Profilio Japan's Lowest Price Level: ¥22,900~|Smart Skin Clinic [Official]

*Number of cases|From September 1, 2023 to April 1, 2025

Until December 31: Year-End Special Discount Price Jimbocho & Yokohama Clinic limited time
frequency Normal price special price Price per cc
1 time (2cc) 52,800 yen 47,800 yen 23,900 yen
2 sets (2cc x 2) 99,600 yen 93,600 yen(¥46,800 per session) 23,400 yen
3 sets (2cc x 3) 139,800 yen 137,400 yen(1 time 45,800 yen) 22,900 yen

Our free consultations are not conducted by cosmetic counselors like those at major clinics, but directly by specialized physicians.

For this reason, we are very popular with clients who are new to beauty, as we do not push sales at any point during the free consultation. Please feel free to make an appointment.

Before/After Profhilo Injections

  • Instantly improve sagging and wrinkles across the entire face (under the eyes, outer corners of the eyes, cheeks, and neck)
  • Improving neck wrinkles
  • Improvement of veins and wrinkles on the back of the hand

What is PROFHILO?

Profilo Product Images

What is a PROFILO injection?Injectable moisturizers, next-generation hyaluronic acid."The treatment is an injectable treatment called

The official trade name is Profhilo®, a product that has been on the market since 2015 and is a hyaluronic acid created with a patented technology called NAHYCO™ by the Italian company IBSA.

This is the latest treatment that can simultaneously treat sagging skin and improve skin quality, and is attracting attention in the cosmetic medicine industry.


PROFHILO is called the next generation of "hyaluronic acid," but many people recognize that conventional hyaluronic acid is"Bridges."It will be called hyaluronic acid.PROFHILO is "non-cross-linked" hyaluronic acidThis will be the case.

The major difference between cross-linked and non-cross-linked is whether it spreads. PROFHILO, a non-cross-linked hyaluronic acid, spreads from the site of injection and produces a broad spectrum of effects.

Effect|Profilo has a skin rejuvenation effect.

Profilo has the following benefits

z Improvement of wrinkles and sagging skin
0 Effect of improving firmness and elasticity (increased freshness)
0 Lifting effect
0 Natural volume increase

Effect

When can the effects be felt after the treatment?

When can the effects be felt after the treatment?

Dr. Ishii

The feeling of the effect varies from person to person, but it is often felt gradually from a few days to a few weeks after injection. The maximum effect is usually felt around one month after injection.

How long do the effects last?

How long do the effects last?

Dr. Ishii

It is estimated to last from 6 months to 1 year. For continued effectiveness, we recommend regular injections as maintenance.

Our Clinic's Signature Profilo

Adopted "Profhilo®".

CurrentlyIntroduced in more than 80 countriesIt is a hyaluronic acid with a proven track record. More than 500,000 cases have been reported worldwide, as well as AMEC & AESTHETICS awards,Hyaluronic acid is recognized worldwide for its safety and effectivenessIt is.

Profibro is the only treatment that can remodel the skin without the use of instruments.

Some customers at Smart Skin Clinic express concerns, saying, "Because the prices are low, I worry whether the products are genuine."

To address such concerns,We open new formulations on the spot and show them to you.This has helped our customers to feel secure.

Comparison of Our Hospital and Other Hospitals

Comparison Chart with Other Hospitals

Comparison Chart with Other Hospitals

Why choose our clinic?
Please note the clear differences.

  • Price (Face 2cc)

    General Market Trends and Prices
    Once ¥65,000 to ¥80,000
    twice ¥130,000 to ¥170,000
    3 times Approximately 200,000 yen
    *Based on our research (September 2025 / median price range listed on major clinics' websites in the Kanto region)
    Smart Skin Clinic
    Once 49,800 yen
    twice 95,600 yen
    3 times 137,400 yen
    Total price display
    Consultation and acupuncture included
    Compared to other hospitals, the maximum
    Save ¥74,400!
  • Display and Additional Fees

