Jalpro HMW 


What is JALPRO|Skin growth injection formulation using non-cross-linked hyaluronic acid and amino acids 

Jalpro is an injectable formulation consisting of non-cross-linked hyaluronic acid and amino acids, and is recently referred to as a "skin growth" formulation because of its ability to "rejuvenate the skin from within" and "restore the skin's own elasticity and resilience. 

JalPro is available in three formulations, Classic, HMW, and Super Hydro, each with different expected effects. 

The difference in effectiveness is due to the difference in molecular weight of the main ingredient, non-cross-linked hyaluronic acid. For a more detailed overview of Jalpro and the differences between the three formulations, please see this page. 

Smart Skin Clinic (Tokyo, Japan)
JALUPRO (JALUPRO) | Smart Skin Clinic (Jimbocho, Tokyo) With the introduction of JALUPRO water light injections, [Super Hydro] Discount Campaign is now in effect!

This article describes in detail the Jalpro HMW, one of the three formulations. If you are interested, please read on. 

What is Jalpro HMW|Fulling out wrinkles and lines on the neck, and plumping out the cheeks of the scruffy cheeks. 

Effectiveness of Jalpro HMW 

The main ingredients of JalPro HMW are high molecular weight non-cross-linked hyaluronic acid and amino acids, but the effect of JalPro HMW is achieved in two major ways. 

The first is the skin-nurturing effect of non-cross-linked hyaluronic acid and amino acids, which is common to the JalPro series. 

The second is the effect of the molecular weight of the "high molecular weight" non-cross-linked hyaluronic acid. The effect of this high molecular weight non-cross-linked hyaluronic acid can also be said to be a characteristic of Jalpro HMW. 

[Jalpro's skin growth effect. 

The skin growth effect of JalPro appears as a synergistic effect of the ECM remodeling effect of non-cross-linked hyaluronic acid and amino acids. 

When injected into the skin, non-cross-linked hyaluronic acid diffuses in multiple directions, activating the surrounding tissue in the process. The activated cells increase collagen, elastin, and fibroblasts in the dermis layer, which increases firmness and elasticity and rejuvenates the skin. 

This effect.ECM Remodelingand is touted as a skin-nurturing effect. 

And the amino acids in JalPro are essential for cell generation, regeneration, and repair of damaged skin. Glycine, in particular, is an important amino acid when considered in terms of collagen production. 

In other words, while stimulating cell growth, amino acids essential for generation and repair can be given at the same time, thus creating a synergistic effect of skin rejuvenation. 

Effects of high molecular weight non-cross-linked hyaluronic acid 

High molecular weight non-cross-linked hyaluronic acid refers to non-cross-linked hyaluronic acid with a large molecular weight. 

We explained earlier that non-cross-linked hyaluronic acid diffuses in multiple directions, but the larger the molecular weight, the harder it is to pass through the spaces between skin cells. Also, because of its large molecular weight, it is less likely to be broken down or absorbed. 

In other words, they are less likely to diffuse out of the injected site, stay there, and take longer to break down than low-molecular weight ones. 

In addition, hyaluronic acid itself swells and gains volume when it binds with drawn-in moisture, so when injected into wrinkles and hollows, the area is less noticeable. 

Features of Jalpro HMW 

HMW (High Molecular Weight) means high molecular weight, and as the name implies, the effect obtained by high molecular weight non-cross-linked hyaluronic acid can be said to be a characteristic of Jalpro HMW. 

Although some parts are repetitive, they can be summarized as follows.

  • Stays where it is injected due to its viscous nature and resistance to spreading 
  • Injected site attracts moisture to form volume 
  • Volume increase can be expected to lift sagging skin and lift it up. 
  • Long-lasting effect of 6-12 months due to resistance to degradation 

Because of these characteristics, JalPro HMW is said to be effective for engraved wrinkles and dimples. 

Jalpro HMW is recommended for 

  • To reduce the appearance of deep wrinkles such as neck wrinkles and lines 
  • To plump up cheek moss, hollows around the eyes and temple area. 
  • I want to have firmness and luster on my cheeks. 
  • lift up 

You have the above concerns, 

  • I don't want people to notice that I've done something. I want a treatment that changes naturally. 
  • I want the downtime to be less than 3 days. 

This treatment is recommended for those who wish to 

Time of effect onset 

Around a few days after the treatment, you will begin to notice an improvement in skin texture, such as "skin feeling smoother and softer. 

The peak effect is felt a few weeks after the procedure, when wrinkles and sagging are reduced and the overall elasticity and firmness of the skin is improved. 

Although the effects can be felt even after a single treatment, it is necessary to have regular treatments in order to maintain the effects. 

Duration of effect 

Jalpro HMW is said to last about 6 to 12 months. 

The duration of the effect depends on the skin's reaction, the amount injected, the patient's lifestyle and usual skin care, and therefore varies from person to person. 

With a series of regular treatments, a more long-lasting improvement in skin quality can be expected. 

