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What is Cellular Regenerative Medicine Exosome Infusion Therapy? A doctor thoroughly explains the effects, cost price, and side effects.
I've heard a lot about exosome infusions lately, but what kind of treatment?"
Is it really anti-aging? How much does it cost? I'm worried about side effects and risks..."
Attracting attention in the field of regenerative medicineExosome infusionThe first is the "Positive" treatment. Interest is growing, especially among the cosmetically conscious, but there is still little information available on this new treatment method, and many people may feel uneasy about it.
This article is about exosome infusion.What is the exosome anyway?From the basic knowledge that,Expected effects, cost price, disadvantages, side effects, and points to consider when choosing a clinicThe latest medical findings will be used to provide detailed explanations of everything from
If you are considering exosome infusion, or even if you are just "gathering information first," we hope you will find this information useful.
The first time you purchase Exosome derived from umbilical cord is 18,400 yen and up ／.
We offer high-quality umbilical cord-derived exosome infusions at reasonable prices.
▶ Exosome infusion at Smart Skin Clinic Details and fees
What are exosomes anyway? Transmitters between cells
To understand exosome infusion, we first need to know about the substance "exosomes".
Basic Information on Exosome
Exosomeis an extremely small granule-like substance with a diameter of 50 to 150 nm (nanometers) that is secreted by almost all cells in our body. 1 nm is one billionth of a meter, so tiny that it cannot be seen with the naked eye or even with a conventional microscope.
Inside the exosomes are the following important components
- nucleic acid(microRNA, messenger RNA, DNA, etc.)
- protein
- growth factor
- cytokine(Cell-to-cell signaling molecules)
They serve as "blueprints" or "instructions" for cell regeneration and repair.
Why Exosomes Are Called "Messengers of Regeneration"
The most important functions of the exosome are"Cell-to-cell communication."It is.
Once secreted by cells, exosomes travel throughout the body in blood and lymph fluid to deliver various information to cells in remote locations. For example, they convey instructions such as, "This part of the body is damaged and I want you to repair it," or "I want you to activate aging cells.
Because of this function, exosomes are"A tool for cell-to-cell communication."and ... andMessenger of Renewal."It is called
Exosomes are being studied at the Tokyo Metropolitan Institute of Gerontology and Geriatric Medicine and other research institutes around the world, and are expected to be applied to regenerative medicine and disease treatment.
What is an exosome infusion? How it works and its features explained
How Exosome infusion works
Exosome infusionis a treatment in which exosomes contained in "stem cell culture supernatant fluid," which is secreted in the process of culturing stem cells, are administered directly into blood vessels through intravenous infusion.
Stem cell culture supernatant fluid is the supernatant fluid produced when stem cells are cultured. It contains hundreds of active ingredients, including exosomes, growth factors, immunomodulating factors, and nerve regeneration factors.
Why "intravenous infusion"? Systemic action is the key.
In addition to intravenous infusion, there are other methods of administering exosomes, such as injections (topical administration) and nasal drops. Among these, the main reasons for choosing intravenous infusion areSystemic effects."It is.
Exosomes administered directly into blood vessels travel throughout the body in the bloodstream. They then act on cells in all organs, including the skin, hair, brain, internal organs, and blood vessels.
Exosomes are so small that they can move freely between tissues through blood vessel walls. When they find damaged or aging cells, they gather there to promote repair and activation. This function is calledHoming effect."This is why the Exosome infusion is considered to be effective for "whole body anti-aging".
What to expect from an exosome infusion
Exosomes have diverse functions, including anti-inflammatory, antioxidant, tissue repair, and angiogenesis. These actions are expected to have the following effects
1. skin beautification and anti-aging effects
Exosomes are found in the dermal layer of the skin.fibroblastand promotes the synthesis of collagen and elastin.
Rohto research has reported that exosomes inhibit fibroblast senescence and promote the synthesis of dermal components.
Specifically, the following skin beautifying effects can be expected.
- Improved skin elasticity and luster
- Improvement of wrinkles and sagging
- Reduction of spots and dullness
- Pore tightening
- Increased skin clarity
2. recovery from fatigue and malaise
Acting on cells throughout the body, exosomes support recovery from fatigue at the cellular level.
Those who have actually undergone the treatment have reported that their fatigue was reduced after just one infusion and that they feel more awake in the morning. This treatment is popular among those suffering from chronic fatigue and malaise.
3. improvement of immunity and alleviation of allergy symptoms
Exosomes have the ability to regulate the function of immune cells. By balancing immune function, it may reduce the risk of catching colds and alleviate allergic symptoms such as atopic dermatitis and hay fever.
4. improvement of sleep quality and cognitive function
Exosomes also reach the brain and promote the repair and activation of brain cells. It is expected to improve insomnia, improve concentration, and support memory.
Research is also underway on its effects on the causative agents of Alzheimer's disease (amyloid beta and tau protein), and its ability to maintain and improve cognitive function is also attracting attention.
