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What is Retuo (Elravie Re2O /BNAJU)? Effectiveness, Downtime, and Differences from Other Preparations
Rituo injection (doctor's manual injection)
| one (object) (2cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 72,900 yen | 36,450 yen |
| 3 times (20%Off) | 184,000 yen (1 time 61,333 yen) | 30,666 yen |
| two (long cylindrical things) (4cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 117,000 yen | 29,250 yen |
| 3 times (20%Off) | 304,000 yen (1 time 101,333 yen) | 25,333 yen |
| three (long cylindrical things) (6cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 171,000 yen | 28,500 yen |
| 3 times (20%Off) | 456,000 yen (1 time 152,000 yen) | 25,333 yen |
Need for anesthesia｜High
Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.
Rituo Aqueous Light Injection
| one (object) (2cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 59,400 yen | 29,700 yen |
| 3 times (20%Off) | 148,000 yen (1 time 49,333 yen) | 24,666 yen |
| two (long cylindrical things) (4cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | ¥99,000 | 24,750 yen |
| 3 times (20%Off) | 256,000 yen (1 time 85,333 yen) | 21,333 yen |
| three (long cylindrical things) (6cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 135,000 yen | 22,500 yen |
| 3 times (20%Off) | ¥360,000 (1 time 120,000 yen) | 20,000 yen |
Need for anesthesia｜High
Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.
My skin has lost its elasticity."
They are so dry that superficial care just can't keep up."
I keep using skin boosters, but I can't seem to notice any change in my skin."
What's all this talk on social networking sites about rituo, and what does it all add up to?"
Do you have any of these concerns or questions?
Hello, we are Smart Skin Clinic, a cosmetic dermatology clinic with over 10,000 injections per year.
Conventional skin boosters provide "nutrition" to the skin, so to speak. In contrast, Rituo is a treatment that replaces the "bone structure" of the skin itself. That is why it is an option for those who have not been satisfied with conventional treatments.
In this article, we will provide a thorough explanation of how Rituo works, its effects, downtime, and how it differs from other skin boosters from a cosmetic dermatologist's point of view.
Chief Director of Smart Skin Clinic Group
stone Kouta
career
Graduated from Juntendo University School of Medicine
Tokyo Women's Medical University Hospital and related facilities
Worked at a major beauty clinic in Tokyo
Affiliation / Qualifications
Japan Surgical Society Specialist
Japanese Society of Anti-Aging Medicine
What is Re2O? Treatment Features
Re2O (product name: Elravie Re2O in Korea, BNAJU in Japan) is a skin booster formulation developed by Humedix in Korea.
It features a new approach and main ingredients never seen before.
[Lituo Features.
- Approach that complements skin structure
- The main component is hADM
What is the difference from conventional skin boosters? The idea of "direct supplementation
If you are having difficulty experiencing results after trying conventional skin boosters, your skin's structural and regenerative capabilities may be weakened.
Conventional skin boosters inject PDRN, PDLLA, and porcine collagen to "activate cells and promote the synthesis of skin constituent substances.
On the other hand,Rituo is characterized by "an approach that directly replenishes the dermal layer with the very structure (ECM) that serves as the scaffold for firmness and elasticity that is lacking.It is. It is like putting new pillars in a house whose foundation has collapsed. By "rebuilding" the skin's foundation, fibroblasts that produce collagen and elastin are activated.
Our bodies are made up of "cells" and "non-cells.
The components present on the "outside" (i.e., extracellular) of the cell are collectively referred to as the ECM (Extracellular Matrix).We call it the "Matrix. Matrix means "structure or foundation.
The ECM, which includes, for example, collagen, elastin, hyaluronic acid, and growth factors, plays a role in signal transduction between cells and provides the basis for cells to interact with the surrounding tissue.
When the ECM is in place, the skin is more likely to maintain firmness and elasticity.
ECM abundant in young skinIt is. Collagen is constantly produced and maintained through interaction with fibroblasts.
Contrary to,When the ECM is disrupted by aging and UV radiation, collagen fragmentation increases and fibroblasts are more likely to fail.It is known that
What is the main ingredient "hADM"? Adopts a collagen structure derived from human skin
Lituo.Contains 150 mg of human acellular dermal matrix (hADM) as the main ingredientThe company is doing so.
hADM is derived from human skin tissue by completely removing the cells and fatty substances that cause immune reactions and extracting only the ECM structure. Although "human-derived."There are no "cells themselves" in the product, only collagen structures.and are unlikely to cause foreign body reactions or rejection.