Hyaluronic acid and Botox 

JalPro HMW is considered effective for deep wrinkles and dimples, but hyaluronic acid and Botox are also commonly considered for wrinkles and dimples as well. 

Here is a brief description of hyaluronic acid and Botox. 

hyaluronic acid 

Hyaluronic acid here refers to cross-linked hyaluronic acid, which has been conventionally used in the aesthetic medicine field. It is also called "filler" and is used as a filler to fill existing facial wrinkles, sagging, uneven skin tone, volume enhancement, and contouring. 

While JalPro has a fluid shape similar to the body's natural hyaluronic acid, cross-linked hyaluronic acid (hyaluronic acid filler) uses a cross-linking agent to link hyaluronic acids together, resulting in a more viscous gel-like shape. Once injected, it is concentrated locally and stays in place, making it difficult to move. Because it takes time to break down, the effect is long-lasting, and a single treatment is said to last from several months to over a year. It is the most mainstream procedure for improving wrinkles and dimples. 

Difference from Jalpro HMW

Characteristics of Cross-linked Hyaluronic Acid (Hyaluronic Acid Filler)

  • Cross-linked hyaluronic acid (hyaluronic acid filler) physically creates volume and fills in gaps, whereas JalPro HMW naturally increases volume by stimulating its own collagen production 
  • No skin growth effect because hyaluronic acid is not diffused. 
  • Immediate and long-lasting effects 
  • Risk of thromboembolism in blood vessels if accidentally entered into blood vessels 


Botox is a procedure in which botulinum toxin preparations are injected to primary weaken muscle movement. It is used for dynamic wrinkles that appear with facial expressions, such as the forehead and eye wrinkles. 

Jalpro HMW is used for wrinkles that are already present, regardless of expression. 

In other words, the choice between JalPro HMW or Botox should be based on whether the wrinkles you are suffering from are wrinkles that are already carved or wrinkles that appear due to facial expressions. 

Downtime and Risks of Jalpro HMW 

Down time 

Downtime Symptoms 

  • Pain or tenderness at the injection site 
  • Redness, swelling, and itching at the injection site 
  • internal hemorrhage 

Internal bleeding is what is called a bruise. The medical mechanism is that the blood vessels in the skin are defeated and blood flows out and then hardens in the skin. Whether or not internal bleeding occurs depends on the skill of the doctor and the physical characteristics of the person undergoing the procedure, so it is expected to occur in a few percent of cases.

Most downtime symptoms disappear within a day or two (basically within 24 hours). 

If internal bleeding occurs, it will gradually fade over a week or two. 

'Will it interfere with my work or my life after the procedure?' 
How many days do you need to keep it hidden..." 

Some may be concerned about such things as 

As a conclusion, it is said that the bumps that appear immediately after the injection often settle down within about 3 hours after the procedure and disappear within 48 hours at the most.

Depending on the area, internal bleeding may occur and needle marks may be noticeable, but in most cases they can be adequately covered up with concealer. Makeup cannot be applied on the day of the procedure, so if this is a concern for you, you will need to cover it up with a mask or hat. 

Areas prone to internal bleeding are the eye area and temples, and areas where needle marks are more visible are the cheeks. However, since the procedure is performed with an extremely fine needle, internal bleeding does not necessarily spread over a large area. In most cases, the bleeding can be concealed with makeup, but those who are concerned may find it reassuring to schedule a day off from work the day after the procedure. 

Risks of JALPRO 

Non-cross-linked hyaluronic acid, such as Jalpro, is generally considered safe. 

The reason, 

  • No cross-linking agents are used ... avoiding allergic reactions, immune reactions, and inflammation caused by cross-linking agents. 
  • Similar properties to hyaluronic acid present in the body ... Low risk of thromboembolism 

The three Jalpro formulations are also highly safe, as they are certified as Class 3 medical devices under the CE Mark. 
(CE Mark is an indicator for evaluating the safety of medical devices in the EU, and Class 3 is the highest level.) 

Disadvantages of Jalpro HMW 

There are no major disadvantages to note for JalPro. The minor disadvantages are listed below. 

  • Effects are not permanent, so repeated treatments are necessary to continue to obtain results. 
  • There is no immediate effect before the effect can be felt (on the contrary, the result will be natural slowly). 
  • Effects vary from person to person. 
  • Temporary redness and swelling may occur after injection. These usually resolve in a few days, but may affect the immediate appearance of the procedure 

Treatment area/method 

JalPro HMW is injected along areas of concern such as wrinkles and lines, or locally into sunken areas 

Recommended number/frequency of treatments|Schedule of treatments 

  • Once every 2-3 weeks, set of 4 times 
  • After that, maintenance should be performed every six to nine months. 

Those who cannot be treated 

Basically, it is possible to perform the procedure unless you have some serious illness or inflammation in the area to be treated. 

The following information is provided for reference only, as we are obliged to include it to inform "those who are not eligible for the treatment". 

