin Clinic Group

IshiiIshii KotaKota

Career

Graduated from Juntendo University School of Medicine

Worked at Tokyo Women's Medical University Hospital and affiliated facilities

Worked at a major aesthetic clinic in Tokyo

Affiliations / Qualifications

Board-certified specialist, Japan Surgical Society

Board-certified specialist, Japanese Society of Anti-Aging Medicine

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For those with these concerns

  • My nasolabial folds have deepened, andIt makes me look a lot older all of a sudden…
  • Hyaluronic acid isI'm worried it might look unnatural...
  • Surgery and major medical treatments areI want to avoid that…
  • Since I don't want anyone to find out,I prefer treatments with minimal downtime.
  • Want a treatment with long-lasting results

For those of you who are facing these kinds of challenges,Our clinic's personalized PRP injectionsIt has been selected.

Case Photos (Before/After)

Personalized PRP Injection Case Study: Nasolabial Folds, Front View, 3 Months Post-Treatment: Before/After
Personalized PRP Injection Case Study: Nasolabial Folds, Front View, 3 Months Post-Treatment: Before/After
Personalized PRP Injection Case Study: Nasolabial Folds (Oblique View) – 3 Months Post-Treatment: Before/After
Personalized PRP Injection Case Study: Entire Face, Woman in Her 50s, 3 Months Post-Treatment: Before/After
Personalized PRP Injection Case Study: Entire Face, Male in His 50s, 3 Months Post-Treatment: Before/After
Treatment name Personalized PRP Injection
Before: Before Treatment
After: Following the completion of one treatment session
Treatment details This is an injection treatment that combines PRP extracted from the patient’s own blood with growth factors (FGF). It enhances the skin’s regenerative capacity and improves deep wrinkles, such as nasolabial folds. The volume, depth, and injection sites are customized for each individual.
Treatment period and number of sessions Typically, only one treatment session is required*In cases where the results are insufficient, additional treatments may be performed.
Treatment price 136,400 yen to 208,000 yen*The price range varies because there is a trial plan.
Main risks and side effects
  • Mild redness, swelling, or bruising may occur after the injection, but these symptoms usually subside on their own within a few days.
  • You may experience mild pain or a sensation of a lump at the injection site, but these symptoms are usually temporary and can be alleviated with proper aftercare.
  • In very rare cases, allergic reactions or the formation of tumors at the treatment site have been reported. If you experience any concerning symptoms, a doctor will examine you directly and provide appropriate care.
  • Results vary from person to person, and we cannot guarantee the same outcome for every patient.
If you have any concerns, you can discuss them directly with a doctor during a free consultation.

Number of PRP Treatment Cases

1,000and more

*Jimbocho Branch (Eligibility Period: June 2023 – March 14, 2026) and Yokohama Branch (Eligibility Period: July 2025 – March 14, 2026)

What Is Personalized PRP Injection?

PRP (platelet-rich plasma) is,Extracted from your own blood,This ingredient is rich in growth factors.
By enhancing the skin's own regenerative ability,It improves nasolabial folds at their root.

STEP 01: Blood Draw STEP 01

Blood Draw

We will draw a small amount of blood. The procedure is the same as for a regular blood test.

STEP 02 Purification STEP 02

Purification

We purify PRP to a high concentration and blend it with growth factors (FGF).

STEP 03 Injection STEP 03

Injection

It precisely injects the appropriate amount into the optimal layer.

Just like hyaluronic acidRather than “physically filling in wrinkles,”your own cells regenerate the tissue,Therefore,The result looks extremely natural.

PRP contains platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and other factors that promote collagen production, improve blood flow, and facilitate cell repair.

Guiding you to the solution that’s best for you,Four Points of Personalization

Rather than relying solely on a doctor's judgment,In every step of the processBacked by clinical data.
So, the end result isIt's stable and natural.

Personalized Diagnosis
PERSONALIZE 01

Personalized Diagnosis

Based on case dataAnalyze body structure and skin condition.Is PRP really the best option?We'll assess the situation before making a proposal.

Personalized Purification
PERSONALIZE 02

Personalized Purification

Based on numerous clinical results,We have derived,Our clinic’s proprietary purification protocol.

Personalized Design
PERSONALIZE 03

Personalized Design

The tissue lifts most naturallyCalculate the position and quantity, andFirst, create the design plan, then proceed with the treatment.

Personalized Injection
PERSONALIZE 04

Personalized Injection

Across the entire groupOver 24,000 injections performed annually.The right amount to the right layer,We'll deliver it right on target.

Difference from hyaluronic acid injections

Comparison point Personalized PRP Injection Hyaluronic acid injections
Treatment details Injects PRP extracted from your own blood to promote skin regeneration Injects synthetic hyaluronic acid to add volume
Results Natural firmness and plumpness Overfilling can result in an unnatural-looking bulge
Duration Lasts as long as 4 to 5 years Absorbed within roughly 6 months to a year
Downtime Virtually none (normal activities OK from the same day) May cause bruising or swelling
Safety No foreign-body reaction, since it uses your own blood Carries a risk of foreign-body reaction
Treatment Time Approx. 20 minutes Approx. 15-30 min.

