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What Are Personalized PRP Injections (for Forehead Wrinkles and Hollows)? | A Doctor Explains the Effects, Costs, and Downtime
"I've heard PRP injections are effective for forehead wrinkles, but are they really effective? How safe is it?"
"I've heard that injections combining PRP with FGF can be risky, but what's the truth?"
"I just want to improve the wrinkles and indentations on my forehead."
"I want to do something about my forehead wrinkles, so I've been comparing options like Botox injections and hyaluronic acid filler. But I'm wondering if there's a way to do it without losing my natural expression..."
Hello, I'm a physician at Smart Skin Clinic, a cosmetic dermatology clinic. Do any of these questions or concerns sound familiar?
In this article,Ministry of Health, Labour and Welfare – Accredited Facility for Regenerative Medicine Provision PlanSmart Skin Clinic, a cosmetic dermatology clinic, offers a clear, expert explanation. (*Type 2 and Type 3 Regenerative Medicine Provision Plan, approval number: NA8230001)
*If you'd like to know the prices, you can jump to the relevant section from the table of contents below.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What Is Personalized PRP Injection?
PRPF injection isa treatment that injects a formulation combining PRP (platelet-rich plasma) with added FGF (fibroblast growth factor)..
PRP: An ingredient extracted from your own blood, rich in growth factors
FGF: Fibroblast growth factor. An ingredient that powerfully promotes skin regeneration
By combining these two, the treatment is said to have a greater effect on the dermis than conventional PRP therapy.
Case Photos (Before/After)
This is a case of a man in his 50s, 3 months after personalized PRP injection.
We assessed the whole face to design the treatment, then customized the injections to target areas with wrinkles.
This is a case of a woman in her 50s, 3 months after personalized PRP injection.
We assessed the whole face to design the treatment, then customized the injections to target areas with wrinkles.
The Role of Growth Factors
Growth factors are a general term for proteins and peptides that promote cell growth, division, and differentiation. They have drawn particular attention in aesthetic medicine for the major role they play in skin rejuvenation and regeneration.
Key growth factors include the following:
- EGF (Epidermal Growth Factor): Helps skin regeneration
- FGF (Fibroblast Growth Factor): Increases collagen and elastin to plump up the skin
- IGF (Insulin-like Growth Factor): Generates new cells and helps reduce damage caused by aging
Mechanism of Personalized PRP injection: why is it effective for forehead wrinkles?
PRP injections work on forehead wrinkles mainly through the following five mechanisms:
1. Promoting Collagen Production
Platelet-derived growth factor (PDGF) and FGF in PRP stimulate fibroblasts, promoting collagen production and improving the skin's firmness and elasticity. This helps improve the skin laxity that causes forehead wrinkles.
2. Promoting elastin production
FGF also promotes elastin production. Elastin is a key protein that maintains skin elasticity, and increasing it helps improve expression lines on the forehead.
3. Improving skin thickness
PRP works to thicken the dermal layer of the skin. This makes indentations on the forehead less noticeable and creates an overall more youthful impression.
4. Boosting circulation
Vascular endothelial growth factor (VEGF) promotes the formation of new blood vessels. This improves circulation and activates skin metabolism.
5. Tightens pores and enhances radiance
The skin-regenerating effect of growth factors also helps tighten pores on the forehead. It also activates cells on the skin's surface, giving the forehead a naturally radiant glow.
Three Features of Personalized PRP Injection
1. Natural Rejuvenation Effect
Because it uses your own cells, the result looks natural. It enhances the skin's own regenerative ability, so it doesn't create the stiff expression sometimes associated with Botox.
2. Personalized Treatment
At our clinic, we adjust the concentration and volume of PRP and design each injection individually according to each patient's skin condition and goals.
3. Duration and Cost Performance
Given the mechanism of PRPF injection, results are achieved by working within the skin itself, so medium- to long-term effects can be expected.
*The duration of the effect varies from person to person.
