"I wonder what Dermapen × Exosome is and what kind of effects it has." "I'm thinking of getting Dermapen × Exosome, and I'd like to have it done somewhere even a little more affordable."
Do you have any of these questions or concerns?
In this article, a cosmetic dermatology clinic—which is a Ministry of Health, Labor and Welfare-certified facility for regenerative medicine provision plans—will provide an easy-to-understand explanation from a professional perspective. (*Certification No. NA8230001 for Type II and Type III Regenerative Medicine Provision Plans)
*If you’d like to know the fees, you can jump to the relevant section using the table of contents below.
Supervisor Information
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
TOC
What Is the Dermapen 4?
Dermapen is a skin treatment device. The tip of the device is fitted with multiple needles finer than a strand of hair. Inserting these ultra-fine needles into the skin triggers a process inside the skin known as the "wound-healing mechanism," which helps improve skin quality.
What is the wound-healing mechanism?
Humans have a natural ability to repair cells, and minor injuries (wounds) heal on their own. When cells are damaged, their response of trying to return to their original state is called wound healing. Many people have experienced how the skin feels smooth once a scab has healed—that, too, is wound healing.
It also acts not only on the dermis deep within the skin but on the epidermis, the shallow layer of the skin, normalizing skin turnover and thereby helping to address clogged keratin, spots, and more.
Dermapen can be used on its own, but in many cases an "introductory serum" is used at the same time. This is because the channels created by Dermapen allow the serum to penetrate deep into the skin. (Normally, the skin's surface barrier prevents products from penetrating deep into the skin.)
What is an exosome?
Exosomes (also called exosomes) are granular substances 50–150 nm in diameter (a nanometer being one billionth of a meter) that are secreted by cells. Their surface contains cell-membrane-derived lipids and proteins, while their interior holds intracellular substances such as nucleic acids (microRNA, messenger RNA, DNA, etc.) and proteins.
Exosomes secreted by cells exist not only between cells but also in bodily fluids (blood, spinal fluid, urine, etc.), circulating throughout the body. An important function of exosomes that has drawn attention is their use in transmitting information between cells. As mentioned, exosomes contain nucleic acids, proteins, and more inside them. Because it has been reported that the nucleic acids (microRNA, messenger RNA) of the secreting cell are conveyed to the receiving cell via exosomes and remain functional, exosomes are thought to act as a communication tool between cells.
As described here, exosomes are substances present within the body that function as an "information-transmission tool between cells."
The actions of these exosomes have been found to include activating cells, promoting angiogenesis, and suppressing inflammation (anti-inflammatory action). As a result, they are associated with effects such as skin beautification, anti-aging, treatment and prevention of disease, recovery from fatigue, and relief of insomnia.
With Dermapen 4 × Exosome, exosomes with these effects can be delivered directly into the skin.
What is Dermapen 4 × Exosome?
This treatment improves skin quality by creating microscopic channels in the skin with Dermapen 4 and introducing exosomes directly into the skin through them.
Recommended if you have any of these concerns
I want to improve acne scars (craters, hyperpigmentation)
I want firm, radiant-looking skin
Reduce the appearance of pores
I want beautiful skin like Koreans have
Effect
Effect
Enhances the skin's ability to regenerate
Improvement of skin quality
Improvement of enlarged pores and clogged pore plugs
Improvement of acne scars (craters, hyperpigmentation)
Promotes the skin's natural cell repair to create more youthful skin
Renews the skin and revitalizes its functions
While the Dermapen 4 alone offers skin rejuvenation benefits, the introduction of exosomes further enhances those effects.
Exosomes accelerate wound closure by inhibiting the TGF-β receptor, and by scar formation, while regulating collagen fiber distribution and supporting the regeneration of skin appendages (such as hair, sebaceous glands, nerves, and blood vessels), thereby promoting wound healing.
The following research paper demonstrates the effectiveness of the Dermapen combined with an exosome delivery solution.
This study conducted a comparative experiment on patients with aging skin to evaluate the use of an exosome-containing solution (HACS) in combination with microneedling (Dermapen).