Treatment details

Personalized PRP InjectionInjects PRP extracted from your own blood to promote skin regeneration
Hyaluronic acid injectionsInjects synthetic hyaluronic acid to add volume

Results

Personalized PRP InjectionNatural firmness and plumpness
Hyaluronic acid injectionsOverfilling can result in an unnatural-looking bulge

Duration

Personalized PRP InjectionLasts as long as 4 to 5 years
Hyaluronic acid injectionsAbsorbed within roughly 6 months to a year

Downtime

Personalized PRP InjectionVirtually none (normal activities OK from the same day)
Hyaluronic acid injectionsMay cause bruising or swelling

Safety

Personalized PRP InjectionNo foreign-body reaction, since it uses your own blood
Hyaluronic acid injectionsCarries a risk of foreign-body reaction

Treatment Time

Personalized PRP InjectionApprox. 20 minutes
Hyaluronic acid injectionsApprox. 15-30 min.

We recommend PRP for those who want a natural, seamless result.

Causes of nasolabial folds and how PRP works

The causes of nasolabial folds are,It's not just sagging.
Loss of skin elasticity, fat atrophy,Since this results from cumulative volume loss,Comprehensive care isThis leads to a fundamental solution.

Three actions of PRP

1
Promotes collagen production in the skin The growth factors contained in PRPActivates fibroblasts, andPromotes the production of collagen and elastinPromotion.As a result, skin elasticity improves, andThe depth of nasolabial folds is reduced.
2
Improves blood flow and promotes skin regeneration Vascular endothelial growth factor (VEGF) promotes angiogenesis, andImproves blood flow to the skin.Skin cell metabolism becomes more active, andMy skin has improved, andIt enhances firmness and radiance.
3
Restores volume in the subcutaneous tissue Thanks to the regenerative effects of PRP,Cell repair in the subcutaneous tissue is promoted, andCompensates for volume loss.The skin has regained its thickness, andThe shadow of the nasolabial foldsIt will be less noticeable.

Features of Personalized PRP Injection

Results Last Approximately 4 to 5 Years
Typically Completed in a Single Session
A Non-Surgical Injectable Treatment
Natural Rejuvenation Without a Sense of Discomfort
Little to no downtime
Treatment by an Injection Specialist Clinic
Tailored to each individual
Personalized treatment
Certified by the Ministry of Health, Labor and Welfare
Regenerative Medicine Provider

Pricing

Personalized PRP Injection 20% OFF Now On

We are currently running a campaign in which all areas are 20% OFF the regular price.

Campaign Period: December 1, 2025 – August 31, 2026

MenuRegular PriceLimited-time discount through 8/31
(20%Off)
Once208,000 yen166,400 yen
Monitor 1 session178,000 yen142,400 yen
Second area (face)166,400 yen¥133,120
Monitor
Second Area (Face)
136,400 yen¥109,120
*All prices include tax.
*We offer self-pay (non-insured) treatments only; insurance does not apply.

Prices are shown all-inclusive, covering consultation and needle fees.
There is no separate upselling on the day.

Monitor Requirements

Intended Use| We may publish the photos on our website, Instagram, and similar media with the eye area concealed, or show them to other patients as treatment examples [please picture typical case photos].
Procedure|You will pay the regular price at your first visit, and the difference (between the regular price and the monitor price) will be refunded when your monitor photos are taken (approximately 3 months after treatment as a guide)

First of all,You're welcome to just come in for a free consultation.

"I'm nervous about deciding on a treatment right away..."That's what most people say.
Counseling at our clinic is,This is not intended to be a treatment.

  • Sales and Upselling areNone at all
  • "Just listen to what I have to say,We also welcome you to “take your time to consider it at home.”
  • Includes a doctor's consultation.Whether it applies or not, andAll the way through to assessing the final resultI can confirm that
  • All-inclusive, covering consultation fees and other costsTransparent pricing.There are no additional charges on the day of the event.
Book a Free Consultation

Reception Hours: Weekdays 11:00 a.m.–8:00 p.m. / Saturdays and Sundays 10:00 a.m.–7:00 p.m.

