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What Is a Juvelook Injection? | A Doctor Explains the Effects, Cost, and Number of Sessions
*Number of cases | For the period from December 1, 2023 to September 1, 2024
1st time: 10% discount
10% Discount
[Through August 31] Limited-time discount available!
▼ Tap to select a treatment method
| Injection volume | Single-session fee | Fee for a set of 3 sessions |
|---|---|---|
| 3cc |
|
|
| 4cc |
|
|
| 6cc |
|
|
✓ Want to improve the evenness of the skin texture across the whole face
✓ Want to minimize downtime
✓ Want to finish the treatment quickly
| Injection volume | Single-session fee | Fee for a set of 3 sessions |
|---|---|---|
| 3cc |
|
|
| 4cc |
|
|
| 6cc |
|
|
✓ Want focused care for specific concerns, such as acne-scar hollows or fine lines under the eyes
✓ Want the physician to tailor the injection while assessing the skin condition
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Hatchobori Clinic Exclusive PriceAn additional 20%OFF off the discounted price
Vital injctor Treatment
| Injection volume | Once Hatchobori Clinic Exclusive Price | 3 sets Hatchobori Clinic Exclusive Price |
|---|---|---|
| 3cc | 33,120 yen 26,496 yen | 61,401 yen(6,822 yen per cc) |
| 4cc | 40,482 yen 32,385 yen | 76,416 yen(6,368 yen per cc) |
| 6cc | 49,482 yen 39,585 yen | 93,849 yen(5,213 yen per cc) |
Physician hand-administered treatment
| Injection volume | Once Hatchobori Clinic Exclusive Price | 3 sets Hatchobori Clinic Exclusive Price |
|---|---|---|
| 3cc | ¥46,620 37,296 yen | 90,201 yen(10,022 yen per cc) |
| 4cc | ¥58,320 46,656 yen | 115,084 yen(9,590 yen per cc) |
| 6cc | ¥84,420 67,536 yen | 170,841 yen(9,491 yen per cc) |
*All prices include tax.
*We offer self-pay (non-insured) treatments only; insurance does not apply.
*Limited to treatments at the Hatchobori Clinic
Water Light Injection add-on medication campaign now on
Those receiving a Water Light Injection are eligible for the following two options:
1. High-concentration vitamin C or glutathione can be added for +1,000 yen per session (regular standalone price: 21,800 yen)
2. Skin Botox can be added for +2,000 yen/session (regular standalone price 23,800 yen)
3. addition of Rejuran generic (Chiara Reju) is available at +9,800 yen/(1cc)
Juvelook, a skin booster formulation that became hugely popular in South Korea starting in 2023, has seen an increasing number of clinics in Japan begin offering it since the second half of 2023. Smart Skin Clinic, a cosmetic dermatology clinic with over 24,000 annual injection procedures, provides a detailed explanation of this popular treatment. We’ve also included information on our clinic’s pricing, so please check it out if you’re interested in the treatment.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
Juvelook Case Photos (Before/After)
Treatment Name Juvelook Injection: Before: Before treatment; After: After 3 treatment sessions
Treatment Details The Juvelook Injection is a treatment that involves directly injecting moisturizing ingredients into the dermis to improve skin elasticity and firmness. It is also expected to be effective in improving acne scars (craters), fine lines, and dry skin, leading to a healthy and dewy complexion overall. It promotes collagen production and aims to provide comprehensive skin care.
Treatment Duration and Number of Sessions Typically, one course consists of 3 sessions spaced one month apart.
Major Risks and Side Effects Temporary redness, swelling, or bruising may occur after the injection, but these usually subside within a few days. You may experience mild pain or discomfort at the treatment site, but this can be alleviated with proper care. In rare cases, an allergic reaction may occur, and results may vary from person to person.
Treatment Price 31,980–79,980 yen (per session) *The price range varies depending on the treatment method (manual injection by a physician or hydrafacial) and dosage, as there are multiple plans available.
Acne scars (craters)
Treatment Name Juvelook Injection: Before: Before treatment; After: After 3 treatment sessions
Treatment Details The Juvelook Injection is a treatment that involves directly injecting moisturizing ingredients into the dermis to improve skin elasticity and firmness. It is also expected to be effective in improving acne scars (craters), fine lines, and dry skin, leading to a healthy and dewy complexion overall. It promotes collagen production and aims to provide comprehensive skin care.