Because the three-dimensional structure of ECM is retained intact, after injection, your own fibroblasts can easily utilize this scaffold to produce collagen.
Rituo is a treatment that aims to improve texture while supplementing the foundation that supports the skin's structure.It is.
Attention in Korea! The "5th generation" skin booster after Rejuran and Jubeluk?
In Korea, in recent years, the lituoFifth Generation Skin Boosters."The expression is seen as an introduction.
This is one of the metaphors used to convey in an easy-to-understand way that this is a "new wave" of attention following Riguran and Jubeluk. In fact, since its launch in November 2024, Lituo has spread rapidly in Korea, expanding to about 1,000 trading partners as of August 2025, according to Korean press reports.
Here is something you need to be aware of.
To this "generation XX" calling,There is no uniform official or academic standard.We recommend that you be aware that it is only a "marketing expression" since the way it is arranged and defined differs depending on the media, clinic, and manufacturer.
In fact, some clinics position Rituo as the "fourth generation" while others refer to it as the "fifth generation.
For this reason, the clinic does not view Rituo as a "fifth generation" only,A new category of formulation focused on ECM (extracellular matrix)/hADM (cell-free allogeneic dermis)We believe it is more accurate to understand it as
The following is an example of a convenience classification used in the Korean aesthetic medicine market and is not an academically standardized generational classification.
Non-cross-linked hyaluronic acid-based (HA formulation used in water light injections)
Main approach
Immediate water retention and hydration
Ridjulan, Rizne, etc.
Main approach
Polynucleotide (PN) preparations to support repair and regeneration
Jubeluk, Turienne, etc.
Main approach
Stimulation of collagen neogenesis by PDLLA (poly-D,L-lactic acid)
Exosome/secretome system, etc.
Main approach
Regeneration support using extracellular vesicles and related bioactive factors
Lituo, Serdiem, Jubuachell.hADM / ECM system
Main approach
Approaches oriented toward reconstruction of skin structure using ECM components derived from hADM (human acellular dermis)
Effects you can expect from Rituo｜Changing the foundation of the skin
Rituo is a treatment that focuses on the skin's foundation to address the loss of firmness, texture disorder, and dryness associated with aging.
- Improvement of pores and texture
- improvement of elasticity
- Improvement of dry skin
- Redness improvement
- Improvement of spots and dullness
Improvement of pore size and texture
The cause of pore problems is not only sebum, but also a loss of firmness and texture.
As collagen density in the dermis is restored, the structure supporting the pores is strengthened and the texture is improved.The product is designed to be used for the first time in the world. By reflecting light evenly, it is possible to achieve the impression that pores are less noticeable.
Restoration of elasticity and resilience
The ECM is replenished and becomes a prop,Activation of fibroblasts. Resultant increased collagen and elastin production.The elasticity is restored as if it is being pushed back from the inside.
This is a natural change as the dermis is rebuilt over weeks to months.
Improvement of dry skin
ECM also contains proteoglycans, which improve the water retention environment of the dermis.
Unlike hyaluronic acid, which "moisturizes the surface,It improves dry skin because it restores water retention from the skin's structure.
As a result of the improved texture and moisture, many people feel a translucent and toned effect.
Improvement of redness
Redness can be caused by multiple factors, including inflammation, poor barrier function, visible capillaries, and friction.
hADM is known to act as a scaffold for wound healing and collagen formation, and is expected to improve post-inflammatory redness.
This is one of the most promising effects for those who suffer from chronic redness and acne scarring.
However, since there are many different factors that contribute to redness, it is necessary to determine if it is indicated.
In addition, a randomized split-face double-blind study published in February 2026 compared the skin conditions of 20 patients injected with a test formulation containing phADM on one side and a non-cross-linked hyaluronic acid formulation on the opposite side for 20 weeks. The test side reported greater improvement than the control side in skin density, volume, elasticity, wrinkles, pores, water content, barrier function, and pigment/redness indices.
For whom Rituo is recommended
Rituo is recommended for those who have the following problems
- Those who are concerned about wrinkles, loss of elasticity, and pores.
- Those who feel limited to superficial care due to persistent dryness.
- Those who want a natural finish and do not want the "over-implanted" look of hyaluronic acid.
- Those who have tried skin boosters but feel they are not enough
Comparison｜Rituo Liguran Jubeluk
The table compares the differences between typical skin boosters.
| (data) item | Lituo. | REJURAN | Juvelook |
| Principal component | hADM (human-derived cell-free dermis) | PN (polynucleotide derived from salmon) | PDLLA (polylactic acid derivative) |
| approach | Replenish ECM scaffolds, reinforce foundation, activate fibroblasts. | DNA fragments to promote skin regeneration | Stimulates and increases collagen production |
| Duration | 6-12 months | More than 12 months | 12-24 months |
| Primary indications | Pores, spots and dullness, texture | Sagging, fine lines and dark circles around the eyes | Acne scars, pores |
Combination of multiple formulations is also possible. For details, please consult us at the counseling session.