Treatment Flow

1
Free Consultation Regarding your concerns and requests,Please feel free to ask us about anything.At our clinic, sales and upselling areSince there isn't any,It's perfectly fine to just come in for a consultation.
2
Examination Personalized PRP InjectionsWhether it applies or not,How should I design it?Will I be able to do it naturally,From that perspective, the current situation is...We will conduct a thorough examination.*Included in the free consultation.
3
Individually Designed As the name “Personalize” suggests,Everyone's skin condition is different, andThe desired outcomes also differ.Therefore, we will handle each case carefully and individuallyWe will handle the design.We use our expert eye to create the optimal design.
4
Blood Draw PRP uses your own bloodThis falls under the category of regenerative medicine.Just imagine a regular blood drawIt's okay.
5
PRP Extraction, PRP + FGF Purification
(Waiting time: about 1 hour)
From the customer's own blood,At the on-site processing facilityWe perform PRP extraction and processing.This is a delicate process, andSince this will take some time,It will take about an hour for our customersYou will need to wait.(You are free to go out.)
6
Anesthesia Anesthesia is administered before the treatment, soPain during PRP injections isThere are almost none.
7
Injection Performed According to the Design Based on the design we had envisioned beforehandThe appropriate amount of PRPAt the optimal location and depthWe will inject it with precision.
8
End of Treatment — Head Home You may go home immediately after your treatment.Redness may appear around the injection site, but,It's a flush like the one you get when you're slightly tipsy, so,It's not that noticeable.

If you have any questions, please consult directly with a physician

To help ease any concerns as much as possible, at our clinic
During a free consultation, a doctor will speak with you directlyHere is my answer.
Whether or not to undergo the treatment depends on,
Please take your time to consider it after that.

Consult a doctor during a free consultation

There is absolutely no sales or upselling.

Treatment details

Treatment Time Approx. 20 minutes
Anesthesia Anesthesia is applied before the treatment, so there is little to no pain. You can receive treatment with peace of mind.
Follow-up visits You can go home the same day as your treatment. No follow-up visits are required.
Post-treatment precautions Please avoid strong stimulation to the injection site for one week after treatment.
Contraindications ・Those currently undergoing treatment for a malignant tumor (please consult your doctor if you are currently in treatment)
・Those who are pregnant or breastfeeding (please consult your doctor before treatment)
Risks and Side Effects Mild redness, swelling, or bruising may occur after the procedure, but these symptoms usually subside on their own within a few days.
You may experience mild pain or a sensation of a lump at the injection site, but these symptoms are usually temporary and can be alleviated with proper aftercare.
In very rare cases, allergic reactions or the formation of tumors at the treatment site have been reported. If you experience any concerning symptoms, a doctor will examine you directly and provide appropriate care.
Results vary from person to person, and the same outcome cannot be guaranteed for every patient.
*Please note that the growth factor (bFGF) preparation used in this treatment is considered off-label for cosmetic purposes and is not covered by the Pharmaceutical Side Effect Victim Relief System.

Our personalized PRP injection uses a proprietary protocol to minimize these risks to the greatest extent possible,
providing a safer treatment.

FAQ

How many treatments are needed?

Basically, treatment is completed in a single session. Results vary by individual, but many patients are satisfied with the outcome after just one treatment.

Do personalized PRP injections hurt?

Anesthesia is applied before treatment, so there is little to no pain. If you have any concerns, please consult us beforehand.

How much downtime is there?

There is virtually no downtime. Some redness may appear right after treatment, but it usually settles down within a few hours.

Can I apply makeup right after the treatment?

You should avoid strong stimulation to the injection site on the day of treatment, but you can wear makeup as usual starting the next day.

Can personalized PRP injections be used for areas other than nasolabial folds?

Yes, it’s possible. We can treat a wide range of areas, including dark circles under the eyes, forehead wrinkles, sunken eyes, wrinkles around the mouth, and the backs of the hands. If there are any areas you’re concerned about, please feel free to consult with us.

Are there any side effects or risks?

Because your own blood is used, there is virtually no risk of a foreign body reaction. That said, mild redness or swelling may occur after treatment, but it typically settles down within a few days.

Please feel free to reach out first

We welcome your questions, concerns, and free counseling bookings regarding Personalized PRP injection.
We'll propose the treatment plan best suited to your concerns.

Book a Free Consultation

There is never any high-pressure sales, so please consult with us with confidence.

Our Commitment to Addressing Your Skin Concerns

Various facial concerns, such as,It's not just a matter of appearance...No.For daily joy and a sense of self-worthI think this is an important issue that concerns us all,I'm thinking about it.

As we get older ourselves,"I wonder if my nasolabial folds have gotten a little deeper...""My dark circles are a little noticeable today, so I might look tired..."I even found myself worrying about that.

Just one change in your face,Fashion and interpersonal relationshipsI started to enjoy it, andTo enjoy life even moreYou might find yourself able to do it.
We offer personalized PRP injections,It's not just about improving the appearance, but rather,A Positive Outlook on Life ItselfA trigger for being caughtWe consider this to be a treatment that will result in...
Under the supervision of a board-certified specialist in anti-aging medicine,No sales or upsellingWe are fully committed to providing sincere medical care.

It is true that this is a costly treatment.But more than that,"I want to enjoy the rest of my life more."For customers who think,Delivering Tangible Value"Investment"If that is the case,We are convinced.

About the physician supervision of this site

This site is operated under the supervision of a Smart Skin Clinic supervising physician.

This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.

  • Scope of supervision: treatment descriptions, risks and side effects, price display
  • Last supervision date: June 26, 2025
*Treatment effects vary from person to person. Please be sure to consult a physician regarding side effects and risks.
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