Lately, I've grown increasingly concerned about the changes that come with age. I felt I'd reached the limits of self-care when it came to sagging around my mouth, hollow cheeks, nasolabial folds, sunken temples, and the wrinkles and hollows under my eyes. I found Smart Skin Clinic through an online search,and it had extremely high reviews,so I decided to come here. I chose Profhilo because I wanted minimal downtime, safety, and rejuvenation of my whole face. Treatment began right after the consultation, with injections at five points on each side of my face, ten in total. The moment of the needle is just a slight prick, but the discomfort builds as the solution goes in. Still, it's not painful enough to require anesthesia. After the procedure, the injection sites swell a little like mosquito bites, but it's mild enough to hide with a mask and doesn't interfere with heading home. In my case, one spot under my eye bruised, and I'm still covering it with a mask for work. I expect the bruise to fade in about 10 days. On day 1 after the procedure, my cheeks felt fuller. It's now day 5, andthe results far exceed what I imagined,and I couldn't be happier.
Profilio Japan's Lowest Price Level: ¥22,900~|Smart Skin Clinic [Official]

*Number of cases | For the period from September 1, 2023 to April 1, 2025
_横浜院限定・価格訴求(5000円OFF)_2172x724_01.jpg)
| Sessions | Regular Price | Special Price | Per 1 cc Price |
|---|---|---|---|
| 1 session (2cc) | 52,800 yen | 49,800 yen | 24,900 yen |
| Set of 2 (2cc x 2) | 99,600 yen | 95,600 yen(47,800 yen per session) | 23,900 yen |
| Set of 3 (2cc x 3) | 139,800 yen | 137,400 yen(45,800 yen per session) | 22,900 yen |
At our clinic, free consultations are handled directly by specialized physicians, not by cosmetic counselors as at large clinics.
For this reason, there is no hard selling at any point during the free consultation, which has made it very popular even with clients who are new to cosmetic care. Please book with confidence.
Before/After Profhilo Injections


- Help improve sagging and wrinkles across the whole face at once (under the eyes, outer corners of the eyes, cheeks, and neck)
- Help improve neck wrinkles
- Help improve tendons and wrinkles on the back of the hands
What is Profhilo?

What is a Profhilo injection?"An injectable moisturizer" and "next-generation hyaluronic acid"These are the names given to this injectable treatment.
Its official product name is "Profhilo®." On the market since 2015, it is a hyaluronic acid produced using NAHYCO™, a patented technology developed by the Italian company IBSA.
Because it is a cutting-edge treatment that can address sagging and improve skin quality at the same time, it is drawing attention within the cosmetic medicine field
Profhilo is called the next-generation "hyaluronic acid," but the conventional hyaluronic acid most people are familiar with is"cross-linked"hyaluronic acid.Profhilo is a "non-cross-linked" hyaluronic acid.That is the key distinction.
The major difference between cross-linked and non-cross-linked lies in whether it spreads. Profhilo, a non-cross-linked hyaluronic acid, spreads out from the injection site to deliver its effects over a wide area.
Effect | Profhilo has a skin-rejuvenating effect
Profhilo offers the following benefits.
〇 Improvement of wrinkles and sagging
〇 Improvement of firmness and elasticity (enhanced, dewy skin)
〇 Lifting effect
〇 Natural volume enhancement

When can the effects be felt after treatment?

When can the effects be felt after treatment?
Dr. IshiiHow soon the effects are felt varies from person to person, but they are often felt gradually from a few days to a few weeks after the injection. The maximum effect is usually felt around one month after the injection.
How long do the effects last?

