For those who suffer from wrinkles on the face and neck. Next generation hyaluronic acid treatment selected by 100 cosmetic doctors for its high praise |To regain a youthful impression...

Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
Introduction: We, too, have struggled with wrinkles
"Every time I look in the mirror, I notice the wrinkles on my face and neck…"
Do you find yourself thinking this way? Deep wrinkles etched at the corners of the eyes and mouth, and horizontal lines appearing on the neck. As the years go by, wrinkles seem only to increase.
The delicate areas around the eyes, mouth, and neck in particular are prone to wrinkles. Every time you smile, look surprised, or tilt your head, the wrinkles are thrown into sharp relief… Even if they don't bother you, having someone point them out can shake your confidence in an instant.
But you are not alone.More people than you might imagine struggle with wrinkles on the face and neck..
As we age, it is only natural for collagen and elastin—which maintain the skin's firmness and elasticity—to decrease.
What matters most is a positive mindset—accepting who you are now while striving to move closer to your ideal self. Wrinkles are proof of a life well lived. In fact, you can even choose to see them as attractive.
That said, you probably still want to keep a youthful look… There is a treatment that can meet exactly that wish.
Today, we would like to introduce "Profhilo injections," a treatment generating a great deal of buzz among cosmetic doctors.
"Profhilo injections" are attracting attention as a next-generation hyaluronic acid injection. A major feature is that they can address wrinkles not only on the face but also on the neck. They help restore firmness and elasticity from within the skin, so you can achieve a natural, youthful appearance.
Next-generation hyaluronic acid: What is Profhilo?

What is a Profhilo injection?"An injectable moisturizer" and "next-generation hyaluronic acid"These are the names given to this injectable treatment.
Its official product name is "Profhilo®." On the market since 2015, it is a hyaluronic acid produced using NAHYCO™, a patented technology developed by the Italian company IBSA.
Because it is a cutting-edge treatment that can address wrinkles and improve skin quality at the same time, it is drawing attention within the cosmetic medicine field
Also,Unlike ordinary hyaluronic acid, Profhilo injections do not remain in the skin as a solid mass—which is a major advantage.
Using too much ordinary hyaluronic acid carries the risk of an unnatural-looking face, as shown in the post below, but with Profhilo, the next-generation hyaluronic acid, there is no such risk.


Profhilo injections are effective for concerns like these
- I want to improve wrinkles and sagging across the entire face (under the eyes, outer corners of the eyes, cheeks, and neck) all at once, while also improving my skin quality
As mentioned earlier, unlike ordinary hyaluronic acid, Profhilo injections do not remain in the skin as a solid mass.
As a result, as shown in the case photos below,an exceptionally natural rejuvenation can be achieved.is what it makes possible.


If you overdo ordinary hyaluronic acid injections, you run the risk of an unnatural-looking face, as in Ms. Honezawa's post below; a major advantage of Profhilo injections is that they carry no such risk.
Effect | Profhilo has a skin-rejuvenating effect
Profhilo offers the following benefits.
〇 Improvement of wrinkles and sagging
〇 Improvement of firmness and elasticity (enhanced, dewy skin)
〇 Lifting effect
〇 Natural volume enhancement

When can the effects be felt after treatment?

When can the effects be felt after treatment?
Dr. IshiiHow soon the effects are felt varies from person to person, but they are often felt gradually from a few days to a few weeks after the injection. The maximum effect is usually felt around one month after the injection.
How long do the effects last?

