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What Is a Jalupro Injection? | A Doctor Explains the 3 Types of Effects, Costs, and How to Choose
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What is a Jalupro injection?
An injectable preparation used in skin-nurturing treatments, designed to "rejuvenate the skin from within" and help "the skin itself regain firmness and elasticity."
Jalupro is an injectable preparation made mainly of non-cross-linked hyaluronic acid and amino acids. Depending on the molecular size of its main ingredient, non-cross-linked hyaluronic acid, there are three types with different compositions: "Jalupro Classic," "Jalupro HMW," and "Jalupro Super Hydro."
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
Three types of Jalupro｜Classic, HMW, and Super Hydro
Jalupro's "Classic," "HMW," and "Super Hydro" each offer different expected effects, and the appropriate preparation is chosen according to your concern.
- Jalupro Classic｜For improving fine lines and dark circles around the eyes and moisturizing the whole complexion
- Jalupro HMW｜For neck wrinkles and nasolabial folds, and to plump up hollow cheeks
- Jalupro Super Hydro (also known as the "Tightening Injection")｜For skin rejuvenation, improving sagging, and tightening
We've briefly summarized the three preparations in a table.
| Classic | HMW | Superhydro | |
| Concerns Expected Effects | Dark circles under the eyes (Blue circles, dark circles) Wrinkles at the corners of the eyes Fine lines Dry skin Want firmer, more radiant skin Want to improve these issues naturally | I want to plump up the sunken areas of my cheeks Want firmer, more radiant cheeks Wrinkles on the neck and nasolabial folds Want a facelift | Prevent Sagging Face・ cheek sagging Want a lift Neck Wrinkles and Nasolabial Folds Skin Tightening Dry Skin |
| Non-crosslinked hyaluronic acid | Low molecular weight | High molecular weight | Low and high molecular weight |
| Amino acids | 4 types Glycine L-proline L-leucine L-lysine | 4 types Glycine L-proline L-leucine L-lysine | 7 types Glycine L-proline L-leucine L-lysine Alanine Valine Arginine |
| Peptides | — | — | 3 types Acetyl decapeptide-3 Oligopeptide-24 Acetyl tetrapeptide5 |
The detailed characteristics of each of the three types are explained in the article below.
The table shows the ingredients of each preparation and the kinds of concerns each is good for. But for those who aren't sure what the main ingredient—non-cross-linked hyaluronic acid—actually is, we'd like to give a brief explanation of it.
What is non-cross-linked hyaluronic acid?
"Non-crosslinked hyaluronic acid" refers to hyaluronic acid that has not been crosslinked.
Since "crosslinking" involves bonding hyaluronic acid molecules together so they do not separate, non-crosslinked hyaluronic acid is hyaluronic acid that spreads freely within the body.
When non-cross-linked hyaluronic acid is injected into the skin, it diffuses and penetrates widely, so the hyaluronic acid reaches every corner of the skin. Because hyaluronic acid has "a strong moisturizing effect that attracts and retains water" and "the property of activating surrounding cells," the hyaluronic acid that spreads throughout the skin increases the skin's moisture and activates cells (fibroblasts), boosting firmness and elasticity.
Incidentally, promoting increased skin firmness and elasticity by activating fibroblasts—the cells that generate the various cells of the skin tissue—is called ECM remodeling treatment.
The effects of Jalupro injections
The effects of Jalupro, used in skin-nurturing treatments, arise from the synergy between the ECM remodeling effect of non-cross-linked hyaluronic acid and the skin repair and regeneration effects of the amino acids formulated alongside it.
Jalupro's formulations differ according to the molecular weight of the non-cross-linked hyaluronic acid, so here is a brief explanation of the characteristics associated with different molecular weights of non-cross-linked hyaluronic acid.
