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What is Cellular Regenerative Medicine Exosome Infusion Therapy? A doctor thoroughly explains the effects, cost price, and side effects.
"I keep hearing about exosome IV drips lately, but what kind of treatment is it?"
"Does it really have anti-aging effects?" "About how much does it cost?" "I'm worried about side effects and risks…"
Gaining attention in the field of regenerative medicine.Exosome infusionInterest is growing, especially among those with a keen sense for beauty, but because it is still a new treatment there is little information available, and many people may feel uneasy about it.
In this article, regarding exosome IV drips,"What exactly are exosomes?"Starting from that basic knowledge,the effects you can expect, typical costs, drawbacks, side effects, and points for choosing a clinicwe explain in detail, all based on the latest medical findings.
Whether you are considering an exosome IV drip or simply "gathering information first," we hope you will find this helpful.
＼ Umbilical cord-derived exosomes from 18,400 yen for your first session ／
Our clinic offers high-quality umbilical cord-derived exosome IV drips at reasonable prices.
▶ For details and pricing of Smart Skin Clinic's exosome IV drip, click here
What are exosomes in the first place? Messengers between cells
To understand exosome IV drips, we first need to learn about the substance called "exosomes."
Basic information about exosomes
Exosomesare extremely small, granule-like particles measuring 50 to 150 nm (nanometers) in diameter, secreted by nearly all cells in our body. Since 1 nm is one billionth of a meter, they are so tiny that they cannot be seen with the naked eye or even with an ordinary microscope.
Inside exosomes are the following important components:
- Nucleic acids(microRNA, messenger RNA, DNA, etc.)
- Proteins
- Growth factors
- Cytokines(cell-to-cell signaling molecules)
These serve as a kind of "blueprint" or "set of instructions" needed for cell regeneration and repair.
Why exosomes are called "messengers of regeneration"
The most important function of exosomes is"cell-to-cell communication.".
Once secreted by cells, exosomes travel throughout the body via the blood and lymph, delivering various information to cells in distant locations. For example, they convey instructions such as "this area is damaged, so please repair it" or "please reactivate these aged cells."
Because of this function, exosomes are"a tool for cell-to-cell communication"and"messengers of regeneration."as they are known.
Exosome research is being conducted at research institutions around the world, including the Tokyo Metropolitan Institute for Geriatrics and Gerontology, and holds promise for applications in regenerative medicine and disease treatment.
What is an exosome IV drip? An explanation of how it works and its features
How the exosome IV drip works
Exosome infusionis a treatment that administers exosomes—contained in the "stem cell culture supernatant" secreted during the process of culturing stem cells—directly into the bloodstream via intravenous drip.
Stem cell culture supernatant is the supernatant fluid produced when stem cells are cultured. It contains hundreds of active ingredients, including exosomes as well as growth factors, immunomodulatory factors, and nerve regeneration factors.
Why an "IV drip"? Its whole-body action is the key
Besides IV drip, methods of administering exosomes include injection (local administration) and nasal spray. Among these, the main reason an IV drip is chosen is"its whole-body action.".
Exosomes administered directly into the bloodstream circulate throughout the body via the blood flow. They then act on the cells of every organ, including the skin, hair, brain, internal organs, and blood vessels.
Because exosomes are so small, they can pass through blood vessel walls and move freely between tissues. When they find damaged or aged cells, they gather there and promote repair and activation. This function is calledthe "homing effect,"and it is why exosome IV drips are considered effective for "whole-body anti-aging."
Effects you can expect from an exosome IV drip
Exosomes have a variety of actions, including anti-inflammatory, antioxidant, tissue repair, and angiogenic effects. Through these actions, the following effects are anticipated.
1. Skin beautification and anti-aging effects
Exosomes act on the fibroblasts in the dermal layer of the skinfibroblastsand promote the synthesis of collagen and elastin.
Research by Rohto Pharmaceutical has reported that exosomes suppress the senescence of fibroblasts and promote the synthesis of dermal components.