    General trend
    Consultation fee, needle cost, anesthesia, medication cost, etc.separatelymay occur
    Smart Skin Clinic
    Total cost (including consultation and acupuncture)
    No upsells on the day
  • Counseling System

    General trend
    Beauty Counselor-Centered Information
    Smart Skin Clinic
    Physician direct response
    No hard selling
  • Transparency of Formulations

    General trend
    Explanation of the delivery confirmationif not
    Smart Skin Clinic
    Open on the spot and present
  • Profilio Case Results

    General trend
    by the institutionNon-public · Variabilityant
    Smart Skin Clinic
    Over 2,500 cases
    September 1, 2023–September 1, 2025 Our hospital's tally
  • Same-day treatment

    General trend
    In some cases, we may need to reschedule for another day.
    Smart Skin Clinic
    Same-day appointments available※

※Comparisons reflect "general trends" and serve as a guideline for our clinic's operational policy. Results may vary depending on the clinic and timing. Additionally, if you have only booked a free consultation, same-day treatment may not be possible depending on availability. We appreciate your understanding.

Why is our clinic so affordable?

Kota Ishii, Chairman

Kota Ishii

Smart Skin Clinic Chairman

Japanese Society of Anti-Aging Medicine

"Cosmetic medicine doesn't have to be expensive."
It's an answer I arrived at precisely because I myself was a patient.

Hello, I'm Ishii, the Chairman. As a physician myself, I have also undergone various cosmetic treatments as a patient. Through this experience, I developed a strong conviction: "I want to provide truly effective treatments at prices everyone can comfortably afford to continue."

Smart Skin Clinic meticulously eliminates costs unrelated to treatment quality—such as extravagant interiors and excessive advertising expenses—and passes these savings directly to our prices. We invite you to discover our commitment: prioritizing customer satisfaction above all, not just affordability.

We promise value beyond the price Our commitment
  • The same physician will be responsible throughout. Doctors take responsibility for everything from initial consultation to aftercare, not leaving it solely to counselors.
  • Open the package in front of the patient To eliminate any concerns about the medication, we will always open a new package in front of you for your confirmation.
  • Ultra-fine needles for pain relief The director personally selects ultra-fine needles (34G). Our advanced techniques minimize discomfort during treatment.
  • No upsells whatsoever The displayed price is the total amount, including consultation fees, needle costs, and all other charges. There is no need to worry about the price increasing later.

A specialist in anti-aging medicine with over 2,500 Profilo treatment casesThe treatment is performed by

At Smart Skin Clinic,A specialist in anti-aging medicine with over 2,500 procedures performed exclusively with Profhilo and advanced technical expertise.will always be in charge of the treatment.

This minimizes downtime swelling and pain during the procedure as well as the quality of the finished product.

Below are some customer testimonials.

Koyuki (from Hot Pepper Beauty)

Lately, I've become increasingly concerned about the changes brought on by aging. I felt my self-care routine had reached its limits when it came to sagging around the mouth, sunken cheeks, nasolabial folds, hollow temples, and wrinkles and hollows under the eyes. I found Smart Skin Clinic through an online search,It had extremely high user reviews.I chose this option because I wanted minimal downtime, safety, and overall facial rejuvenation, which led me to select Profhilo. The procedure began immediately after the consultation, with injections administered at five points on each side of my face, totaling ten points. The initial prick of the needle was mild, but the pain increased as the solution was injected. However, it wasn't painful enough to require anesthesia. After the procedure, the injection sites swelled slightly, like mosquito bites, but it was easily concealed with a mask and didn't interfere with going home. In my case, I had one site under my eye that bruised, and I'm currently covering it with a mask for work. I expect this bruise will fade in about 10 days. On day 1 post-procedure, my cheeks felt fuller. It's now day 5 after the procedure, and...Results far exceeding expectationshas been obtained.

