Profilio Japan's Lowest Price Level: ¥22,900~|Smart Skin Clinic [Official]

*Number of cases | For the period from September 1, 2023 to April 1, 2025

Special Discount Price Through July 31 Jimbocho & Yokohama Clinic Limited Time
Sessions Regular Price Special Price Per 1 cc
Price
1 session (2cc) 52,800 yen 49,800 yen 24,900 yen
Set of 2 (2cc x 2) 99,600 yen 95,600 yen(47,800 yen per session) 23,900 yen
Set of 3 (2cc x 3) 139,800 yen 137,400 yen(45,800 yen per session) 22,900 yen

At our clinic, free consultations are handled directly by specialized physicians, not by cosmetic counselors as at large clinics.

For this reason, there is no hard selling at any point during the free consultation, which has made it very popular even with clients who are new to cosmetic care. Please book with confidence.

Before/After Profhilo Injections

  • Help improve sagging and wrinkles across the whole face at once (under the eyes, outer corners of the eyes, cheeks, and neck)
  • Help improve neck wrinkles
  • Help improve tendons and wrinkles on the back of the hands

What is Profhilo?

Profilo Product Images

What is a Profhilo injection?"An injectable moisturizer" and "next-generation hyaluronic acid"These are the names given to this injectable treatment.

Its official product name is "Profhilo®." On the market since 2015, it is a hyaluronic acid produced using NAHYCO™, a patented technology developed by the Italian company IBSA.

Because it is a cutting-edge treatment that can address sagging and improve skin quality at the same time, it is drawing attention within the cosmetic medicine field


Profhilo is called the next-generation "hyaluronic acid," but the conventional hyaluronic acid most people are familiar with is"cross-linked"hyaluronic acid.Profhilo is a "non-cross-linked" hyaluronic acid.That is the key distinction.

The major difference between cross-linked and non-cross-linked lies in whether it spreads. Profhilo, a non-cross-linked hyaluronic acid, spreads out from the injection site to deliver its effects over a wide area.

Effect | Profhilo has a skin-rejuvenating effect

Profhilo offers the following benefits.

〇 Improvement of wrinkles and sagging
〇 Improvement of firmness and elasticity (enhanced, dewy skin)
〇 Lifting effect
〇 Natural volume enhancement

Effect

When can the effects be felt after treatment?

When can the effects be felt after treatment?

Dr. Ishii

How soon the effects are felt varies from person to person, but they are often felt gradually from a few days to a few weeks after the injection. The maximum effect is usually felt around one month after the injection.

How long do the effects last?

How long do the effects last?

Dr. Ishii

They are said to last from about 6 months to 1 year. For lasting results, we recommend regular injections for maintenance.

Our Clinic's Signature Profhilo

We use "Profhilo®."

Currentlyit has been introduced in more than 80 countriesand is a hyaluronic acid with an extensive track record. More than 500,000 cases have been reported worldwide, and it has also received AMEC & AESTHETICS awards,a hyaluronic acid whose safety and effectiveness are recognized worldwide.

Profhilo is the only treatment that can remodel the skin without the use of a device.

Some patients at Smart Skin Clinic tell us, "Because the prices are so low, I worry whether the product is genuine."

To ease such concerns,we open a brand-new formulation on the spot and show it to you,which gives our patients peace of mind.

Comparing our clinic with others

Comparison Chart with Other Hospitals

Comparison Chart with Other Hospitals

Why choose our clinic?
Please note the clear differences.