Simply put, the results showed that “when exosomes (HACS) were applied to one side of the same person’s face and saline solution was applied to the other side, a comparison of wrinkles, elasticity, hydration, and pigmentation revealed greater improvement on the exosome (HACS) side.”
The Global Aesthetic Improvement Scale score was significantly higher on the exosome-containing solution treated side than on the control side (p = 0.005). Objective measurements using various devices, including PRIMOS Premium, Cutometer MPA 580, Corneometer CM 825, and Mark-Vu, confirmed clinically greater improvement in skin wrinkles, elasticity, hydration, and pigmentation on the HACS-treated side than on the control side. The histopathological evaluation results were consistent with the clinical findings. No serious adverse events were observed.
Recommended number/frequency of treatments | How many times should I have it?
This is a question we're often asked during actual counseling, so we'll explain it just as we would tell you at the clinic.
"How many Dermapen × Exosome sessions is ideal?"
I think it would be a good idea to take it about 5 to 10 times.
"What is the ideal interval between sessions?"
I think a one-month interval would be best.
*The reason we don't speak in absolutes is that with cosmetic dermatology treatments, results vary from person to person, so we're neutrally conveying the methods generally recommended in cosmetic dermatology and by manufacturers. While we don't make guarantees, we generally recommend receiving treatment at the number of sessions and frequency described above.
Benefits/Drawbacks
Benefits
Delivers skin-quality improvement
Compared with Dermapen alone, it delivers greater results in a similar amount of time
Compared with Dermapen alone, the anti-inflammatory action of exosomes helps reduce downtime
Compared with exosome IV drips and the like, it targets the skin intensively, delivering a greater effect on the skin
Drawbacks
There is pain from the Dermapen
There is downtime (reduced compared with Dermapen alone thanks to the anti-inflammatory action of exosomes)
More expensive than Dermapen alone
Features of Smart Skin Clinic’s Dermapen × Exosomes
We use the official exosome formulation from DermapenWorld, the maker of the Dermapen device
There are various types of exosome solutions available, but at our clinic, we use “MG-EXO-SKIN™,” the official exosome formulation produced by the manufacturer of the Dermapen device.
Because it is an official formulation from the maker of Dermapen, it works well with the Dermapen without any compatibility issues.
Because approximately 7,000 exosomes can be attached to the tip of a single 33G Dermapen 4™ needle, Dermapen is an efficient device that delivers exosomes to the skin without compromising them.
The six active ingredients in "MG-EXO-SKIN™" besides exosomes
Our exosome introductory serum contains not only exosomes but six other active ingredients. Each ingredient and its action is described below.
① HylaFuse™ Hyaluronic acid of three different molecular weights
・A penetration enhancer that increases the delivery of active ingredients ・Provides strong moisturizing power
② Calphasomes™ A calcium phosphate compound ・A penetration enhancer that stimulates lamellar granules and fibroblasts to increase ceramide and collagen synthesis.
③ Sodium Ascorbyl Phosphate Stabilized Vitamin C ・A versatile redox agent that soothes pigmentation while removing reactive oxygen species.
④ Zinc PCA A zinc salt ・Reduces inflammation and supports wound healing through re-epithelialization.
⑤ Panthenol Provitamin B5 ・A wound-healing agent with a strong moisturizing effect. ・Associated with tissue repair and regeneration.
⑥ Aloe Vera A plant-derived ingredient with antioxidant properties ・A plant-derived ingredient with anti-inflammatory and antioxidant properties. Rich in bioflavonoids, polyphenols, and tannins with strong healing properties.
More than 200 cases of Dermapen 4 × Exosome
At our clinic, we offer Dermapen 4 as a skin-quality improvement treatment. The number of cases using Dermapen 4 with the exosome introductory serum is more than 200.
*For the period from June 23, 2023 to October 31, 2024.
The physician sets the appropriate Dermapen needle depth after an examination
Dermapen 4 allows the needle depth to be adjusted. Deeper is not necessarily more effective; there is an appropriate depth depending on your concerns and the area of skin.
After examining you, the physician determines the depth appropriate for you before performing the treatment.
