Treatment of laugh lines with PRP injections (expected to last longer than 5 years)|Smart Skin Clinic Yahoo!


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"I just want to get rid of my nasolabial folds."
"I've been comparing options for my nasolabial folds — hyaluronic acid injections, facelifts, thread lifts — but I'm afraid of surgery. Isn't there a way to get a natural-looking result?"
Hello, I'm a physician at Smart Skin Clinic, a cosmetic dermatology clinic. Do any of these questions or concerns sound familiar?
This article offers a clear explanation from the perspective of the director of Smart Skin Clinic.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
Do you have any of these concerns?
Ugh… it got deeper again…
Nasolabial folds that grow deeper as we age.
- Nasolabial folds so pronounced you're afraid to smile
- Sagging around the mouth that has crept up on you before you knew it
It really shakes your confidence when someone points it out…
What is different from my skin back in my teens?
The difference is…
The collagen and elastin that kept your skin looking beautiful have decreased with age.
This is one of the causes of nasolabial folds.
That said,
we don't really recommend conventional hyaluronic acid injections or facelifts…
Risks of hyaluronic acid injections (cross-linked type)
- There is a risk of blood clots
- Clots form inside the blood vessels and block the flow
- When this happens, it can lead to serious conditions such as heart attack and stroke
- They give an immediate volumizing effect, but are absorbed within 6–12 months
- They can feel off, and a lingering sense of a foreign object may remain
- Overdoing hyaluronic acid injections carries a risk of an unnatural look
Risks of a facelift
- There is a risk of infection associated with surgery
- There are risks associated with anesthesia
- Long downtime (around 1–2 weeks)
- It may leave scars for life
To you, who matter to us
Procedures that carry high risk and burden,
we do not recommend.
So, what should you do?
Not to worry.
- Relatively low risk of blood clots
- Less sensation of a foreign substance
Let us introduce a new treatment. It is…
PRP injections into the nasolabial folds.
What Is PRP Injection?
PRP injection is a treatment that uses components drawn from your own blood to plump up the skin.
Blood contains tiny particles called "platelets." These platelets have the ability to heal wounds and produce new substances. In a PRP injection, a small amount of blood is first drawn from your arm. Only the platelets are extracted from that blood, concentrated, and then injected into your skin.
Once injected, the PRP begins to work within the skin, increasing collagen and elastin, the components that make skin look plump. This is the mechanism by which wrinkles and sagging are improved.
Three Features of PRP Injection
1. Long-lasting effects
The effecttypically lasts 5 years or moreBecause a single treatment offers long-lasting effects, our patients are very pleased with the results.
2. Natural-looking results
Because it uses components derived from your own body, the result looks natural. The risk of the lingering unnaturalness sometimes seen with hyaluronic acid injections is small.
3. Customized treatment
At our clinic, we adjust the concentration and injection volume to suit each patient’s skin condition and goals, and design the injections on an individual basis.
Compared with hyaluronic acid injectable fillers, this approach allows for a more finely tailored design to match your needs.
Mechanism of PRP injections: why are they effective for nasolabial folds?
The main reasons PRP injections are effective for nasolabial folds are the followingFour Mechanismsis due to
1. Promoting Collagen Production
PRP injections promote collagen production, improving the skin's firmness and elasticity. This helps improve the sagging skin that causes nasolabial folds.
2. Promoting elastin production
PRP injections also promote elastin production. Elastin is an important protein that maintains skin elasticity, and increasing it makes the skin around the nasolabial folds more supple.
3. Improving skin thickness
The dermal layer of the skin is thickened by the action of PRP injections. This helps make nasolabial folds less noticeable.
4. Boosting circulation
PRP injections promote the formation of new blood vessels. Blood circulation improves and skin metabolism is activated. This leads to an overall improvement in skin quality around the nasolabial folds.
The combined action of these mechanisms helps improve the appearance of nasolabial folds.
PRP Injection Is Recommended For
Those concerned about nasolabial folds
Those who have noticed more visible expression lines
Those concerned about sagging cheeks
Those who want to restore firmness
and elasticity to the skin overall
Those who want a natural-looking result
PRP Injection Pricing at Smart Skin Clinic
PRP injection price list at Smart Skin Clinic (private-pay treatment)
This treatment offers a duration of around 5 years.
| Once | 145,600 yen |
| Price per area when treating 2 or more areas | 116,480 yen |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Prices are shown all-inclusive, covering consultation and needle fees.
There is no separate upselling on the day.
PRP Injection Procedure
- Blood draw: A small amount of blood is drawn from the patient's arm
- Extracting components from the blood: a special centrifuge is used to extract the skin-plumping components
- Adding nutrients: nutritional components are added to the extracted blood components
- Injection design: we create the design best suited to your concerns
- Injection: a fine needle is used to inject the skin around the nasolabial folds
The needles used are extremely fine, minimizing pain. Anesthetic cream can also be used if needed.
Precautions and Side Effects
PRP injections may cause the following temporary side effects:
・Mild swelling or bruising at the injection site
・Temporary pain or discomfort
In rare cases, infection or an inflammatory reaction may occur, but our strict hygiene management keeps these risks to a minimum.
FAQ
Q1: Is PRP injection painful?
A1: Because we use an extremely fine needle and can apply anesthetic cream if needed, most patients experience only mild discomfort.
Q2: When can I expect to notice results?
A2: Results vary by individual, but most patients begin to notice a gradual effect from around 2 to 4 weeks. The full effect often appears after 3 to 6 months.
Q3: How many sessions are typically needed?
A3: A single treatment usually lasts for more than 5 years. (*Results may vary from person to person.)
Summary
PRP injection is a treatment to improve nasolabial folds. Because it uses ingredients from your own body, the results look natural. It may be able to address even deeply etched nasolabial folds and is expected to offer long-lasting effects.
At Smart Skin Clinic, we draw on our expertise in injection-based treatments to offer PRP injections.
Since results and duration vary by individual, we recommend a personal consultation for more detail. Let's find the nasolabial fold treatment that's right for you.
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of Smart Skin Clinic's supervising physicians.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
This page is operated as a medical institution's website in accordance with the Medical Advertising Guidelines revised and enforced in June 2018, and is produced under the supervision of our supervising physician.
Physician Who Supervised This Page

Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
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