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Personalized PRP Injection for Nasolabial Folds
Concerned about your nasolabial folds?
Nasolabial folds deepen with age. Hyaluronic acid and thread lifts can risk looking unnatural — we understand the concern. There is a way to improve nasolabial folds naturally, without surgery and without discomfort.
- No scalpel, natural-looking results
- Completed in a single treatment, with results lasting 4 to 5 years
- Virtually no downtime — makeup is fine the same day
- Uses your own biological components, so there's no foreign-body sensation to worry about
In this article,Ministry of Health, Labour and Welfare – Accredited Facility for Regenerative Medicine Provision Plan Smart Skin Clinic, a cosmetic dermatology clinic, explains it clearly from a specialist's perspective.
(*Type II and Type III Regenerative Medicine Provision Plan accreditation number: NA8230001)
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
For those with these concerns
- Nasolabial folds deepen, suddenly making you look older
- Worried hyaluronic acid might look unnatural
- Want to avoid surgery or major procedures
- Prefer a treatment with minimal downtime so no one notices
- Want a treatment with long-lasting results
Patients with these concerns choose our Personalized PRP injection.
Case Photos (Before/After)
Treatment name Personalized PRP injection: Before treatment / After 1 treatment
Treatment details Personalized PRP injection combines PRP (platelet-rich plasma) extracted from your own blood with growth factor (FGF) in a single injectable treatment. It works to enhance the skin's regenerative power, aiming to improve deep wrinkles such as nasolabial folds and marionette lines. It also helps support skin firmness and elasticity for a more youthful look. Because the treatment is personalized to each patient's individual concerns and skin type, it can deliver an even higher level of satisfaction.
Treatment period and number of sessions Usually completed in a single session *In some cases, an additional session may be performed if the effect is insufficient
Main risks and side effects Mild redness, swelling, or bruising may occur after the injection, but this typically resolves within a few days. You may notice mild pain or a lump-like sensation at the injection site, which can be eased with proper aftercare. In rare cases, an allergic reaction or lump formation at the treatment site has been reported. Results vary from person to person, and the same outcome cannot be guaranteed for every patient.
Treatment price 136,400 to 208,000 yen *The price range reflects the availability of a monitor plan
This is a case of a man in his 50s, 3 months after personalized PRP injection.
We assessed the whole face to design the treatment, then customized the injections to target areas with wrinkles.
This is a case of a woman in her 50s, 3 months after personalized PRP injection.
We assessed the whole face to design the treatment, then customized the injections to target areas with wrinkles.
What Is Personalized PRP Injection?
PRP (platelet-rich plasma) is plasma containing a high concentration of platelets extracted from the patient's own blood, and because it is rich in growth factors, it promotes collagen production and tissue repair.
In recent years it has drawn attention in the field of regenerative medicine and is used in aesthetic medicine as a skin rejuvenation treatment.
It also improves blood flow and supports cell repair, making it effective for improving wrinkles and sagging.
Difference from hyaluronic acid injections
| Comparison point | Personalized PRP Injection | Hyaluronic acid injections |
|---|---|---|
| Treatment details | Injects PRP extracted from your own blood to promote skin regeneration | Injects synthetic hyaluronic acid to add volume |
| Results | Natural firmness and plumpness | Overfilling can result in an unnatural-looking bulge |
| Duration | Lasts as long as 4 to 5 years | Absorbed within roughly 6 months to a year |
| Downtime | Virtually none (normal activities OK from the same day) | May cause bruising or swelling |
| Safety | No foreign-body reaction, since it uses your own blood | Carries a risk of foreign-body reaction |
| Treatment Time | Approx. 20 minutes | Approx. 15-30 min. |
Recommended for those who want a natural, comfortable finish.
Causes of nasolabial folds and how PRP works
Nasolabial folds aren't caused by sagging skin alone — they result from a combination of aging and deterioration across several areas. Reduced skin elasticity, fat atrophy, and volume loss in the subcutaneous tissue all contribute, and addressing these factors together leads to a more fundamental improvement.
Three actions of PRP
Features of Personalized PRP Injection
Our Commitment to Addressing Your Skin Concerns
As we've gotten older ourselves, we've had similar worries — "Have my nasolabial folds gotten a little deeper?" or "My dark circles seem more noticeable today, and I look tired..."
A single change in your face can help you enjoy fashion and relationships more, and enjoy life even more. We see Personalized PRP injection not simply as a way to improve appearance, but as a treatment that can be a catalyst for viewing life itself more positively. Overseen by a board-certified physician of the Japan Society of Anti-Aging Medicine, we are committed to honest care with no sales pitches or upselling.
It's true that this is a high-cost treatment. But we firmly believe it is an "investment" that delivers real value to patients who want to enjoy the years ahead even more.
Treatment Flow
Pricing
| Menu | Regular Price | Limited-time discount through 7/31 (20% Off) |
| Once | 166,400 yen | |
| Monitor 1 session | 142,400 yen | |
| Second area (face) | ¥133,120 | |
| Monitor Second Area (Face) | ¥109,120 |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Prices are shown all-inclusive, covering consultation and needle fees.
There is no separate upselling on the day.
Monitor Requirements
①Intended Use| We may publish the photos on our website, Instagram, and similar media with the eye area concealed, or show them to other patients as treatment examples [please picture typical case photos].
②Procedure｜You will pay the regular price at your first visit, and the difference (between the regular price and the monitor price) will be refunded when your monitor photos are taken (approximately 3 months after treatment as a guide)
If you have any questions, please consult directly with a physician
To help ease any concerns as much as possible, at our clinic
rather than staff,our physicians respond to youdirectly via Instagram DM.
Not only before your appointment,but also after booking and up until your visit,
whenever you have any concerns, feel free to reach outas many times as you like.
Treatment details
・Those who are pregnant or breastfeeding (please consult your doctor before treatment)
You may notice mild pain or a lump-like sensation at the injection site, which can be eased with proper aftercare.
In rare cases, an allergic reaction or lump formation at the treatment site has been reported.
Results vary from person to person, and the same outcome cannot be guaranteed for every patient.
Our personalized PRP injection uses a proprietary protocol to minimize these risks to the greatest extent possible,
providing a safer treatment.
FAQ
FAQ
Q. How many sessions are required?
Basically, treatment is completed in a single session. Results vary by individual, but many patients are satisfied with the outcome after just one treatment.
Q. Is personalized PRP injection painful?
Anesthesia is applied before treatment, so there is little to no pain. If you have any concerns, please consult us beforehand.
Q. How much downtime is there?
There is virtually no downtime. Some redness may appear right after treatment, but it usually settles down within a few hours.
Q. Can I wear makeup right after treatment?
You should avoid strong stimulation to the injection site on the day of treatment, but you can wear makeup as usual starting the next day.
Q. Can personalized PRP injection be used for areas other than nasolabial folds?
Yes, it can. It can be used on a wide range of areas, including dark circles, forehead wrinkles, hollows under the eyes, wrinkles around the mouth, and the back of the hands.
If you have any areas of concern, please feel free to consult with us.
Q. Are there any side effects or risks?
Because your own blood is used, there is virtually no risk of a foreign body reaction. That said, mild redness or swelling may occur after treatment, but it typically settles down within a few days.
Please feel free to reach out first
We welcome your questions, concerns, and free counseling bookings regarding Personalized PRP injection.
We'll propose the treatment plan best suited to your concerns.
There is never any high-pressure sales, so please consult with us with confidence.
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last supervision date: June 26, 2025