Smart Skin Clinic in Tokyo Yokohama, where prurial densify is inexpensive [from 31,840 yen].

"What exactly is Pluryal?"
"I'm looking for a clinic to receive Pluryal and comparing my options."
"It seems there are several kinds of Pluryal—what's the difference?"
Hello, I am a doctor at Smart Skin Clinic, an aesthetic dermatology clinic.
Do you have any of these questions or concerns?
In this article,A detailed description of each of the four types in the Pluryal Densifier seriesour cosmetic dermatology clinic will explain in an easy-to-understand way.
What is the Pluryal (PLURYAL) Densifier series?
The Pluryal (PLURYAL) Densifier series is a new injectable formulation using biostimulator technology.
Developed by MD Skin Solutions of Luxembourg,it is used in more than 20 countries, primarily across Europe,and is a product drawing considerable attention.
Pluryal comes in the following four types:
- Pluryal Silk (PLURYAL SILK)
- Pluryal Densify (PLURYAL DENSIFY)
- Biosculpture (PLURYAL BIOSCULPTURE)
- Pluryal Hair Density (PLURYAL HAIR DENSITY)
These products provide comprehensive solutions for a wide range of needs, from eye care to full-face rejuvenation and even hair growth.
Main ingredient of the Pluryal (PLURYAL) Densifier series
This series'main ingredient of the flagship products is polynucleotide (PN),a highly purified DNA fragment derived from salmon.
PN offers the following effects:
- Increased skin hydration
- antioxidant action
- anti-inflammatory action
- Promotes fibroblast proliferation
- DNA repair and regeneration
- Promotion of angiogenesis
Thanks to these effects, the Pluryal (PLURYAL) Densifier series delivers more than just temporary improvement; it revitalizes the natural functions of the skin and hair for long-term improvement in quality.
Features and benefits of each product
Now, we'll explain the features and benefits of each product in detail.
1. Pluryal Silk (PLURYAL SILK)
Pluryal Silk (PLURYAL SILK)is a groundbreaking product developed specifically for the eye area.The first in the world to receive CE approval exclusively for use around the eyesso it does.
Key features:
- Effective for fine wrinkles around the eyes and mouth
- High expectations for improving dark circles
- A formulation designed to suit delicate areas
For details, seethe Pluryal Silk (PLURYAL SILK) articlePlease see it.
2. Pluryal Densify (PLURYAL DENSIFY)
Pluryal Densify (PLURYAL DENSIFY)isSpecialized in improving the skin quality of the entire facea product that is
Key features:
- Non-cross-linked hyaluronic acid added to PN andMannitolblended in a proprietary way
- Whole-face skin-quality improvement is possible
- Effective for improving firmness and radiance
For details,the Pluryal Densify (PLURYAL DENSIFY) articleexplains it.
3. Biosculpture (PLURYAL BIOSCULPTURE)
Biosculpture (PLURYAL BIOSCULPTURE)is a product that promotes three-dimensional rejuvenation.
Key features:
- A special blend of three types of hyaluronic acid
- Facial contouring effect
- moreDeep wrinkles and saggingAddresses
For details,The Pluryal Biosculpture (PLURYAL BIOSCULPTURE) articleexplains it.
4. Pluryal Hair Density (PLURYAL HAIR DENSITY)
Pluryal Hair Density (PLURYAL HAIR DENSITY)isSpecialized in hair growtha product that is
Key features:
- Can be used on the scalp, eyebrows, and beard
- Effective for male pattern hair loss (AGA) and female pattern hair loss (FAGA)
- Supports hair growth and increases hair thickness
For more information,the Pluryal Hair Density (PLURYAL HAIR DENSITY) articleplease check it out.
The difference between Pluryal and Rejuran: an accurate comparison and how to choose
A question we receive from many people"the difference between Pluryal and Rejuran"is what we'll explain here.
1. The difference in main ingredient and purity
Both formulationshave polynucleotide (PN) as their main ingredient,but there is a significant difference.
- Pluryal:
- Proteins are completely removed, making the PN purity extremely high.
- The allergy risk is very low.
- Rejuran:
- A certain amount of protein remains.
