Lately, I've become increasingly concerned about the changes brought on by aging. I felt my self-care routine had reached its limits when it came to sagging around the mouth, sunken cheeks, nasolabial folds, hollow temples, and wrinkles and hollows under the eyes. I found Smart Skin Clinic through an online search,It had extremely high user reviews.I chose this option because I wanted minimal downtime, safety, and overall facial rejuvenation, which led me to select Profhilo. The procedure began immediately after the consultation, with injections administered at five points on each side of my face, totaling ten points. The initial prick of the needle was mild, but the pain increased as the solution was injected. However, it wasn't painful enough to require anesthesia. After the procedure, the injection sites swelled slightly, like mosquito bites, but it was easily concealed with a mask and didn't interfere with going home. In my case, I had one site under my eye that bruised, and I'm currently covering it with a mask for work. I expect this bruise will fade in about 10 days. On day 1 post-procedure, my cheeks felt fuller. It's now day 5 after the procedure, and...Results far exceeding expectationshas been obtained.
Profilio Japan's Lowest Price Level: ¥22,900~|Smart Skin Clinic [Official]

*Number of cases|From September 1, 2023 to April 1, 2025
| frequency | Normal price | special price | Price per cc |
|---|---|---|---|
| 1 time (2cc) | 52,800 yen | 47,800 yen | 23,900 yen |
| 2 sets (2cc x 2) | 99,600 yen | 93,600 yen(¥46,800 per session) | 23,400 yen |
| 3 sets (2cc x 3) | 139,800 yen | 137,400 yen(1 time 45,800 yen) | 22,900 yen |
Our free consultations are not conducted by cosmetic counselors like those at major clinics, but directly by specialized physicians.
For this reason, we are very popular with clients who are new to beauty, as we do not push sales at any point during the free consultation. Please feel free to make an appointment.
Before/After Profhilo Injections


- Instantly improve sagging and wrinkles across the entire face (under the eyes, outer corners of the eyes, cheeks, and neck)
- Improving neck wrinkles
- Improvement of veins and wrinkles on the back of the hand
What is PROFHILO?

What is a PROFILO injection?Injectable moisturizers, next-generation hyaluronic acid."The treatment is an injectable treatment called
The official trade name is Profhilo®, a product that has been on the market since 2015 and is a hyaluronic acid created with a patented technology called NAHYCO™ by the Italian company IBSA.
This is the latest treatment that can simultaneously treat sagging skin and improve skin quality, and is attracting attention in the cosmetic medicine industry.
PROFHILO is called the next generation of "hyaluronic acid," but many people recognize that conventional hyaluronic acid is"Bridges."It will be called hyaluronic acid.PROFHILO is "non-cross-linked" hyaluronic acidThis will be the case.
The major difference between cross-linked and non-cross-linked is whether it spreads. PROFHILO, a non-cross-linked hyaluronic acid, spreads from the site of injection and produces a broad spectrum of effects.
Effect|Profilo has a skin rejuvenation effect.
Profilo has the following benefits
z Improvement of wrinkles and sagging skin
0 Effect of improving firmness and elasticity (increased freshness)
0 Lifting effect
0 Natural volume increase

When can the effects be felt after the treatment?

When can the effects be felt after the treatment?
Dr. IshiiThe feeling of the effect varies from person to person, but it is often felt gradually from a few days to a few weeks after injection. The maximum effect is usually felt around one month after injection.
How long do the effects last?

How long do the effects last?
Dr. IshiiIt is estimated to last from 6 months to 1 year. For continued effectiveness, we recommend regular injections as maintenance.
Our Clinic's Signature Profilo
Adopted "Profhilo®".
CurrentlyIntroduced in more than 80 countriesIt is a hyaluronic acid with a proven track record. More than 500,000 cases have been reported worldwide, as well as AMEC & AESTHETICS awards,Hyaluronic acid is recognized worldwide for its safety and effectivenessIt is.
Profibro is the only treatment that can remodel the skin without the use of instruments.
Some customers at Smart Skin Clinic express concerns, saying, "Because the prices are low, I worry whether the products are genuine."
To address such concerns,We open new formulations on the spot and show them to you.This has helped our customers to feel secure.