How long do the effects last?
Dr. IshiiThey are said to last from about 6 months to 1 year. For lasting results, we recommend regular injections for maintenance.
Our Clinic's Signature Profhilo
We use "Profhilo®."
Currentlyit has been introduced in more than 80 countriesand is a hyaluronic acid with an extensive track record. More than 500,000 cases have been reported worldwide, and it has also received AMEC & AESTHETICS awards,a hyaluronic acid whose safety and effectiveness are recognized worldwide.
Profhilo is the only treatment that can remodel the skin without the use of a device.
Some patients at Smart Skin Clinic tell us, "Because the prices are so low, I worry whether the product is genuine."
To ease such concerns,we open a brand-new formulation on the spot and show it to you,which gives our patients peace of mind.

Comparing our clinic with others
Comparison Chart with Other Hospitals
Why choose our clinic?
Please note the clear differences.
-
Price (Face 2cc)
General Market Trends and PricesOnce ¥65,000 to ¥80,000*Based on our research (September 2025 / median price range listed on major clinics' websites in the Kanto region)
2 sessions ¥130,000 to ¥170,000
3 times Approximately 200,000 yenSmart Skin ClinicOnce 49,800 yen
2 sessions 95,600 yen
3 times 137,400 yenAll-inclusive price shownConsultation and acupuncture includedCompared to other hospitals, the maximumSave ¥74,400! -
Display and Additional Fees
General trendConsultation fee, needle cost, anesthesia, medication cost, etc.separatelymay occurSmart Skin ClinicTotal cost (including consultation and acupuncture)
No upsells on the day -
Counseling System
General trendBeauty Counselor-Centered InformationSmart Skin ClinicPhysician direct response
No hard selling -
Transparency of Formulations
General trendExplanation of the delivery confirmationif notもSmart Skin ClinicOpen on the spot and present -
Profilio Case Results
General trendby the institutionNon-public · VariabilityYesSmart Skin ClinicOver 2,500 casesSeptember 1, 2023–September 1, 2025 Our hospital's tally -
Same-day treatment
General trendIn some cases, we may need to reschedule for another day.Smart Skin ClinicSame-day appointments available※
※Comparisons reflect "general trends" and serve as a guideline for our clinic's operational policy. Results may vary depending on the clinic and timing. Additionally, if you have only booked a free consultation, same-day treatment may not be possible depending on availability. We appreciate your understanding.
Why is our clinic so affordable?
Kota Ishii
Chairman, Smart Skin Clinic
An Anti-Aging Society board-certified specialist with over 2,500 Profhilo proceduresperforms the treatment
At Smart Skin Clinic,An Anti-Aging Society board-certified specialist with extensive experience of over 2,500 procedures with Profhilo alone and advanced technical skillwill always be in charge of the treatment.
This helps ensure not only a high-quality finish but also keeps downtime swelling and pain during the procedure to a minimum.
Below we share some patient testimonials.
Consistently highly rated in patient reviews
Google Reviews 4.5/5.0