[Low-molecular-weight non-cross-linked hyaluronic acid]
Because of its small molecular weight, it diffuses widely and deeply through the gaps between cells. It can deliver the benefits of hyaluronic acid to every corner of the skin, so the entire complexion is moisturized
[High-molecular-weight non-cross-linked hyaluronic acid]
Because of its large molecular weight, it has properties such as being harder to diffuse, harder to break down, and more likely to stay at the injection site. Furthermore, the hyaluronic acid itself binds with the water it attracts and swells into a gel-like state, which adds volume to the injected area
Characteristics of Jalupro｜Skin repair and regeneration effects from amino acids
Jalupro's amino acids include glycine, L-proline, L-leucine, and L-lysine, which are essential for generating and regenerating cells and repairing damaged skin. Glycine in particular is an important amino acid from the standpoint of collagen production.
In other words, Jalupro activates fibroblasts through non-cross-linked hyaluronic acid while at the same time delivering into the skin the amino acids essential for cell generation and repair, so a synergistic skin-rejuvenation effect can be expected.
When do the effects begin to appear?｜"When will I feel the effects? Is a single session effective?"
Although there are three types of Jalupro, there is a common trend regarding when the effects become apparent.
However, since the way the effects manifest varies from person to person, please consider the following timeframes as a general guideline.
The effects of Jalupro begin to appear within a few days after injection. These effects feel like "my skin has more firmness and radiance" or "somehow my skin is in good condition."
Clear, tangible effects such as "wrinkles becoming less noticeable" or "sagging improving" are said to appear about one month after injection.
Effects can be felt even from a single treatment, but to maintain the results, regular treatments are necessary.
Duration of effect
The duration of the effect depends on the skin's response, the amount injected, and the patient's lifestyle and daily skincare, so it varies from person to person.
Below are reference durations for each preparation.
Jalupro Classic｜about 6 to 9 months
Jalupro HMW｜about 6 to 12 months
Jalupro Super Hydro｜about 6 months
Skin-nurturing injectable preparations often compared with Jalupro
Among skin-nurturing injectable preparations, Profhilo and Sunekos are often compared with Jalupro.
What is the difference between Jalupro and Profhilo?
Profhilo is an injectable preparation containing a high concentration of two types of non-cross-linked hyaluronic acid—high and low molecular weight—making it similar to Jalupro Super Hydro.
The difference between the two preparations is the presence or absence of ingredients other than non-cross-linked hyaluronic acid: Profhilo consists solely of pure hyaluronic acid.
Both formulations share the ability to act on the dermis and regenerate skin tissue through ECM remodeling. However, the two formulations differ in their fundamental approaches to achieving skin rejuvenation.
Since Profhilo is designed to target subcutaneous tissue and Jalupro Super Hydro is designed to target ligaments, the expected effects also differ.
[Profhilo]
It also acts on the subcutaneous tissue, which lies deeper than the dermal layer, aiming to add volume from the subcutaneous tissue. It is effective at naturally adding volume to the skin of the subcutaneous tissue in the face and neck.
[Jalupro Super Hydro]
It also aims to regenerate the fibrous tissue called ligaments. Ligaments are fibers that connect bone and skin; as they break or stretch with age, they cause the skin to sag. As the ligaments are regenerated, sagging skin is lifted, so it may be expected to help tighten the skin of the mid-face (care for sagging).
What is the difference between Jalupro and Sunekos?
There are two types of Sunekos—Sunekos 200 and Sunekos 1200—and Sunekos 200 is often compared to Jalupro Classic.
In conclusion, it’s safe to say that these two are similar formulations.
Sunekos 200 is a preparation combining low-molecular-weight non-cross-linked hyaluronic acid and six amino acids (glycine, L-proline, L-lysine, L-alanine, L-valine, and L-leucine) in a patented ratio.
Both products have similar ingredients, and their claimed benefits—such as “improved firmness and elasticity” and “reduction of fine lines”—overlap significantly.
There is no clear data indicating which one is superior. Since results vary from person to person, choose the one that works best for you.