  • Price (Face 2cc)

    General Market Trends and Prices
    Once ¥65,000 to ¥80,000
    2 sessions ¥130,000 to ¥170,000
    3 times Approximately 200,000 yen
    *Based on our research (September 2025 / median price range listed on major clinics' websites in the Kanto region)
    Smart Skin Clinic
    Once 49,800 yen
    2 sessions 95,600 yen
    3 times 137,400 yen
    All-inclusive price shown
    Consultation and acupuncture included
    Compared to other hospitals, the maximum
    Save ¥74,400!
  • Display and Additional Fees

    General trend
    Consultation fee, needle cost, anesthesia, medication cost, etc.separatelymay occur
    Smart Skin Clinic
    Total cost (including consultation and acupuncture)
    No upsells on the day
  • Counseling System

    General trend
    Beauty Counselor-Centered Information
    Smart Skin Clinic
    Physician direct response
    No hard selling
  • Transparency of Formulations

    General trend
    Explanation of the delivery confirmationif not
    Smart Skin Clinic
    Open on the spot and present
  • Profilio Case Results

    General trend
    by the institutionNon-public · VariabilityYes
    Smart Skin Clinic
    Over 2,500 cases
    September 1, 2023–September 1, 2025 Our hospital's tally
  • Same-day treatment

    General trend
    In some cases, we may need to reschedule for another day.
    Smart Skin Clinic
    Same-day appointments available※

※Comparisons reflect "general trends" and serve as a guideline for our clinic's operational policy. Results may vary depending on the clinic and timing. Additionally, if you have only booked a free consultation, same-day treatment may not be possible depending on availability. We appreciate your understanding.

Why is our clinic so affordable?

Kota Ishii, Chairman

Kota Ishii

Chairman, Smart Skin Clinic

Board-certified specialist, Japanese Society of Anti-Aging Medicine

"Cosmetic medicine doesn't have to be expensive."
It's an answer I arrived at precisely because I was once a patient myself.

Hello, I'm Ishii, the Chairman. As a physician, I have also received a variety of cosmetic treatments as a patient myself. Through that experience, I came to hold a strong conviction: I want to offer genuinely effective treatments at prices everyone can comfortably continue.

Smart Skin Clinic thoroughly cuts costs that have nothing to do with treatment quality—such as lavish interiors and excessive advertising—and passes those savings back to you in our prices. Beyond affordability, we invite you to discover our commitment to putting patient satisfaction first.

Our commitment: promising value that goes beyond the price
  • The same physician cares for you throughout Rather than leaving things to counselors, a physician takes responsibility for everything from your examination to aftercare.
  • Products opened in front of you To remove any worry about "what's in this product," we always open a new, unused product in front of you for your confirmation.
  • Ultra-fine needles to reduce pain We use ultra-fine needles (34G) personally selected by the director. Our advanced technique helps keep discomfort during treatment to a minimum.
  • No upselling whatsoever The listed price is the all-inclusive total, covering the examination fee, needle costs, and everything else. There's no need to worry about the price going up later.

An Anti-Aging Society board-certified specialist with over 2,500 Profhilo proceduresperforms the treatment

At Smart Skin Clinic,An Anti-Aging Society board-certified specialist with extensive experience of over 2,500 procedures with Profhilo alone and advanced technical skillwill always be in charge of the treatment.

This helps ensure not only a high-quality finish but also keeps downtime swelling and pain during the procedure to a minimum.

Below we share some patient testimonials.

Koyuki (from Hot Pepper Beauty)

Lately, I've grown increasingly concerned about the changes that come with age. I felt I'd reached the limits of self-care when it came to sagging around my mouth, hollow cheeks, nasolabial folds, sunken temples, and the wrinkles and hollows under my eyes. I found Smart Skin Clinic through an online search,and it had extremely high reviews,so I decided to come here. I chose Profhilo because I wanted minimal downtime, safety, and rejuvenation of my whole face. Treatment began right after the consultation, with injections at five points on each side of my face, ten in total. The moment of the needle is just a slight prick, but the discomfort builds as the solution goes in. Still, it's not painful enough to require anesthesia. After the procedure, the injection sites swell a little like mosquito bites, but it's mild enough to hide with a mask and doesn't interfere with heading home. In my case, one spot under my eye bruised, and I'm still covering it with a mask for work. I expect the bruise to fade in about 10 days. On day 1 after the procedure, my cheeks felt fuller. It's now day 5, andthe results far exceed what I imagined,and I couldn't be happier.