Jumomaro (from Hot Pepper Beauty)

I've always wanted to improve the sagging and wrinkles under my eyes, and since this site had good reviews, I made an appointment.The staff, the teachers, everyone was very pleasant.I felt completely at ease receiving my first treatment. I wanted to improve the sagging and wrinkles under my eyes. I was interested in injections like hyaluronic acid. After consulting, I opted for the Snekos injection. Relativelywith no downtimeBefore the treatment, I was anxious about how I'd feel the next day, but I was relieved to find I was back to normal within about 30 minutes after the session. After consulting with the practitioner, I received an explanation of the desired treatments and other details, then chose what suited me best at the moment. I then immediately went to the treatment room for the session, which finished in about 15 minutes. I was told that receiving four sessions every two weeks would maintain the results for about a year, so I decided to undergo the four sessions.

Ms. B (from Hot Pepper Beauty)

I was concerned about sagging around my mouth and jawline, as well as nasolabial folds, and was searching for a treatment that could lift and tighten these areas. I had previously received a similar treatment at this clinic and experienced its effectiveness, so I continue to come here.The teacher's knowledge and skills are outstanding.I have decided on this clinic for my anti-aging treatments,You can trust us with complete peace of mind..More affordable than other clinics and easier to continueEven if you're not familiar with beauty treatments, I think you'll find it easy to consult with us. I had the Shopping Lift performed on areas of concern like my jawline, mouth area, and nasolabial folds. I noticed the effect on my nasolabial folds almost immediately the next day. Within about a week to ten days...Experience skin firmness and radiance, with a natural liftIt's done. You always respond to questions so thoughtfully, and not only are your rates reasonable,There are absolutely no markups or excessive recommendations.You can feel at ease. The reception staff are also very approachable, creating an atmosphere that makes it easy to visit even if you're not comfortable with beauty clinics.

Mika (from Hot Pepper Beauty)

We always appreciate your support.My skin has really improved.I feel it. AndThe prices are also reasonable compared to other clinics.This time, I requested Jalpro for the fifth time. I chose Jalpro because it has shown the most visible results so far, and because other clinics recommended treatments unrelated to my specific concerns.I asked the director I trust to handle it.The pain is there. But I take deep breaths while enduring it, telling myself this will make my skin beautiful again. On the day of the treatment, my face looks a bit puffy. The next day, that puffiness turns into just the right amount of youthful-looking swelling, which I like. I'm extremely satisfied at this point. The director is kind and explains everything thoroughly. I've been taking my own before-and-after photos since getting Jalpro injections.Visibly becoming more beautifulAt another clinic, I had a skin diagnosis done, and although my actual age is 39,Skin age: 32was.I truly believe it was the right thing to do.

Pisan (from Hot Pepper Beauty)

The reason I chose this clinic isMore affordable than other clinicsNevertheless,It had high user reviews.After consulting with the clinic about the facility and receiving the doctor's explanation, I decided to proceed with the treatment. I'm glad I chose this clinic for my procedure. No waiting time, smoothReception desk, escort to the examination room,Accurate advice and explanations from doctorsI was anxious about the pain, but since it was my first session, they said they could accommodate reducing the planned 60 needles down to 40.I also appreciated the proposal for treatments with lower costs, which gave me a strong sense of trust. Immediately after the treatment, my nasolabial folds seemed noticeably reduced. I felt a firm lift in the lower part of my face, and my makeup applied beautifully. This Shopping Lift is so convenient and quick. Next time, I'd like to try it again with a few more threads. It was my first time at a beauty clinic, and I was hesitant, wondering what to do...I am satisfied with the treatment I received.This clinicThere's no hard sell, and considering the price, it's very reasonable.

e e (from Google)

This is my second visit. Last time, I had Jalpro treatment for my nasolabial folds,The results were quite significant compared to previous nasolabial fold treatments.So, I came in this time hoping to improve the fine lines on my forehead. Since it's the cheapest formulation in Jalpro, I was actually a little worried you might recommend the more expensive one instead.Without being pressured to buyThe treatment was performed using Jalpro Classic as is. Jalpro Classic was quite painful. While I admit I have a low pain tolerance, the surface anesthesia alone wasn't sufficient, so I had to request additional block anesthesia midway through. Even then,You handled it without so much as a frown.Thank you very much. I plan to return next month for treatment of my nasolabial folds and sunken cheeks.This is a clinic I'd like to keep visiting.