Treatment Duration and Number of Sessions Typically, one course consists of 3 sessions spaced one month apart.
Major Risks and Side Effects Temporary redness, swelling, or bruising may occur after the injection, but these usually subside within a few days. You may experience mild pain or discomfort at the treatment site, but this can be alleviated with proper care. In rare cases, an allergic reaction may occur, and results may vary from person to person.
Treatment Price 31,980–79,980 yen (per session) *The price range varies depending on the treatment method (manual injection by a physician or hydrafacial) and dosage, as there are multiple plans available.
(Source)Juvelook Official
What Is Juvelook?
Juvelook is an injectable formulation that combines non-crosslinked hyaluronic acid with “poly-DL-lactic acid (PDLLA)” , and is classified as a “skin booster.”
After injection, it is slowly absorbed by the body over the course of 1 to 2 years. During this time, it stimulates fibroblasts to naturally increase collagen and elastin production, resulting in long-lasting effects.
Because it is made from lactic acid, a substance that also occurs naturally in the human body, it is unlikely to trigger allergies and offers a high level of safety.
In English, Juvelook is spelled "JUVELOOK."
It is a coined word combining JUVE (youth, vitality, energy) and LOOK (appearance, expression).
It is also a highly safe formulation that has been approved by the U.S. Food and Drug Administration (FDA) —the agency equivalent to Japan’s Ministry of Health, Labor and Welfare—and the Korea Food and Drug Administration (KFDA) .
A skin booster originating in South Korea and certified by the KFDA
Juvelook won an award in Korea's consumer skin booster category for two consecutive years (2022, 2023).
A total of 41 brands, including Starbucks, Terra, and Jubelk, were selected for the 2023 Korea Consumer Award (Korea Consumer Award, 2023).
Juvelook is gaining attention as the next-generation skin booster from Rejuran. In South Korea, more than 400,000 people have already received the treatment. (As of December 2023)
Types of Juvelook
It is not widely known, but there are actually two types of Juvelook, as follows.
- Juvelook
- Juvelook Volume = Lenisna
Since Juvelook (No. 1) is the more familiar one, you can assume that "Juvelook" refers to No. 1.
Juvelook Volume (No. 2) is often called "Lenisna" in Japan, whereas in Korea it is more commonly called "Juvelook Volume."
The Difference Between Juvelook and Juvelook Volume (Lenisna)
- What is the difference between the two?
Dr. IshiiConcentration and particle size. These change the way volume is produced. As its name suggests, Juvelook Volume (Lenisna) excels at adding volume, making it well suited to deep folds such as the nasolabial folds.
Click here for more information on Juvelook Volume (Lenisna).
The Four Features of Juvelook
1. Long-lasting effect
Poly-DL-lactic acid (PDLLA) continuously stimulates the fibroblasts within the skin, which in turn promotes collagen production. After injection, it is slowly broken down into water and carbon dioxide within the skin over one to two years. For this reason, unlike conventional hyaluronic acid formulations, Juvelook is a formulation that nurtures the skin over an extended period.
The official Juvelook YouTube video below explains how Juvelook works. (*The video is in English.)
2. Fewer side effects
Juvelook uses a drug called poly-DL-lactic acid (PDLLA). Poly-lactic acid formulations in the same category as Juvelook include Sculptra and Maccume.
Sculptra had angular, pointed particles that strongly irritated surrounding cells and carried a risk of causing subcutaneous lumps.
Maccume is a delivery agent for Potenza. It greatly reduced the risk of the subcutaneous lumps that tended to occur with Sculptra. However, because it is not approved by the Korea Food and Drug Administration (KFDA), it cannot be injected directly into the skin.
Unlike Sculptra and Maccume, Juvelook is made so that its particles are round in shape. As a result, there is virtually no risk of forming subcutaneous lumps. It has also been approved by the Korea Food and Drug Administration (KFDA) and the U.S. FDA.
3. Customized treatment possible with localized injection
Juvelook can be injected not only across the whole area but also into localized spots. This makes it possible to address not only the entire face but also localized concerns. For example, it can address the following localized areas.
- Acne scars and scar indentations
- Fine lines and sagging under the eyes
- Pores on the nose
4. Extensive medical data
Juvelook is widely used in Korea, and many research papers on its efficacy and safety have been published.
As one example, the following paper discusses the efficacy of PDLA (approximately equivalent to Juvelook) for acne scars.
