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Jalupro HMW
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What is Jalupro | A skin-nurturing injectable formulation of non-cross-linked hyaluronic acid and amino acids
Jalupro is an injectable formulation composed of non-cross-linked hyaluronic acid and amino acids. Because it can "rejuvenate the skin from within" and "help the skin itself regain firmness and elasticity," it has recently also been called a "skin-nurturing" formulation.
Jalupro comes in three formulations—Classic, HMW, and Super Hydro—each with different expected effects.
The difference in effects comes down to the difference in the molecular weight of the main ingredient, non-cross-linked hyaluronic acid. For a more detailed overview of Jalupro and the differences between the three formulations, please see this page.
This article explains "Jalupro HMW," one of the three formulations, in detail. If you are interested, please read on.
What is Jalupro HMW | Plumping neck wrinkles and nasolabial folds, and filling out hollow cheeks
The effects of Jalupro HMW
The main ingredients of Jalupro HMW are high-molecular-weight non-cross-linked hyaluronic acid and amino acids, and its effects arise mainly in two ways.
The first is the skin-nurturing effect of non-cross-linked hyaluronic acid and amino acids, common to the entire Jalupro series.
The second is the effect of the molecular weight of the "high-molecular-weight" non-cross-linked hyaluronic acid. This effect of high-molecular-weight non-cross-linked hyaluronic acid can also be said to be the defining feature of Jalupro HMW.
[Jalupro's skin-nurturing effect]
Jalupro's skin-nurturing effect appears as a synergy between the ECM remodeling effect of non-cross-linked hyaluronic acid and the amino acids.
When injected into the skin, non-cross-linked hyaluronic acid spreads in multiple directions, activating the surrounding tissue in the process. The activated cells increase collagen, elastin, and fibroblasts in the dermal layer, boosting firmness and elasticity and rejuvenating the skin.
This effect is called ECM remodeling, and it is touted as a skin-nourishing benefit.
And the amino acids in Jalupro are essential ingredients for cell generation and regeneration and for repairing damaged skin. Glycine in particular is an important amino acid from the standpoint of collagen production.
In other words, because it can stimulate cell growth while simultaneously supplying the amino acids essential for generation and repair, a synergistic effect for skin rejuvenation can be expected.
[Effects of high-molecular-weight non-cross-linked hyaluronic acid]
High-molecular-weight non-cross-linked hyaluronic acid refers to non-cross-linked hyaluronic acid with a large molecular weight.
We explained earlier that non-cross-linked hyaluronic acid spreads in multiple directions, but the larger the molecular weight, the harder it is to pass through the spaces between skin cells. Also, because of its large molecular weight, it is less readily broken down or absorbed.
In other words, compared with low-molecular-weight forms, it is less likely to diffuse away from the injected site and stays there, and takes longer to break down.
In addition, since hyaluronic acid itself swells and gains volume when it binds with the moisture it draws in, injecting it into wrinkles and hollows makes those areas less noticeable.
Features of Jalupro HMW
HMW (High Molecular Weight) means high molecular weight, and as the name suggests, the effect obtained from high-molecular-weight non-cross-linked hyaluronic acid can be called the defining feature of Jalupro HMW.
Although some points overlap, they can be summarized as follows.
- Due to its viscous nature and resistance to spreading, it stays where it is injected
- At the injected site, it draws in moisture to create volume
- Through this added volume, sagging skin can be lifted and firmed
- Because it is resistant to breakdown, its effects are long-lasting, at 6 to 12 months
Because of these features, Jalupro HMW is said to be effective for etched-in wrinkles and hollows.
Jalupro HMW is recommended for people like these
- Want to reduce the appearance of deep wrinkles such as neck wrinkles and nasolabial folds
- Want to plump up hollow cheeks, hollows around the eyes, and the temple area
- I want firmness and radiance in my cheeks
- Lift-up
If you have concerns like the above and
- don't want others to notice that you've "had something done," preferring a treatment with natural-looking change
- want the downtime to be over within three days
then this treatment can be recommended for you
Timing of when the effects appear
From around a few days after the treatment, you begin to notice improvements in skin texture, such as your skin feeling smoother and softer.
The effects are felt at their peak from around a few weeks after the treatment, when wrinkles and sagging decrease and the skin's overall elasticity and firmness feel improved.
Effects can be felt even from a single treatment, but to maintain the results, regular treatments are necessary.
Duration of effect
Jalupro HMW is said to last about 6 to 12 months.
The duration of the effect depends on the skin's response, the amount injected, and the patient's lifestyle and daily skincare, so it varies from person to person.
With regular repeated treatments, a longer-lasting improvement in skin quality can be expected.
Frequently compared treatments | Hyaluronic acid and Botox
Jalupro HMW is considered effective for deeper wrinkles and hollows, and hyaluronic acid and Botox are likewise treatments often considered for improving wrinkles and hollows.
