The disadvantages and side effects of exosome infusion explained by a physician in an easy-to-understand manner.
I'd like to try the exosome infusion, but I'm worried about any downsides or side effects."
Is it true that if I get an exosome infusion I won't be able to donate blood?"
'Isn't an exosome infusion dangerous?'
Do you have these questions or concerns about Exosome infusion?
Exosome infusion is a treatment that can provide rejuvenation and other benefits. Many people may be interested in this treatment.
Every treatment involves a small number of side effects and disadvantages. Of course, if the benefits do not outweigh the disadvantages, the treatment is not acceptable. Nevertheless, risks should be avoided whenever possible.
The cosmetic dermatology clinic explains the safety and risks of "exosome infusion," which is also handled by Smart Skin Clinic, from a medical standpoint.
Disadvantages and side effects of exosome infusion
Exosome infusion has the following five major disadvantages and side effects
(1) Common side effects: side effects that are not specific to exosome infusion but occur with infusions in general
(2) No longer be able to donate blood or have blood transfusions
(iii) May worsen if cancer is present.
(iv) Uncertainty of effects.
(5) High cost
We will now go on to explain in detail the disadvantages and side effects of each.
(1) General side effects
Common side effects of exosome infusion include "pain, redness, and swelling at the puncture site" and "anaphylactic reactions.
Pain, redness, and swelling at the puncture site
Side effects that appear not only with exosomes but also with infusions in general include pain, redness, and swelling due to the needle puncture. These symptoms subside within a few days.
However, if IV fluid leaks out of the blood vessels during the infusion, symptoms such as swelling and tingling around the blood vessels will appear, and if left untreated, symptoms will gradually intensify. If you notice any abnormalities after the start of the infusion, please contact our staff immediately.
anaphylactic reaction
A rare side effect to Exosomes is an "anaphylactic reaction". (*This is true for other infusions as well, not just exosomes.)
An anaphylactic reaction is the most severe form of allergic reaction.
An allergic reaction is an excessive immune response to a "normally harmless" substance that has entered the body. Typical symptoms include sneezing, itching, and rashes.
Furthermore, if an "anaphylactic reaction" occurs, the patient may go into shock for a short period of time, with a drop in blood pressure and loss of consciousness, requiring immediate treatment such as a muscular injection of adrenaline.
When administering an exosome infusion, the doctor will determine the appropriateness of the procedure after interviewing the patient in advance about his/her history of allergies and physical condition on the day of the infusion, and will confirm that there are no allergic reactions during the infusion. If you experience any symptoms such as rash, itching, or urticaria during or after the infusion, please consult the clinic staff immediately.
Multiple punctures may be performed.
One of the disadvantages of IV infusion in general, not just exosomes, is that in some cases, the needles are inserted repeatedly. Each time the needle is inserted, pain and internal bleeding occur. When internal bleeding appears, it is dark purple at first, but gradually fades to a yellowish color over a week or two, and finally disappears.
Some people are prone to multiple pricks of IVs and injections because of difficulty in seeing blood vessels. For example, if there is a lot of subcutaneous fat, it is difficult to see blood vessels and it is difficult to prick them.
In some cases, regardless of how easy or difficult it is to puncture a blood vessel, the nurse's lack of skill may result in repeated re-stabbing.
(2) No longer be able to donate blood or have blood transfusions
As a rule, patients who receive exosome infusion are not allowed to have blood transfusions or donate blood after treatment.
Exosomes are considered a relatively safe treatment, but because they are derived from living organisms, they may be infected with unknown viruses that cannot be detected by current testing methods.
Because the safety of the recipient of the transfusion cannot be fully confirmed, blood donation should be discouraged after exosome therapy.
(iii) May worsen if cancer is present.
Exosomes have the potential to aggravate the presence of cancer.
Exosomes act as messengers between cells, carrying information-bearing substances such as RNA and proteins. Therefore, when injected into the body, they may carry bad information as well as good information contained in the original organism. If exosomes taken from a living organism containing cancer cells are used, they may cause the cells into which they are injected to become cancerous.
In addition, cancer has the properties of self-growth, invasion, and metastasis. If the person receiving the infusion has cancer, the Exosome infusion may enhance the properties of the cancer cells and cause them to multiply. It is advisable to undergo testing prior to receiving an exosome infusion to rule out the possibility of cancer.
Here, we review the current literature investigating EVs and aging with an emphasis on consequences for the maintenance of human healthspan. Intriguingly, the biological utility of EVs both in vitro and in vivo and across contexts depends on the states of the source cells or tissues. As such, EVs secreted by cells in an aged or pathological state may impose detrimental consequences on recipient cells, while EVs secreted by youthful or healthy Thus, it is critical to understand both functions of EVs and tip the balance toward their beneficial effects as Thus, it is critical to understand both functions of EVs and tip the balance toward their beneficial effects as an anti-aging intervention.