5. improvement of hair growth and thinning hair
Since hair is also made up of cells, exosomes can be expected to improve thinning hair and hair loss, as well as hair elasticity and strength, by working on hair matrix cells. Exosomes are also attracting attention as a new option for the treatment of thinning hair in women.
6. vascular rejuvenation
Exosomes promote anti-inflammation and anti-oxidation of vascular endothelial tissue, leading to elastic and supple blood vessels. Rejuvenation of vascular age may lead to prevention of stroke and myocardial infarction.
7. improvement of menopausal symptoms and male function
It is also expected to be effective in alleviating symptoms of menopause caused by changes in hormone balance and improving male functions such as ED (erectile dysfunction).
8. effect on the sequelae of novel coronavirus
The anti-inflammatory effects of exosomes have also shown promise in alleviating symptoms of the aftereffects of novel coronavirus infection (fatigue, brain fog, etc.).
Types of Exosomes｜Comparison of differences by origin
Exosomes are classified into three main types depending on the site (origin) from which they are harvested. It is important to understand the differences because the exosomes used differ from clinic to clinic.
| origin | source (e.g. of a signal) | feature |
|---|---|---|
| Umbilical cord-derived | Umbilical cord (cord blood) | More than 14 times more active ingredients than other sources. Rich in the rejuvenating protein GDF-11. Considered to be of the highest quality. |
| Fat-derived | adipose tissue | Relatively easy to collect. Often used in cosmetic clinics. |
| Bone marrow and dental pulp derived | Bone marrow and tooth center | Research is ongoing, but collection is difficult. |
especiallyUmbilical cord-derived exosomesis rich in GDF-11, an active ingredient for the skin and involved in rejuvenation, and is expected to have a high anti-aging effect.
💡 For those looking for umbilical cord-derived exosomes
We use high quality umbilical cord derived exosomes that are MISEV2018 compliant. We offer it at a reasonable price starting from 18,400 yen for the first time.
▶ For more information on umbilical cord-derived exosome infusion, click here.
Cost of exosome infusion
Exosome infusion ismedical treatment at one's own expenseand therefore are not covered by health insurance. Costs vary widely depending on the clinic, the type of exosomes used, and the dosage.
General cost price
| (data) item | cost price |
|---|---|
| Cost per transaction | 30,000-200,000 yen |
| Umbilical cord derived (high quality) | 50,000-150,000 yen/times |
| Fat-derived | 30,000-80,000 yen/times |
| Recommended frequency | About 5 to 10 times |
| Recommended Frequency | Once every 1 to 2 weeks |
Reasons for high costs
There are two main reasons why the cost of exosome infusion is so high
- Rarity of raw materials: Especially cord blood-derived products are rare because they can only be collected at birth.
- Complexity of the manufacturing process: Requires advanced techniques and equipment for stem cell culture, purification of supernatant fluid, and quality control.
Duration of effect and need for continuity
The effects of exosome infusion areAbout 1 to 3 monthsIt is said that the effect will gradually fade with time. Therefore, regular treatments are necessary if the effect is to be maintained.
Most clinics recommend 5-10 intensive treatments every 1-2 weeks at first, followed by monthly maintenance.
＼ Cheaper than the market price! From 18,400 yen for the first umbilical cord-derived product
Smart Skin Clinic offers high-quality umbilical cord-derived exosomes at the lowest price in the industry; a course of 10 sessions costs 17,900 yen per session.
▶ See price list and course details
Disadvantages and cautions of exosome infusion
Exosome infusion has advantages as well as disadvantages and things to be aware of. Be sure to understand them before undergoing the procedure.
Disadvantage 1: You will not be able to donate blood.
When you get an exosome infusion,(You will not be able to donate blood or have a blood transfusion after this date.. This is based on the policy of the Ministry of Health, Labor and Welfare, because current testing methods cannot completely confirm the safety of blood when treated with human-derived tissue.
Also,You will no longer be able to register with the bone marrow bank.If you are considering blood or bone marrow donation in the future, please consider carefully.
Demerit 2: High cost
As mentioned above, each session will cost several tens of thousands to several hundred thousand yen. The total cost is even higher because it must be continued to maintain its effectiveness.
Disadvantage 3: Requires regular visits to the hospital.
The effects are not permanent, so regular visits to the clinic are necessary to continue receiving the treatment, which takes about 15 to 30 minutes per session, but can be burdensome for busy people.
Disadvantage 4: Insufficient long-term evidence
Exosome infusion is a relatively new therapy and there is not yet sufficient clinical data on its long-term effectiveness and safety. Although research is ongoing, it is important to understand that we are not at a stage where we can say with certainty that it is absolutely effective.
Side effects and risks of exosome infusion
General side effects (mild)
Most of the possible side effects of exosome infusion are similar to those of a typical infusion.
- Pain, redness, swelling, and internal bleeding at the puncture site
- Temporary health problems such as headache, nausea, etc.
These usually resolve spontaneously within a few hours to a few days.