Specifically, the following skin-beautifying effects can be expected:
- Improved skin firmness and radiance
- Improvement of wrinkles and sagging
- Reduction of dark spots and dullness
- Pore tightening
- Increased skin clarity
2. Recovery from fatigue and relief of sluggishness
By acting on cells throughout the body, exosomes support recovery from fatigue at the cellular level.
Patients who have actually received the treatment have reported that "my fatigue eased after a single drip" and "I wake up feeling more refreshed in the morning." It is a popular treatment among those troubled by chronic fatigue and sluggishness.
3. Improved immunity and relief of allergy symptoms
Exosomes have the ability to regulate the function of immune cells. By balancing immune function, they may make you less prone to catching colds and may help ease allergy symptoms such as atopic dermatitis and hay fever.
4. Improved sleep quality and cognitive function
Exosomes also reach the brain and promote the repair and activation of brain cells. They are anticipated to help improve insomnia, enhance concentration, and support memory.
Research is also progressing on their effect on the substances that cause Alzheimer's-type dementia (amyloid beta and tau protein), and their potential to help maintain and improve cognitive function is attracting attention.
5. Improved hair growth and thinning hair
Because hair is also made up of cells, exosomes acting on the hair matrix cells can be expected to help improve thinning hair and hair loss and enhance hair firmness and body. They are also drawing attention as a new option for treating thinning hair in women.
6. Rejuvenation of blood vessels
Exosomes promote anti-inflammation and antioxidation of the vascular endothelial tissue, helping to guide blood vessels toward becoming more elastic and supple. Rejuvenating your vascular age may also help with the prevention of stroke, myocardial infarction, and similar conditions.
7. Improvement of menopausal symptoms and male function
They are also anticipated to help ease menopausal symptoms caused by changes in hormone balance and to improve male functions such as ED (erectile dysfunction).
8. Effect on the aftereffects of COVID-19
Thanks to the anti-inflammatory action of exosomes, they are also anticipated to help ease the symptoms of the aftereffects of COVID-19 infection (fatigue, brain fog, etc.).
Types of exosomes｜Comparing the differences by origin
Exosomes are broadly classified into three types depending on the site (origin) from which they are harvested. Since the exosomes used differ from clinic to clinic, it is important to understand the differences.
| origin | Source | Features |
|---|---|---|
| Umbilical cord-derived | Umbilical cord (cord blood) | Contains more than 14 times the active ingredients of other sources. Rich in the rejuvenating protein GDF-11. Considered the highest quality. |
| Fat-derived | Adipose tissue | Relatively easy to harvest. Frequently used in aesthetic clinics. |
| Bone marrow– and dental pulp–derived | Bone marrow and the center of teeth | Research is progressing, but harvesting is difficult. |
especiallyUmbilical cord-derived exosomesare rich in active ingredients beneficial to the skin as well as GDF-11, which is involved in rejuvenation, and can be expected to offer a high anti-aging effect.
💡 For those looking for umbilical cord-derived exosomes
Our clinic uses high-quality, MISEV2018-compliant umbilical cord-derived exosomes. We offer them at a reasonable price, starting from 18,400 yen for your first session.
▶ For details on umbilical cord-derived exosome IV drips, click here
Typical cost of an exosome IV drip
Exosome IV drip isBecause it iselective (self-pay) treatment, health insurance does not apply. Costs vary widely depending on the clinic, the type of exosomes used, and the dosage.
General cost range
| Item | Typical cost |
|---|---|
| Cost per session | 30,000 to 200,000 yen |
| Umbilical cord-derived (high quality) | 50,000 to 150,000 yen per session |
| Fat-derived | 30,000 to 80,000 yen per session |
| Recommended number of sessions | About 5 to 10 sessions |
| Recommended frequency | Once every 1 to 2 weeks |
Reasons for the high cost
There are two main reasons why exosome IV drips are expensive:
- Rarity of the raw materials: umbilical cord blood-derived material in particular can only be collected at the time of birth, giving it high scarcity value.
