juvelock aquatic injection

Jubeluk Eye Catch v02

What are the benefits of the Jubeluk aquatic light injections?"
Is there any pain or downtime associated with JUVELUX Hydroxyphosphorescent Injections?"
What makes it different from other formulations?" What's the difference between it and a manual formulation?"

Do you have any of these questions about Jubelc water light injections?

Hello. I am a doctor at Smart Skin Clinic, a cosmetic dermatology clinic.

We will explain about JUVELUX hydroxyapatite injections in an easy-to-understand manner from a professional standpoint so that these questions and concerns can be resolved.


What is JUVELUX Aqueous Light Injection?

JUVELUX Aqueous Light Injection refers to a procedure in which a preparation called "JUVELUX" is injected with a machine called "Aqueous Light Injection".

First, we will discuss JUVELUX and aquatic light injections, respectively.

What is Jubeluk?

JUVELUX is a skin booster formulation combining "polylactic acid (PDLLA)" and "non-cross-linked hyaluronic acid.

What is polylactic acid (PDLLA)?

Polylactic acid is produced by utilizing a natural extract from potato starch, such as corn and potatoes.

It promotes collagen production.

What is non-cross-linked hyaluronic acid?

There are two types of hyaluronic acid: cross-linked and non-cross-linked.

Hyaluronic acid is quickly absorbed as it is, and the cross-linked type has been treated to delay its absorption and degradation in the body. By filling the skin with a mass of hyaluronic acid deep within the skin, the elasticity and firmness of the skin are supplemented, and it is used for volume enhancement and shaping.

The non-cross-linked hyaluronic acid contained in JUVELUX is soft hyaluronic acid that has not been cross-linked. As hyaluronic acid permeates the skin, it naturally replenishes skin firmness and elasticity and increases its volume.

Skin booster formulations are those that boost (accelerate) the effect on the skin.

As the word "juvelook" means "youthful look," it is also called a collagen booster because its injection into the skin stimulates fibroblasts, which in turn promote collagen production by their own power, thereby improving skin quality.

What is Aquatic Light Injection?

Suiko-injection is a syringe with nine ultrafine needles. By injecting the drug quickly while suctioning the skin, the drug can be injected evenly into the dermal layer with minimal pain.

The depth of the needle to be injected, time spent in the skin, and suction pressure can be optimally set according to the purpose, and a variety of drugs can be selected.

[Features of water-light injections

  • Uniform list of depth and injection volume
  • Minimal internal bleeding.
  • Less skin indentation after injection
  • Minimal downtime

See also this article for more information about water light injections.

How to inject JUVELUX

JUVELUX can be injected by (1) aqueous injections, (2) manual injection by a doctor, (3) Potenza, or (4) dermapen. At Smart Skin Clinic, you can choose from methods (1) and (2).

With so many different ways to inject a patient, one may wonder, "What is the best method?" "Is aqueous injections the best way to treat my condition?" Some people may wonder, "What is the best way to treat my symptoms?

The characteristics of each treatment method are as follows

Vital InjectorDoctor's handshakepotenza
(Microneedle RF Machine)
Suitable for treatment of the entire face
Uniform depth and injection volume
Minimal downtime
... with minimal internal bleeding.
Less pain
Less skin indentation.
Can inject concentrated injections into areas of concern according to symptoms
・ Lean injection is possible.
Suitable for localized areas such as acne scars and craters
Suitable for treatment of the entire face
Uniform depth and injection volume
Wound healing for beautiful skin
Skin revitalization by RF irradiation
Tightening and lifting

Manual injection by a physician is a method of injecting with a syringe while the physician checks the skin condition and adjusts the depth and dosage for each area.

Potenza is a microneedle RF machine, which injects a formulation by applying suction pressure after an ultra-fine needle is inserted and RF waves emanate from the tip of the needle.

*Please see this article for more information on Jubeluk injections (hand injections by a physician).

Recommended for

To give a more specific example, JUVELUX hydroxyapatite injections are recommended for the following

  • Concerned about pores
  • Concerned about acne scars
  • I want my skin to be firm and elastic.
  • Red face, fine lines and wrinkles
  • Overall, the skin is becoming calloused.
  • Resistant to compensating treatments such as hyaluronic acid
  • Unsatisfied with laser treatment
  • Want to strengthen their own collagen production
  • I want to improve my skin texture

Before and after photos

Jubeluk skin texture improvement case (1)
Jubeluk skin quality improvement case (3)
Jubeluk skin quality improvement case (2)

5 Features of JUVELUX Aqueous Light Injection

JUVELUX Hydroxyapatite Injection has five exciting features.