  • Pregnant or nursing mothers
  • Persons with abnormal immune function or with a history of such abnormality, and persons receiving immunosuppressive therapy.
  • Those prone to keloid formation, hypertrophic scars and hyperpigmentation
  • Those with bleeding tendency or using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin
  • Excessive sunburn, eczema, dermatitis, highly inflamed acne, or scabs at the site of Jalpro injection


Our Fees 

doctor's help

1 bottle (3cc)79,800Yen → 59,800 yen
Three Courses
(3cc x 3)
239,400 yen →directional marker or indicator 173,400 yen
(per time)57,800 yen)
4 sets
(3cc✕ 4)
319,200 yen →directional marker or indicator 227,200 yen
(per time)56,800 yen)

Price quotes 

The price for JalPro HMW at beauty clinics in the Kanto area ranges from 60,000 yen to 120,000 yen per session (*As of April 2024). 

Flow of treatment 


You can easily make reservations with your mobile phone.

Reception (desk)

This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.

Counseling and medical examination

Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.

JalPro injection

After the marking is carried out, the injection is carried out while talking to the patient.

After-sales service

We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.

Returning home

More Information 

Treatment Time20~30 minutes (not including counseling)
Recommended number and frequency of treatmentsIt is recommended to do a set of 4 sessions, spaced 1~2 weeks apart.
After that, maintenance is recommended every six to nine months.
Down timeAbout 24 hours
Treatment on the day of counselingPossible
MakePossible immediately after the treatment
Skin carePossible immediately after the treatment
ShowerPossible from the same day
PainIf a surface anesthesia is applied, the stinging pain of the prick will be reduced.
There is not that much pain while the drug is being injected.
*There are individual differences.

We also recommend the following treatments 

In addition to Jalpro HMW, there are several other effective treatments for neck wrinkles, laugh lines, and cheek lumps. Please refer to the table below for a brief description of skin growth injection formulations so that you can easily compare them with JalPro HMW. 

Skin Growth Injection Products|GOURI Injection, JUVELUX VOLUME (RENISNA), PROFILO, SUNECOS 1200 

Skin growth injectable products similar to JalPro include GOURI injections, Jubelq Volume (Renisna), Profibro, and Snecos 1200. 

Skin growth injection formulation effective for neck wrinkles, laugh lines, and cheek lumps
preparation                    feature 
 Jalpro HMW Product image (white background)
Jalpro HMW 
Preparation containing high molecular weight non-cross-linked hyaluronic acid and four amino acids Skin regeneration by the amino acids contained together
Restoration synergies can be expected. 
GOURI formulation photo
The world's first liquid type PCL (polycaprolactone) containing formulation developed 
Liquid type PCL is a liquid form of medical threads used for thread lift. 
uberg volume 
Combination of poly(lactic acid) (PDLLA: Poly-DL-lactic acid) and non-cross-linked hyaluronic acid 
Polylactic acid is an aggregate of lactic acid obtained by fermentation of starch, which is completely decomposed into water and carbon dioxide in the body 
Can be used to treat deep wrinkles (lines, marionette lines, gorgon lines, etc.) and indentations on the forehead and temples. 
Longer effect duration of 1 to 2 years 
PROFHILO injection 
Preparations containing high concentrations of high molecular weight and low molecular weight non-cross-linked hyaluronic acid 
Penetrates deeper than the dermis layer and can be expected to increase volume from the subcutaneous tissue 
Not only does it increase the volume of wrinkles and dimples, but it also improves the overall texture of the skin at the same time. 
Image 1: Professional Dietetics Sunekos 1200 Sunekos 1200 1 box (1)
 SUNEKOS 1200 
Injection formulation containing a patented ratio of medium molecular weight non-cross-linked hyaluronic acid and 6 types of amino acids 
Less effective for moderate or deeper wrinkles 
Excellent moisturizing and immediate improvement 
Reasonable compared to other formulations 
*A common effect of these preparations is that when injected, they promote the activation of fibroblasts, which in turn promotes the production of collagen, resulting in a natural volume enhancement effect.
*SNECOS 1200 is not available at this clinic.

Other procedures|Hyaluronic acid, Botox, PRP therapy 

hyaluronic acid 

  • Cross-linked hyaluronic acid (hyaluronic acid filler) physically creates volume and fills gaps 
  • No skin growth effect because hyaluronic acid is not diffused. 
  • Immediate effect and long duration
  • Risk of thromboembolism in blood vessels if accidentally entered into blood vessels 


  • Injection of a botulinum toxin preparation to primary weaken muscle movement
  • Used for dynamic wrinkles that appear with facial expression, such as the forehead and eye corners (not effective for wrinkles that already exist regardless of facial expression). 

PRP Therapy 

  • A procedure in which concentrated platelets (= plasma) are extracted from the patient's own blood and injected into the skin. 
  • This plasma is rich in growth factors, which promote skin self-repair and regeneration 
  • Low risk of allergic reactions and rejection because it is made from one's own blood 
  • Not only improves wrinkles and dimples, but also improves the overall texture of the skin, and can be used to treat scars