NMN infusion therapy｜Smart Skin Clinic (Jimbocho, Tokyo)
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What does an NMN infusion look like?"
I heard that NMN infusion is good for anti-aging, and I want to know more about it."
Is it true that NMN infusion is good for improving insomnia and relieving fatigue?"
Hello. I am a doctor at Smart Skin Clinic, a cosmetic dermatology clinic.
Do you have any of these questions or concerns?
In this article,Ministry of Health, Labour and WelfareThe following is an easy-to-understand explanation from a professional standpoint by a cosmetic dermatology clinic that is a member of the "Aesthetic Dermatology Clinic".
(* Type II and Type III Regenerative Medicine Provisioning Plans Accreditation Number: NA8230001)
*If you would like to know the rates, you can jump to the appropriate section from the table of contents below.
What is NMN infusion?
Summary
The procedure involves administering an ingredient called NMN through intravenous infusion or injection.
Ingestion of NMN in the body is expected to improve physical and cognitive functions and have anti-aging effects. In a book titled "LIFESPAN: A World Without Aging," Dr. David A. Singlais, Professor of Medicine at Harvard Medical School, reported the results of his research, which became a major topic of conversation.
What is NMN?
NMN stands for Nicotinamide MonoNucleotide.
NMN has a structure similar to vitamin B3 and is naturally present in the body, and it plays a role in repairing various organs and tissues in the body. Foods such as edamame, broccoli, and avocados contain trace amounts of NMN. However, if you try to get NMN from food, you must eat unrealistic amounts. For example, to consume 100 mg of NMN, you need to consume about 56 broccoli plants and 126 avocados.
NMN is converted in the body into a substance called NAD, which is distributed throughout the body and activates the sirtuin gene (longevity gene).
The activation of the sirtuin gene activates the body's cells, resulting in various anti-aging effects such as clearer skin.
NAD is an essential coenzyme for intracellular energy production and activates the sirtuin gene (longevity gene), which is believed to play an important role in controlling aging. Aging is believed to be one of the causes of the age-related decrease in NAD.
Therefore, it is said that continuous supplementation of NAD can provide anti-aging benefits.
Effect
NMN has a variety of effects, which can be summarized in one word: anti-aging effects.
In addition, anti-aging effects are not effects that can be realized immediately tomorrow. On the other hand, the effects that can be felt immediately tomorrow include the following
[Immediate effect].
- Relief of insomnia
- Improvement of fatigue
- Improvement of muscle pain
Medium- to long-term effects (anti-aging)
- Increased skin luster and elasticity
- Improved metabolism
- Improved physical and muscular strength
- Increased cognitive function.
- Hormonal balance is regulated
- Autonomic nervous system is regulated
Effects on skin
NMN acts on various tissues and cells via the sirtuin gene. It also acts on skin cells, increasing collagen, etc., and is expected to improve skin luster and elasticity.
Effects on physical and muscular strength
NMN is expected to increase metabolism and strengthen muscle function.
We confirmed that healthy older men can safely consume 250 mg of NMN per day for 12 weeks on a continuous basis and that it significantly increases NAD+ and NAD+-related metabolites in the blood. The results indicate that NMN improves muscle strength and performance. Therefore, continuous oral intake of NMN may be a very effective means of preventing age-related muscle weakness such as sarcopenia.
Nicotinamide mononucleotide (NMN) improves motor function in elderly men (Department of Diabetes and Metabolism, The University of Tokyo Hospital) (reported in May 2022)
Effect on Diet
Studies have shown that NMN is also effective in supporting enzymes involved in intracellular energy production. Therefore, NMN is expected to improve lipid metabolism and burn stored fat more efficiently, and may be useful as part of obesity elimination and weight loss.
Those who cannot be treated
- Allergy to NMN.
- Currently suffering from an infectious disease or immunosuppressed state
- Pregnancy and lactation
- Have a blood disorder, such as a coagulation disorder, or are taking anticoagulants
- Have an autoimmune disease or a disease related to the immune system
- (Caution is required.) Has not had a recent physical examination or is uncertain about his/her health status.
- Persons with allergic diseases
Risks and Side Effects
No specific risks or side effects have been reported for NMN infusion.
There are possible risks and side effects that may occur during the following infusion-based procedures.
- Rarely, an anaphylactic reaction (acute allergic reaction) may occur
- Pain at puncture site, internal bleeding, neuropathy
- Other physical symptoms such as headache, nausea, etc.
Safety Information
No serious side effects have been reported at this time.
The following information is available
A research group led by Professor Yutaka Ito and his colleagues at the University of Washington in the United States was the first in the world to demonstrate that NMN can be safely administered to healthy humans.
In Japan, a group at Keio University Hospital conducted clinical trials as follows and concluded that it can be safely administered to humans.
Ten healthy men aged 40-60 years took 100-500 mg of NMN three times a day at an average interval of two months. There were no changes in blood pressure or pulse, and tests of liver and kidney function showed no abnormalities.
World's First Anti-Aging Candidate, NMN, Can Be Safely Administered to Humans" (Keio University School of Medicine)
The safety of 300 mg of NMN administered intravenously was confirmed in a human clinical study at Hyogo Medical University.