- The allergy risk is slightly higher compared with Pluryal.
2. Comparison of product lineups
Both formulations come in several products, but their characteristics differ.
Pluryal:
- Pluryal Silk: exclusively for the eye area
- Pluryal Densify: for the whole face
- Pluryal Biosculpture: for three-dimensional rejuvenation
- Pluryal Hair Density: for hair growth
Rejuran:
- Rejuran I: for the eye area
- Rejuran S: for acne scars
- Rejuran Healer: for the whole face
- Rejuran HB: enhanced moisturizing effect, reduced-pain type
Pluryal has more clearly separated applications for each product, notably including a product dedicated to three-dimensional rejuvenation (Biosculpture). Rejuran HB, on the other hand, is known as a product with enhanced moisturizing properties.
3. The difference in effect
- Pluryal:
- Good balance of immediate and lasting effects
- Strong three-dimensional rejuvenation effect
- In addition to improving skin quality, improvement of the contours can also be expected
- Rejuran:
- The effect emerges gradually
- Highly effective at improving skin quality
- Particularly effective at improving acne scars
*However, since there are four types of each, the characteristics and effects differ for each formulation.
4. The difference in indications
- Pluryal:
- Eye care
- Full-face rejuvenation
- Improvement of facial contours
- Hair growth
- Rejuran:
- Improvement of skin quality across the whole face
- Improvement of acne scars
- Pore tightening
- Enhanced moisturizing effect, reduced pain (especially HB)
5. Cost comparison
In general, Rejuran tends to cost more than Pluryal.However, specific prices vary by product, procedure, and clinic, so please check with each clinic for details.
6. How to choose: which one should you pick?
The following criteria may help you choose the right one.
When you should choose Pluryal:
- Those with concerns about allergies
- Those seeking more immediate results
- Those who also wish to improve facial contours at the same time
- Those who want treatment specialized in eye-area care
- Those who would also like to expect hair-growth benefits
- Those who want to keep costs somewhat lower
When you should choose Rejuran:
- Those who want to take their time improving their skin quality
- Those whose main goal is to improve acne scars
- Those who prioritize pore tightening
- Those seeking a particularly moisturizing effect (Rejuran HB)
- Those who prefer a formulation with a long track record
Summary
Both Pluryal and Rejuran are excellent formulations, but there are clear differences in their characteristics and effects. Pluryal allows a more multifaceted approach and is characterized by a good balance between immediate and lasting effects. Rejuran, on the other hand, specializes in improving skin quality and works steadily over time.
The best choice varies depending on your skin condition and concerns, the results you expect, and your budget. Please use this as a reference and choose the formulation best for you through a consultation at the clinic.
Advantages of the Pluryal (PLURYAL) Densifier series
The Pluryal series offers many advantages. Here are some of the main ones.
- A comprehensive approach: It can address a wide range of concerns, from the eyes to the whole face and even the scalp.
- Natural finish: It promotes the body's natural regeneration process, so there is nothing unnatural about the result.
- Long-term effects: Beyond temporary improvement, the effect emerges gradually with continued use.
- Low risk: Because highly purified ingredients are used, the allergy risk is low.
- Customizable: The best product can be selected to match each person's concerns.
Smart Skin Clinic's PluryalOur characteristic | Our "attention to detail" with injectable formulations
Following our director's philosophy, we perform injections with the following "attention to detail."
Smart Skin Clinic's " commitment " to Water Light Injection
Pricing
Silk (manual injection by a physician)
| 2cc | Price | Per 1 cc Price |
| Once | 44,800 yen | 22,400 yen |
| 3 times | 119,400 yen (per session 39,800 yen) | 19,900 yen |
| 4 sessions | 155,200 yen (per session 38,800 yen) | 19,400 yen |
Densify (Water Light Injection treatment)
| 1 bottle (2cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥42,120 | ¥21,000 |
| 3 times (20% off) | ¥102,720 (per session 34,¥240) | ¥17,120 |
| 4 sessions (20% off) | 127,360 yen (per session 31,840 yen) | ¥15,920 |
| 2 bottles (4cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥60,120 | ¥15,030 |
| 3 times (20% off) | 155,520 yen (per session 51,840 yen) | ¥12,960 |
| 4 sessions (20% off) | 191,360 yen (per session 47,840 yen) | ¥11,960 |
| 3 bottles (6cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥82,620 | ¥13,770 |
| 3 times (20% off) | ¥210,720 (per session ¥70,240) | ¥11,700 |
| 4 sessions (20% off) | ¥271,360 (per session 67,840 yen) | ¥11,300 |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
- For easier comparison with other clinics' listings, we also offer a "3cc" option.
