Exosome infusion [umbilical cord derived]|Smart Skin Clinic (Jimbocho, Tokyo)

Exosome infusion eye catcher

You are hearing more and more about "exosome infusion" along with keywords such as rejuvenation and anti-aging.

Smart Skin Clinic, a cosmetic dermatology clinic, will explain in a professional and easy-to-understand manner the question of what an exosome infusion is.

For those who are considering receiving exosome infusion, the features and fees of our clinic are also described, so please continue reading from the items of interest in the table of contents.


What is exosome infusion therapy?


Exosome infusion

By administering an ingredient called exosome into the blood vessels, this intravenous infusion treatment is expected to have anti-aging and other effects on the entire body.

What is an exosome?

Exosomes are substances originally found in the body. In medical terms, they are small cellular vesicles encased in a lipid bilayer membrane that are actively secreted by various cells and play an important role in intercellular communication.

Through this role of intercellular communication, exosomes exert diverse effects, including anti-apoptotic, anti-inflammatory, neurogenic, and angiogenic effects. As a result of exerting these effects, they provide so-called anti-aging effects.

What is an exosome?

Exosomes are granule-like substances 50-150 nm (nanometers: one billionth of a meter) in diameter secreted by cells.

One important function of exosomes that has been highlighted is that they are used to transfer information between cells. Exosomes are thought to act as communication tools between cells.

Tokyo Metropolitan Institute of Gerontology and Geriatric Medicine

What is an exosome?

Types of exosomes (origin)

Exosomes can be said to come in three types because there are three main sites (origins) from which they are harvested.

These will be the following three

  • Umbilical cord-derived
  • Fat-derived
  • Bone marrow and dental pulp derived


The effects that can be expected from exosome infusion are as diverse as the images below. This is due to the fact that exosomes are involved in intercellular communication and act in a way that activates cells, as well as acting throughout the body.

We will pick up a few of the diverse effects and explain them in detail.

Expected Benefits of Exosomes

Anti-aging(Rejuvenation), effects on the whole body

Anti-aging is a comprehensive concept, not just a part of the body, or rejuvenation at the cellular level, which is invisible to the eye.

Exosome infusion acts on cells throughout the body and is expected to achieve anti-aging results.

Relieve fatigue and maintain health

Exosomes acting throughout the body can be expected to help recover from fatigue at the cellular level. Cell repair and anti-inflammatory effects of exosomes are thought to be involved.

Effects on skin

As shown in the Rohto study below, exosomes act on fibroblasts, which are cells deep in the skin, to synthesize collagen and elastin, which affect skin elasticity and luster. This is expected to have a skin beautifying effect.

We found that it inhibits fibroblast senescence via exosomes and promotes the synthesis of dermal components such as collagen and elastin.

Rohto Pharmaceuticals] Discovered an ingredient (glycogen/tetrapeptide-5) that inhibits fibroblast aging via exosomes, which is attracting attention in regenerative medicine research.

Effects on the brain (improved insomnia, improved concentration, improved cognitive function)

The cell repair and anti-inflammatory effects of exosomes are thought to have a positive effect on the brain as well, and can be expected to improve insomnia and improve concentration by healing the brain.

Exosomes are thought to have a potential effect on Alzheimer's disease-causing agents such as amyloid-β and tau proteins, and are expected to have a positive effect on cognitive function.

Reduced downtime

Exosomes are transported throughout the body via the bloodstream and move freely between tissues, exerting anti-inflammatory, antioxidant, and cell repair effects through angiogenesis and other actions.

This mechanism is expected to accelerate wound healing and reduce downtime.

Effect on hair

Just as it acts on the skin, etc., hair is made of "cells," so exosomes act on hair and may be expected to improve elasticity, firmness, and even gray hair.

Effects on immunity and allergic diseases

It has been suggested that exosomes may contribute to improved immunity, as described in the following medical article.

These results indicate that circulating exosomes containing spike proteins play an important role in effective immunization following mRNA-based vaccination. This is further evidenced by the induction of humoral and cellular immune responses in mice immunized with exosomes carrying spike proteins.

Sandhya Bansal, et al. Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines. J Immunol (2021) 207 (10): 2405- 2410.

In this video, Takafumi Horie (Holliemon) and Dr. Yamakawa explain about exosomes.