Difference from Rejuran (PN formulation): "Create" or "Replenish" the structure
Rejuran is a preparation that "stimulates" collagen production by acting directly on fibroblasts through the injection of DNA fragments (PN: polynucleotides). Although it is excellent in terms of signal input to cells, its effectiveness is limited when the "scaffold" where collagen is produced is depleted.
Rituo is complementary to Riguran because it replenishes its "scaffolding" itself.
Rejuvenate cells with Rejuran while also providing the foundation for ECM with Rituo.The combination of the two is expected to have a synergistic effect.
In addition, while Rejuran was highly effective, its unique consistency (viscosity) made it painful to inject. Rituo is recommended for those who have been frustrated by the pain of Rejelan.
Difference from Jubelq (PDLLA): immediate effect and natural volume
JUVELUX is a PDLLA (polylactic acid derivative) based formulation that combines the immediate firmness of the hyaluronic acid component with the delayed stimulation of collagen production by PDLLA. It is long-lasting and has strength in improving sagging and lack of volume.
There is a difference between "ECM foundation replenishment (Lituo)" and "stimulation of collagen production (JUVELUX)," which can be used for different symptoms and purposes.is a good idea.
How to think about pain and anesthesia during the procedure
Rituo is not as painful as Riguran, but there is some needle pricking pain during the procedure.
Surface anesthesia (cream anesthesia) is used to alleviate pain, and the anesthesia is allowed to take effect for 20 to 30 minutes before the procedure. Furthermore, cooling, use of a thin needle, and control of the injection speed are used to minimize discomfort during the procedure.
Downtime and side effects/risks
How long will the redness, swelling, internal bleeding, and unevenness last?
The main downtime symptoms and estimated duration are as follows
- Redness and swelling: Same day of treatment to 2 days
- Unevenness and bulging at the injection site: Flattens naturally in about 1-3 days
- Internal bleeding: 1-2 weeks
Although there are individual differences, in most cases, work and makeup can be performed the next day. However, some internal bleeding may occur in areas with thin skin, such as under the eyes. If you have an important event coming up before the procedure, it is recommended that you allow plenty of time for the procedure.
Risk of allergy, inflammation, lumps, etc.
In rare cases, the following risks may arise
- Prolonged inflammation and swelling at the injection site
- Lump (nodule) formation
- allergic reaction
Rituo removes the cells and fatty components that cause immune reactions. In addition, human-derived preparations are less likely to cause immune reactions than animal-derived preparations.
Downtime symptoms usually diminish with time. If pain, itching, or increased redness is observed, an infection or allergic reaction may occur. Please contact the clinic promptly for treatment.
Safety
Rituo is an injectable formulation composed of human-derived ingredients and does not use synthetic ingredients.
Of course, the risk of infection cannot be said to be zero because the product is derived from human tissue, but Lituo's hADM is made from raw materials processed at an FDA (U.S. Food and Drug Administration) approved facility and is also approved by the MFDS (Korea Food and Drug Safety Administration).
However, it is not a drug approved by the Ministry of Health, Labor and Welfare. Since it is a human tissue-derived product, please check with your doctor or the Japanese Red Cross Society in advance as to whether or not you can donate blood after the procedure.
Those who need attention
Please consult your doctor in advance if you fall into any of the following categories
- Patients with autoimmune diseases (SLE, scleroderma, etc.)
- Those who have had allergic reactions to injections or cosmetic treatments in the past
- Keloidal constitution
- Persons with blood coagulation abnormalities or taking anticoagulants or antiplatelet drugs
Those who are not eligible for the treatment
- Pregnant or nursing
- Those with infection or inflammation at the treatment site
Aftercare and daily life precautions after the procedure
Here are some tips on how to spend your time without increasing redness and swelling.
- Makeup: Possible from the day after the procedure
- Strenuous exercise, sauna, and rock bath: Avoid for about 1 week after the surgery.
- Drinking: Avoid drinking on the day of the event, and moderate the following day and beyond.
- UV protection: Since the skin is more sensitive after the procedure, it is important to use sunscreen and avoid UV rays
- Skin Care: Keep skin moisturized and support skin regeneration
To reduce swelling and internal bleeding, avoid irritation, cooling and rest are effective.
