Profilo Japan's lowest price 39,800 yen~|Smart Skin Clinic [Tokyo

*Number of cases|From September 1, 2023 to March 31, 2024

Our free consultations are not conducted by cosmetic counselors like those at major clinics, but by specialized doctors directly. For this reason, we do not push sales at all during the free consultation, which is very popular among our customers who are new to cosmetics. Please feel free to make an appointment.



Profilo Product Images

What is a PROFILO injection?Injectable moisturizers, next-generation hyaluronic acid."The treatment is an injectable treatment called

The official trade name is Profhilo®, a product that has been on the market since 2015 and is a hyaluronic acid created with a patented technology called NAHYCO™ by the Italian company IBSA.

This is the latest treatment that can simultaneously treat sagging skin and improve skin quality, and is attracting attention in the cosmetic medicine industry.

PROFHILO is called the next generation of "hyaluronic acid," but many people recognize that conventional hyaluronic acid is"Bridges."It will be called hyaluronic acid.PROFHILO is "non-cross-linked" hyaluronic acidThis will be the case.

The major difference between cross-linked and non-cross-linked is whether it spreads. PROFHILO, a non-cross-linked hyaluronic acid, spreads from the site of injection and produces a broad spectrum of effects.

Profibro injections are effective for the following problems

  • To improve sagging and wrinkles on the entire face (under eyes, eye corners, cheeks, and neck) at once, while also improving skin texture
  • Dark circles under the eyes
  • Under eye hollows are bothering me.
  • Fine lines at the corners of the eyes
  • Concerned about moss and sagging of the cheeks
  • I want to improve neck wrinkles.
  • Stripes and wrinkles on the back of the hands
  • I want to rejuvenate my entire face naturally.
  • I want immediate results in skin treatment.
Profilo case photo (2)

Effect|Profilo has a skin rejuvenation effect.

Profilo has the following benefits

z Improvement of wrinkles and sagging skin
0 Effect of improving firmness and elasticity (increased freshness)
0 Lifting effect
0 Natural volume increase


These effects are achieved by the following properties of hyaluronic acid

  • Moisturizing effect
  • Promotes tissue repair and regeneration
  • Support for cell movement
  • Regulation of cell proliferation and differentiation

These properties will be explained based on the following cross-sectional view of the skin.

The skin consists of three layers, each with its own role

  • Epidermis|Barrier function
  • Dermis|Regulates elasticity and firmness
  • Subcutaneous tissue|Insulation and heat retention functions
  1. Moisturizing effect
    Hyaluronic acid has the ability to attract and retain large amounts of moisture in the skin. After being injected into the skin, hyaluronic acid absorbs the surrounding moisture and brings moisture into the skin. This plumps the skin from the inside out, smoothing the surface and improving the appearance of fine wrinkles and roughness caused by dryness.

  2. Promotes tissue repair and regeneration
    In the skin, hyaluronic acid activates fibroblasts in the dermis. As a result, the production of new collagen and elastin is stimulated, assisting in the recovery of damaged skin and skin regeneration. This treatment in which damaged skin undergoes tissue repair and recovery is called ECM remodeling treatment.
What is ECM Remodeling Treatment?

First, ECM stands for "Extracellular Matrix," which refers to the outer crevice of the cell.

ECM remodeling treatment means remodeling (restructuring) the outer part of these cells, in other words, creating new ones. The cells referred to here are fibroblasts, and the gaps outside the fibroblasts are collagen, elastin, hyaluronic acid, etc.

It is difficult to describe in abstract terms, so I will explain in concrete terms to make it easier to understand.

First, skin firmness, elasticity, and flexibility are produced by collagen and elastin, which are fibrous tissues in the dermis layer, and hyaluronic acid, a gel-like substance that fills in the gaps. And it is fibroblasts that produce these three tissues.

Elastic fibrous tissue that serves as the skin's foundation as a three-dimensional mesh-like framework

It is responsible for providing elasticity to the skin and keeping it flexible enough to return to its original shape even when the skin stretches and contracts with the movement of facial expressions. Also plays a role in holding collagen fibers together so that they do not fall apart, helping to maintain the three-dimensional framework of collagen

hyaluronic acid
A substance that fills in the gaps between collagen, elastin, and other fibrous tissues. It has a strong ability to attract water, and when bound to water, it swells to a gel-like state and plays a central role in maintaining the elasticity and moisture of the skin.