Personalized PRP Injection Is Recommended For
- Those concerned about forehead wrinkles
- Those who have started to notice expression lines
- Those concerned about indentations on the forehead
- Those concerned about enlarged pores on the forehead
- Those who want naturally radiant forehead skin
- Those who want a natural-looking result
- Those worried that Botox might stiffen their facial expression
Features of Our Personalized PRP Injection
1. A Clinic Specializing in Injectable Treatments
Our clinic is focused on injectable treatments and has built up extensive knowledge and experience in this field.
・Injection techniques designed to minimize pain
・Treatment personalized for each patient
2. Expertise in Regenerative Medicine
・A regenerative medicine provider approved by the Ministry of Health, Labour and Welfare (holds a Type 2 Regenerative Medicine Provision Plan number)
・Physicians certified by the Japanese Society of Anti-Aging Medicine on staff
3. Treatment That Combines Injectable and Regenerative Medicine Expertise
・Draws on experience in injectable treatments together with regenerative medicine insight
・Personalized treatment plans tailored to each patient's condition and goals
Pricing
Typical PRPF Injection Prices in Tokyo
The typical price range for PRPF injection in Tokyo is200,000 to 400,000 yen(as of August 1, 2024).
Smart Skin Clinic Price List
| Menu | Regular Price | Limited-time discount through 7/31 (20% Off) |
| Once | 166,400 yen | |
| Monitor 1 session | 142,400 yen | |
| Second area (face) | ¥133,120 | |
| Monitor Second Area (Face) | ¥109,120 |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Prices are shown all-inclusive, covering consultation and needle fees.
There is no separate upselling on the day.
Monitor Requirements
①Intended Use| We may publish the photos on our website, Instagram, and similar media with the eye area concealed, or show them to other patients as treatment examples [please picture typical case photos].
②Procedure｜You will pay the regular price at your first visit, and the difference (between the regular price and the monitor price) will be refunded when your monitor photos are taken (approximately 3 months after treatment as a guide)
Comparison with Other Treatments
1. Comparison with Hyaluronic Acid Injection
・PRPF: Uses ingredients derived from your own body, so allergy risk is low, with long-term skin regeneration benefits
・Hyaluronic acid: Provides an immediate volumizing effect, but is absorbed within 6 to 12 months. It also carries a risk of vascular occlusion, requiring caution when injected near blood vessels such as under the eyes or between the brows
2. Comparison with Laser Treatment
・PRPF: Works deep within the skin for long-lasting results
・Laser: Mainly addresses surface-level concerns and requires multiple sessions
3. Comparison with Surgical Procedures
・PRPF: Non-invasive with fast recovery and natural-looking results
・Surgical procedures: Can achieve dramatic change, but carry greater risk and downtime
Personalized PRP Injection Procedure
- Blood draw: A small amount of blood is drawn from the patient's arm
- PRP extraction: PRP is extracted using a specialized centrifuge
- FGF addition: FGF is added to the extracted PRP
- Injection design: Individually designed to address the specific concerns you want to resolve
- Injection: A fine needle is used to inject into the skin under the eyes
The needles used are extremely fine, minimizing pain. Anesthetic cream can also be used if needed.
Precautions and Side Effects
PRPF injection is relatively safe, but it may cause temporary side effects such as:
・Mild swelling or bruising at the injection site
・Temporary pain or discomfort
In rare cases, infection or an inflammatory reaction may occur. At our clinic, strict hygiene protocols and skilled technique help minimize these risks.
FAQ
Q1: Is PRPF injection painful?
A1: Because we use an extremely fine needle and can apply anesthetic cream if needed, most patients experience only mild discomfort.
Q2: When can I expect to notice results?
A2: Results vary by individual, but most patients begin to notice a gradual effect from around 2 to 4 weeks. The full effect often appears after 3 to 6 months.
Summary
PRPF injection is an effective treatment for improving forehead wrinkles and indentations. Because it uses your own cells, it is safe and delivers natural-looking results.
At Smart Skin Clinic, we draw on our expertise in both injectable treatments and regenerative medicine to provide personalized PRP injections.
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last supervision date: June 26, 2025