Jumomaro (from Hot Pepper Beauty)

I'd long wanted to improve the sagging and wrinkles under my eyes, and since this site had good reviews, I made an appointment.The staff and the doctor were all very pleasant,so I felt at ease receiving my first treatment. I wanted to improve the sagging and wrinkles under my eyes, and I was interested in injections like hyaluronic acid. After the consultation, I went with Sunekos injections. It was relativelydowntime-free,and while I'd been anxious beforehand about how I'd look the next day, I was relieved to be back to normal about 30 minutes after the treatment. After consulting with the doctor and hearing about the treatments I was considering and other details, I chose what best suited me at this point. I then went straight to the treatment room, and it was over in about 15 minutes. I was told that four sessions every two weeks would help maintain the results for about a year, so I decided to do the four-session course.

Ms. B (from Hot Pepper Beauty)

I was concerned about sagging around my mouth and jawline as well as my nasolabial folds, and I was looking for a treatment that could lift and firm these areas. I'd had a similar treatment at this clinic before and could feel its effects, so I keep coming back.The doctor's knowledge and skill are outstanding,and since I've settled on this clinic for my anti-aging care,I can entrust it with complete peace of mind..More affordable than other clinics and easier to keep upso even if you're not well-versed in beauty treatments, I think you'll find it easy to consult with them. I had the Shopping Lift performed on the areas I was concerned about—my jawline, mouth area, and nasolabial folds. My nasolabial folds seemed to improve almost immediately the next day. Within about a week to ten days,I could feel firmer, more radiant skin and a natural lift.It was done. They always answer questions so carefully, and not only are the prices reasonable,there are absolutely no markups or excessive recommendations,so I feel at ease. The reception staff are all approachable too, creating an atmosphere that's easy to visit even for those who find beauty clinics intimidating.

Mika (from Hot Pepper Beauty)

You always take such good care of me,and I can feel my skin getting so much better.Andthe prices are also more reasonable than at other clinics.This time I had Jalupro for the fifth time. I chose Jalupro because it has given me the most visibly noticeable results so far, and because other clinics kept recommending things unrelated to my concerns,so I went to the director I trust.There is pain. But I take deep breaths and get through it, telling myself my skin will be beautiful again. On the day, my face looks a little puffy. The next day it settles into just the right amount of swelling that makes me look younger, which I actually like. I'm thrilled at this point. The director kindly and thoroughly explains everything. I've been taking my own before-and-after photos since getting Jalupro injections, andI'm visibly getting more beautiful.At another clinic I had a skin analysis done, and although my actual age is 39,my skin age was 32.That was the result.I truly, sincerely feel it was the right thing to do.

Pi (from Hot Pepper Beauty)

The reason I chose this clinic is thatit's more affordable than other clinics,and yetit had high reviews.During the consultation I learned about the clinic and heard the doctor's explanation, then decided to go ahead with the treatment—and I'm so glad I chose this clinic for my procedure. With no waiting time, thereception and the guidance to the exam room were smooth,and the doctor gave precise advice and explanations.I was anxious about the pain, but since it was my first time, they reassured me they could reduce the planned 60 threads to 40 if needed,and they even suggested lower-cost treatment options, which gave me great confidence in them. Right after the treatment, my nasolabial folds looked so much less noticeable I wondered if they'd already faded. I felt a firm tautness in the lower part of my face, and my makeup went on beautifully. This Shopping Lift is so easy and quick. Next time I'd like to try it again with a few more threads. It was my first time at a beauty clinic and I hesitated over what to do, butI'm satisfied with the treatment I received.This clinicdoesn't push unnecessary recommendations, and considering the price, it's very reasonable.

e e (from Google)

This is my second visit. Last time I had Jalupro treatment for my nasolabial folds, andthe results were quite significant compared with any nasolabial-fold treatment I'd tried before,so this time I came hoping to improve the fine lines on my forehead. Since it's the most affordable formulation in the Jalupro range, I was honestly a little worried they might steer me toward a pricier option, butthere was no hard selling at all,and they went ahead with the Classic just as I'd wanted. Jalupro Classic was quite painful. I'll admit I have a low pain tolerance, but topical anesthesia alone wasn't enough, so I asked for block anesthesia partway through. Even then,they handled it without so much as a frown,for which I'm very grateful. I plan to come back next month for treatment of my nasolabial folds and hollow cheeks.This is a clinic I want to keep visiting.

