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What Is Jalpro Classic? | A Doctor Explains Its Effects, Costs, and Downtime
"I'm curious about Jalupro Classic—what kind of treatment is it?"
"I wonder how much Jalupro Classic costs. There are so many clinics, so I'd like to compare a few before deciding."
Combining non-cross-linked hyaluronic acid with amino acids, Jalupro Classic penetrates deeply into the skin and is designed to help restore firmness and elasticity from within.
Cost-effective and easy to start thanks to minimal downtime and low risk, this injectable formulation meets a wide range of needs—from women in their 20s and 30s considering cosmetic treatment for the first time, to women in their 40s and beyond seeking natural anti-aging.
In this article, the cosmetic dermatology team at Smart Skin Clinic explains, from a professional perspective and in easy-to-understand terms, how Jalupro Classic helps restore youthful-looking skin, along with its mechanism and effects. If you are interested, we invite you to read on.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What is Jalupro｜A skin-conditioning injectable formulation of hyaluronic acid and amino acids
Jalupro is an injectable formulation composed of non-cross-linked hyaluronic acid and amino acids. It is designed to help restore natural firmness and elasticity to the skin, and for this reason it is referred to as a "skin-conditioning" formulation.
Jalupro comes in three series—Classic, HMW, and Super Hydro—each designed to address different skin concerns and needs.
If you would like an overview of the three Jalupro series and how they differ, please see this page.
The "Classic" formulation introduced in this article is the most fundamental in the Jalupro series and is considered well suited to everyday beauty maintenance.
What is Jalupro Classic｜For improving fine lines and dark circles around the eyes and hydrating the skin overall
Effects of Jalupro Classic
The effects of Jalupro Classic combine the "skin-conditioning" benefits common to the whole series with the effects of Classic's distinctive "low-molecular-weight non-cross-linked hyaluronic acid."
[What is the "skin-conditioning" effect shared across the Jalupro series?]
It is the synergy between the ECM remodeling effect of non-cross-linked hyaluronic acid and the skin repair and regeneration effect of the amino acids blended with it.
First, the ECM remodeling effect refers to how non-cross-linked hyaluronic acid, penetrating into the dermal layer, activates fibroblasts—helping to repair damaged tissue and generate new cells. Put simply, non-cross-linked hyaluronic acid promotes the production of collagen, elastin, and hyaluronic acid in the dermal layer, helping the skin regain elasticity and firmness for a healthier appearance.
Next, the skin repair and regeneration effect of the amino acids refers to the action of the four amino acids in the formulation (glycine, L-proline, L-leucine, and L-lysine).
These amino acids are essential to the generation and regeneration of cells and to repairing damaged skin, and glycine in particular is an important amino acid from the standpoint of collagen production.
In other words, Jalupro activates fibroblasts through non-cross-linked hyaluronic acid while at the same time delivering into the skin the amino acids essential for cell generation and repair, so a synergistic skin-rejuvenation effect can be expected.
[Effects of "low-molecular-weight non-cross-linked hyaluronic acid"]
First, the difference between the three Jalupro series lies in the molecular weight of the non-cross-linked hyaluronic acid that is the main ingredient of each.
Because the main ingredient of Classic is low-molecular-weight non-cross-linked hyaluronic acid, its distinctive effects can be understood as those brought about by low-molecular-weight non-cross-linked hyaluronic acid.
To begin with, non-cross-linked hyaluronic acid—like the hyaluronic acid naturally present in the body—is not bound to other hyaluronic acid molecules, which makes it easy to spread. In addition, its small molecular weight allows it to diffuse widely and deeply in multiple directions through the gaps between cells. This means the benefits of hyaluronic acid can be delivered to every corner of the skin, hydrating it overall.
Features of Jalupro Classic
The features of Jalupro Classic can also be described as the effects of the low-molecular-weight non-cross-linked hyaluronic acid explained above.
- With its smooth, fluid texture, it diffuses and penetrates over a wide area, so it can help improve overall skin quality rather than just specific areas (it is not suited to deep wrinkles or hollows).
- Highly hydrating, it may help improve fine lines and rough skin caused by dryness.
- Its small molecular weight means it is broken down and absorbed quickly.
Jalupro Classic is the most fundamental formulation in the Jalupro series, designed to rejuvenate and hydrate the skin.