Jalupro injection case photos (before/after)
Downtime and risks of Jalupro
Downtime for Jalupro
Downtime symptoms
・Pain or tenderness at the injection site
・Redness, swelling, and itching at the injection site
Bruising
Bruising refers to what is commonly known as a “bruise.” Medically speaking, it occurs when blood vessels beneath the skin rupture, causing blood to leak out and then clot beneath the skin.
Whether subcutaneous hemorrhage occurs depends on the physician’s technical skill and the patient’s physical characteristics, so it is expected to occur in a few percent of cases. (It is difficult to prevent subcutaneous hemorrhage solely through technical skill.)
Downtime symptoms mostly disappear within a day or two (basically within 48 hours)
If bruising occurs, it gradually fades over one to two weeks.
"I wonder if this treatment will get in the way of my work..."
"I wonder how many days I'll need to conceal it after this treatment..."
"I wonder how much it will affect my daily life..."
Do you have concerns or questions like these about downtime?
Our aesthetic dermatology team will explain these points so that your questions are answered without your having to ask the doctor directly at the clinic.
To get straight to the point, any unevenness after the injection will subside within about three hours following the procedure.
Depending on the treatment area, you may experience some bruising or noticeable needle marks, but in most cases, these can be easily concealed with concealer or similar products.
Since you cannot wear makeup immediately after the procedure, you’ll need to cover the area with a mask or hat if it bothers you, but you can resume wearing makeup the next day.
Areas prone to bruising include the area around the eyes and the temples, while the cheeks are where needle marks tend to be most noticeable. However, since the procedure uses extremely fine needles, even if bruising occurs, it won’t spread widely or become very dark.
It’s often mild enough to be covered with makeup, but if you’re concerned, you might feel more at ease by scheduling your day so you don’t have any plans the day after the procedure.
Risks of Jalupro
Non-cross-linked hyaluronic acids such as Jalupro are generally considered safe.
The reasons are:
- No cross-linking agents are used... avoiding allergic reactions, immune reactions, and inflammation caused by cross-linking agents
- Properties similar to the hyaluronic acid naturally present in the body... low risk of thromboembolism
Furthermore, the three Jalupro preparations are certified as Class 3 medical devices under the CE Mark, which also indicates a high level of safety. They have been marketed and used in many countries. (The CE Mark is an indicator for evaluating the safety of medical devices in the EU, and Class 3 indicates the highest level.)
Drawbacks
Jalupro has no major disadvantages worth noting. The minor disadvantages are as follows.
- The effects are not permanent, so repeated treatments are needed to maintain results.
- It is not fast-acting before the effect can be felt (to put it another way, the result comes on slowly and looks natural).
- Results vary from person to person
- Temporary redness and swelling may occur after injection. These usually resolve within a few days but may affect appearance right after the treatment.
- Some preparations are more expensive than others.
Treatment Area / Method
- Classic・・・・・Injected broadly into areas of concern
- HMW・・・・・・・・Injected along areas of concern such as wrinkles and nasolabial folds
- Super Hydro・・Recommended injection points
Recommended number / frequency of treatments | Treatment schedule
[Classic / HMW]
- A set of 4 sessions, once every 2 to 3 weeks
- After that, maintenance about once every 6 to 9 months
[Super Hydro]
- 3 sessions at intervals of about 1 month
- After that, leave 6-month intervals and have maintenance whenever you feel the need
Characteristics of Jalupro at Smart Skin Clinic｜Our "commitment" to injectable preparations
Who cannot receive this treatment
In principle, the treatment can be performed unless you have some serious illness or inflammation in the area to be treated.
The following is provided as reference information, since we are obliged to include it to inform "those who are not eligible for the treatment," so please take a quick look through it.