Here we give a brief explanation of hyaluronic acid and Botox.
Hyaluronic acid
The hyaluronic acid referred to here is the cross-linked hyaluronic acid conventionally used in the field of aesthetic medicine. Also called a "filler," it is used as a filling agent for existing facial wrinkles and sagging, uneven skin surface, volume enhancement, and contouring.
Whereas Jalupro has a form with fluidity similar to the natural hyaluronic acid present in the body, cross-linked hyaluronic acid (hyaluronic acid filler) uses a cross-linking agent to bind hyaluronic acid molecules together, resulting in a more viscous, gel-like form. Once injected, it stays concentrated locally and does not move easily. Because it takes time to break down, its effects are long-lasting, and a single treatment is said to last from several months to over a year. It is the most mainstream treatment for improving wrinkles and hollows.
Features of cross-linked hyaluronic acid (hyaluronic acid filler)
- Cross-linked hyaluronic acid (hyaluronic acid filler) physically creates volume and fills in gaps, whereas Jalupro HMW naturally adds volume by promoting your own collagen production
- Because the hyaluronic acid does not diffuse, there is no skin-nurturing effect
- Fast-acting, with long-lasting effects
- If accidentally injected into a blood vessel, there is a risk of thromboembolism within the vessel
Botox
Botox is a treatment in which a botulinum toxin preparation is injected to temporarily weaken muscle movement. It is used for dynamic wrinkles that appear with facial expressions, such as on the forehead and at the outer corners of the eyes.
Jalupro HMW is used for wrinkles that already exist, regardless of facial expression.
In other words, when choosing between Jalupro HMW and Botox, it is best to base the decision on whether the wrinkles that concern you are already etched in or appear with facial expressions.
Downtime and risks of Jalupro HMW
Downtime
Downtime symptoms
- Pain or tenderness at the injection site
- Redness, swelling, and itching at the injection site
- Bruising
Bruising refers to what is commonly called a "bruise." The medical mechanism is that blood vessels within the skin rupture, blood leaks out, and then clots within the skin. Whether or not bruising occurs depends on the physician's skill and the physical characteristics of the person receiving the treatment, so it is expected to occur in a few percent of cases.
In most cases, downtime symptoms disappear within a day or two (basically within 24 hours).
If bruising occurs, it gradually fades over one to two weeks.
"Will it interfere with my work or daily life after the treatment?"
"About how many days will I need to keep it hidden..."
Some people may be concerned about such things.
To put the conclusion first, the bumps that form right after the injection often settle within about 3 hours after the treatment, and are said to disappear within 48 hours at the most.
Depending on the area, bruising may occur and needle marks may be noticeable, but in most cases they can be adequately covered with concealer or the like. Makeup cannot be applied on the day of the treatment, so if it really bothers you, you may need to cover it with a mask or hat; from the next day, makeup is possible.
Areas prone to bruising include the area around the eyes and the temples, while the cheeks are where needle marks tend to be most noticeable. However, since the procedure uses extremely fine needles, even if bruising occurs, it won’t spread widely or become very dark.
It’s often mild enough to be covered with makeup, but if you’re concerned, you might feel more at ease by scheduling your day so you don’t have any plans the day after the procedure.
Risks of Jalupro
Non-cross-linked hyaluronic acids such as Jalupro are generally considered safe.
The reasons are:
- No cross-linking agents are used... avoiding allergic reactions, immune reactions, and inflammation caused by cross-linking agents
- Properties similar to the hyaluronic acid naturally present in the body... low risk of thromboembolism
In addition, the three Jalupro formulations are certified as Class 3 medical devices under the CE mark, which also indicates their high safety.
(The CE mark is an indicator that evaluates the safety of medical devices in the EU, and Class 3 indicates the highest level.)
Disadvantages of Jalupro HMW
Jalupro has no major disadvantages worth noting. The minor disadvantages are as follows.
- The effects are not permanent, so repeated treatments are needed to maintain results.
- It is not fast-acting before the effect can be felt (to put it another way, the result comes on slowly and looks natural).
- Results vary from person to person
- Temporary redness and swelling may occur after injection. These usually resolve within a few days but may affect appearance right after the treatment.
Treatment Area / Method
Jalupro HMW is injected along areas of concern such as wrinkles and nasolabial folds, or locally into sunken areas
Recommended number / frequency of treatments | Treatment schedule
- A set of 4 sessions, once every 2 to 3 weeks
- After that, maintenance about once every 6 to 9 months
Who cannot receive this treatment
In principle, the treatment can be performed unless you have some serious illness or inflammation in the area to be treated.
The following is provided as reference information, since we are obliged to include it to inform "those who are not eligible for the treatment," so please take a quick look through it.