How long do the effects last?
Dr. IshiiThey are said to last from about 6 months to 1 year. For lasting results, we recommend regular injections for maintenance.
Profhilo's characteristic | Penetrating power that reaches deep and wide in multiple directions
So far we have explained the properties of hyaluronic acid. Here, we will explain the characteristics of Profhilo, which also incorporate those properties of hyaluronic acid.
Penetrating power that reaches deep and wide in multiple directions"

Profhilo at Smart Skin Clinic
We use "Profhilo®."
As of 2020,it has been introduced in more than 80 countriesand is a hyaluronic acid with an extensive track record. More than 500,000 cases have been reported worldwide, and it has also received AMEC & AESTHETICS awards,a hyaluronic acid whose safety and effectiveness are recognized worldwide.
Profhilo is the only treatment that can remodel the skin without the use of a device.
At Smart Skin Clinic, weA Japanese Society of Anti-Aging Medicine specialist with over 1,000 Profhilo proceduresperforms the treatment
At Smart Skin Clinic,A Japanese Society of Anti-Aging Medicine specialist with extensive experience and advanced skill from more than 1,000 procedures with Profhilo alone.will always be in charge of the treatment.
This helps ensure not only a high-quality finish but also keeps downtime swelling and pain during the procedure to a minimum.
Below, we share comments we have actually received from our patients.
Since it was on my face, I was worried about injection marks (bruising), but the doctor's technique was excellent and there was zero…
Excerpt from a Smart Skin Clinic review on Hot Pepper Beauty
I had the injection on my way home from work and took care to wash my face gently when bathing; when I woke up the next day,the marks that had looked like mosquito bites had completely disappeared.There was no need for unnecessary face washing before the treatment, and the treatment itself was over quickly in 15-20 minutes. I'm looking forward to my second session on 1/11.
The doctor is remarkably quick to understand and is exceptionally skilled at picking up on what you want.Having had many consultations at cosmetic surgery clinics, this is a clinic I would recommend.!!!!
The treatment, and the needle work, is very skillful. It does hurt, but the finish is outstanding..
Smart Skin Clinic's commitment to injection treatment
Following our director's philosophy, we perform injections with the following "attention to detail."
Safety
Because Profhilo contains no chemicals such as cross-linking agents and no biological agents,it can be considered highly safe..
Specifically,it is less likely to cause allergic reactions and the like.That is the point.
The reason for this is that Profhilo contains no "cross-linking agent."
Cross-linking agents may cause allergic reactions, immune reactions, and inflammation. Although very infrequent, allergic reactions have been reported. Conventional hyaluronic acid injectables contain a substance called a cross-linking agent.
Also,Profhilo's high level of safety has been noted in several published papers.
Based on three years of post-market experience, the safety profile of the medical device in this study is favorable.
Daniel Cassuto, et al. (2020) Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.
Smart Skin Clinic's Profhilo consistently earns high ratings in reviews on Google, Hot Pepper, KireiPass, and more
At Smart Skin Clinic, we think carefully about what our patients truly need and thoroughly cut out unnecessary costs, allowing us to deliver affordability, high quality, and high satisfaction all at once.
As a result,we earn high ratings across a variety of review sites, including Google and Hot Pepper Beauty.we have earned.
As a result, about 80% of those who visit us once return for repeat treatment.
Google review rating 4.5/5.0 (97 reviews)