（Interestingly, the biological utility of EVs (extracellular vesicles ≒ exosomes) is both in vitro and in vivo,Ex.It depends on the state of the cells and tissues. Thus, EVs secreted from aging or diseased cells may have detrimental consequences for recipient cells, while EVs secreted from youthful or healthy cells may promote functional improvement. Therefore, it is important to understand both functions of EVs and their successful use as an anti-aging intervention.
Reference
Brian V Lananna, Shin-Ichiro Imai. "Friends and foes: Extracellular vesicles in aging and rejuvenation. "FASEB bioAdvances. 2021 Oct;3(10);787-801. doi: 10.1096/fba.2021-00077.
(iv) Uncertainty of effects.
Exosome infusion has many promising effects, but there are some aspects that cannot be said to be "100% effects". There are two main reasons for this.
(1) It is a new treatment method and data are scarce, so it is impossible to say for sure. There are some studies that have shown efficacy, but this means that the number of clinical studies itself is still small when compared to conventional treatment methods.
(2) There are variations in the purification, storage, and reproducibility of exosomes, and the usefulness of exosomes based on frequency and frequency has not been established.
However, it is important to check where the exosomes are derived from. Exosomes can come from umbilical cords, amnion, dental pulp, fat, etc., and their regenerative capacity varies depending on their origin.
Umbilical cord cells are younger than those derived from other tissues and are expected to be more effective.
The umbilical cord is the "umbilical cord" that sends nourishment from the mother to the fetus. Umbilical cord blood, collected immediately after it is cut off during delivery, is used for a variety of medical treatments.
In addition, exosomes derived from umbilical cord have been verified to "promote the synthesis of collagen, which is necessary for skin rejuvenation" in the following paper.
Our in vitro results showed that USC-CM Exos integrate in Human Dermal Our in vitro results showed that USC-CM Exos integrate in Human Dermal Fibroblasts (HDFs) and consequently promote cell migration and collagen synthesis of HDFs. Results showed that Exo-Green labeled USC-CM Exos approached the outermost layer of the epidermis after 3 h and gradually approached the epidermis after 18 Moreover, increased expressions of Collagen I and Elastin were found after 3 days of treatment on human skin. results showed that USC-CM Exos is absorbed into human skin, it promotes Collagen I and Elastin synthesis in the skin, which are essential to skin The results showed that USC-CM Exos is absorbed into human skin, it promotes Collagen I and Elastin synthesis in the skin, which are essential to skin rejuvenation and shows the potential of USC-CM integration with the cosmetics or therapeutics.
(Japanese) In vitro results showed that exosomes extracted from human umbilical cord blood-derived mesenchymal stem cells (USC-CM Exos) accumulated in human dermal fibroblasts (HDFs) and consequently promoted cell migration and collagen synthesis in HDFs. Furthermore, the skin permeability of USC-CM Exos was evaluated using human skin tissue. The results showed that Exo-Green labeled USC-CM Exos approached the outermost layer of the epidermis after 3 hours and gradually approached the epidermis after 18 hours. Furthermore, increased expression of collagen I and elastin was observed after 3 days of administration to human skin. These results indicate that USC-CM Exos is absorbed into human skin and promotes the synthesis of collagen I and elastin, which are essential for skin rejuvenation, and indicate the possibility of integrating USC-CM with cosmetics and therapeutic agents.
Citation.
Yoon-Jin Kim, Sae Mi Yoo, Hwan Hee Park, Hye Jin Lim, Yu-Lee Kim, Seunghee Lee, Kwang-Won Seo, Kyung-Sun Kang." Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin." Biochemical and biophysical research communications. 2017 11 18;493(2);1102-1108. pii: S0006-291X(17)31817-X.
(5) High cost
Exosome infusion is an unrestricted treatment and is not covered by insurance.
The fee structure varies from clinic to clinic.Approx. 50,000-200,000 yenIt is.
The reasons why exosomes are relatively expensive compared to other infusions are that they use rare items such as umbilical cords, and that each process, such as harvesting, culturing, and extracting cells from a healthy living organism, is costly.
The effect is not permanent, so treatment is required approximately every month to achieve the desired effect. Since each clinic has its own ideas about the number of times and frequency of treatments required, please consult with them thoroughly at the counseling session to ensure that you are satisfied with the treatment.
Exosome infusion at Smart Skin Clinic
Have your questions about the side effects and disadvantages of exosome infusion been answered?
Exosome infusion is a treatment that can inject exosomes directly through blood vessels, thus enabling the effects of exosomes to be felt throughout the body. Although there are disadvantages, if understood and understood well, the attractive benefit of rejuvenation at the cellular level can be expected.
At Smart Skin Clinic, we strive to eliminate the disadvantages described in this article as much as possible, and we handle infusions with umbilical cord-derived exosomes with a purity of 991 TP3T. Please refer to the following article for a detailed explanation of our exosome infusion, including data, if you are interested.
References
If you like this article, please
Follow !