MI YO (from Google)

Explanation, speed, treatment, price. Everything was very satisfying.I asked you various questions about things I didn't understand or wanted to know, but you answered all of them.Thank you for your kind response.Also,I appreciate your honest answers.That's why I don't usually make immediate decisions, but I'm glad I was able to make one today. With hardly any waiting timeThe entire process—from counseling to treatment completion to payment—took less than an hour. The speed was impressive. The treatment was meticulous, and I felt less pain than usual, which made me think, "Maybe a skilled practitioner causes less discomfort?" The price was also cheaper than the place I used to go to.I found this clinic to be highly satisfying and one I can continue visiting, as it prioritizes speed, treatment quality, and price—all of which are important to me.A clinic in Tokyo with quite good value for moneyI think so. It seems like I can continue going there with peace of mind.

S T (from Google)

I was hoping to get rid of the dark circles under my eyes and searched online for good treatments, which led me here. With so many types of injections available, I was unsure which to choose. The doctor recommended a newer medication called Neo Found instead of the Snekos injection, so I decided on that. They offered a discounted course for four sessions, but I just wanted to try it once for now. It cost ¥34,500.No initial consultation fee or examination fee charged—very reasonable.It was my first time getting an injection around my eyes, so I was really scared, but the female doctorYou administered the treatment gently and carefully, with almost no pain at all.The procedure went smoothly. While topical anesthesia costs a bit extra, the doctor didn't push it, suggesting, "Why not try it without anesthesia first? If it hurts, we can add it next time." I tried it without anesthesia and experienced almost no pain, so I'm glad I followed the doctor's advice. Afterward, I was surprised to see the swelling under my eyes in the mirror. But it seems to have been absorbed quickly—by the second day, it looked completely natural. Now, with makeup on, you can't even see the tiny needle marks.The dark circles under my eyes that had troubled me for years have also disappeared.That's amazing. Next time, I think I'll sign up for the course.

Ms. Miho Sato (from Google)

I recently had a hydrating injection. As others have mentioned,No sales whatsoever, , The reception staff and the doctor are both very nice! I visited several other hospitals too, but I grew tired of the upsell tactics during counseling sessions and felt uneasy about the assembly-line approach to treatment... Here,Nothing of the sort ever happened.So I could focus solely on the treatment! I look forward to seeing you again next month.🙇

Yuka T (from Google)

Several years ago, I had treatment for under-eye bags and dark circles, but it left me with wrinkles that made me look older, which troubled me. I decided to explore another treatment option and compared several clinics. Smart Skin Clinic offered various medications and treatment methods, so I went for a consultation hoping to find a suitable treatment. I explained my concerns, had my condition assessed, and received a Senecosporm treatment. They carefully and meticulously applied it to the areas I was concerned about. No bruisingCurrently in downtime, things are settling down a bit, but I'm looking forward to the final results. From booking to treatment, both the doctor and staff conveyed genuine sincerity.There was no hard selling, no unnecessary upselling or cross-selling, and the service was very pleasant. Also, avoid unnecessary costs and keep overall expenses low.The price range is also kept low.I think. It's convenient and I'm grateful.

IRO code (from Google)

Since childhood, I've had atopic dermatitis and sensitive skin. Every time I got an injection, I'd get bruising, and considering the downtime, I couldn't just go in casually. But when I consulted the doctor at Smart Skin Clinic about my bruising concerns,Very carefully, taking time to slowly infuseYou were able to do so. No bruising on the face, neck, or under the eyes‼︎It was my first time experiencing something like this, so I was really happy. The bumpy areas that had been treated in the evening gradually flattened out by nightfall,There will be no impact on tomorrow's work.I really felt glad I went through with it. Even with appointments, some clinics still make you wait, but at Smart Skin Clinic, from check-in to the doctor's consultation, the procedure, and checkout,Smooth and smart, just as the name suggestsIt was. I think it's a clinic where all interactions are courteous, with no unnecessary elements whatsoever—simple and clean.Profilio is priced lower than any other clinic, making it easier to continue treatment.I am very satisfied.