For more on the proper Dermapen needle depth, please also see the following article.
There are exosome treatments other than the Dermapen.
In addition to direct application to the skin, there is also a method of administration via IV drip. This procedure is known as an exosome IV drip.
While Dermapen × Exosome delivers a greater direct effect on the skin, administering it intravenously into the body can provide a variety of other benefits.
In principle, the treatment can be performed unless you have some serious illness or inflammation in the area to be treated.
The following is provided as reference information, since we are obliged to include it to inform "those who are not eligible for the treatment," so please take a quick look through it.
Those who are pregnant or breastfeeding
Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those prone to keloid formation, hypertrophic scars, or pigmentation disorders
Those with a bleeding tendency, or those using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin
Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Dermapen × Exosome treatment site
Downtime | Risks/Side Effects
Dermapen × Exosome involves the following downtime symptoms, risks, and side effects.
Redness and swelling [always occur] After the treatment, especially during the first 24 to 48 hours, the skin may become red and swollen. This is a normal part of the process and a natural reaction to the treatment. This condition is temporary and usually settles down within a few days.
Risk of infection [rare] The Dermapen leaves microscopic channels in the face, and there is a risk of infection if bacteria enter through them. In most cases this will not occur as long as you avoid touching your face too much and keeping it unclean after the treatment.
Peeling To promote the production of new skin cells, the old skin may peel off naturally. This is part of the recovery process and is normal. When peeling occurs, it's important to keep the skin properly moisturized and avoid direct sunlight.
Pain and discomfort You may feel some pain during the treatment, but this is felt differently from person to person. The same applies to discomfort after the treatment, which usually eases quickly.
Excessive inflammatory response Those with sensitive skin or certain skin conditions may show an excessive reaction. For this reason, we provide a detailed consultation before the treatment to accurately assess your skin condition.
If you have any concerns or questions, please feel free to reach out, no matter how small.
Post-treatment precautions/aftercare
During the downtime period, please keep the following in mind.
Avoid highly irritating skincare products during the downtime period. Please refrain from using products containing hydroquinone or retinol for about two weeks.
Avoid strenuous exercise, saunas, and prolonged sun exposure.
Keep the treatment area clean, and do not forcibly touch or rub it.
"Dermapen + Exosome" × "Exosome IV Drip": Smart Skin Premium Program
Special first-time price
60,800 yen ⇒ 39,800 yen
Once
60,800 yen
3 sets
166,500 yen (55,500 yen per session)
Set of 5 sessions
249,800 yen (49,960 yen per session)
Set of 7 sessions
319,800 yen(45,685 yen per session)
Set of 10 sessions
397,500 yen (39,750 yen per session)
All prices include tax * This special first-visit price cannot be combined with other campaigns * Our clinic offers private (self-pay) treatment only; insurance does not apply.
During the consultation, please feel free to discuss any concerns you may have. Rest assured, there is no pushy sales.
STEP
Dermapen 4 × Exosome treatment
After administering anesthesia, we configure the settings to suit your skin and perform the treatment.
STEP
Aftercare
We will provide detailed instructions on how to care for the treated area and what to keep in mind in your daily life. In addition, with a focus on prevention and maintenance, we recommend appropriate home care products—such as oral medications and skincare products—that can help alleviate your concerns.
STEP
Going Home
FAQ
How often and how many times should I receive it?
Dr. Ishii
A single session is effective, but we recommend about 4 to 5 sessions every 4 to 6 weeks.
Can I have other treatments at the same time?
Dr. Ishii
As a rule, please avoid other treatments on the same day. Our clinic also offers laser and chemical peels, but we ask that they not be combined.
Will I no longer be able to donate blood?
Dr. Ishii
Blood donation is possible. If exosomes are injected into the skin, as with Dermapen or Water Light Injection, it's fine. If they enter the bloodstream, you will no longer be able to donate blood.
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines
Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
Scope of supervision: treatment descriptions, risks and side effects, price display
Last Reviewed: August 1, 2026
*Treatment effects vary from person to person. Please be sure to consult a physician regarding side effects and risks.
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Dr. Ishii