Intradermal injection of PDLA may be used as an effective treatment with fewer side effects in patients with acne scars of Fitzpatrick skin types III-IV.
Hyeong JH et al. (2022). Intradermal Injection of Poly-D, L-Lactic Acid Using
Microneedle Fractional Radiofrequency for Acne Scars: An Open-Label Prospective Trial, DERMATOLOGIC SURGERY December 2022, Volume 48-12
Recommended for
- Those who have not achieved satisfactory results with laser treatment
- Those concerned about uneven acne scars
- Those concerned about fine lines under the eyes
- Those who want to improve skin firmness and elasticity
- Those who want to refine the appearance of open pores
- Those who want to improve their skin quality
- Those concerned about wrinkles on the neck
Effect
Through the dual action of poly-DL-lactic acid (PDLLA) and non-cross-linked hyaluronic acid, it improves skin quality from within, helping guide the skin toward a firm, radiant condition.
- Improvement of skin quality
- Enhanced firmness and radiance
- Improvement of fine lines
- Pore reduction
- Scar improvement
- Improvement of acne scars (pigmentation and craters)
PDLLA produces collagen continuously over one to two years, so long-term effects can also be expected.
When PDLLA is injected into the dermis deep within the skin, it is gradually broken down and absorbed into water and CO2 over about one to two years. During this time, it stimulates the fibroblasts in the dermis and activates the production of collagen and elastin.
Similarly, non-cross-linked hyaluronic acid also activates collagen and elastin production within the dermis by stimulating fibroblasts.
TreatmentArea
There are two main treatment approaches.
1. Full face
With full-face injection, the product is injected broadly across the entire face, the whole forehead, the whole cheeks, and so on. Effects such as pore treatment and improved skin quality can be expected.
2. Localized
Injections are placed precisely into the frown lines, fine lines around the eyes, acne scars, and similar areas. This is the recommended approach when there are specific areas of concern.
Which layer is it injected into?
Injectable formulations vary in both their ingredients and intended purposes.
Therefore, it is extremely important to administer each formulation at the appropriate “depth” and “volume” to ensure optimal results.
With Juvelook, the main injection layer is "from the middle to the deep layers of the dermis."
The skin is structured in layers, starting from the surface: the "epidermis," the "dermis" (comprising the superficial, middle, and deep layers), the "subcutaneous fat layer," and the "muscle layer," each of which plays a distinct role. The middle to deep layers of the dermis provide structural support for the skin and play a key role in its firmness and elasticity.
The middle to deep layers of the dermis are where Juvelook's ingredients and intended effects are most effective, and this is the medical rationale behind our clinic's decision to inject this formulation into this specific area.
Treatment Method
There are three main ways to inject Juvelook.
- Manual injection by a physician
- Water Light Injection (mechanical)
- Potenza
1. Manual injection by a physician
The physician checks the condition of the skin and injects at the appropriate depth and dosage for each area. The injection is performed using a syringe.
2. Water Light Injection (mechanical injection)
The term "Water Light Injection" is sometimes used as the name of a drug or formulation, but more often it is used as the name of a "machine."
Once the drug is loaded into the Water Light Injection machine and the injection depth and dosage per injection are set on the machine, it can keep injecting at a fixed depth and dosage. With Water Light Injection, a nurse performs the procedure.
3. Potenza
Potenza is a type of treatment device known as microneedle RF. It is sometimes called an advanced version of the Dermapen.
After ultra-fine needles are inserted, RF waves (radio waves) are emitted from the tips of the needles. This creates channels in the skin, into which the formulation (Juvelook) is delivered through what is known as a drug delivery system.
Benefits/Drawbacks
Benefits
One advantage of Juvelook is that, in addition to a variety of skin-improving effects such as firmness, radiance, and crater improvement, the action of PDLLA can provide long-term skin-quality improvement over one to two years.
Drawbacks
Juvelook has no major disadvantages, but the article below explains the finer disadvantages in detail.
Who cannot receive this treatment
Those who are pregnant or breastfeeding
Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
Those prone to keloid formation, hypertrophic scarring, or pigmentation disorders
Those with a bleeding tendency, or those taking non-steroidal anti-inflammatory drugs such as aspirin or anticoagulants such as warfarin
- Those who have excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Juvelook injection site
Risks and Side Effects
At the needle puncture site:
Redness, swelling, pain, edema
Bruising
Temporary raised bumps
Downtime
Redness and raised bumps may occur at the injection site, but in most cases they return to normal in about 24 hours.
Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, though not always. If bruising occurs, it gradually fades over 10 to 14 days.
Pricing
1st time: 10% discount
10% Discount
Water Light Injection add-on medication campaign now on
Those receiving a Water Light Injection are eligible for the following two options:
1. High-concentration vitamin C or glutathione can be added for +1,000 yen per session (regular standalone price: 21,800 yen)
2. Skin Botox can be added for +2,000 yen/session (regular standalone price 23,800 yen)
3. addition of Rejuran generic (Chiara Reju) is available at +9,800 yen/(1cc)
Our cc breakdown of JuvelookOfficial dissolution method of Juvelook.
This information is provided because we often receive inquiries about it.
Our "cc notation" for Juvelook is the cc notation for Juvelook created using the official dissolution method of the Juvelook formulation.
What this means is that the drug Juvelook is not used as-is, but is usually dissolved in saline in the proportions prescribed by Juvelook, then mixed thoroughly, and then the dissolved Juvelook is used.
[Through August 31] Limited-time discount available!
▼ Tap to select a treatment method
| Injection volume | Single-session fee | Fee for a set of 3 sessions |
|---|---|---|
| 3cc |
|
|
| 4cc |
|
|
| 6cc |
|
|
✓ Want to improve the evenness of the skin texture across the whole face
✓ Want to minimize downtime
✓ Want to finish the treatment quickly
| Injection volume | Single-session fee | Fee for a set of 3 sessions |
|---|---|---|
| 3cc |
|
|
| 4cc |
|
|
| 6cc |
|
|
✓ Want focused care for specific concerns, such as acne-scar hollows or fine lines under the eyes
✓ Want the physician to tailor the injection while assessing the skin condition
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Hatchobori Clinic Exclusive PriceAn additional 20%OFF off the discounted price
Vital injctor Treatment
| Injection volume | Once Hatchobori Clinic Exclusive Price | 3 sets Hatchobori Clinic Exclusive Price |
|---|---|---|
| 3cc | 33,120 yen 26,496 yen | 61,401 yen(6,822 yen per cc) |
| 4cc | 40,482 yen 32,385 yen | 76,416 yen(6,368 yen per cc) |
| 6cc | 49,482 yen 39,585 yen | 93,849 yen(5,213 yen per cc) |
Physician hand-administered treatment
| Injection volume | Once Hatchobori Clinic Exclusive Price | 3 sets Hatchobori Clinic Exclusive Price |
|---|---|---|
| 3cc | ¥46,620 37,296 yen | 90,201 yen(10,022 yen per cc) |
| 4cc | ¥58,320 46,656 yen | 115,084 yen(9,590 yen per cc) |
| 6cc | ¥84,420 67,536 yen | 170,841 yen(9,491 yen per cc) |
*All prices include tax.
*We offer self-pay (non-insured) treatments only; insurance does not apply.
*Limited to treatments at the Hatchobori Clinic
[Reference] How to Choose the Dosage (cc)
- For easier comparison with other clinics' listings, we also offer a "3cc" option.
- That said, for the whole face (full face), 3cc does not provide sufficient "density," so if you are seeking the maximum effect, we suggest using the following as a guide when choosing.
- [Pattern 1] Lighter treatment is fine for the forehead and the area below the nose ⇒ 3cc
- [Pattern 2] The area below the nose can be a little lighter, but I want thorough treatment above the nose ⇒ 4cc
- [Pattern 3] I want thorough treatment across the whole face, including below the nose ⇒ 6cc
- If you are unsure, the physician will confirm your wishes on the day and suggest the optimal volume (please rest assured that we never upsell unnecessarily).
For those worried that "cheap prices mean it's diluted or fake"
In conclusion, at Smart Skin Clinic, we provide genuine Juvelook at the standard concentration and using the standard administration method.
However, we understand that some of you may feel uneasy, thinking, “It’s so cheap, it’s actually scary…,” “Could they be diluting it with water…?” or “Are they using a counterfeit product…?”
To alleviate your concerns, we would like to explain our clinic’s approach and the characteristics of the Juvelook medication.
Juvelook is a "powder" product
Unlike drugs such as Profhilo and Sunekos, Juvelook comes in a box as a "powder" rather than a liquid. (See the image below.)
Because it is a powder, the following points are essential.
- It must be mixed with saline solution to dissolve it (there is a proper reconstitution method specified by the Juvelook manufacturer).
