Japan's lowest price level】Personalized PRP Injection: Radical treatment for laugh lines (long lasting over 5 years)|Smart Skin Clinic

Personalized PRP Injection — All Treatment Areas 30% OFF
Campaign period: July 1, 2025 – July 31, 2025
"I've heard PRP injections work well for nasolabial folds, but do they really work? How safe is it?"
"I've heard that injections combining PRP with FGF can be risky, but what's the truth?"
"I just want to get rid of my nasolabial folds."
"I've been comparing options for my nasolabial folds — hyaluronic acid injections, facelifts, thread lifts — but I'm afraid of surgery. Isn't there a way to get a natural-looking result?"
Hello, I'm a physician at Smart Skin Clinic, a cosmetic dermatology clinic. Do any of these questions or concerns sound familiar?
In this article,Registered with a Type 2 Regenerative Medicine Provision Plan Number from the Ministry of Health, Labour and WelfareAs a cosmetic dermatology clinic specializing in regenerative medicine, we provide a clear explanation from a professional standpoint.
*If you'd like to know the prices, you can jump to the relevant section from the table of contents below.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What Is Personalized PRP Injection?
Smart Skin Clinic’s personalized PRP injections area treatment that injects a formulation combining PRP (platelet-rich plasma) with added FGF (fibroblast growth factor)..
PRP: An ingredient extracted from your own blood, rich in growth factors
FGF: Fibroblast growth factor. An ingredient that powerfully promotes skin regeneration
By combining these two, PRPF injection is designed to deliver more powerful results than conventional PRP therapy.
In addition, because Smart Skin Clinic does the following, even greater results can be achieved:
✔️ Precise diagnosis of each individual’s condition
✔️ Tailor-made dosage design
✔️ Precise injection by a skilled doctor
Personalized PRP Injection case photos (Before/After)
The nasolabial folds are dramatically improved.This is something you can see for yourself.
This effect lasts about 5 years—this is a major feature of personalized PRP injections.







Three Features of Personalized PRP Injection
1. Long-term results and cost performance
The effecttypically lasts 5 years or more. Because the results of a single treatment last for an extended period, it offers excellent cost performance.
2. Natural rejuvenation effect
Because it uses ingredients derived from your own body, the results look natural. It enhances the skin's own regenerative power, so there is no unnatural appearance.
3. Customized treatment
At our clinic, we adjust the concentration and injection volume to suit each patient’s skin condition and goals, and design the injections on an individual basis.
Mechanism of Personalized PRP injections: why are they effective for nasolabial folds?
The main reasons personalized PRP injections are effective for nasolabial folds are as follows:Four Mechanismsis due to
1. Promoting Collagen Production
The platelet-derived growth factor (PDGF) and FGF contained in personalized PRP injections stimulate fibroblasts. As a result, collagen production is promoted, improving skin firmness and elasticity. This helps improve the sagging skin that causes nasolabial folds.
2. Promoting elastin production
FGF also promotes elastin production. Elastin is a key protein that maintains skin elasticity, and increasing it helps the skin around the nasolabial folds become more supple.
3. Improving skin thickness
Through the action of personalized PRP injections, the dermal layer of the skin becomes thicker. This reduces the appearance of nasolabial folds and gives an overall more youthful impression.
4. Boosting circulation
Vascular endothelial growth factor (VEGF) promotes the formation of new blood vessels. Improved circulation activates skin metabolism, leading to an overall improvement in skin quality around the nasolabial folds.
The combined action of these mechanisms helps improve the appearance of nasolabial folds.
Personalized PRP Injection Is Recommended For
Those concerned about nasolabial folds
Those who have noticed more visible expression lines
Those concerned about sagging cheeks
Those who want to restore firmness
and elasticity to the skin overall
Those who want a natural-looking result
The strengths of Smart Skin Clinic’s Personalized PRP Injections
1. Specialists in Injectable Treatments
・Optimal injections backed by extensive experience and advanced technique
・A proprietary injection technique that minimizes pain
Treatment customized for each patient
2. Experts in Regenerative Medicine
・A regenerative medicine provider approved by the Ministry of Health, Labour and Welfare (holds a Type 2 Regenerative Medicine Provision Plan number)
・Access to the latest insights through physicians certified by the Japanese Society of Anti-Aging Medicine
3. The Advantage of Combining Injectable and Regenerative Medicine Expertise
・Delivers more effective, safer treatment
・Optimal treatment plans tailored to each patient's condition and goals
Our Commitment to Addressing Your Skin Concerns
As we've gotten older ourselves, we've had similar worries — "Have my nasolabial folds gotten a little deeper?" or "My dark circles seem more noticeable today, and I look tired..."
A single change in your face can help you enjoy fashion and relationships more, and enjoy life even more. We see Personalized PRP injection not simply as a way to improve appearance, but as a treatment that can be a catalyst for viewing life itself more positively. Overseen by a board-certified physician of the Japan Society of Anti-Aging Medicine, we are committed to honest care with no sales pitches or upselling.
It's true that this is a high-cost treatment. But we firmly believe it is an "investment" that delivers real value to patients who want to enjoy the years ahead even more.
Pricing
Typical PRP Injection Prices in Tokyo
The typical price of PRP injections in Tokyo isAround 300,000–400,000 yen(as of August 1, 2024).
Smart Skin Clinic Price List
Personalized PRP Injection — All Treatment Areas 30% OFF
Campaign period: July 1, 2025 – July 31, 2025
| Once | 208,000 yen |
| [Monitor] 1 session | 178,000 yen |
| Price per area when treating 2 or more areas | 166,400 yen (20% off the regular price) |
| [Monitor] 2nd area | 136,400 yen |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Prices are shown all-inclusive, covering consultation and needle fees.
There is no separate upselling on the day.
Monitor Requirements
①Intended Use| We may publish the photos on our website, Instagram, and similar media with the eye area concealed, or show them to other patients as treatment examples [please picture typical case photos].
②Procedure|You pay the regular price at your first visit, and we refund the difference (between the regular price and the monitor price) at the time of the monitor photo shoot (approximately one month after treatment as a guide).
Why we can deliver both "high quality" and "some of the lowest prices in the nation"The reasons we can achieve this
In fact, more than 90% of aesthetic clinics carry too many unnecessary costs to offer their patients the best possible price.
Guided by this awareness of the problem, we created an aesthetic clinic completely unlike the conventional norm.
(1) Areas with low rent
(2) Cutting back on lavish interiors
(3) Cutting back on excess staffing
(4) Cutting back on excessive advertising spend
This is how we deliver something other clinics can't match: the "High-quality personalized PRP injectionsoffered at one of the lowest prices nationwide" we're able to achieve.
Smart Skin Clinic consistently earns high ratings in reviews on Google, Hot Pepper, KireiPass, and more.
At Smart Skin Clinic, we think carefully about what our patients truly need and thoroughly cut out unnecessary costs, allowing us to deliver affordability, high quality, and high satisfaction all at once.
As a result,we earn high ratings across a variety of review sites, including Google and Hot Pepper Beauty.we have earned.
As a result, about 80% of those who visit us once return for repeat treatment.
Google review rating 4.5/5.0 (97 reviews)