Raran-san (from Hot Pepper Beauty)

While researching prices for Rejuran, I discovered there's a generic version of Rejuran. Smart Skin Clinic was the place offering it. When I checked the cost, compared to what I'd been paying at other clinics, it was...Quite affordable pricingSince it was available, I made an appointment right away. At other clinics, they try to push other treatments or add-ons, and it's a hassle to decline, but Smart Skin ClinicThere is absolutely no such sales pitch.I was very pleased that the consultation focused solely on the treatments I requested. The doctor provided counseling and addressed my questions regarding my goal of skin nurturing.Your clear explanation helped me understand and I'm satisfied with it.So I had the treatment that day. This time it was machine-applied, soThere was no bruising. The receptionist's courteous service left a favorable impression, and both the nurse and the procedure itself were completed efficiently and quickly. The clinic interior felt very clean and had a simple layout, reflecting the cost-conscious approach.The treatment fees are lower than at other clinics.I felt that way. I was very satisfied with everything.

Consistently receives high ratings in customer reviews

Google Reviews 4.5/5.0

Hot Pepper Beauty 4.57/5.00

Evaluation of Kireipas4.30/5.00

Kumapon Evaluation4.71/5.00

Evaluation of Kang Nam Onni9.3/10.0

Smart Skin Clinic's Profhilo: Japan's Lowest Prices

Until December 31: Year-End Special Discount Price Jimbocho & Yokohama Clinic limited time
frequency Normal price special price Price per cc
1 time (2cc) 52,800 yen 47,800 yen 23,900 yen
2 sets (2cc x 2) 99,600 yen 93,600 yen(¥46,800 per session) 23,400 yen
3 sets (2cc x 3) 139,800 yen 137,400 yen(1 time 45,800 yen) 22,900 yen

The price is indicated as all-inclusive, including consultation and needle fees.
There is no separate upsell on the day of the event.

Need for anesthesia|Low

Price quotes

At beauty clinics in the Kanto area, the market price is 65,000-80,000 yen per treatment to inject Profibro into the face, 130,000-170,000 yen for a set of two treatments, and approximately 200,000 yen for three treatments.

※As of September 2025

FAQ

How often and how many times should I take the course?
Dr. Ishii

Although a single session can be effective, we recommend one of the following as the most effective method
(1) The first and second sessions will be done at one-month intervals, and the same pattern will be continued every year thereafter.
(2) The first and second sessions are performed at one-month intervals, and then continued every six months thereafter.

The skin remodeling effect of PROFHILO increases the extracellular matrix, resulting in skin rejuvenation. Without maintenance, the extracellular matrix will gradually decrease "due to aging" after the peak of treatment. For this reason, we recommend the above procedure.

Do you feel pain?
Dr. Ishii

Although it depends on the individual, we use a thin needle, but you may feel a slight stinging pain. It is also said that the center of the face is more sensitive to pain.

How long is the downtime?
Dr. Ishii

Redness will subside in about 24 hours.

Does it work after just one visit?
Dr. Ishii

You can see results after just one session. You'll feel the lifting effect immediately afterward. However, most people notice the full effects 3 to 4 weeks later, once the skin remodeling process is complete.

Safety

PROFHILO contains no cross-linking agents or other chemicals or biological agents.Highly safeIt can be said that

Specifically,Less likely to cause allergic reactions, etc.This is the case.

The reason for this is that PROFHILO does not contain a "cross-linking agent".

Cross-linking agents can cause allergic reactions, immune reactions, and inflammation. Allergic reactions have been reported to occur, although they are very infrequent. Conventional hyaluronic acid injectables contain a substance called a cross-linker.

Also,The high safety profile of PROFHILO has been mentioned in several papers.

Based on 3 years of post-market experience, the safety profile of the medical devices in this study is good

Daniel Cassuto, et al. (2020)Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.

Those who cannot be treated

Pregnant or nursing mothers

Those with abnormal immune function or a history of such abnormality, and those undergoing immunosuppressive therapy.