Hot Pepper Beauty rating 4.57/5.00

KireiPass rating4.30/5.00

Kumapon rating4.71/5.00

Gangnam Unni rating9.3/10.0

A price comparison between the usual fees at clinics in the Kanto region and Smart Skin Clinic
Typical going rate
At aesthetic clinics in the Kanto region, the market rate for injecting Profhilo into the face is around 65,000–80,000 yen per session, 130,000–170,000 yen for a set of two, and about 200,000 yen for three.
*Surveyed in February 2024.
Smart Skin Clinic's Profhilo injection price, among the most affordable in Japan
At Smart Skin Clinic, through thorough cost-reduction and other efforts, we maintain prices that are among the most affordable in Japan.
| Sessions | Regular Price | Special Price | per vial |
|---|---|---|---|
| 1 session (2cc) | 52,800 yen | 49,800 yen | 49,800 yen |
| Set of 2 (2cc x 2) | 99,600 yen | 95,600 yen | 47,800 yen |
| Set of 3 (2cc x 3) | 139,800 yen | 137,400 yen | ¥45,800 |
Below, regular prices
| 1 session (2cc) | |
| Set of 2 (2cc x 2) | (1st vial 52,800 yen) (2nd vial 46,800 yen) |
| Set of 3 (2cc x 3) | (52,800 yen for the 1st vial) (46,800 yen for the 2nd vial) (3rd vial40,200 yen) |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
*Profhilo uses a set of designated injection points known as the BAP technique (treatment at bio-aesthetic points), so at essentially any clinic 2cc covers the treatment area described above.
Prices are shown all-inclusive, covering consultation and needle fees.
There is no separate upselling on the day.
Need for anesthesia | Low
This treatment generally does not require anesthesia.
We would like to keep this pricing, so if you would like numbing cream we charge[5,500 yen (tax included) per session]for it. (*This is because anesthesia adds about 20 minutes to the treatment time.)
Monitor Requirements
①Intended Use|We may publish your photos on our website, Instagram, and similar media with the eye area concealed, or show them to other patients as treatment examples [please picture typical case photos].
②Procedure|You pay the regular price at your first visit, and we refund the difference (between the regular price and the monitor price) when the monitor photos are taken (3 to 7 days after the second treatment).
Who cannot receive this treatment
Those who are pregnant or breastfeeding
Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders
Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin
Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Profhilo injection site
Risks and Side Effects
At the needle puncture site:
Redness, swelling, pain, edema
Bruising
Temporary raised bumps
Downtime
Redness and raised bumps may occur at the injection site, but in most cases they return to normal in about 24 hours.
Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, though not always. If bruising occurs, it gradually fades over 10 to 14 days.
Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
After marking is done, we perform the injection while checking in with you as we go.
We explain in detail how to care for the treated area and what to keep in mind in daily life. From a prevention and maintenance standpoint, we also suggest suitable home care, such as oral medications and skincare products that can support improvement of your concerns.
Details
| Treatment Time | About 15 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | A set of 2 treatments spaced at least 6 weeks apart is recommended. After that, maintenance about once every six months is recommended. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | A slight pricking sensation when the needle is inserted. |
FAQ
- How often and how many times should I receive it?
Dr. IshiiResults can be gained even from a single session, but for the most effective approach we recommend one of the following.
① Have the first and second sessions one month apart, then continue the same pattern once a year thereafter.
② Have the first and second sessions one month apart, then continue every six months thereafter.
*Profhilo's skin remodeling effect increases the extracellular matrix and rejuvenates the skin. Without maintenance, the extracellular matrix gradually decreases "due to aging" after the treatment reaches its peak. For this reason, we recommend the approach above.- Does it hurt?
Dr. IshiiIt varies from person to person. We use a fine needle, but you may feel a slight pricking sensation. The center of the face is also said to be more sensitive to pain.
- How long is the downtime?
Dr. IshiiRedness subsides in about 24 hours.
- Is one session effective?
Dr. IshiiResults can be gained in a single session, and the lifting effect can be felt right away. That said, many people notice the effects from 3 to 4 weeks later, as skin remodeling progresses.
Introducing other injectable treatments at Smart Skin Clinic for those with skin-quality concerns
In addition to Profhilo injections, Smart Skin Clinic also offers other injection treatments that are effective for improving skin quality.


If you are interested in the Juvelook injection shown in the case photo above, please refer to the link below.
Legal Notices
Profhilo treatment includes procedures using medications or medical devices not approved in Japan. The medications and devices used are personally imported at the discretion of our clinic's physicians.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Smart Skin Clinic
Smart Skin Clinic
A clinic built on the concept of "making aesthetic medicine more accessible and smart."
Rather than spending on ornate interiors, we keep fit-out costs down, and rather than adding equipment indiscriminately, we carefully select only the devices we need to keep equipment costs down.
We aim to "make aesthetic medicine more accessible" for you.

Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialties: Aesthetic Dermatology (aesthetic dermatology, medical hair removal, medical body contouring)
Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialties: Aesthetic Dermatology (aesthetic dermatology, medical hair removal, medical body contouring)
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of Smart Skin Clinic's supervising physicians.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
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