Do not rub the injection site strongly on the day of treatment or the day after.
Wash your face gently and avoid harsh cosmetics, scrubs, and peels for about a week.
When does the effect start? How many times do I need? How long does it last?
- Immediately after: Some degree of firmness
- 2-4 weeks after surgery: Collagen production by ECM reconstruction
- Peak: 1 to 2 months after the end of the first course (3 sessions)
- Duration: 6-12 months approx.
- Maintenance interval: Every 3-6 months
Postoperative course
- Immediately after: physical filling sensation due to injection
- After 3-5 days: Improved blood circulation, improved skin barrier function and thickness
- After 1 to 2 weeks: Improvement of pores, texture, redness, fine lines and wrinkles, collagen regeneration
- After 3-4 weeks: Improvement of spots and dullness, improvement of firmness
The effects of Lituo appear in stages over a period of 2 to 4 weeks.
The injected hADM scaffold is expected to activate fibroblasts, resulting in the formation of new collagen and elastin.
Ideal way to go: why 3 times (1 course) every 3-4 weeks is recommended
Rituo is designed to be performed three times every three to four weeks in accordance with the cycle of cellular restructuring, which is called a "one course" treatment.
One treatment is effective, though,Multiple sessions can repeatedly promote the three steps of ECM replenishment, fibroblast activation, and collagen production.Therefore, the effect is more stable.
Maintenance intervals for long-lasting effectiveness
Maintenance every 3-6 months after completion of 1 courseIt is recommended to maintain the effectiveness of the treatment.
ECM naturally decreases with age. Continued supplementation with Lituo will help maintain the skin's foundation in good condition over the long term.
Combination with other treatments
Replenishing the skin's structure with Rituo may increase its response to subsequent treatments.The doctor will decide whether or not the combination is possible and in what order, so please let us know your preference at the consultation.
For example, the following combinations are possible
Photofacial *Jimbocho clinic only
It aims to improve skin surface blemishes, dullness, and redness, and to improve skin quality and firmness.
Photofacial is a machine that delivers a special light called IPL (Intense Pulsed Light).
It destroys melanin pigment to lighten spots and acts on small blood vessels that are the source of redness. In addition, it acts on the dermis to stimulate the production of collagen and elastin, and as a result, it is expected to produce firmness and elasticity.
ZAF (high frequency)
This combination improves the internal structure of the skin and stimulates collagen production.
ZAF is a radiofrequency treatment that can deliver heat energy three-dimensionally from the dermal layer to the subcutaneous fat layer. It is expected to solve multiple skin problems at the same time, such as a double chin, sagging facial lines, improvement of laugh lines and marionette lines, and tightening of skin firmness, luster, and pores.
Usage guidelines
- Injection volume: 1 to 2 vials for the entire face
- Injection area: Entire face/under the eyes/frown lines/cheeks/tumples/neck/mouth area
Rituo is controlled in units of "1 vial (1 bottle)" and each vial contains a high concentration of 150 mg of hADM (human-derived cell-free dermis). This one vial is dissolved in an optimally balanced solution and injected so that it is evenly distributed over the entire face.
As a general rule, injections are made evenly over the entire face, but can be arranged depending on the desired result.
Not only can it improve the skin texture of the entire cheek area, but it can also be applied to age-exposed areas such as under the eyes, neck, and mouth.The product is a formulation that is
If you are not sure where and how much to inject, the doctor will suggest an appropriate amount during the consultation.
Flow of treatment
You can easily make reservations with your mobile phone.
This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.
Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.
After applying surface anesthesia, the injection is carried out while you are being asked.
We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.
Smart Skin Clinic Fees
Rituo injection (doctor's manual injection)
| one (object) (2cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 72,900 yen | 36,450 yen |
| 3 times (20%Off) | 184,000 yen (1 time 61,333 yen) | 30,666 yen |
| two (long cylindrical things) (4cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 117,000 yen | 29,250 yen |
| 3 times (20%Off) | 304,000 yen (1 time 101,333 yen) | 25,333 yen |
| three (long cylindrical things) (6cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 171,000 yen | 28,500 yen |
| 3 times (20%Off) | 456,000 yen (1 time 152,000 yen) | 25,333 yen |
Need for anesthesia｜High
Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.