MI YO (from Google)

The explanation, the speed, the treatment, the price— everything was highly satisfying.I asked all sorts of questions about things I didn't understand or wanted to know, and every one of themwas answered thoughtfully and thoroughly.Also,I was impressed that they gave honest answers.That's why—though I don't usually make on-the-spot decisions—I was glad I could decide right there today. With hardly any waiting,everything from counseling to the completed treatment and payment was done within an hour. The sense of efficiency was great. The treatment was careful, too, and I felt less pain than usual, which made me think, "Maybe a skilled doctor causes less discomfort." The price was also lower than the place I used to go to.For someone like me who values speed, quality of treatment, and price, this is a clinic I feel very satisfied visiting.I think it's a clinic in Tokyo with really great value for money.I feel I can keep coming here with peace of mind.

S T (from Google)

I'd been hoping to fix the dark circles under my eyes and searched online for good treatments, which led me here. With so many types of injections available, I was unsure, but the doctor told me about a newer product called NEOFOUND rather than Sunekos injections, so I went with that. There was a value course for a set of four sessions, but I wanted to try it once for now, so I did a single session. At 34,500 yen,with no initial or examination fee charged, it was very reasonable.It was my first time getting an injection around my eyes, so I was really scared, but the female doctoradministered it so gently and carefully that there was almost no pain,and it went smoothly. Topical anesthesia does cost a little extra, but there was no pressure—she suggested, "Let's try it without anesthesia first, and if it hurts we can add it next time." I tried without it and felt almost no pain, so I'm glad I followed her advice. When I looked in the mirror afterward, I was surprised by the puffiness under my eyes, but it seems to have absorbed quickly—by day two today it looks completely natural, and with makeup you can't even see the tiny needle marks.The blue dark circles that troubled me for years are gone, too.It's amazing. Next time I think I'll sign up for the course.

Ms. Mihoko Sato (from Google)

I recently had a Water Light Injection. As others have written,there was no sales pressure at all,, and the reception staff and the doctor all give a great impression! I've been to several other clinics, but I'd grown tired of fending off upsells during counseling and uneasy about assembly-line treatments... Here,nothing of the sort happened,so I could focus solely on the treatment! I look forward to coming again next month 🙇

Yuka T (from Google)

A few years ago I had treatment for under-eye sagging and dark circles, but it left me with wrinkles that made me look older, which troubled me. Deciding to look into another treatment, I compared several clinics, and since Smart Skin Clinic offered a variety of products and methods, I went in for a consultation hoping to find one that suited me. I shared my concerns, had my condition assessed, and received Sunekos Performa. They injected it carefully and precisely into the areas I was concerned about. With no bruising,I'm now in the downtime period and things are settling a little, but I'm looking forward to the final result. From booking through treatment, both the doctor and staff came across as genuinely sincere,with no hard selling and no unnecessary upselling or cross-selling, and I found the whole experience very pleasant. They also avoid spending on unnecessary things, and overallthe prices are kept low,I think. I'm grateful it's so easy to keep visiting.

IRO code (from Google)

Since childhood I've had atopic dermatitis and sensitive skin, and I'd bruise every time I got an injection. Given the downtime, I couldn't just casually go in. But when I told the doctor at Smart Skin Clinic about my concerns with bruising,they injected very carefully, taking their time to go slowly,which they were able to do for me. There was no bruising on my face, neck, or under my eyes‼︎This was a first for me, and I was so happy. The bumpy areas from the evening treatment gradually flattened out by night,and I could tell it wouldn't affect my work the next day,which made me truly glad I went through with it. While some clinics keep you waiting even with an appointment, at Smart Skin Clinic everything—from reception to the doctor's consultation, the treatment, and payment—was smooth, a truly "smart" flow just as the name suggests.That was my experience.Profhilo here is also more affordable than at any other clinic, making it easy to keep up,and I'm very satisfied.