Those who are pregnant or breastfeeding
Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders
Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin
・Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Jalupro injection site
Pricing
Pricing for Jalupro Super Hydro (manual, physician-administered)
| Sessions (2.5 cc) | Through August 31Discount price | Per 1 cc Price |
|---|---|---|
| Once | 49,800 yen | 23,900 yen |
| 2 sessions | 95,600 yen (47,800 yen per session) | ¥19,120 |
| 3 times | 137,400 yen (¥45,800 per session) | ¥18,320 |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Hatchobori Clinic Exclusive PriceAn additional 20%OFF off the discounted price
| Sessions (2.5 cc) | Through August 31 Hatchobori Clinic Exclusive Price | Per 1 cc Price |
|---|---|---|
| Once | 49,800 yen 39,840 yen | 15,936 yen |
| 2 sessions | 95,600 yen 76,480 yen(38,240 yen per session) | 15,296 yen |
| 3 times | 137,400 yen 109,920 yen(36,640 yen per session) | 14,656 yen |
*All prices include tax.
*We offer self-pay (non-insured) treatments only; insurance does not apply.
*Limited to treatments at the Hatchobori Clinic
Pricing for Jalupro Classic (manual, physician-administered)
| 3cc | Price | Per 1 cc Price |
| 1 bottle | 39,800 yen | 13,270 yen |
| 4 bottles | 139,200 yen (34,800 yen per session) | 11,600 yen |
Pricing for Jalupro HMW (manual, physician-administered)
| 3cc | Price | Per 1 cc Price |
| 1 bottle | 59,800 yen | 19,930 yen |
| 3 bottles | 173,400 yen (per session 57,800 yen) | 19,270 yen |
| 4 bottles | 227,200 yen (per session 56,800 yen) | 18,900 yen |
Pricing for Jalupro Young Eye (manual, physician-administered)
| 1 dose (1 cc) | 39,000 yen |
| 3 times | ¥105,000 (¥35,000 per session) |
Water Light Injection (mechanical)
JALUPRO (Classic)
| 3cc | Price | Per 1 cc Price |
|---|---|---|
| Once | 29,800 yen | ¥9,933 |
| 4 sessions | 107,200 yen (¥26,800 per session) | ¥8,933 |
| 6cc | Price | Per 1 cc Price |
|---|---|---|
| Once | 47,880 yen | 7,980 yen |
| 4 sessions | 179,520 yen (per session44,¥880) | 7,480 yen |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Market pricing
The typical price range for Jalupro at aesthetic clinics in the Kanto region is as follows (*surveyed February 2024).
| Classic | Per session: 40,000–80,000 yen; 4 sessions: 130,000–160,000 yen |
| HMW | Per session: 70,000–150,000 yen |
| Superhydro | Per session: 100,000–160,000 yen; 2 sessions: 170,000–300,000 yen |
Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
After marking is done, we perform the injection while checking in with you as we go.
We will provide detailed instructions on how to care for the treated area and what to keep in mind in your daily life.
In addition, with a focus on prevention and maintenance, we recommend appropriate home care products—such as oral medications and skincare products—that can help alleviate your concerns.
Details
| Treatment Time | About 20 to 30 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | [Classic/HMW] ・It is recommended to complete a set of four treatments, spacing them 1–2 weeks apart. ・After that, maintenance treatments are recommended approximately once every six to nine months. 【Super Hydro】 ・It is recommended to complete a set of two sessions with a two-week interval between them. ・After that, maintenance is recommended approximately once every six to nine months. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | If you've had a topical anesthetic applied, the sharp, pricking pain when the needle goes in will be reduced. There isn't much pain while the medication is being injected. |
We also recommend these treatments
At Smart Skin Clinic, we focus on skin-conditioning injectable treatments. We currently offer 11 formulations, so we can suggest a treatment suited to your concerns and budget.
If you are not sure which treatment is right for you, please feel free to come in just for a consultation first.
We have briefly summarized the characteristics of the other injectable formulations, so please take a look if you are interested.