Because it delivers moisture and nourishment to the skin and supports its natural resilience, it is often chosen as an entry-level treatment in anti-aging care.
Jalupro Classic is recommended for those who
- Want to address dark circles under the eyes (bluish and dark-toned circles)
- Are bothered by crepey wrinkles or fine lines at the outer corners of the eyes
- Have dry skin
- I want firmness and radiance
If you have concerns like these,
don't want others to notice that you've "had something done," preferring a treatment with natural-looking change
want the downtime to be over within three days
then this treatment can be recommended for you
Timing of when the effects appear
From around a few days after treatment, you may begin to notice improvements in skin texture—such as skin that "feels smoother and softer" or "just feels somehow better."
The effect tends to peak several weeks after treatment, when you may notice changes such as "more firmness and radiance" and "fine lines becoming less noticeable."
Effects can be felt even from a single treatment, but to maintain the results, regular treatments are necessary.
Duration of effect
The effects of Jalupro Classic are said to last around 6 to 9 months.
However, the duration of the effect depends on your skin's response, the amount injected, and your lifestyle and everyday skincare, so it varies from person to person.
A frequently compared treatment｜Sunekos 200
Sunekos comes in two types, Sunekos 200 and Sunekos 1200, and Sunekos 200 is often compared with Jalupro Classic.
In conclusion, it is best to understand these two as similar preparations.
Sunekos 200 is a preparation combining low-molecular-weight non-cross-linked hyaluronic acid and six amino acids (glycine, L-proline, L-lysine, L-alanine, L-valine, and L-leucine) in a patented ratio.
Both formulations have similar ingredients and share many of the same claimed benefits, such as "improved firmness and elasticity and the reduction of fine wrinkles."
There is no clear data showing that one is superior to the other. Since effects vary from person to person, choose whichever suits you best.
Downtime and risks of Jalupro Classic
Downtime
Downtime symptoms
- Pain or tenderness at the injection site
- Redness, swelling, and itching at the injection site
- Bruising
Internal bleeding refers to what is commonly called a "bruise." In medical terms, blood vessels within the skin rupture, blood leaks out, and it then clots within the skin. Whether bruising occurs depends on the doctor's skill and the physical characteristics of the person receiving treatment, so it may be expected to occur in a small percentage of cases. (Ensuring zero bruising in 100% of cases is difficult to control through technique alone.)
Downtime symptoms mostly disappear within a day or two (basically within 48 hours)
If bruising occurs, it gradually fades over one to two weeks.
"I wonder if this treatment will get in the way of my work..."
"I wonder how many days I'll need to conceal it after this treatment..."
"I wonder how much it will affect my daily life..."
Do you have concerns or questions like these about downtime?
Our aesthetic dermatology team will explain these points so that your questions are answered without your having to ask the doctor directly at the clinic.
To get straight to the point, the small bumps that appear after injection often settle within about 3 hours of the procedure and are said to disappear within 48 hours at the most.
Depending on the area, bruising may occur and needle marks may be noticeable, but in most cases they can be adequately concealed with concealer or the like.
You cannot wear makeup right after the treatment, so if it really bothers you, you may need to cover it with a mask or hat, but makeup can be worn from the next day.
Areas prone to bruising are around the eyes and the temples, and the area where needle marks tend to be most visible is the cheeks. However, since the treatment is performed with an ultra-fine needle to begin with, even if bruising occurs, it does not spread darkly over a wide area.
In most cases it can be concealed with makeup, but if you are concerned, it may put your mind at ease to schedule things so that you don't have plans the day after the treatment.
Risks
Non-cross-linked hyaluronic acids such as Jalupro are generally considered safe.
The reasons are:
- No cross-linking agents are used... avoiding allergic reactions, immune reactions, and inflammation caused by cross-linking agents
- Properties similar to the hyaluronic acid naturally present in the body... low risk of thromboembolism
Furthermore, the three Jalupro preparations are certified as Class 3 medical devices under the CE Mark, which also indicates a high level of safety. They have been marketed and used in many countries. (The CE Mark is an indicator for evaluating the safety of medical devices in the EU, and Class 3 indicates the highest level.)
Disadvantages of Jalupro Classic
Jalupro has no major disadvantages worth noting. The minor disadvantages are as follows.
- The effects are not permanent, so repeated treatments are needed to maintain results.