Rare possible side effects
- anaphylactic reaction(Acute allergic reaction)
Although very rare, allergic reactions such as vomiting, abdominal pain, decreased blood pressure, and difficulty breathing may occur. If you have had allergic reactions to injections or infusions in the past, be sure to consult your doctor in advance.
Relationship to Cancer
The relationship between exosomes and cancer is an ongoing medical debate.
Some studies suggest that exosomes may promote the growth of existing cancer cells. On the other hand, others report that it inhibits cancer cell growth, and no conclusions have been reached.
In any case, at this time, most clinics refrain from performing the procedure if the patient is undergoing treatment for cancer or has a history of cancer.
People who cannot receive exosome infusion
The following patients may not be eligible for Exosome infusion
- Undergoing treatment for a malignant tumor (cancer) or not yet in remission for 5 years.
- Pregnant or nursing
- Currently suffering from an infectious disease
- Immunosuppressed
- Those who have had allergies to exosome-related procedures in the past.
- Persons with autoimmune diseases
- Patients with blood disorders such as coagulation abnormalities
- Patients taking anticoagulants
- Those considering blood donation, transfusion, or bone marrow donation in the future
If you are unsure if this applies to you, please discuss this with your physician during counseling.
5 points to check when selecting a clinic
The formulations used, prices, and quality control systems for exosome infusion vary widely from clinic to clinic. To ensure that you receive the treatment with peace of mind, check the following points.
1. origin and quality standards of exosomes
Check which origin (umbilical cord, fat, bone marrow, etc.) exosomes are used. Also,MISEV2018(Guidelines of the International Society for the Study of the Endoplasmic Reticulum) is also a measure of quality.
2. accreditation and qualification as a medical institution
Ministry of Health, Labor and Welfare.Approval of the plan for providing regenerative medicine, etc.A clinic that has received a certification is a facility that has met the national standards. Check to see if the accreditation number is published.
3. whether or not there is a medical examination/explanation by a physician
Make sure that there is a doctor's consultation before the procedure and that the risks and side effects are adequately explained. It is best to avoid clinics that do not provide sufficient explanations or force you to sign a contract.
4. transparency of fee structure
Make sure that the fee schedule is clearly disclosed, that there are no additional fees, and that you know the details of the course contract in advance. It is important to do research in advance to avoid problems such as "I was recommended an expensive course when I went for counseling.
5. after-sales follow-up system
It is also helpful to check if there is a system for responding to any changes in physical condition after the treatment and if there is a consultation service.
Frequently Asked Questions about Exosome Infusion
Q. Can I feel the effects even after just one visit?
A. Although there are individual differences, some people feel "less tired" or "better skin tone" after even one treatment. However, it is recommended to continue the treatment for 5 to 10 times to feel the firm effect.
Q. How long does the procedure take?
A. The infusion itself takes about 15-30 minutes. Including the counseling and consultation, the initial session should be expected to take about one hour.
Q. Is there any pain?
A. As with a regular infusion, there is a stinging pain when the needle is inserted. There is almost no pain during the procedure.
Q. Is there any downtime?
A. Almost never. You can return to makeup and daily life immediately after the procedure.
Q. What is the difference from NMN infusion?
A. NMN infusion is a treatment that increases cellular energy production by administering a coenzyme precursor called "NAD+". Exosome infusion activates cells through intercellular communication. Because of their different mechanisms of action, some patients use both together.
Q. How long do the effects last?
A. Generally speaking, it takes about 1 to 3 months. It depends on individual differences and lifestyle.
Summary｜Exosome infusion is a regenerative medicine aiming at "total body rejuvenation
Exosome infusion is a form of regenerative medicine in which exosomes contained in stem cell culture supernatant solution are administered into blood vessels and work on cells throughout the body to produce anti-aging effects.
Expected Effects:
- Skin care and anti-aging
- Relief of fatigue and malaise
- Improved immunity
- Improved sleep quality and cognitive function support
- Hair growth and thinning hair improvement
- Rejuvenation of blood vessels
Disadvantages to note:
- No longer able to donate blood or bone marrow
- High cost (30,000-200,000 yen per visit)
- Continuity is necessary to maintain effectiveness.
- Long-term evidence is developing.
If you are considering exosome infusion, we recommend that you fully understand the advantages and disadvantages, choose a reliable clinic, and consult with a doctor before making a decision.
Exosome infusion at Smart Skin Clinic
This hospital is located inMinistry of Health, Labour and Welfare(Certification number: NA8230001). high-quality umbilical cord-derived exosomes that are MISEV2018 compliant and in compliance with the Japanese Society for Regenerative Medicine guidance,From 18,400 yen for the first timeThe company offers the lowest prices in the industry for
- ✓ Use of umbilical cord-derived exosomes (14 times more active ingredients)
- ✓ MISEV2018 compliant quality control
- ✓ From 18,400 yen for the first time, 17,900 yen per session for a course of 10 sessions
- ✓ Expanded in Tokyo (Jimbocho) and Yokohama
*This article is intended to provide medical information, but effects may vary from person to person. Please consult your physician before considering a procedure.