Feature➀Newest skin booster formulation for natural volume enhancement

Known skin booster formulations include Skin Botox, hyaluronic acid, Rejuran, Chanel Milan, and Exosome, with Jubelq being the latest.

JUVELUX's ability to stimulate collagen production by the skin's own power can create healthy, naturally hydrated skin.

Feature 2: Longer duration of effect

Polylactic acid, a component of JUVELUX, is slowly broken down in the body over a period of one to two years after injection, resulting in a long-lasting effect time.

While it is being broken down, it stimulates fibroblasts, which continue to increase collagen and elastin, resulting in firmness and elasticity.

Feature 3) Polylactic acid (PDLLA) contained in raw materials does not remain in the body

Polylactic acid was originally a component widely used in thread lifts, surgical sutures, and as a vascular grafting material.
After injection, it is finally decomposed into water and carbon dioxide, which are absorbed by the body. Since no foreign substance remains, there are no indentations when touched.

Feature (4) JUVELUX is a highly safe formulation with FDA and KFDA approval

JUVELUX has been approved by the U.S. Food and Drug Administration (FDA) and the Korea Food and Drug Administration (KFDA), the equivalent of Japan's Ministry of Health, Labor and Welfare, and each has confirmed its safety.

However, it has not been approved in Japan.

Feature 5: Abundant medical data

Various research papers have been published on the collagen incremental effects of PDLLA (≈Jubeluk).

It is suggested that PDLLA increases collagen synthesis by regulating macrophages to increase NRF2 expression, stimulating ASCs proliferation and secretion of TGF-β and FGF2. This increases collagen synthesis and reduces soft tissue volume loss due to aging.

Seyeon Oh, Suk Bae Seo, Gunpoong Kim, Sosorburam Batsukh, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun. Poly-D,L-Lactic Acid Filler Increases Extracellular Matrix by Modulating Macrophages and Adipose-Derived Stem Cells in Aged Animal Skin. 2023 Jun 01;12(6); pii: 1204.

A total of 16 patients seeking skin rejuvenation were included in the study. All participants received two or three treatments, with a four-week treatment interval. (omitted) Statistically significant differences were observed in all signs of aging before and after treatment, including fine lines and wrinkles, skin texture, irregular pigmentation, telangiectasia, and facial erythema. Half (50%) of patients reported an overall improvement of 50% or more. No serious adverse events were observed. Histological examination showed an increase in dermal collagen and elastic fibers.

Suk Bae Seo, Hyunwoo Park, Ju Young Jo, Hwa Jung Ryu. Skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary Journal of cosmetic dermatology. 2024 Mar;23(3);794-802. doi: 10.1111/jocd.16085.

This is consistent with the hypothesis that PDLLA stimulates angiogenesis and rejuvenation of aging skin. This study showed that PDLLA, PN, or CaHA results in angiogenesis in aging skin, possibly by increasing levels of HSP90, HIF-1α, and VEGF and increasing collagen synthesis.

Seyeon Oh, Suk Bae Seo, Gunpoong Kim, Sosorburam Batsukh, Kuk Hui Son, Kyunghee Byun. Poly-D,L-Lactic Acid Stimulates Angiogenesis and Collagen International journal of molecular sciences. 2023 Apr 28;24(9); pii: 7986.

Effects of JUVELUX aqueous light injections

JUVELUX water light injections can be expected to have the following effects

  • Improves skin elasticity, firmness, and texture
  • Improved pore size
  • Improvement of acne scars

Effect on skin elasticity, firmness, and texture

When fibroblasts are stimulated by JUVELUX, the production of collagen, elastin, and hyaluronic acid is stimulated, leading to improved skin texture.

Collagen creates elasticity in the skin, while elastin acts like rubber that binds collagen together and gives the skin its suppleness.

Hyaluronic acid prevents dryness by retaining moisture.

Effect on pore size

The main causes of open pores are excessive sebum production and sagging due to aging.

When collagen is increased by JUVELUX, sagging skin is improved, which also reduces the appearance of pores.

Smart Skin Clinic's "specialties" of hydroxyapatite injections ".