Rituo Aqueous Light Injection
| one (object) (2cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 59,400 yen | 29,700 yen |
| 3 times (20%Off) | 148,000 yen (1 time 49,333 yen) | 24,666 yen |
| two (long cylindrical things) (4cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | ¥99,000 | 24,750 yen |
| 3 times (20%Off) | 256,000 yen (1 time 85,333 yen) | 21,333 yen |
| three (long cylindrical things) (6cc) | limited discount price | per cc Price |
|---|---|---|
| Once (10%Off) | 135,000 yen | 22,500 yen |
| 3 times (20%Off) | ¥360,000 (1 time 120,000 yen) | 20,000 yen |
Need for anesthesia｜High
Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.
FAQ
- Can I receive treatment while pregnant or breastfeeding?
-
We do not provide treatment to pregnant or nursing mothers because the safety of such treatment has not been confirmed. Please feel free to consult with us after childbirth or after breastfeeding ends.
- Are there any precautions that should be taken as a human-derived preparation?
-
Cellular components of Rituo have been removed under strict quality control. However, because it is a human tissue-derived preparation, the risk of infection is theoretically not zero.
- Can I have sensitive skin?
-
Sensitive skin itself is not an absolute contraindication. However, depending on the cause of the existing redness and inflammation, it may be better to prioritize skin care treatment or topical treatment first. Please consult your doctor in advance.
- Does it help with dark circles under the eyes?
-
It may be appropriate for problems involving thinning and loss of firmness of the skin under the eyes. However, since dark circles have different causes, such as blue, brown, and shadow dark circles, the indication must be determined in a consultation.
- Can I donate blood?
-
Since this is a human tissue-derived product, the Japanese Red Cross Society's criteria will determine whether or not blood donation is acceptable after the procedure. Please check with your doctor or the Japanese Red Cross Society for details.
- Can I have it on the same day as other treatments?
-
The availability of the combination depends on the treatment, the area, and the skin condition. Our doctors will make a decision based on the details of the procedure on the day of the consultation, so please let us know your preference at the time of consultation.
- When will I start to feel the effects?
-
Most people feel a slight sensation of firmness immediately after the treatment, but the true effect of ECM reconstruction is seen 2 to 4 weeks after the treatment, with most people feeling it 1 to 2 months after completing the first course (3 sessions).
Our Commitment
Because Rituo is a powder formulation that is dissolved, appropriate concentration adjustment and uniform injection technique to avoid lumps are required. At our clinic, the injection is done by hand by a doctor who is well versed in the delicate characteristics of this formulation.
By directly controlling the depth, volume, and angle of the injection using advanced technology with more than 10,000 injections per year, the active ingredients are evenly distributed in the dermal layer according to the thickness and structure of the skin in each area to achieve the desired effect.
We also keep up to date with the latest information on various skin boosters, including Rituo, to provide safe and effective treatments.
Our doctors will propose the best plan according to each person's skin condition and needs. No pressure sales will be applied.
Rituo to Smart Skin Clinic.
Rituo is an injection treatment that focuses on the skin's foundation, rather than merely adding moisture.
Unlike conventional injectables, this treatment approaches multifaceted skin problems such as firmness, elasticity, pores, dryness, and wrinkles by focusing on the skin's foundation by rebuilding the entire scaffold that produces collagen and elastin.
If you are struggling with skin texture that has lost its firmness with age or has not improved with anything you have done, Rituo may be an option for you.
Please contact us for a free consultation.
More Information
| Treatment Time | Approximately 30 minutes (excluding counseling) |
| Recommended number and frequency of treatments | It is recommended to perform sets of 3 times at 3-4 week intervals After that, maintenance is recommended every 3 to 6 months. |
| Down time | About 24 hours |
| Treatment on the day of counseling | Possible |
| Make | Available starting the next day |
| Skin care | Can be done immediately after the procedure (done gently) |
| Shower | Possible from the same day |
| Pain | There is a stinging pain when the needle is inserted. |
*There are individual differences.
Legal description
Re2O (Re2O / BNAJU) treatment includes the use of medicines or medical devices that are not approved in Japan. The medicines and devices used in the treatment have been imported on a private import basis under the judgment of our physicians.
Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".
Reference
Clinic List
Jimbocho Institute
〒101-0054
EX Kanda Nishiki-cho Building 8F (general reception), 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo 7F
Business hours: Monday-Friday 11:00-20:00 / Saturday and Sunday 10:00-19:00
Yokohama Institute of Technology
〒221-0835
TS Plaza Bldg. 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Business hours: 10:00-19:00
About the physician supervision of this site
This site is operated under the supervision of a physician supervised by Smart Skin Clinic.
This page was revised and enacted in June 2018. Medical Advertising Guidelines We produce and provide information based on
- Scope of supervision: treatment description, risks and side effects, price labeling
- Last supervision date: June 26, 2025