Hydrophotoluminescence injection x Rejuran

I was wondering, "What are the effects of Rejuran Hydrophotonic Injections? How is it different from other procedures?"

Is the pain and downtime with Rejuran painful?"

How many treatments should I have? How often?"

Do you have any of these questions about Rejuran Hydrophotonic Injections?

Hello, this is Aesthetic Dermatology and Smart Skin Clinic.

We will explain what Rejuran Hydrophoton Injection is, its effects, how it is performed, the recommended number and frequency of treatments, downtime, and how to spend time after the surgery from a medical standpoint.

*Please press the item you are interested in from the table of contents below to jump to it.

What is "Suiko-injection x [Rejuran formulation]"?

Rejuran Hydrophoton Injection is a skin texture improvement treatment that directly injects a drug called Rejuran into the dermal layer using a special injector.

The synergistic effect of "the cosmetic effect of Rejuran to activate skin cells" and "the wound-healing action of Suikoh Injection" can be expected.

What is Aquatic Light Injection?

Hydroxyapatite injections are a treatment in which the drug is injected like a stamp with nine ultrafine needles per shot.

When the needle is set, suction pressure causes the ultrafine needle to penetrate the skin, and the drug is injected evenly at the pre-set depth. When the needle leaves the skin, the injection is complete. By creating a wound with the needle, the procedure utilizes the "wound healing" function that is inherent to human nature, and is expected to increase collagen production.

See also this article for more information about water light injections.

What is Rejuran?

Rejuran is a formulation containing polydeoxynucleotides (PDRN), which are extracted from salmon DNA, as the active ingredient, and has the effect of enhancing the skin's self-regenerating ability.

Polydeoxynucleotides (PDRN) have various effects, such as increasing growth factor production, promoting capillary circulation, anti-inflammatory effects, and DNA resynthesis. It also contains "astaxanthin," an ingredient with excellent antioxidant properties. In addition, there are several types of Rejuran, such as "for the eye area only" and "with anesthesia.

See also this article for more information about Rejuran.

Various studies have reported on the effectiveness of Rejuran, including the following paper.

Rejuran injection showed the highest elasticity and collagen composition for wrinkles in the corner of the eyes compared to phosphate buffered saline and Ivoire® (hyaluronic acid formulation) injection, with significant differences in texture and wrinkle depth.

Chang Sik Pak, Jongho Lee, Hobin Lee, Jaehoon Jeong, Eun-Hee Kim, Jinwook Jeong, Hyeyeon Choi, Byunghwi Kim, Sujin Oh, Iksoo Kim, Chan Yeong Heo. A phase III, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy A phase III randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy, and safety between polynucleotide filler and hyaluronic acid filler in the correction of crow's feet: a new concept of regenerative filler . Journal of Korean medical science. 2014 Nov;29 Suppl 3(Suppl 3);S201-9. doi: 10.3346/jkms.2014.29.S3.S201.

Polynucleotide (PN) filler injection on one side of the periorbital area and non-cross-linked hyaluronic acid (HA) filler injection on the opposite side were compared. The rate of improvement in skin elasticity and hydration decreased over time in both groups, with a higher rate of improvement in the PN group, and a higher rate of improvement in rough skin and pore volume in the PN group than in the HA group.

Ye Jin Lee, Hak Tae Kim, You Jin Lee, Seung Hwan Paik, Young Seon Moon, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Joon Min Jung, Chong Hyun Won. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. The Journal of dermatological treatment. 2022 Feb;33(1);254-260. doi: 10.1080/09546634.2020.1748857.

Differences in Rejuran treatment methods

There are several treatment methods for Rejuran, including "water light injections", "manual injection by a doctor" and "dermapen". The advantages and disadvantages of each are compared.