- Complexity of the manufacturing process: culturing stem cells, purifying the supernatant, and quality control all require advanced techniques and equipment.
Duration of effect and the need to continue
The effects of an exosome IV dripabout 1 to 3 monthsare said to gradually fade over time. Therefore, regular treatments are necessary if you wish to maintain the results.
Many clinics recommend an initial intensive phase of about 5 to 10 sessions every 1 to 2 weeks, followed by maintenance about once a month.
＼ Cheaper than the going rate! Umbilical cord-derived from 18,400 yen for your first session ／
Smart Skin Clinic offers high-quality umbilical cord-derived exosomes at among the lowest prices in the industry; with the 10-session course, the cost comes to 17,900 yen per session.
▶ See the price list and course details
Drawbacks and points to note about exosome IV drips
Exosome IV drips have not only benefits but also drawbacks and points to be aware of. Be sure to understand these before undergoing treatment.
Drawback 1: You will no longer be able to donate blood
Once you receive an exosome IV drip,you will no longer be able to donate blood or receive a blood transfusion thereafter.This is based on the policy of the Ministry of Health, Labour and Welfare, because current testing methods cannot completely verify the safety of blood after treatment using human-derived tissue.
Also,You will also no longer be able to register with the bone marrow bank.If you are considering donating blood or bone marrow in the future, please give this careful thought.
Drawback 2: High cost
As noted above, each session costs from tens of thousands to well over one hundred thousand yen. Because ongoing treatment is needed to maintain the results, the total cost is even higher.
Drawback 3: Requires regular visits
Because the effects are not permanent, you need to visit regularly to continue receiving treatment. Each session takes about 15 to 30 minutes, but this can be a burden for those with busy schedules.
Drawback 4: Insufficient long-term evidence
Exosome IV drips are a relatively new treatment, and there is not yet sufficient clinical data on their long-term effectiveness and safety. Research is progressing, but it is important to understand that we are not yet at a stage where anyone can assert that it is "definitely effective."
Side effects and risks of exosome IV drips
Common side effects (mild)
The possible side effects of an exosome IV drip are mostly the same as those of a typical IV drip.
- Pain, redness, swelling, and bruising at the puncture site
- Temporary discomfort such as headache or nausea
These usually subside on their own within a few hours to a few days.
Rare possible side effects
- Anaphylactic reaction(acute allergic reaction)
Although very rare, allergic reactions such as vomiting, abdominal pain, drop in blood pressure, and difficulty breathing may occur. If you have ever had an allergic reaction to an injection or IV drip in the past, please be sure to consult your physician beforehand.
Regarding the relationship to cancer
The relationship between exosomes and cancer remains a subject of ongoing medical debate.
Some studies suggest that exosomes may promote the growth of existing cancer cells. On the other hand, other reports indicate that they suppress cancer cell growth, so no conclusion has been reached.
In any case, at present most clinics refrain from performing the procedure on those currently undergoing cancer treatment or with a history of cancer.
Those who cannot receive an exosome IV drip
Those who fall into the following categories may not be able to receive an exosome IV drip:
- Those undergoing treatment for a malignant tumor (cancer), or for whom fewer than 5 years have passed since remission
- Those who are pregnant or breastfeeding
- Those currently suffering from an infectious disease
- Those in an immunosuppressed state
- Those who have had an allergic reaction to an exosome-related treatment in the past
- Those with autoimmune diseases
- Those with a blood disorder such as a coagulation abnormality
- Those taking anticoagulant medication
- Those considering donating blood, receiving a transfusion, or donating bone marrow in the future
If you are unsure whether any of these apply to you, please discuss it with the physician during your counseling session.
5 points to check when choosing a clinic
The formulations used, prices, and quality control systems for exosome IV drips vary widely from clinic to clinic. To receive treatment with peace of mind, check the following points.