Comparison of Our Hospital and Other Hospitals
Comparison Chart with Other Hospitals
Why choose our clinic?
Please note the clear differences.
-
Price (Face 2cc)
General Market Trends and PricesOnce ¥65,000 to ¥80,000*Based on our research (September 2025 / median price range listed on major clinics' websites in the Kanto region)
twice ¥130,000 to ¥170,000
3 times Approximately 200,000 yenSmart Skin ClinicOnce 49,800 yen
twice 95,600 yen
3 times 137,400 yenTotal price displayConsultation and acupuncture includedCompared to other hospitals, the maximumSave ¥74,400! -
Display and Additional Fees
General trendConsultation fee, needle cost, anesthesia, medication cost, etc.separatelymay occurSmart Skin ClinicTotal cost (including consultation and acupuncture)
No upsells on the day -
Counseling System
General trendBeauty Counselor-Centered InformationSmart Skin ClinicPhysician direct response
No hard selling -
Transparency of Formulations
General trendExplanation of the delivery confirmationif notもSmart Skin ClinicOpen on the spot and present -
Profilio Case Results
General trendby the institutionNon-public · VariabilityantSmart Skin ClinicOver 2,500 casesSeptember 1, 2023–September 1, 2025 Our hospital's tally -
Same-day treatment
General trendIn some cases, we may need to reschedule for another day.Smart Skin ClinicSame-day appointments available※
※Comparisons reflect "general trends" and serve as a guideline for our clinic's operational policy. Results may vary depending on the clinic and timing. Additionally, if you have only booked a free consultation, same-day treatment may not be possible depending on availability. We appreciate your understanding.
Why is our clinic so affordable?
Kota Ishii
Smart Skin Clinic Chairman
A specialist in anti-aging medicine with over 2,500 Profilo treatment casesThe treatment is performed by
At Smart Skin Clinic,A specialist in anti-aging medicine with over 2,500 procedures performed exclusively with Profhilo and advanced technical expertise.will always be in charge of the treatment.
This minimizes downtime swelling and pain during the procedure as well as the quality of the finished product.
Below are some customer testimonials.
Consistently receives high ratings in customer reviews
Google Reviews 4.5/5.0