Manual Striking by PhysiciansDeliver the required amount of drug to the required depth.
Almost no leakage of chemicals
The result depends on the skill of the doctor.
High price
dermapenThe dermapen itself is highly effective in the form of a microscopic needle puncture.
Suitable for skin resurfacing due to the application of chemicals
Difficult for drugs to penetrate into the skin
Vital InjectorUniformly injects drugs to the desired depth
Cheaper than a doctor's manual
The drug may not be injected 100% into the skin and a small amount may leak (not necessarily 30% leakage, but several % to 10%).

Manual injection by a physician has the advantage of delivering the drug only where it is needed, but the finished product is dependent on the skill of the physician.

Dermapen, like hydrophoton injections, uses multiple ultrafine needles that are inserted like a stamp. Because the drug is applied over the needle holes, it is suitable for treatment of skin surfaces such as acne and pores, but its disadvantage is that it is difficult for the drug to penetrate into the skin.

Because nine stitches per shot can be injected together, the speed and pressure of the water light injections are constant. It has the advantage of being able to inject the drug evenly to the desired depth, which is difficult to achieve with other treatment methods. However, if you want to change the injection amount for different areas, you need to make detailed adjustments on a case-by-case basis.

Effects of Hydrophoton Injection x Rejuran

Rejuran hydrophoton injections are expected to work on fibroblasts to promote angiogenesis and have an anti-inflammatory effect.

As a result, you will notice an improvement in skin luster, makeup application, fine lines and wrinkles, pores, and sagging skin.

For people whorecommendation

Hydrophotoretic injections with Rejuran are recommended for people with the following skin concerns

  • Skin is very dry and needs moisture
  • To improve skin texture
  • To improve skin elasticity and luster
  • Pores are prominent, blackened, and need tightening
  • I want elasticity, I want to improve lines.
  • To improve spots, dullness, and melasma
  • To improve fine lines and dark circles
  • Concerned about acne scars
  • I want a natural finish.

People who cannot receive Rejuran Hydrofluorescent Injection

The following persons are not eligible for the treatment.

  • Pregnant or nursing mothers
  • Persons with abnormal immune function or with a history of such abnormality, and persons receiving immunosuppressive therapy.
  • Those prone to keloid formation, hypertrophic scars and hyperpigmentation
  • Those with bleeding tendency or using non-steroidal anti-inflammatory analgesics such as aspirin or anticoagulants such as warfarin
  • Excessive sunburn, eczema, dermatitis, highly inflamed acne, or scabs at the site of hydroxyapatite injection
  • Those with fish allergies

Differences between Rejuran and other formulations

Various formulations are used for water light injections, but what makes Rejuran different from other formulations?

Hyaluronic acid is a typical agent used in aquatic light injections. When volume is created by injected ingredients, such as hyaluronic acid, the volume will return to normal as the ingredients are absorbed by the body.

On the other hand, Rejelan does not physically increase volume, but rather regenerates the skin and increases collagen by itself, making it difficult for the skin to return to its original state.

When the effect of Rejuran Aqueous Light Injection appears, duration, and frequency of injection.

The effects of Rejuran are visible after 2 to 4 weeks, and while a single session is effective, the effects are more noticeable with repeated sessions.

After 3 to 4 treatments spaced 2 to 4 weeks apart, the effect can be expected to last for a year or more. After that, maintenance every 6 months to 1 year is recommended.

Smart Skin Clinic's "commitment" to water light injections ".

Rejuran Hydrophoton Injection flow and treatment time

The procedure takes about 30-40 minutes excluding counseling and about 60 minutes including anesthesia.
The flow of the treatment is as follows

Counseling and medical examination

When the handle piece is set on the skin, suction pressure causes the needle to pierce the skin.

Drug is injected uniformly at a pre-set depth.

When the needle leaves the skin, the injection is complete.

Returning home

Pain from Rejuran hydrophoton injections

Rejuran hydrophoton injections are only painful to the point of tingling.

By injecting while suctioning, pain is reduced compared to manual injection. Since the needle is ultrafine and 9 needles can be injected at once, the amount of injections per injection is large, and since repeated injections are unnecessary, pain is also reduced. However, the pain felt varies from person to person.