Jubeluk Aqueous Light Injection Procedure Pain

JUVELUX injections are performed with anesthesia cream and local anesthesia prior to injection, and the injection is performed with an ultra-fine needle, so there is almost no pain during the procedure.

A stinging pain may be felt when applying the anesthetic needle, and heat may be felt when injecting the water-light injections.

Need for anesthesia|High

Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.

If you are anxious about pain, laughing anesthesia can be used to alleviate it, but Smart Skin Clinic does not recommend excessive anesthesia, which can be economically and physically burdensome.

Downtime of JUVELUX aqueous light injections

No matter how effective the treatment is, it is difficult to undergo the procedure if the downtime is heavy. However, it is safe to say that the downtime for JUVELUX Hydroxyapatite Injection is relatively light.

Downtime duration and symptoms of JUVELUX aqueous light injections

[Downtime period

  • almost none

Downtime Symptoms

  • Redness: several days
  • Swelling: several days
  • Thinning sensation: several days
  • Needle scar: several days
  • Internal bleeding: 1 to 2 weeks

There are some postoperative symptoms, but they are rarely noticeable enough to interfere with daily life, and last about a week at most. All of them will settle down with time.

Internal bleeding takes time to fade away, but it gradually fades to the point that it can be covered with makeup such as a covering foundation or concealer.

How to spend the downtime of JUVELUX aqueous light injections

After JUVELUX Hydrofluorescent Injection, please be careful of the following actions to avoid wasting the effect.

very dayRefrain from washing face and skin care for about half a day to promote drug penetration
Shower bath available.
Do not knead or rub hard.
next dayFacial cleansing foam can be used.
make-up allowed
Approx. 3 days
(until redness subsides)
Refrain from using cleansers, skin care products, and topical medications that contain peeling ingredients
Approx. 1 weekRefrain from massaging the face.
OtherMoisturizing and UV protection are essential.

Although invisible to the eye, the postoperative skin is in the process of healing.

Avoid irritation due to the delicate condition, and try to keep the skin moisturized and protected from ultraviolet rays.
In addition, to avoid augmenting downtime symptoms, avoid activities that stimulate blood circulation.

Jubeluk The risks of aqueous injections are "allergy" and "infection."

The risks of JUVELUX Hydrophotonics injections include "allergy" and "infection". If you are aware of the precautions beforehand, you can avoid some of the risks.

Although JUVELUX is a relatively safe preparation, there is no possibility of allergy. In addition, patients who are allergic to hyaluronic acid or metal cannot undergo the procedure. If you have any other concerns, please consult us in advance.

To avoid infection, you should take precautions yourself, such as not touching the skin unnecessarily after the surgery and refraining from wearing makeup on the day of the surgery.
Downtime symptoms will abate over time, but if pain, swelling, or heat in the affected area increases, medical attention is required because infection is suspected.

Please contact the clinic as soon as you notice symptoms.

When JUVELUX Aqueous Light Injection is effective and how long it lasts

JUVELUX hydroxyapatite injections have both short-term and medium- to long-term effects.

[Short-term effects
Immediately after, water retention and moisturizing effects by hyaluronic acid can be expected.

[Medium- to long-term effects
As the polylactic acid is broken down, fibroblasts are stimulated, and the skin growth effect is gradually observed.
The effect can be felt after 2-3 weeks and lasts for 1-2 years.

After one course of treatment, the effect lasts about one year.

Effects may vary from person to person.

Number of JUVELUX Aqueous Light Injections and Interval between treatments

Once a month x 3 times = 1 course

After completion of one course, one course per year

Although JUVELUX hydroxyapatite injections can be effective even once, regular maintenance is more effective if the goal is to improve skin texture.


Campaign price for introduction of Aqueous Light Injection Jubeluk is now available.

Once51,800 yen → Total price
(14,600 yen per cc)
3 sets155,400 yen → 119,400 yen
(39,800 yen per session)
Once69,000 yen → 51,920 yen
(12,980 yen per cc)
3 sets207,000 yen → 149,400 yen
(49,800 yen per session)
Once103,600 yen → 58,800 yen
(9,800 yen per cc)
3 sets310,800 yen → 164,400 yen
(54,800 yen per session)

Need for anesthesia|High

Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.

There will be no upsells other than those indicated in the price listings on the day of the event.