- That said, for the whole face (full face), 3cc does not provide sufficient "density," so if you are seeking the maximum effect, we suggest using the following as a guide when choosing.
- [Pattern 1] Lighter treatment is fine for the forehead and the area below the nose ⇒ 3cc
- [Pattern 2] The area below the nose can be a little lighter, but I want thorough treatment above the nose ⇒ 4cc
- [Pattern 3] I want thorough treatment across the whole face, including below the nose ⇒ 6cc
- If you are unsure, the physician will confirm your wishes on the day and suggest the optimal volume (please rest assured that we never upsell unnecessarily).



Hair Density (Water Light Injection treatment)
| 1 bottle (2cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | 44,820 yen | ¥22,410 |
| 3 times (20% off) | ¥117,120 (per session ¥39,040) | ¥19,520 |
| 5 sessions (20% off) | 187,200 yen (per session ¥37,440) | ¥18,720 |
| 10 sessions (20% off) | 342,400 yen (per session 34,¥240) | ¥17,120 |
| 2 bottles (4cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥71,820 | ¥17,950 |
| 3 times (20% off) | ¥189,120 (per session 63,040 yen) | ¥15,760 |
| 5 sessions (20% off) | 307,200 yen (per session 61,¥440) | ¥15,360 |
| 10 sessions (20% off) | 582,400 yen (per session 58,¥240) | ¥14,560 |
| 3 bottles (6cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
|---|---|---|
| Once (10% off) | ¥98,820 | ¥16,470 |
| 3 times (20% off) | ¥258,720 (per session ¥86,240) | ¥14,380 |
| 5 sessions (20% off) | 419,200 yen (per session ¥83,840) | 14,000 yen |
| 10 sessions (20% off) | 798,400 yen (per session ¥79,840) | 13,300 yen |



Frequently Asked Questions (FAQ)
Q1: Which product should I choose?
A: The best product varies according to each person's concerns and goals. For example, for eye-area care,Pluryal Silkfor full-face skin-quality improvement,Pluryal Densifyand for hair growth,Pluryal Hair Densityis recommended. For details, please see each product's article or consult us during counseling.
Q2: When can I expect to notice results?
A: It varies by product and individual, but in general you'll gradually begin to feel the effect after 2-4 weeks, with the maximum effect appearing after 2-3 months. The effect continues with ongoing use.
Q3: Are there any side effects?
A: The Pluryal (PLURYAL) Densifier series has very few side effects. In rare cases, temporary redness or swelling at the injection site may occur, but this usually improves naturally within a few days.
Q4: Can it be combined with other cosmetic treatments?
A: Yes, it can be combined with many cosmetic treatments. However, in some cases appropriate spacing between treatments may be required.
Summary: Why the Pluryal (PLURYAL) Densifier series is chosen
The Pluryal (PLURYAL) Densifier series offers a variety of advantages.
- Wide-ranging coverage: It can address a variety of concerns—the eyes, the whole face, and the scalp.
- High safety: It holds CE approval and is manufactured under strict quality control.
- Natural finish: Because it enhances the natural functions of the skin and hair, there is nothing unnatural about the result.
- Long-term effects: You can expect not only immediate effects but also long-term improvement in quality.
By selecting the best product to match individual concerns and goals, you can achieve more effective rejuvenation and cosmetic improvement.
For details, please also see each product's article (Pluryal Silk,Pluryal Densify,Pluryal Biosculpture,Pluryal Hair Density).
Restore your own unique beauty with the Pluryal (PLURYAL) Densifier series! Please feel free to visit our clinic for a consultation.
Physician Who Supervised This Page

Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
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