1. The origin of the exosomes and their quality standards
Check which origin (umbilical cord, adipose, bone marrow, etc.) the exosomes come from. In addition,MISEV2018whether they comply with these guidelines (from the International Society for Extracellular Vesicles) is also a measure of quality.
2. Accreditation and qualifications as a medical institution
The Ministry of Health, Labour and Welfare'scertification of the plan for providing regenerative medicineA clinic that has obtained this is a facility that meets national standards. Check whether the certification number is publicly disclosed.
3. Whether there is a consultation and explanation by a physician
Check whether there is a physician's examination before the procedure and whether the risks and side effects are adequately explained. It is safest to avoid clinics that provide insufficient explanation or that pressure you into a contract.
4. Transparency of the fee structure
Confirm in advance whether the fee schedule is clearly disclosed, whether there are any additional charges, and the details of any course contract. Doing your research beforehand is important to avoid trouble such as "I was pushed toward an expensive course when I went for counseling."
5. Aftercare system
It is also reassuring to check whether there is a system for responding to any changes in your condition after the procedure and whether there is a point of contact for consultation.
Frequently asked questions about exosome IV drips
Q. Can I feel the effects even after just one session?
A. There are individual differences, but some people feel "less tired" or notice "better skin condition" after even a single treatment. However, to truly experience solid results, continuing for about 5 to 10 sessions is recommended.
Q. How long does the procedure take?
A. The IV drip itself takes about 15 to 30 minutes. Including counseling and consultation, you should allow about one hour for your first visit.
Q. Is it painful?
A. As with a regular IV drip, there is a slight pricking sensation when the needle is inserted. There is almost no pain during the procedure itself.
Q. Is there any downtime?
A. Almost none. You can return to wearing makeup and to your daily life immediately after the procedure.
Q. What is the difference from an NMN IV drip?
A. An NMN IV drip is a treatment that administers a precursor of the coenzyme "NAD+" to boost the cells' energy production. An exosome IV drip activates cells through cell-to-cell communication. Because their mechanisms of action differ, some patients use both together.
Q. How long do the effects last?
A. Generally, they are said to last about 1 to 3 months. This also varies depending on individual differences and lifestyle.
Summary｜The exosome IV drip is a regenerative medicine treatment aiming for "whole-body rejuvenation"
The exosome IV drip is one form of regenerative medicine in which exosomes contained in stem cell culture supernatant are administered into the bloodstream and act on cells throughout the body to bring about anti-aging effects.
Effects you can expect:
- Skin beautification and anti-aging
- Recovery from fatigue and relief of sluggishness
- Improved immunity
- Improved sleep quality and support for cognitive function
- Improved hair growth and thinning hair
- Rejuvenation of blood vessels
Drawbacks to note:
- You will no longer be able to donate blood or bone marrow
- High cost (30,000 to 200,000 yen per session)
- Ongoing treatment is needed to maintain results
- Long-term evidence is still developing
If you are considering an exosome IV drip, we recommend that you fully understand the benefits and drawbacks, choose a clinic you can trust, and consult thoroughly with a physician before deciding.
The Exosome IV drip at Smart Skin Clinic
Our clinic hasMinistry of Health, Labour and Welfare – Accredited Facility for Regenerative Medicine Provision Plan(Certification number: NA8230001). We provide high-quality umbilical cord-derived exosomes that are MISEV2018-compliant and in line with the Japanese Society for Regenerative Medicine's guidance,from 18,400 yen for your first sessionat among the lowest prices in the industry.
- ✓ Uses umbilical cord-derived exosomes (more than 14 times the active ingredients)
- ✓ MISEV2018-compliant quality control
- ✓ From 18,400 yen for your first session; 17,900 yen per session with the 10-session course
- ✓ Available in Tokyo (Jimbocho) and Yokohama
*This article is intended to provide medical information, but results may vary from person to person. If you are considering a procedure, please be sure to consult a physician.