- It is not fast-acting before the effect can be felt (to put it another way, the result comes on slowly and looks natural).
- Results vary from person to person
- Temporary redness or swelling may occur after injection. These usually resolve within a few days but can affect your appearance immediately after the procedure.
Treatment method / treatment areas
Injected over a wide area into the areas of concern
Number and frequency of treatments / treatment schedule
[Classic]
- A set of 4 sessions, once every 2 to 3 weeks
- After that, maintenance about once every 6 to 9 months
Features of Smart Skin Clinic｜Our commitment to injectable formulations
Who cannot receive this treatment
In principle, the treatment can be performed unless you have some serious illness or inflammation in the area to be treated.
The following is provided as reference information, as we are obligated to share it with those who may not be suitable for treatment. We kindly ask that you take a moment to review it.
- Those who are pregnant or breastfeeding
- Those with abnormal immune function or a history of it, and those undergoing immunosuppressive therapy
- Those prone to keloid formation, hypertrophic scars, or pigmentation disorders
- Those with a bleeding tendency, or those using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin
- Those with excessive sunburn, eczema, dermatitis, severely inflamed acne, or scabs at the Jalupro injection site
Pricing
Our Pricing
Jalupro Classic, manual injection by a physician
| 3cc | Price | Per 1 cc Price |
| 1 bottle | 39,800 yen | 13,270 yen |
| 4 bottles | 139,200 yen (34,800 yen per session) | 11,600 yen |
Jalupro Classic Water Light Injection (mechanical)
| 3cc | Price | Per 1 cc Price |
|---|---|---|
| Once | 29,800 yen | ¥9,933 |
| 4 sessions | 107,200 yen (¥26,800 per session) | ¥8,933 |
| 6cc | Price | Per 1 cc Price |
|---|---|---|
| Once | 47,880 yen | 7,980 yen |
| 4 sessions | 179,520 yen (per session44,¥880) | 7,480 yen |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Market pricing
At beauty clinics in the Kanto region, the going rate for Jalupro Classic is between 40,000 and 80,000 yen per session (as of June 2026).
Treatment Flow
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
After marking is done, we perform the injection while checking in with you as we go.
We provide detailed guidance on caring for the treated area and on precautions for daily life. We also suggest appropriate home care from the standpoint of prevention and maintenance, such as oral medications and skincare products that may help improve your concerns.
Details
| Treatment Time | About 20 to 30 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | [Classic] It is recommended as a set of 4 sessions, spaced 1 to 2 weeks apart. After that, maintenance about once every six to nine months is recommended. |
| Downtime | About 24 hours |
| Treatment on the day of counseling | Available |
| Makeup | Possible right after the treatment |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | If topical anesthesia is applied, the stinging pain of the needle prick is reduced. There is little pain while the drug is being injected. |
We also recommend these treatments
At Smart Skin Clinic, we focus on skin-conditioning injectable treatments. We currently offer 11 formulations, so we can suggest a treatment suited to your concerns and budget.
If you are not sure which treatment is right for you, please feel free to come in just for a consultation first.
We have briefly summarized the characteristics of the other injectable formulations, so please take a look if you are interested.
Skin-conditioning injectable formulations｜Sunekos 200, Rejuran i
Improvement of concerns around the eyes (fine lines, sagging, lack of firmness)
| Preparation | Features |
|---|---|
 Jalupro Classic | A formulation containing low-molecular-weight non-cross-linked hyaluronic acid and four types of amino acids ・The amino acids included alongside it may offer a synergistic effect for skin regeneration and repair Suited to hydrating the skin overall and improving fine lines caused by dryness |
 SUNEKOS 200 | A formulation containing low-molecular-weight non-cross-linked hyaluronic acid and six types of amino acids in a patented ratio ・Suited to hydrating the skin overall and improving fine lines caused by dryness More reasonably priced than other preparations |
 Rejuran i | The Rejuran series has as its main ingredient polynucleotide (PDRN) extracted from salmon DNA. Rejuran i, also known as a salmon injection, is a formulation specialized for concerns around the eyes ・PDRN is designed to promote cell growth and repair as well as new blood vessel formation, and may help with bluish dark circles caused by poor circulation and dark circles caused by sagging. Provides anti-inflammatory and antioxidant action from astaxanthin |
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last supervision date: June 26, 2025