Pain can be reduced by cooling the affected area beforehand and using a surface anesthetic. For those who are anxious about needles and pain, it is recommended to confirm the availability of laughing anesthesia, which has an anxiety-relieving effect.

Downtime, Side Effects, and Risks of Rejuran Hydrophoton Injection

Downtime, side effects, and risks of Rejuran Hydrophoton Injection are presented.

Rejuran Aqueous Light Injection Downtime Duration and Symptoms

Downtime period is approximately 2-3 days.

Because the needle is inserted into the skin, there will be redness at the injection site and bumpy bumps on the skin, which will gradually recede and return to normal in about 24 hours.

Due to the nature of the treatment, subcutaneous bleeding may occur at the needle puncture site, although not always. If subcutaneous bleeding spots occur, they will gradually disappear over a period of 10-14 days.

For more information about the downtime of hydroxyapatite injections, please also see here.

Rejuran What is the pain after aqueous injections? How to relieve it?

Postoperative pain is mild, but the perception of pain varies from person to person.

If the pain is painful, cooling can relieve it. Wrap a coolant in a clean cloth and apply it intermittently to the affected area.

Risks associated with Rejuran Hydrophoton Injection

In addition to downtime symptoms, other side effects of Rejuran x Hydroxyapatite injection treatment include the following

  • pigmentation
  • infection
  • allergy

Swelling, pain, and redness should subside over time, but if they intensify, infection may be present. Consult the clinic.

Rejuran is not suitable for those who are allergic to fish, as it contains ingredients extracted from salmon DNA.

How to spend time after Rejuran x Hydroxyapatite injection

There is no major impact on daily life after Rejuran x Hydroxyapatite injection, but please note the following points.

  • Skin care: Possible immediately after the treatment
  • Shower: possible on the same day
  • Makeup: possible after about 24 hours

After the procedure, the skin is trying to repair the needle puncture wound. Please avoid prolonged bathing, strenuous exercise, massage, and other activities that increase blood circulation, which can impede recovery.

Advantages and disadvantages of Rejuran x Hydrophoton injection

The following are the advantages and disadvantages of Rejuran x Hydrophoton injections.


  • Less pain compared to manual hammering
  • Can be approached deep into the skin.
  • Can be injected to the eye area.
  • Short treatment time
  • Effects are felt immediately after downtime.
  • Needle pricking gives bounce.


  • Needle scars remain after the procedure.
  • Downtime.
  • Effects are not permanent.

How to maximize the effects of Rejuran Hydrophoton Injection

In order to maximize the effects of Rejuran Hydrophoton Injection, the following points should be considered.

  1. Select a reliable clinic based on performance and reviews.
  2. Share your concerns and ideals in a counseling session, confirm indications, treatment details, downtime, and fees, and resolve any questions you may have.
  3. Take precautions
  4. Receive regular treatment.

The level of skill varies from doctor to doctor, even for the same procedure. Check the indications, share your ideals, and work on what you can do on your own.

Treatment Time30~40 minutes (not including counseling)
Recommended number and frequency of treatmentsAlthough it varies depending on the drug, we recommend 3 to 4 sessions at roughly 2 to 4 week intervals.
Down timeAbout 2 to 3 days
Treatment on the day of counselingPossible
MakePossible after about 24 hours
Skin carePossible immediately after the treatment
ShowerPossible from the same day
PainThere is a stinging pain when the needle is inserted.
*There are individual differences.

For water light injections, go to Smart Skin Clinic.

Smart Skin Clinic is committed to providing smart medical care by cutting back on ornate decor and unnecessary costs and carefully selecting equipment.

Smart Skin Clinic's aquatic light injections have 9 ultra-fine needles, depth can be adjusted from 0.6 to 1.2 mm under the skin, and the injection volume can be controlled. The fee is clearly indicated.

If you have any questions, please feel free to consult with us at a free consultation. Our doctors will assess the indications and propose the most appropriate treatment.