- Those who are pregnant or breastfeeding
- Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
- Those prone to keloid formation, hypertrophic scars, or pigmentation disorders
- Those with a bleeding tendency, or those using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin
- Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Jalupro injection site
Pricing
Pricing for Jalupro HMW (manual, physician-administered)
| 3cc | Price | Per 1 cc Price |
| 1 bottle | 59,800 yen | 19,930 yen |
| 3 bottles | 173,400 yen (per session 57,800 yen) | 19,270 yen |
| 4 bottles | 227,200 yen (per session 56,800 yen) | 18,900 yen |
Market pricing
The typical price for Jalupro HMW at aesthetic clinics in the Kanto region is 60,000 to 120,000 yen per session (as of June 2026).
Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
After marking is done, we perform the injection while checking in with you as we go.
We will provide detailed instructions on how to care for the treated area and what to keep in mind in your daily life.
In addition, with a focus on prevention and maintenance, we recommend appropriate home care products—such as oral medications and skincare products—that can help alleviate your concerns.
Details
| Treatment Time | About 20 to 30 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | ・It is recommended to complete a set of four treatments, spacing them 1–2 weeks apart. ・After that, maintenance treatments are recommended approximately once every six to nine months. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | If you've had a topical anesthetic applied, the sharp, pricking pain when the needle goes in will be reduced. There isn't much pain while the medication is being injected. |
We also recommend these treatments
Besides Jalupro HMW, there are several treatments effective for neck wrinkles, nasolabial folds, hollow cheeks, and the like. For skin-nurturing injectable formulations, we have summarized brief explanations in a table so you can easily compare them with Jalupro HMW; please use it for reference.
Skin-nurturing injectable products | GOURI injection, Juvelook Volume (Lenisna), Profhilo, Sunekos 1200
Skin-nurturing injectable products similar to Jalupro include GOURI injections, Juvelook Volume (Lenisna), Profhilo, and Sunekos 1200.
| Skin-nurturing injectable products effective for neck wrinkles, nasolabial folds, hollow cheeks, and the like | |
|---|---|
| Preparation | Features |
 Jalupro HMW | A formulation containing non-crosslinked hyaluronic acid and four types of amino acids. Thanks to the combination of these amino acids, synergistic effects on skin regeneration and repair can be expected |
 GOURI | The world's first formulation containing liquid-type PCL (polycaprolactone) Liquid PCL is a liquid form of the medical sutures used in thread lifts. It is particularly effective for lifting and reducing sagging. |
 Juvelook Volume (Lenisna) | A formulation combining poly-DL-lactic acid (PDLLA) and non-crosslinked hyaluronic acid Poly-DL-lactic acid is a polymer of lactic acid derived from fermented starch, which is completely broken down into water and carbon dioxide within the body Deep wrinkles (nasolabial folds, marionette lines, glabellar lines, etc.), and sunken areas on the forehead and temples The effects last for a long time, typically 1 to 2 years |
 Profhilo | A formulation containing high concentrations of both high-molecular-weight and low-molecular-weight non-crosslinked hyaluronic acid Penetrates even deeper than the dermis, offering a volume-boosting effect originating from the subcutaneous tissue In addition to filling in wrinkles and hollows, it is expected to improve the overall texture of the skin |
 SUNEKOS 1200 | An injectable formulation containing medium-molecular-weight, non-crosslinked hyaluronic acid and six types of amino acids blended in a patented ratio Less effective for moderate to deep wrinkles Excellent for moisturizing and providing immediate results More affordable than other formulations |
*Sunekos 1200 is not offered at our clinic.
Other treatments | Hyaluronic acid, Botox, PRP therapy
Hyaluronic acid
- Cross-linked hyaluronic acid (hyaluronic acid filler) physically creates volume and fills gaps
- Because the hyaluronic acid does not diffuse, there is no skin-nurturing effect
- Fast-acting, with long-lasting effects
- If accidentally injected into a blood vessel, there is a risk of thromboembolism within the vessel
Botox
- A treatment that injects a botulinum toxin preparation to temporarily weaken muscle movement
- Used for dynamic wrinkles that appear with facial expressions, such as on the forehead and at the outer corners of the eyes (not effective for wrinkles that already exist regardless of facial expression)
PRP therapy
- A treatment in which concentrated platelets (= plasma) extracted from your own blood are injected into the skin.
- This plasma is rich in growth factors, which promote the skin's self-repair and regeneration
- Because it is made from your own blood, the risk of allergic reactions or rejection is low
- Beyond improving wrinkles and hollows, it can also be expected to improve the overall texture of the skin and to treat scars
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
Hatchobori Clinic
104-0032
2nd Floor, Tokyo NS Building, 2-29-4 Hatchobori, Chuo-ku, Tokyo
Hours: 10:00 a.m.–7:00 p.m. (Closed from 1:00 p.m. to 2:00 p.m.) / Closed: Mondays and Thursdays
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last Reviewed: August 1, 2026