Skin-nurturing injectable preparations other than Jalupro (Profhilo, Sunekos, Rejuran, Juvelook, Gouri injection)
To share our conclusion first:
[For moisturizing and improving the radiance of the whole complexion, and overall rejuvenation]
Juvelook, Profhilo, Jalupro Super Hydro
[Improving sagging]
Gouri, Juvelook Volume (Lenisna), Jalupro Super Hydro, Profhilo
[Improving deep wrinkles and nasolabial folds]
Gouri, Juvelook Volume (Lenisna), Jalupro HMW
[Improving concerns around the eyes (fine lines, sagging, firmness)]
Sunekos, Rejuran i, Jalupro Classic
[Improving post-acne marks and depressed scars]
Juvelook, Rejuran, Rejuran HB
If you would like more details on each injectable formulation, please read the articles below.
- Sunekos: https://smartskin-clinic.com/menu/injection-infusion/sunekos/
- Juvelook: https://smartskin-clinic.com/menu/injection-infusion/juvelook/
- Gouri injection: https://smartskin-clinic.com/campaign_gouri/
- Profhilo: https://smartskin-clinic.com/menu/injection-infusion/profhilo/#index_id14
- Rejuran: https://smartskin-clinic.com/menu/injection-infusion/rejuran/
For those concerned about sagging, laser-based or surgical procedures (HIFU, thread lift)
Laser-based and surgical procedures are effective at improving sagging. They take a different approach from Jalupro Super Hydro, aiming to tighten and lift the skin.
With surgical procedures as well, results vary from person to person. And to maintain the sagging-improvement effect, these treatments too need to be continued.
*We do not offer HIFU at our clinic.
Frequently asked questions about Jalupro
Q: How long does the treatment take?
A:Excluding counseling, the treatment takes about 20 to 30 minutes.
Q: Can it be done under the eyes?
A:Jalupro Classic can be injected around the eyes, while HMW and Super Hydro are injected according to their recommended injection points. Even if it cannot be injected directly under the eyes, the drug diffuses and penetrates, so the effect can still be felt.
Q: Can I wear makeup after the treatment?
A:Makeup can be worn right after the treatment.
Q: How long does it take for the unevenness (bumps) at the injection site to disappear?
A:After the Classic treatment, uneven bumps appear at the treated area. If a large area is treated, the unevenness may be noticeable right after the injection, but it penetrates deeper and becomes less noticeable within a few hours.
The rate of penetration varies from person to person depending on constitution and metabolism, but if the treatment is done in the morning, the bumps are often no longer noticeable by evening, and they are said to be absorbed within 24 hours.
Q: How often should I have Jalupro injections? Maintenance after the second session
A:The interval between treatments differs between Classic/HMW and Super Hydro.
[Classic / HMW]
From the second session onward, after a total of 4 treatments once every 1 to 2 weeks, maintenance is performed about once every 6 to 9 months.
[Super Hydro]
From the second session onward, after a total of 3 treatments once a month, maintenance is performed about once every 6 months.
Q: Which Jalupro is best if I want treatment on my neck?
A:The recommended preparation differs depending on your reason (concern) for wanting neck treatment.
For existing wrinkles, HMW or Super Hydro is recommended; for small, crepe-like fine lines or for preventive purposes, Classic is said to be effective.
Q: Is there pain during injection? Can I have anesthesia?
A:Although it varies from person to person, you may feel some pain when the needle is inserted and when the medication is injected.
However, at our clinic, we take measures to minimize pain, such as using needles that are thinner than standard ones for the injection. If you consult with us in advance, we can also use anesthesia to reduce the pain.
Q: Can Jalupro be done as a Water Light Injection?
A:Jalupro Classic can be performed as a Water Light Injection.
Legal Notices
Jalupro treatment involves the use of drugs or medical devices not approved in Japan. The drugs and devices used in the treatment are personally imported under the judgment of our clinic's physicians.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Related Pages
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
Hatchobori Clinic
104-0032
2nd Floor, Tokyo NS Building, 2-29-4 Hatchobori, Chuo-ku, Tokyo
Hours: 10:00 a.m.–7:00 p.m. (Closed from 1:00 p.m. to 2:00 p.m.) / Closed: Mondays and Thursdays
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last Reviewed: August 1, 2026