Hot Pepper Beauty 4.57/5.00

KireiPass rating4.30/5.00

Kumapon rating4.71/5.00

Gangnam Unni rating9.3/10.0

Smart Skin Clinic's Profhilo: pricing among the lowest in Japan
_横浜院限定・価格訴求(5000円OFF)_2172x724_01.jpg)
| Sessions | Regular Price | Special Price | Per 1 cc Price |
|---|---|---|---|
| 1 session (2cc) | 52,800 yen | 49,800 yen | 24,900 yen |
| Set of 2 (2cc x 2) | 99,600 yen | 95,600 yen(47,800 yen per session) | 23,900 yen |
| Set of 3 (2cc x 3) | 139,800 yen | 137,400 yen(45,800 yen per session) | 22,900 yen |
Prices are shown all-inclusive, covering consultation and needle fees.
There is no separate upselling on the day.
Need for anesthesia | Low
Market pricing
At aesthetic clinics in the Kanto region, the market rate for injecting Profhilo into the face is around 65,000–80,000 yen per session, 130,000–170,000 yen for a set of two, and about 200,000 yen for three.
*As of September 2025
FAQ
- How often and how many times should I receive it?
Dr. IshiiResults can be gained even from a single session, but for the most effective approach we recommend one of the following.
① Have the first and second sessions one month apart, then continue the same pattern once a year thereafter.
② Have the first and second sessions one month apart, then continue every six months thereafter.
*Profhilo's skin remodeling effect increases the extracellular matrix and rejuvenates the skin. Without maintenance, the extracellular matrix gradually decreases "due to aging" after the treatment reaches its peak. For this reason, we recommend the approach above.- Does it hurt?
Dr. IshiiIt varies from person to person. We use a fine needle, but you may feel a slight pricking sensation. The center of the face is also said to be more sensitive to pain.
- How long is the downtime?
Dr. IshiiRedness subsides in about 24 hours.
- Is one session effective?
Dr. IshiiYou can see results after a single session, and the lifting effect can be felt right away. That said, most people notice the fullest effects 3 to 4 weeks later, as the skin's remodeling (rebuilding) process progresses.
Safety
Because Profhilo contains no chemicals such as cross-linking agents and no biological agents,it can be considered highly safe..
Specifically,it is less likely to cause allergic reactions and the like.That is the point.
The reason for this is that Profhilo contains no "cross-linking agent."
Cross-linking agents may cause allergic reactions, immune reactions, and inflammation. Although very infrequent, allergic reactions have been reported. Conventional hyaluronic acid injectables contain a substance called a cross-linking agent.
Also,Profhilo's high level of safety has been noted in several published papers.
Based on three years of post-market experience, the safety profile of the medical device in this study is favorable.
Daniel Cassuto, et al. (2020) Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.
Who cannot receive this treatment
Those who are pregnant or breastfeeding
Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders
Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin
Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Profhilo injection site
Risks and Side Effects
At the needle puncture site:
Redness, swelling, pain, edema
Bruising
Temporary raised bumps
Downtime
Redness and raised bumps may occur at the injection site, but in most cases they return to normal in about 24 hours.
Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, though not always. If bruising occurs, it gradually fades over 10 to 14 days.
Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
After marking is done, we perform the injection while checking in with you as we go.
We explain in detail how to care for the treated area and what to keep in mind in daily life. From a prevention and maintenance standpoint, we also suggest suitable home care, such as oral medications and skincare products that can support improvement of your concerns.
Details
| Treatment Time | About 15 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | A set of 2 treatments spaced at least 6 weeks apart is recommended. After that, maintenance about once every six months is recommended. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | A slight pricking sensation when the needle is inserted. |
- This limited-time special price may end without notice. Now is your chance to receive it at the lowest price level in Japan.
- Performed by an Anti-Aging Society board-certified specialist with over 10,000 skin-nurturing injection procedures
- A free consultation with a physician (normally valued at 10,000 yen)
- Minimal downtime, with natural improvements and changes that others won't notice
- Trusted with a 90%-plus satisfaction rating across various reviews and ratings
At our clinic, consultations are conducted directly by a physician, not a beauty counselor. There is no hard selling whatsoever, so please feel free to consult with us.
Introducing other injectable treatments at Smart Skin Clinic for those with skin-quality concerns
In addition to Profhilo injections, Smart Skin Clinic also offers other injection treatments that are effective for improving skin quality.




If you're interested, please explore the wide range of treatments we offer via the links below.
Legal Notices
Profhilo treatment includes procedures using medications or medical devices not approved in Japan. The medications and devices used are personally imported at the discretion of our clinic's physicians.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Physician Who Supervised This Page

Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
Smart Skin Clinic
Smart Skin Clinic
A clinic built on the concept of "making aesthetic medicine more accessible and smart."
Rather than spending on ornate interiors, we keep fit-out costs down, and rather than adding equipment indiscriminately, we carefully select only the devices we need to keep equipment costs down.
We aim to "make aesthetic medicine more accessible" for you.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of Smart Skin Clinic's supervising physicians.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
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