They produce collagen, elastin, and hyaluronic acid. Fibroblasts themselves also self-differentiate and proliferate

In other words, the more fibroblasts, collagen, elastin, and hyaluronic acid, the younger and healthier the skin.

Skin sags due to aging and UV rays. Aging causes a decrease in the number of cells (fibroblasts) that produce skin and their function declines. UV rays also destroy collagen, elastin, and other fibrous tissue.

When hyaluronic acid stimulates fibroblast activity, collagen, elastin, and hyaluronic acid are increased and destroyed tissues are repaired. The proliferation of fibroblasts themselves is also stimulated. As a result, the skin regains elasticity and firmness from the inside out and becomes healthier.

This treatment, in which the diminished dermal layer is rebuilt by activating fibroblasts, is called ECM remodeling treatment.

  1. Support for cell movement
    Hyaluronic acid is an important component of the ECM: the extracellular matrix (the interstitial space between cells inside the skin). When the skin's interior is enriched by hyaluronic acid, it facilitates the migration and movement of immune cells and other cells. It also helps deliver nutrients and oxygen to cells in the dermis and supports the elimination of waste products. This effect promotes skin recovery and restores a more even and healthy skin texture.

  2. Regulation of cell proliferation and differentiation
    Hyaluronic acid has a regulatory effect on cell proliferation and differentiation. The specific mechanism is too complex and technical to discuss here, but hyaluronic acid provides signals that promote skin cell proliferation and differentiation in the correct direction. This stimulates the production of new skin cells and assists in skin rejuvenation.

When can the effects be felt after the treatment?

When can the effects be felt after the treatment?

Dr. Smaski.

The feeling of the effect varies from person to person, but it is often felt gradually from a few days to a few weeks after injection. The maximum effect is usually felt around one month after injection.

How long do the effects last?

How long do the effects last?

Dr. Smaski.

It is estimated to last from 6 months to 1 year. For continued effectiveness, we recommend regular injections as maintenance.

Characteristics of PROFILO|Deep and wide penetration in multiple directions

We have discussed the properties of hyaluronic acid. Here, we will explain the characteristics of PROFILO, including the properties of hyaluronic acid.

Penetrating power to penetrate deeply and widely in multiple directions"

This is what makes Profilo unique.

PROFILO is a special formulation of two types of hyaluronic acid, using the NAHYCO™ technology patented internationally by IBSA of Italy.

High molecular weight hyaluronic acid moisturizes the superficial layers of the skin, while low molecular weight hyaluronic acid penetrates deeper into the skin and exerts its effects. These different hyaluronic acid molecules allow Profibro to penetrate more widely and deeply into the epidermis, dermis, and subcutaneous tissue.

This penetration is stronger than that of other non-cross-linked hyaluronic acids and penetrates deeper into the skin.

It is believed that this permeability allows the action of hyaluronic acid to reach the subcutaneous fat in the subcutaneous tissue, making the skin healthier and plumper.

Spreading Features

What is the difference between Profilo and Borite?

What is the difference between Profilo and Borite?

Dr. Smaski.

Borite is also a type of hyaluronic acid, but the major difference is the presence or absence of cross-linking. Borite is a cross-linked hyaluronic acid. Although it is cross-linked hyaluronic acid, it is designed through a special manufacturing process to achieve natural spreading and uniform distribution.
Some of the characteristics of borites include the following
Effective for fine expression lines on the face and wrinkles around the eyes and mouth
Provides elasticity and moisture to the skin, contributing to a more youthful appearance
Long-lasting effect and natural finish
No ECM remodeling effect, so no improvement in skin elasticity or skin growth
Cross-linked hyaluronic acid has risks and side effects such as vascular embolization.

Smart Skin Clinic PROFHILO

Adopted "Profhilo®".

As of 2020Introduced in more than 80 countriesIt is a hyaluronic acid with a proven track record. More than 500,000 cases have been reported worldwide, as well as AMEC & AESTHETICS awards,Hyaluronic acid is recognized worldwide for its safety and effectivenessIt is.

Profibro is the only treatment that can remodel the skin without the use of instruments.

Smart Skin Clinic charges 59,800 yen (including tax) for a single treatment (2 cc per unit), and the reason for this is to make it easier to continue having the treatment.

