PRP Mesotherapy (FAGA, AGA, thinning hair treatment) [Hair Regeneration Treatment].

I'm concerned about my thinning hair, but I'm worried about the side effects of oral medications..."
I want to improve my thinning hair in the most natural way possible."
What options are there for effective treatments for thinning hair in women?"
I've tried oral and topical medications, but I can't continue to use them because of the side effects..."

Hello. I am a doctor at Smart Skin Clinic, a cosmetic dermatology clinic.

Do you have any of these questions or concerns?

For those suffering from female-onset hair loss (FAGA), the choice of treatment is an important issue. In particular, in recent years, there has been an increasing demand for natural treatments with fewer side effects.

This article therefore discusses PRP mesotherapy, a safe treatment using autologous blood-derived components,Ministry of Health, Labour and WelfareThe clinic, which is a member of the Society for Regenerative Medicine, will provide an easy-to-understand explanation from a professional standpoint. (*Type 2 and Type 3 Regenerative Medicine Provision Plan Accreditation Number: NA8230001)

In particular, we will explain in detail from a medical perspective why PRP mesotherapy is attracting attention, who it is suitable for, and what features it has compared to other treatment methods.

*If you would like to know the rates, you can jump to the appropriate section from the table of contents below.

Table of Contents

What is FAGA?

Female Androgenetic Alopecia is a progressive thinning of hair that is unique to women.

Characteristic symptoms

1. loss of hair density

Gradual thinning of the entire top of the head
The hairline is relatively preserved (a major difference from male pattern baldness)
Christmas-tree shaped split openings (characteristic symptom)

2. qualitative changes in hair

Gradual thinning of hair (fine hair)
Loss of firmness and elasticity
Luster decreases
Hair becomes too soft and hard to manage

3. progression pattern

Diffuse: gradual thinning of the entire top of the head
Complete hair removal is often not achieved.
Slow progression (years to decades)

Early symptoms that are easy to recognize

The split in the eyes begins to show.
Increased hair loss when shampooing
Difficulty in keeping hairstyles in place
Scalp becomes transparent.
Decreased hair volume

Difference from androgenetic alopecia (AGA)

AGA is localized hair loss in the frontal and parietal regions
FAGA is diffuse thinning of the entire parietal area of the head
FAGA rarely leads to complete hair loss
FAGA tends to preserve the hairline.

Age and frequency of onset

Most cases occur in the 40s and 50s.
Increased incidence around menopause
It is estimated that about 20% Japanese women experience
Increasing incidence in younger age groups

Causes and Mechanisms of FAGA

The basic premise of FAGA is that the patient has a "genetic predisposition," and then the disease develops and progresses through the following process. Without a genetic predisposition, the following changes basically do not cause the onset of the disease.

1. genetic predisposition: where it all begins

First, it is important to,Genetic factors play a major role in FAGA.That is to say.

Due to this genetic predisposition,Scalp hair follicles are susceptible to male hormones (androgens)This is the case. If you have a family member with thinning hair, it is more likely that you have inherited this genetic predisposition.

2. changes in hormonal balance: triggers for symptoms to begin to appear

As we age,Changes occur in the hormonal balance in the body.Specifically, the process will proceed as follows

First, with aging and menopause,Decrease in female hormones (estrogen)Estrogen is important for hair growth, but this function is weakened. Estrogen has an important function in aiding hair growth, but this function is weakened.
When estrogen decreases, the body's naturalThe influence of male hormones (androgens) is relatively strong.This is because estrogen has the ability to suppress androgenic effects.
In the body, testosterone, a type of androgen, is converted to DHT (dihydrotestosterone), which has stronger effects. This DHT will play an important role in the next stage.

3. effect on hair follicles: the stage when hair begins to change

Hormonal imbalance can cause the following changes in hair follicles, especially in genetically predisposed individuals

DHT binds to androgen receptors in hair follicles on the scalp. In women, these androgen receptors are widely distributed throughout the entire parietal area, making the entire parietal area susceptible. (In men, they may be distributed only on the parietal area and in an M-shape, resulting in the thinning hair characteristic of men.)
In DHT-bound follicles, the period during which hair grows (growth phase) is shortened and the period during which it rests (resting phase) is lengthened.
This change causes hair to gradually become thinner and shorter.

4. visible changes: stages that appear as symptoms

The accumulation of these changes results in the following characteristic symptoms:

Gradual decrease in hair density throughout the top of the head.
Instead of a complete loss of hair in a specific area (this is the difference from male pattern baldness), the entire top of the head thins.
The split ends widen and may take the characteristic "Christmas tree pattern" shape.

Other factors affecting

In addition to these basic mechanisms, the following factors can also influence symptoms

Nutritional impactIron and zinc deficiency: When iron and zinc are deficient, the oxygen and nutrients necessary for hair growth are not adequately supplied, making it difficult for hair to grow.
Influence of external factors: Chemical treatments such as perms and coloring can put a strain on the hair follicles and scalp and can exacerbate symptoms. Inflammation of the scalp from these treatments can also worsen blood flow and further impede hair growth.

Like this,FAGA is not a simple cause, but a disease that develops and progresses due to a combination of genetic predisposition, hormonal imbalance, the resulting effects on hair follicles, and various external factors.They are. Therefore, treatment must take a different approach to each of these factors.

Treatment of FAGA

To understand the treatment of FAGA, let us first briefly review the mechanism of pathogenesis:

[Mechanism of FAGA onset.

Genetic predisposition (base): genetically defined sensitivity to androgens
Alterations in hormonal balance: estrogen reduction and relative increase in androgens
Binding to androgen receptors: DHT action at hair follicles and disruption of growth cycle
Effect on the entire parietal area: progressive thinning and loss of hair density

Current medicine offers the following treatment approaches for each stage of this pathogenic mechanism

1. treatment with oral medication