- After dissolving, it must be "stirred" (mixed thoroughly). If it is not mixed thoroughly, the effect may be uneven, or the ingredients may become unevenly distributed, creating a risk of lumps.
"Stirring" is the key point
At our clinic, we use a genuine Juvelook (JUVELOOK) mixer to stir the formulation thoroughly, as shown below.
The reason for our prices is "waste reduction and greater efficiency."
The reason our clinic is able to keep prices low is not because “we’re diluting the contents” nor because “we’re using counterfeit products”.
It is because, guided by our management and operational philosophy of “Making aesthetic medicine more accessible and smarter,” we thoroughly eliminate waste and maximize operational efficiency.
We maintain rigorous quality control over all processes related to our formulations.
Cocktail Water Light Injection with Rejuran
A cocktail injection blending the Rejuran-generic products "Kiarareju" and "Juvelook."
We offer two versions—one with more Rejuran and one with more Juvelook—so you can choose the one that best suits your concerns.
・Rejuran-heavy cocktail: 4.4 cc Kiarareju + 1.6 cc Juvelook
・Juvelook-heavy cocktail: 2.2 cc Kiarareju + 3.8 cc Juvelook
| Rejuran-heavy cocktail [6cc] | Limited discount price (Through August 31) |
|---|---|
| Once (10% off) | 44,800 yen |
| 3 times (20% off) | 119,520 yen (Per session 39,840 yen) |
| Juvelook-heavy cocktail [6cc] | Limited discount price (Through August 31) |
|---|---|
| Once (10% off) | 49,300 yen |
| 3 times (20% off) | 125,700 yen (Per session 41,900 yen) |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Hatchobori Clinic Exclusive PriceAn additional 10%OFF off the discounted price
Rejuran-heavy cocktail [6cc]
| Sessions | Through August 31 Hatchobori Clinic Exclusive Price |
|---|---|
| Once | 44,800 yen 40,320 yen |
| 3 times | 119,520 yen 107,568 yen(35,856 yen per session) |
Juvelook-heavy cocktail [6cc]
| Sessions | Through August 31 Hatchobori Clinic Exclusive Price |
|---|---|
| Once | 49,300 yen 44,370 yen |
| 3 times | 125,700 yen 113,130 yen(37,710 yen per session) |
*All prices include tax.
*We offer self-pay (non-insured) treatments only; insurance does not apply.
*Limited to treatments at the Hatchobori Clinic
FAQ
- When will I see results?
- Dr. Ishii
You’ll often start to notice results in 2 to 3 weeks.
You can see results even after just one session, but you’re more likely to notice significant changes after completing a set of three sessions.
We also recommend the following effective approach:
・Undergo a set of three sessions at one-month intervals, followed by maintenance treatments every six months to one year.
*Thanks to Juvelook, collagen production continues over time, ensuring that the effects last for a long period. - Is it safe?
- Dr. Ishii
Juvelook is approved by the U.S. FDA and Korea's KFDA and can be considered highly safe.
- How is it different from hyaluronic acid treatment?
- Dr. Ishii
Hyaluronic acid treatment injects cross-linked hyaluronic acid, a firmer form of hyaluronic acid, which physically adds volume to improve wrinkles and similar concerns. Juvelook, on the other hand, achieves a natural increase in volume by boosting the collagen your own body produces.
Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
After marking is done, we perform the injection while checking in with you as we go.
We will provide detailed instructions on how to care for the treated area and what to keep in mind in your daily life.
In addition, with a focus on prevention and maintenance, we recommend appropriate home care products—such as oral medications and skincare products—that can help alleviate your concerns.
Details
| Treatment Time | About 30 to 40 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | - It is recommended to perform a set of three sessions at one-month intervals. - After that, maintenance is recommended about once every six months to one year. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | A slight pricking sensation when the needle is inserted. |
Legal Notices
Juvelook treatment includes procedures using drugs or medical devices that are not approved in Japan. The drugs and devices used in treatment have been imported through personal importation at the discretion of our physicians.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Related Pages
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
Hatchobori Clinic
104-0032
2nd Floor, Tokyo NS Building, 2-29-4 Hatchobori, Chuo-ku, Tokyo
Hours: 10:00 a.m.–7:00 p.m. (Closed from 1:00 p.m. to 2:00 p.m.) / Closed: Mondays and Thursdays
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last Reviewed: August 1, 2026