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NMN infusion therapy｜Smart Skin Clinic
Treatment Flow
You can easily book from your smartphone.
Check-in is smart and simple—just give us your name.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
Please rest assured that the IV drip is administered in the same way as any standard IV.
We will provide detailed instructions on how to care for the treated area and what to keep in mind in your daily life.
In addition, with a focus on prevention and maintenance, we recommend appropriate home care products—such as oral medications and skincare products—that can help alleviate your concerns.
This introductory price cannot be combined with other campaigns.
FAQ
- Is a single session effective?
Dr. IshiiResults vary from person to person, but even a single session can be effective. That said, NMN IV drip therapy tends to deliver more noticeable results when continued over time. We suggest a session once every 2 to 4 weeks, continued for about 3 to 6 months.
- Is the NMN IV drip safe?
- Dr. Ishii
NMN is one of the substances the body produces naturally, and to date there have been no reports of major side effects from IV drips.
- I am taking NMN supplements—can I still receive the IV drip?
- Dr. Ishii
Yes, this is generally possible. Let's determine the dosage, frequency, and other details in consultation with your physician.
Who cannot receive this treatment
- Allergy to NMN
- Those currently affected by an infectious disease or in an immunosuppressed state
- Those who are pregnant or breastfeeding
- Those with a blood disorder such as a coagulation abnormality, or who are taking anticoagulants
- Those with an autoimmune disease or a condition related to the immune system
- (Caution required) Those who have not had a recent medical checkup, or whose state of health is unclear
- Those with allergic conditions
Risks and Side Effects
No risks or side effects specific to NMN IV drips have been reported.
However, the risks and side effects that can occur with IV drip treatments in general, as described below, may apply.
- In rare cases, an anaphylactic reaction (an acute allergic reaction) may occur
- Pain at the puncture site, bruising, and nerve irritation
- Other symptoms such as headache or nausea
Safety Information
At present, no serious side effects have been reported.
The following information is available.
A research group led by Professor Yutaka Ito, together with a team at the University of Washington in the United States, was the first in the world to show that NMN can be safely administered to healthy humans.
In Japan, a group at Keio University Hospital conducted the following clinical trial and concluded that NMN can be safely administered to humans.
Ten healthy men aged 40 to 60 took 100–500 mg of NMN three times in total, at an average interval of two months. There were no changes in blood pressure or pulse, and tests of liver and kidney function showed no abnormalities.
"World's First: Anti-Aging Candidate NMN Shown to Be Safely Administrable to Humans" (Keio University School of Medicine)
Safety in a human clinical trial of intravenous administration of 300 mg of NMN was confirmed at Hyogo Medical University.
Intravenous administration of NMN did not affect electrocardiogram, pulse rate, or blood pressure, nor did it affect metabolic markers in the liver, heart, pancreas, or kidneys. These results indicate that intravenous administration of NMN is safe and beneficial in humans.
Kimura S, et al. Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals. Cureus. 2022 Sep; 14(9): e28812. doi:10.7759/cureus.28812
Recommended Number & Frequency of Treatments
For anti-aging purposes, it is recommended to continue treatment at intervals of about 2 to 4 weeks.
When do the effects appear?
Effects may be expected from a single session, but since anti-aging involves multiple factors such as skin, muscle, and stamina, how quickly effects are felt inevitably varies from person to person.
Short-term effects include relief from insomnia, reduced fatigue, and a clearer head, which can often be felt on the same day or the following day.
Details
| Treatment Time | 15–30 min. |
| Recommended Number & Frequency of Treatments | At least 5 sessions at intervals of about 2 to 4 weeks |
| Downtime | Almost none |
| Treatment on the day of counseling | Available |
| Pain | The slight prick of the needle felt during a standard injection or IV |
Legal Notices and Precautions
The NMN used in this treatment is an unapproved drug and is therefore an unapproved treatment under the Pharmaceuticals and Medical Devices Act. However, in Japan, physicians are permitted to use unapproved drugs under their own responsibility.
Related Pages
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last supervision date: June 26, 2025