Hot Pepper Beauty rating 4.57/5.00

KireiPass rating4.30/5.00

Kumapon rating4.71/5.00

Gangnam Unni rating9.3/10.0

Comparison with Other Treatments
1. Comparison with Hyaluronic Acid Injection
・Personalized PRP injection: a low allergy risk thanks to autologous components, and long-term skin regeneration effects
Hyaluronic acid: gives immediate volume, but is absorbed within 6-12 months. It also carries a risk of vascular occlusion, so care is needed.
2. Comparison with Botox injections
・Personalized PRP injection: improves the skin quality itself and maintains natural expression
Botox: temporarily relaxes facial muscles, which may result in a stiffer expression
3. Comparison with facelift surgery
・Personalized PRP injection: non-invasive, with quick recovery and natural-looking results
Facelift: can achieve dramatic change, but carries significant surgical risk and downtime
Personalized PRP Injection Procedure
- Blood draw: A small amount of blood is drawn from the patient's arm
- PRP extraction: PRP is extracted using a specialized centrifuge
- FGF addition: FGF is added to the extracted PRP
- Injection design: we create the design best suited to your concerns
- Injection: a fine needle is used to inject the skin around the nasolabial folds
The needles used are extremely fine, minimizing pain. Anesthetic cream can also be used if needed.
Precautions and Side Effects
Personalized PRP injections are relatively safe, but the following temporary side effects may occur:
・Mild swelling or bruising at the injection site
・Temporary pain or discomfort
In rare cases, infection or an inflammatory reaction may occur. At our clinic, strict hygiene protocols and skilled technique help minimize these risks.
FAQ
Q1: Are personalized PRP injections painful?
A1: Because we use an extremely fine needle and can apply anesthetic cream if needed, most patients experience only mild discomfort.
Q2: When can I expect to notice results?
A2: Results vary by individual, but most patients begin to notice a gradual effect from around 2 to 4 weeks. The full effect often appears after 3 to 6 months.
Q3: How many sessions are typically needed?
A3: One treatment typically lasts more than 5 years.
Summary
Personalized PRP injections are an effective treatment for improving nasolabial folds. Because they use autologous components, they are safe and offer natural-looking results. Through a complex mechanism, they address nasolabial folds, and long-term results can be expected.
At Smart Skin Clinic, we draw on our expertise in injectable procedures and regenerative medicine to provide the optimal personalized PRP injections.
Since results and duration vary by individual, we recommend a personal consultation for more detail. Let's find the nasolabial fold treatment that's right for you.
Physician Who Supervised This Page

Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
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