Hot Pepper Beauty 4.57/5.00

Evaluation of Kireipas4.30/5.00

Kumapon Evaluation4.71/5.00

Evaluation of Kang Nam Onni9.3/10.0

Smart Skin Clinic's Profhilo: Japan's Lowest Prices
| frequency | Normal price | special price | Price per cc |
|---|---|---|---|
| 1 time (2cc) | 52,800 yen | 47,800 yen | 23,900 yen |
| 2 sets (2cc x 2) | 99,600 yen | 93,600 yen(¥46,800 per session) | 23,400 yen |
| 3 sets (2cc x 3) | 139,800 yen | 137,400 yen(1 time 45,800 yen) | 22,900 yen |
The price is indicated as all-inclusive, including consultation and needle fees.
There is no separate upsell on the day of the event.
Need for anesthesia|Low
Price quotes
At beauty clinics in the Kanto area, the market price is 65,000-80,000 yen per treatment to inject Profibro into the face, 130,000-170,000 yen for a set of two treatments, and approximately 200,000 yen for three treatments.
※As of September 2025
FAQ
- How often and how many times should I take the course?
Dr. IshiiAlthough a single session can be effective, we recommend one of the following as the most effective method
(1) The first and second sessions will be done at one-month intervals, and the same pattern will be continued every year thereafter.
(2) The first and second sessions are performed at one-month intervals, and then continued every six months thereafter.
The skin remodeling effect of PROFHILO increases the extracellular matrix, resulting in skin rejuvenation. Without maintenance, the extracellular matrix will gradually decrease "due to aging" after the peak of treatment. For this reason, we recommend the above procedure.- Do you feel pain?
Dr. IshiiAlthough it depends on the individual, we use a thin needle, but you may feel a slight stinging pain. It is also said that the center of the face is more sensitive to pain.
- How long is the downtime?
Dr. IshiiRedness will subside in about 24 hours.
- Does it work after just one visit?
Dr. IshiiYou can see results after just one session. You'll feel the lifting effect immediately afterward. However, most people notice the full effects 3 to 4 weeks later, once the skin remodeling process is complete.
Safety
PROFHILO contains no cross-linking agents or other chemicals or biological agents.Highly safeIt can be said that
Specifically,Less likely to cause allergic reactions, etc.This is the case.
The reason for this is that PROFHILO does not contain a "cross-linking agent".
Cross-linking agents can cause allergic reactions, immune reactions, and inflammation. Allergic reactions have been reported to occur, although they are very infrequent. Conventional hyaluronic acid injectables contain a substance called a cross-linker.
Also,The high safety profile of PROFHILO has been mentioned in several papers.
Based on 3 years of post-market experience, the safety profile of the medical devices in this study is good
Daniel Cassuto, et al. (2020)Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.
Those who cannot be treated
Pregnant or nursing mothers
Those with abnormal immune function or a history of such abnormality, and those undergoing immunosuppressive therapy.
Those prone to keloid formation, hypertrophic scars and hyperpigmentation
Those with bleeding tendency or using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin
Excessive sunburn, eczema, dermatitis, acne, or scabs at the site of PROFHILO injection
Risks and Side Effects
of the needle puncture site.
Redness, swelling, pain, edema
Intravascular hemorrhage
Temporary protuberance
Down time
Redness and bumps at the injection site may occur, but in most cases will return to normal in about 24 hours.
Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, although not always. If subcutaneous bleeding spots occur, they will gradually disappear over a period of 10-14 days.
Flow of treatment
You can easily make reservations with your mobile phone.
This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.
Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.
After the marking is carried out, the injection is carried out while talking to the patient.
We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.
More Information
| Treatment Time | About 15 minutes (not including counseling) |
| Recommended number and frequency of treatments | It is recommended that two sets of two sessions be performed at least 6 weeks apart. After that, maintenance is recommended about once every six months. |
| Down time | About 24 hours |
| Treatment on the day of counseling | Possible |
| Make | Possible immediately after the treatment |
| Skin care | Possible immediately after the treatment |
| Shower | Possible from the same day |
| Pain | There is a stinging pain when the needle is inserted. |
- This limited-time special price may end without notice. Now is your chance to get it at the lowest price in Japan.
- Anti-Aging Specialist with over 10,000 skin rejuvenation procedures performed
- Free consultation with a physician (normally worth ¥10,000)
- Minimal downtime, natural improvements and changes that go unnoticed by others
- Reliability rated 90% or higher based on various user reviews and satisfaction ratings
At our clinic, consultations are conducted directly by physicians, not beauty consultants. We do not engage in any hard selling, so please feel free to consult with us.
Introduction of other Smaski injectable procedures for those who suffer from skin conditions.
In addition to Profibro injections, Smart Skin Clinic also offers other injection procedures that are effective in improving skin texture.




If you're interested, please take a look at the various services we offer by clicking the link below.
Legal description
Prophylotherapy includes procedures using drugs or medical devices that are not approved in Japan. The medicines and devices used in the treatment have been imported on a personal import basis under the judgment of our physicians.
Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".
Chairman of Smart Skin Clinic Group
stone Kouta
career
Graduated from Juntendo University School of Medicine
Tokyo Women's Medical University Hospital and related facilities
Worked at a major beauty clinic in Tokyo
Affiliation / Qualifications
Japan Surgical Society Specialist
Japanese Society of Anti-Aging Medicine
Smart Skin Clinic
Smart Skin Clinic
The concept of the clinic is to "make cosmetic medicine more accessible and smart. is the concept of the clinic.
Instead of eliminating ornate interiors to reduce interior design costs and installing equipment in the dark, we carefully select the equipment we need and reduce the cost of the equipment.
We aim to "make cosmetic medicine more accessible" for you.
Clinic List
Jimbocho Institute
〒101-0054
EX Kanda Nishiki-cho Building 8F (general reception), 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo 7F
Business hours: Monday-Friday 11:00-20:00 / Saturday and Sunday 10:00-19:00
Yokohama Institute of Technology
〒221-0835
TS Plaza Bldg. 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Business hours: 10:00-19:00
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of the Smart Skin Clinic supervising physicians.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.