Those prone to keloid formation, hypertrophic scars and hyperpigmentation

Those with bleeding tendency or using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin

Excessive sunburn, eczema, dermatitis, acne, or scabs at the site of PROFHILO injection

Risks and Side Effects

of the needle puncture site.

Redness, swelling, pain, edema

Intravascular hemorrhage

Temporary protuberance

Down time

Redness and bumps at the injection site may occur, but in most cases will return to normal in about 24 hours.

Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, although not always. If subcutaneous bleeding spots occur, they will gradually disappear over a period of 10-14 days.

Flow of treatment

STEP
Reservation

You can easily make reservations with your mobile phone.

STEP
Reception (desk)

This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.

STEP
Counseling and medical examination

Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.

STEP
PROFHILO injection

After the marking is carried out, the injection is carried out while talking to the patient.

STEP
After-sales service

We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.

STEP
Returning home

More Information

Treatment TimeAbout 15 minutes (not including counseling)
Recommended number and frequency of treatmentsIt is recommended that two sets of two sessions be performed at least 6 weeks apart.
After that, maintenance is recommended about once every six months.
Down timeAbout 24 hours
Treatment on the day of counselingPossible
MakePossible immediately after the treatment
Skin carePossible immediately after the treatment
ShowerPossible from the same day
PainThere is a stinging pain when the needle is inserted.
*There are individual differences.
Final Call to Action
🙏 Thank you for reading this far!
Until December 31The limited-time special price is almost gone!
If you miss this opportunity, you will be charged the regular price.
Benefits of booking now
  • This limited-time special price may end without notice. Now is your chance to get it at the lowest price in Japan.
  • Anti-Aging Specialist with over 10,000 skin rejuvenation procedures performed
  • Free consultation with a physician (normally worth ¥10,000)
  • Minimal downtime, natural improvements and changes that go unnoticed by others
  • Reliability rated 90% or higher based on various user reviews and satisfaction ratings
Free consultations are also very welcome!
At our clinic, consultations are conducted directly by physicians, not beauty consultants. We do not engage in any hard selling, so please feel free to consult with us.
※Feel free to visit us even just for a free consultation. We do not engage in any high-pressure sales tactics whatsoever.

Introduction of other Smaski injectable procedures for those who suffer from skin conditions.

In addition to Profibro injections, Smart Skin Clinic also offers other injection procedures that are effective in improving skin texture.

If you're interested, please take a look at the various services we offer by clicking the link below.

Smart Skin Clinic|Aesthetic Skin...
Injections & IV Drips | Smart Skin Clinic|Cosmetic Dermatology Group (Jimbocho & Yokohama) "Beauty from within." Reduce the time spent worrying about your skin. And achieve even more beautiful skin. "Beauty from within." Reduce the time spent worrying about your skin. And achieve even more beautiful skin. Exosome treatment...

Legal description

Prophylotherapy includes procedures using drugs or medical devices that are not approved in Japan. The medicines and devices used in the treatment have been imported on a personal import basis under the judgment of our physicians.

Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".

Supervisor Information

Chairman of Smart Skin Clinic Group

stoneheterotopia KoutaHeian era court lady's song (accompanying men's oouta)

career

Graduated from Juntendo University School of Medicine

Tokyo Women's Medical University Hospital and related facilities

Worked at a major beauty clinic in Tokyo

Affiliation / Qualifications

Japan Surgical Society Specialist

Japanese Society of Anti-Aging Medicine

Smart Skin Clinic

Smart Skin Clinic

The concept of the clinic is to "make cosmetic medicine more accessible and smart. is the concept of the clinic.

Instead of eliminating ornate interiors to reduce interior design costs and installing equipment in the dark, we carefully select the equipment we need and reduce the cost of the equipment.

We aim to "make cosmetic medicine more accessible" for you.

CLINIC LIST

Clinic List

About the physician supervision of this site

About the physician supervision of this site


This site is operated under the supervision of the Smart Skin Clinic supervising physicians.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.