Raran (from Hot Pepper Beauty)

While researching Rejuran prices, I learned there's a Rejuran generic, and the place offering it was Smart Skin Clinic. When I checked the cost, compared to the other clinic I'd been going to, it wasconsiderably cheaper,so I booked right away. At other clinics they push other or add-on treatments and it's a hassle to decline, but Smart Skin Clinichad no such sales pitch at all,and I really appreciated that they only recommended the treatment I was there for. The doctor gave me a consultation and, since my goal is nurturing my skin,answered my questions so clearly that I was fully convinced,so I had the treatment that same day. This time it was the mechanical (machine) method, sothere was no bruising. The receptionist's courteous service left a good impression, and the nurse and the treatment itself were done efficiently and quickly. The interior is very clean and simply designed, and since they don't spend on unnecessary things,the treatment fees are lower than at other clinics,or so I felt. I was thoroughly satisfied with everything.

Consistently highly rated in patient reviews

Google Reviews 4.5/5.0

Hot Pepper Beauty 4.57/5.00

KireiPass rating4.30/5.00

Kumapon rating4.71/5.00

Gangnam Unni rating9.3/10.0

Smart Skin Clinic's Profhilo: pricing among the lowest in Japan

Special Discount Price Through July 31 Jimbocho & Yokohama Clinic Limited Time
Sessions Regular Price Special Price Per 1 cc
Price
1 session (2cc) 52,800 yen 49,800 yen 24,900 yen
Set of 2 (2cc x 2) 99,600 yen 95,600 yen(47,800 yen per session) 23,900 yen
Set of 3 (2cc x 3) 139,800 yen 137,400 yen(45,800 yen per session) 22,900 yen

Prices are shown all-inclusive, covering consultation and needle fees.
There is no separate upselling on the day.

Need for anesthesia | Low

Market pricing

At aesthetic clinics in the Kanto region, the market rate for injecting Profhilo into the face is around 65,000–80,000 yen per session, 130,000–170,000 yen for a set of two, and about 200,000 yen for three.

*As of September 2025

FAQ

How often and how many times should I receive it?
Dr. Ishii

Results can be gained even from a single session, but for the most effective approach we recommend one of the following.
① Have the first and second sessions one month apart, then continue the same pattern once a year thereafter.
② Have the first and second sessions one month apart, then continue every six months thereafter.

*Profhilo's skin remodeling effect increases the extracellular matrix and rejuvenates the skin. Without maintenance, the extracellular matrix gradually decreases "due to aging" after the treatment reaches its peak. For this reason, we recommend the approach above.

Does it hurt?
Dr. Ishii

It varies from person to person. We use a fine needle, but you may feel a slight pricking sensation. The center of the face is also said to be more sensitive to pain.

How long is the downtime?
Dr. Ishii

Redness subsides in about 24 hours.

Is one session effective?
Dr. Ishii

You can see results after a single session, and the lifting effect can be felt right away. That said, most people notice the fullest effects 3 to 4 weeks later, as the skin's remodeling (rebuilding) process progresses.

Safety

Because Profhilo contains no chemicals such as cross-linking agents and no biological agents,it can be considered highly safe..

Specifically,it is less likely to cause allergic reactions and the like.That is the point.

The reason for this is that Profhilo contains no "cross-linking agent."

Cross-linking agents may cause allergic reactions, immune reactions, and inflammation. Although very infrequent, allergic reactions have been reported. Conventional hyaluronic acid injectables contain a substance called a cross-linking agent.

Also,Profhilo's high level of safety has been noted in several published papers.

Based on three years of post-market experience, the safety profile of the medical device in this study is favorable.

Daniel Cassuto, et al. (2020) Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.

Who cannot receive this treatment

Those who are pregnant or breastfeeding

Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy

Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders

Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin

Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Profhilo injection site

Risks and Side Effects

At the needle puncture site:

Redness, swelling, pain, edema

Bruising

Temporary raised bumps

Downtime

Redness and raised bumps may occur at the injection site, but in most cases they return to normal in about 24 hours.

Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, though not always. If bruising occurs, it gradually fades over 10 to 14 days.

Treatment Flow

STEP
Booking

You can easily book from your smartphone.

STEP
Reception

A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.

STEP
Counseling & Examination

During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.

STEP
Profhilo injection

After marking is done, we perform the injection while checking in with you as we go.

STEP
Aftercare

We explain in detail how to care for the treated area and what to keep in mind in daily life. From a prevention and maintenance standpoint, we also suggest suitable home care, such as oral medications and skincare products that can support improvement of your concerns.

STEP
Going Home

Details

Treatment TimeAbout 15 minutes (not including counseling)
Recommended Number & Frequency of TreatmentsA set of 2 treatments spaced at least 6 weeks apart is recommended.
After that, maintenance about once every six months is recommended.
DowntimeAbout 24 hours
Treatment on the day of counselingAvailable
MakeupPossible right after the treatment
SkincarePossible right after the treatment
ShowerPossible from the same day
PainA slight pricking sensation when the needle is inserted.
*Results vary from person to person.
Final Call to Action
🙏 Thank you for reading all the way to the end!
Through July 31The limited-time special price is almost gone!
If you miss this opportunity, the regular price will apply.
The benefits of booking now
  • This limited-time special price may end without notice. Now is your chance to receive it at the lowest price level in Japan.
  • Performed by an Anti-Aging Society board-certified specialist with over 10,000 skin-nurturing injection procedures
  • A free consultation with a physician (normally valued at 10,000 yen)
  • Minimal downtime, with natural improvements and changes that others won't notice
  • Trusted with a 90%-plus satisfaction rating across various reviews and ratings
Even a consultation-only visit is more than welcome!
At our clinic, consultations are conducted directly by a physician, not a beauty counselor. There is no hard selling whatsoever, so please feel free to consult with us.
*Please feel free to visit us even just for a free consultation. There is no high-pressure selling whatsoever.

Introducing other injectable treatments at Smart Skin Clinic for those with skin-quality concerns

In addition to Profhilo injections, Smart Skin Clinic also offers other injection treatments that are effective for improving skin quality.

If you're interested, please explore the wide range of treatments we offer via the links below.

[Official] Smart Skin Clinic...
Injection & IV Drip|[Official] Smart Skin Clinic|Cosmetic Dermatology Group (Jimbocho & Yokohama) "Beauty from within." We help you spend less time worrying about your skin, and move toward even more beautiful skin. "Beauty from within." We help you spend less time worrying about your skin, and move toward even more beautiful skin. Exosome IV drip...

Legal Notices

Profhilo treatment includes procedures using medications or medical devices not approved in Japan. The medications and devices used are personally imported at the discretion of our clinic's physicians.

Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."

Physician Who Supervised This Page

Kota Ishii, Chief Medical Director, Smart Skin Clinic

Smart Skin Clinic, Chief Medical Director / Physician

Kota Ishii

We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.

Interview with Director Kota Ishii

Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.

Supervisor Information
Kota Ishii, Chief Medical Director, Smart Skin Clinic Group

Group Chief Director, Smart Skin Clinic Group

IshiiIshii KotaKota

Career

Graduated from Juntendo University School of Medicine

Worked at Tokyo Women's Medical University Hospital and affiliated facilities

Worked at a major aesthetic clinic in Tokyo

Affiliations / Qualifications

Board-certified specialist, Japan Surgical Society

Board-certified specialist, Japanese Society of Anti-Aging Medicine

Smart Skin Clinic

Smart Skin Clinic

A clinic built on the concept of "making aesthetic medicine more accessible and smart."

Rather than spending on ornate interiors, we keep fit-out costs down, and rather than adding equipment indiscriminately, we carefully select only the devices we need to keep equipment costs down.

We aim to "make aesthetic medicine more accessible" for you.

CLINIC LIST

Clinic List

About the physician supervision of this site

About the physician supervision of this site


This site is operated under the supervision of Smart Skin Clinic's supervising physicians.

This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.

This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.