Reference] How to choose the dosage (cc)

JUVELUX dosage guidelines (1)
JUVELEC dosage guidelines (2)
JUVELUX dosage guidelines (3)
Explanation of how to select dosage (cc)
  • We also offer "3cc" for easy consideration in accordance with the notation of other hospitals.
  • On the other hand, 3cc is not enough for the whole face (full face), so if you want the maximum effect, please refer to the following for your choice
  • Pattern 1] The forehead and the area from the nose down can be lighter ⇒ 3cc
  • Pattern 2] The area from the nose down can be lightened a little, but from the nose up, it should be done firmly ⇒ 4cc
  • Pattern (3)] The entire face, including the nose and below the nose, should be done thoroughly ⇒ 6cc
  • If you are not sure, the doctor will confirm your request on the same day and suggest the optimal volume (please be assured that we never upsell unnecessarily).

JUVELUX Aqueous Light Injection Procedure Flow

The procedure flow of JUVELUX Hydrophotonics injections is as follows


You can easily make reservations with your mobile phone.

Reception (desk)

This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.

Counseling and medical examination

Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.

Jubeluk injection

Remove makeup, sunscreen, and dirt before treatment.
Cream anesthesia is applied, local anesthesia is administered, and the injection is carried out while the patient is asked.

After-sales service

We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.

Returning home

Comparison of Jubeluk and Ridjulan

Like Jubeluk, another popular skin booster formulation is Rejuran.

Many people wonder which is better. JUVELUX is designed to promote collagen production, while Rejelan is designed to regenerate skin tissue by stimulating angiogenesis and anti-inflammatory effects, so the expected effects are also different. By choosing the right formulation for you, you will be able to feel the effects more easily.

Juvelook REJURAN
Polylactic acid (PDLLA)ComponentPolynucleotides (PN)
Stimulates the inside of the skin and promotes collagen regeneration
Create natural skin volume
Increased skin elasticity
Pore tightening
Improvement of fine lines and wrinkles
Effectraise the water content
Restoration of skin elasticity
Improvement of fine lines and dark circles around the eyes
Improved skin elasticity and luster
Improvement of fine lines and wrinkles
I want a natural finish.
2 to 3 weeks laterEffectiveness2-4 weeks later
Three times at one-month intervals,
Maintenance every 6 months to 1 year thereafter
Interval CountThree to four treatments spaced about 2 to 4 weeks apart,
Maintenance every 6 months to 1 year thereafter
Slowly decompose over 1-2 yearsDurationMore than 1 year

JUVELUX Comparison of aqueous light injections and hyaluronic acid injections

Hyaluronic acid injections inject a gel hyaluronic acid preparation to physically create volume and shape and improve wrinkles.

JUVELUX stimulates collagen production in the body after penetration of the formulation, naturally increasing skin elasticity.

More Information

Treatment Time30-40 minutes (not including counseling)
Recommended number and frequency of treatmentsIt is recommended that the program be performed in sets of three at one-month intervals.
After that, maintenance is recommended every 6 months to a year.
Down timeAbout 2 to 3 days
Treatment on the day of counselingPossible
MakePossible after 24 hours
Skin carePossible immediately after the treatment
ShowerPossible from the same day
PainThere is a stinging pain when the needle is inserted.

*There are individual differences.

[Legal description

Water Light Injection includes procedures using medicines or medical devices that are not approved in Japan. The medicines and devices used in the treatment have been imported on a personal import basis under the judgment of our physicians.

Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".

The following persons are not eligible for the treatment

  • Have allergies or skin diseases
  • Infectious diseases.
  • Severe acne in progress.
  • Has a bleeding disorder.
  • Uncontrolled diabetic complications and significant disease
  • Pregnant or possibly pregnant
  • keloid constitution

Please contact us if you have any other diseases.

Visit Smart Skin Clinic for Jubeluk aquatic light injections.

Have your questions been answered about JUVELUX hydroxyapatite injections?

JUVELUX Hydroxyapatite Injection is a new skin growth treatment that is safe and requires little or no downtime.
If you are interested in growing healthy skin, please feel free to contact us for a free consultation. As a specialist, we will propose the appropriate treatment after listening to your wishes.

Smart Skin Clinic strives to maintain the quality of its equipment and preparations by eliminating unnecessary costs for its customers. We offer a set fee for each treatment or for the recommended number of treatments (3 treatments for JUVELUX). There is no pressure sales, so please rest assured.