Specialist in the Society of Anti-Aging Medicine with over 1,000 cases of profilo proceduresThe treatment is performed by

At Smart Skin Clinic,Specialist in the Society of Anti-Aging Medicine, with a wealth of experience and high technical skills from more than 1,000 procedures at Profilo alone.will always be in charge of the treatment.

This minimizes downtime swelling and pain during the procedure as well as the quality of the finished product.

Below is a quote from an actual customer.

I was worried about injection marks (internal bleeding) since it was on my face, but the skill is good and zeroThe first is the "M" in the "M".

He injects himself after work, takes care to wash his face softly when bathing, and wakes up the next day,The mark that looked like a mosquito bite was completely gone.I am looking forward to the second session on 1/11. There was no need to wash my face before the treatment, and the treatment itself was quick and easy, taking only 15-20 minutes, and I am looking forward to the second session on 1/11.

The teacher's ability to grasp the moment and to successfully grasp our requests is too high.I have had many cosmetic surgeries and I would recommend this clinic!!!!!

The treatment and the needles are very good. It hurts, but the finish is excellent!.

Excerpt from Hot Pepper Beauty Smart Skin Clinic Review

Smart Skin Clinic's Commitment to Injection Therapy

Our director's policy is to implement the following "particulars" in injections.


PROFHILO contains no cross-linking agents or other chemicals or biological agents.Highly safeIt can be said that

Specifically,Less likely to cause allergic reactions, etc.This is the case.

The reason for this is that PROFHILO does not contain a "cross-linking agent".

Cross-linking agents can cause allergic reactions, immune reactions, and inflammation. Allergic reactions have been reported to occur, although they are very infrequent. Conventional hyaluronic acid injectables contain a substance called a cross-linker.

Also,The high safety profile of PROFHILO has been mentioned in several papers.

Based on 3 years of post-market experience, the safety profile of the medical devices in this study is good

Daniel Cassuto, et al. (2020)Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int.

Smart Skin Clinic's Profilo consistently receives high reviews on Google, Hot Pepper, Kirei Pass, etc.

We, Smart Skin Clinic, have achieved both "low cost," "high quality," and "high satisfaction" by thoroughly considering what is truly necessary for our customers and eliminating unnecessary costs.

By this,Highly rated on Google, Hot Pepper Beauty, and various other review sites.The Company has acquired

As a result, approximately 80% of those who came once were repeat customers.

Hot Pepper Beauty Rating 4.57/5.00

Evaluation of Kireipas4.30/5.00

Kumapon Evaluation4.71/5.00

Evaluation of Kang Nam Onni9.3/10.0

ray (e.g. X-ray)

Fashion-conscious influencers have also visited our clinic

Fashion-conscious influencers have also visited our clinic


New Price: Profhilo has been significantly reduced. (December 20, 2023)

1 time (2cc)129,000 yen → 59,800 yen
2 sets (2cc x 2)258,000 yen → 109,600 yen
(59,800 yen for the first bottle)
(Second bottle 49,800 yen)
3 sets (2cc x 3)258,000 yen → 149,400 yen
(59,800 yen for the first bottle)
(49,800 yen for the second bottle)
(39,800 yen for the third bottle)
Monitor price: 2 sets (2cc x 2)99,800 yen
(49,900 yen per bottle)
All prices include tax.
We are a free clinic and not covered by insurance.
*PROFHILO has a specific area to be injected called the BAP method (treatment to the bioesthetic point), and basically 2cc at any clinic is the above treatment area.

The price is indicated as all-inclusive, including consultation and needle fees.
There is no separate upsell on the day of the event.

Need for anesthesia|Low

This procedure is basically considered anesthesia-free.
We would like to maintain this price, so if you would like cream anesthesia5,500 yen (tax included) / 1 time(*This is because anesthesia will increase the time by about 20 minutes. (*This is because anesthesia will increase the time by about 20 minutes.)

Monitoring Requirements

(i)Usage|We may post the photos on our website, Instagram, etc. with the eye area hidden, or show them to other customers as examples of treatment [please think of them as general case photos].
(2)implementation method|We will refund the difference (between the regular price and the monitor's price) at the time of the monitor's photo shoot (3 to 7 days after the second treatment).