Intravenous administration of NMN did not affect electrocardiogram, pulse rate, or blood pressure, nor did it affect metabolic markers in the liver, heart, pancreas, or kidney. These results indicate that intravenous administration of NMN is safe and beneficial in humans.
Kimura S, et al. Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals. Cureus. 2022 Sep; 14(9): e28812. doi:10.7759/cureus.28812
Recommended number and frequency of treatments
For anti-aging purposes, it is recommended to continue the process for an interval of 2 to 4 weeks.
When does the effect start?
Effects can be expected from a single session, but since anti-aging involves multiple factors such as skin, muscles, and strength, the realization of effects will inevitably vary from person to person.
Short-term effects include relief of insomnia, improvement in fatigue, and a clear head, which can often be felt on the same day or the day after.
Flow of treatment
You can easily make reservations with your mobile phone.
This is a smart and easy receptionist service where you just need to tell us your name.
Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.
Please be assured that the IV infusion is administered in the same way as a regular IV infusion.
We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.
Features of NMN infusion at Smart Skin Clinic
Charge
150 mg
| Initial Price | |
| Once | 24,800 yen |
| 3 times | 69,800 yen (1 time 23,266 yen) |
| 5 times | 109,800 yen (1 time 21,960 yen) |
| 7 times | 144,800 yen (1 time 20,685 yen) |
| 10 times | 189,000 yen (1 time) 18,900 yen) |
300mg
| Initial Price | |
| Once | 34,800 yen |
| 3 times | 99,800 yen (1 time 33,266 yen) |
| 5 times | 148,000 yen (1 time 29,600 yen) |
| 7 times | 198,800 yen (1 time 28,542 yen) |
| 10 times | 269,800 yen (1 time 26,980 yen) |
600 mg
| Initial Price | |
| Once | 52,800 yen |
| 3 times | 152,400 yen (1 time 50,800 yen) |
| 5 times | 244,000 yen (1 time 48,800 yen) |
| 7 times | 327,600 yen (1 time 46,800 yen) |
| 10 times | 448,000 yen (1 time 44,800 yen) |
Exosome infusion + NMN infusion
Exosome 250mg + NMN150mg
| Initial Price | 34,800 yen |
| Once | 42,980 yen |
| 3 times | 124,800 yen (1 time 41,600 yen) |
| 5 times | 198,000 yen (1 time 39,600 yen) |
| 10 times | 349,800 yen (1 time 34,980 yen) |
Exosome 500mg + NMN 300mg
| Initial Price | 49,800 yen |
| Once | 64,980 yen |
| 3 times | 179,700 yen (1 time 59,900 yen) |
| 5 times | 288,800 yen (1 time 57,760 yen) |
| 10 times | 529,800 yen (1 time 52,980 yen) |
Exosomes 1,000 mg + NMN 300 mg
| Initial Price | 79,800 yen |
| Once | 99,800 yen |
| 3 times | 269,980 yen (1 time 89,993 yen) |
| 5 times | 421,000 yen (1 time 84,200 yen) |
| 10 times | 764,480 yen (1 time 76,448 yen) |
Exosome 2,000mg + NMN 600mg
| Initial Price | 131,940 yen |
| Once | 155,340 yen |
| 3 times | 444,420 yen (1 time 148,140 yen) |
| 5 times | 709,200 yen (1 time 141,840 yen) |
| 10 times | 1,283,400 yen (1 time 128,340 yen) |
If you are interested in the contents of the Exosome infusion, please also see the following pages.
FAQ
- Is it effective even if it is done once?
Dr. Smaski.There are individual differences, but even one time is effective. It is recommended to continue NMN infusion therapy once every 2~4 weeks for 3~6 months.
- Is the NMN infusion safe?
- Dr. Smaski.
NMN is one of the substances synthesized by the body, and there have been no reports of major side effects caused by intravenous infusion.
- I am taking NMN supplements, can I get an infusion?
- Dr. Smaski.
Yes, basically possible. The volume, frequency, etc. should be determined in consultation with the physician.
More Information
| Treatment Time | 15~30 min. |
| Recommended number and frequency of treatments | At least 5 times with an interval of 2~4 weeks |
| Down time | almost never |
| Treatment on the day of counseling | Possible |
| Pain | Tingling needle pain during normal injections and infusions |
Legal descriptions and precautions
The NMN used in this treatment is an unapproved drug, etc., and is an unapproved treatment under the Law on Clothing and Medical Devices, etc. However, in Japan, the use of unapproved drugs is permitted under the responsibility of physicians.
Smart Skin Clinic
Smart Skin Clinic
The concept of the clinic is to "make cosmetic medicine more accessible and smart.
The clinic's concept is to make cosmetic medicine more accessible and smart.
The clinic has eliminated gaudy interior design to reduce interior costs, and instead of introducing equipment in the dark, it carefully selects the equipment it needs and reduces the cost of the equipment.
We aim to "make cosmetic medicine more accessible to as many people as possible.
Address: 8F EX Kanda Nishiki-cho Building, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic Dermatology (aesthetic dermatology, medical hair removal, medical slimming)
Address: 8F EX Kanda Nishiki-cho Building, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic Dermatology (aesthetic dermatology, medical hair removal, medical slimming)
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of the Smart Skin Clinic supervising physicians.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.