Price quotes

At beauty clinics in the Kanto area, the market price is 65,000-80,000 yen per treatment to inject Profibro into the face, 130,000-170,000 yen for a set of two treatments, and approximately 200,000 yen for three treatments.

*Surveyed in February 2024.

Those who cannot be treated

Pregnant or nursing mothers

Those with abnormal immune function or a history of such abnormality, and those undergoing immunosuppressive therapy.

Those prone to keloid formation, hypertrophic scars and hyperpigmentation

Those with bleeding tendency or using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin

Excessive sunburn, eczema, dermatitis, acne, or scabs at the site of PROFHILO injection

Risks and Side Effects

of the needle puncture site.

Redness, swelling, pain, edema

Intravascular hemorrhage

Temporary protuberance

Down time

Redness and bumps at the injection site may occur, but in most cases will return to normal in about 24 hours.

Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, although not always. If subcutaneous bleeding spots occur, they will gradually disappear over a period of 10-14 days.

Flow of treatment


You can easily make reservations with your mobile phone.

Reception (desk)

This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.

Counseling and medical examination

Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.

PROFHILO injection

After the marking is carried out, the injection is carried out while talking to the patient.

After-sales service

We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.

Returning home

More Information

Treatment TimeAbout 15 minutes (not including counseling)
Recommended number and frequency of treatmentsIt is recommended that two sets of two sessions be performed at least 6 weeks apart.
After that, maintenance is recommended about once every six months.
Down timeAbout 24 hours
Treatment on the day of counselingPossible
MakePossible immediately after the treatment
Skin carePossible immediately after the treatment
ShowerPossible from the same day
PainThere is a stinging pain when the needle is inserted.
*There are individual differences.


How often and how many times should I take the course?
Dr. Smaski.

Although a single session can be effective, we recommend one of the following as the most effective method
(1) The first and second sessions will be done at one-month intervals, and the same pattern will be continued every year thereafter.
(2) The first and second sessions are performed at one-month intervals, and then continued every six months thereafter.

The skin remodeling effect of PROFHILO increases the extracellular matrix, resulting in skin rejuvenation. Without maintenance, the extracellular matrix will gradually decrease "due to aging" after the peak of treatment. For this reason, we recommend the above procedure.

Do you feel pain?
Dr. Smaski.

Although it depends on the individual, we use a thin needle, but you may feel a slight stinging pain. It is also said that the center of the face is more sensitive to pain.

How long is the downtime?
Dr. Smaski.

Redness will subside in about 24 hours.

Does it work after just one visit?
Dr. Smaski.

The effect can be achieved in just one session. The lifting effect can be felt immediately after the first session. On the other hand, most patients will notice the effect after 3 to 4 weeks of skin remodeling.

Introduction of other Smaski injectable procedures for those who suffer from skin conditions.

In addition to Profibro injections, Smart Skin Clinic also offers other injection procedures that are effective in improving skin texture.

If you are interested in Jubelq injections in the case photo above, please see the link below.

Smart Skin Clinic (Tokyo, Japan)
Vital Injector (Vital Injector) Japan's lowest level 1cc 9,800 yen (Jubeluk now only 23% off) | Smart Skin Clini... June, July Campaign】Discounts for "JUVELUX" and "Kiara Reju (RejuLange generic)" are now available for up to "20%" off 1 time|10% off 3 times set|15% off 4 times set|20...

Legal description

Prophylotherapy includes procedures using drugs or medical devices that are not approved in Japan. The medicines and devices used in the treatment have been imported on a personal import basis under the judgment of our physicians.

Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".

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Smart Skin Clinic

Smart Skin Clinic

The concept of the clinic is to "make cosmetic medicine more accessible and smart. is the concept of the clinic.

Instead of eliminating ornate interiors to reduce interior design costs and installing equipment in the dark, we carefully select the equipment we need and reduce the cost of the equipment.

We aim to "make cosmetic medicine more accessible" for you.

Clinic Reception

Address:EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic dermatology (cosmetic dermatology, medical hair removal, medical slimming)

Address: EX Kanda Nishiki-cho Building 8F, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic dermatology (cosmetic dermatology, medical hair removal, medical slimming)

About the physician supervision of this site

About the physician supervision of this site

This site is operated under the supervision of the Smart Skin Clinic supervising physicians.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.

This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.