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What Is an NMN IV Drip? | A Doctor Explains the Effects, Costs, and Number of Sessions
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"I wonder what an NMN IV drip is really like."
"I heard NMN IV drips are good for anti-aging, and I'd like to learn more."
"Is it true that NMN IV drips help with insomnia and fatigue?"
Hello. I am a physician at Smart Skin Clinic, an aesthetic dermatology clinic.
Do you have any of these questions or concerns?
In this article,Ministry of Health, Labour and Welfare – Accredited Facility for Regenerative Medicine Provision Planour cosmetic dermatology clinic explains it in an easy-to-understand way from a professional standpoint.
(*Type II and Type III Regenerative Medicine Provision Plan accreditation number: NA8230001)
*If you'd like to know the prices, you can jump to the relevant section from the table of contents below.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What Is an NMN IV Drip?
Summary
This is a treatment in which an ingredient called NMN is administered by intravenous drip or injection.
Taking NMN into the body is thought to support physical and cognitive function and offer anti-aging benefits. Its research findings drew wide attention after being featured in "Lifespan: Why We Age – and Why We Don't Have To," a book by Dr. David A. Sinclair, a professor at Harvard Medical School.
What Is NMN?
NMN is an abbreviation for Nicotinamide Mononucleotide.
NMN has a structure similar to vitamin B3 and is a substance that naturally occurs in the body, playing a role in repairing various organs and tissues. Foods such as edamame, broccoli, and avocado contain trace amounts of NMN. However, obtaining meaningful amounts of NMN from food alone is impractical. For example, taking in 100 mg of NMN would require eating roughly 56 heads of broccoli or 126 avocados.
Within the body, NMN is converted into a substance called NAD. NAD circulates throughout the body and activates the sirtuin genes (longevity genes).
When the sirtuin genes are activated, the body's cells become more active, which may bring about a range of anti-aging benefits such as clearer, healthier-looking skin.
NAD is a coenzyme essential for producing energy within cells, and it helps activate the sirtuin genes (longevity genes) believed to play an important role in regulating aging. An age-related decline in NAD is thought to be one of the causes of aging.
For this reason, it is said that continually replenishing NAD may support anti-aging.
Effect
NMN offers a wide variety of effects, which can be summed up in a single phrase as anti-aging benefits.
That said, anti-aging benefits are not something you feel right away the next day. Effects that may be felt more immediately include the following.
[Immediate effects]
- Relief from insomnia
- Reduced fatigue
- Relief from muscle soreness
[Medium- to long-term effects (anti-aging)]
- Improved skin radiance and firmness
- Enhanced metabolism
- Improved stamina and muscle strength
- Better cognitive function
- More balanced hormones
- A more balanced autonomic nervous system
Effects on the skin
Acting through the sirtuin genes, NMN influences a wide range of tissues and cells. It also acts on skin cells, helping to boost collagen and other components, which may improve skin radiance and firmness.
Benefits for stamina and muscle strength
NMN may help boost metabolism and strengthen muscle function.
In a study, healthy older men who took 250 mg of NMN per day for 12 weeks were able to do so safely on an ongoing basis, and their blood levels of NAD+ and NAD+-related metabolites increased significantly. The results indicated that NMN improved muscle strength and performance. This suggests that continued oral intake of NMN may be a very useful approach to preventing age-related declines in muscle strength, such as sarcopenia.
Nicotinamide mononucleotide (NMN) improves motor function in older men (Department of Diabetes and Metabolism, The University of Tokyo Hospital) (reported May 2022)
Benefits for weight management
Studies have reported that NMN may also help support the enzymes involved in energy production within cells. For this reason, NMN is expected to help improve lipid metabolism and burn stored fat more efficiently, and it may be useful as part of a weight-management approach.
Who cannot receive this treatment
- Allergy to NMN
- Those currently affected by an infectious disease or in an immunosuppressed state
- Those who are pregnant or breastfeeding
- Those with a blood disorder such as a coagulation abnormality, or who are taking anticoagulants
- Those with an autoimmune disease or a condition related to the immune system
- (Caution required) Those who have not had a recent medical checkup, or whose state of health is unclear
- Those with allergic conditions
Risks and Side Effects
No risks or side effects specific to NMN IV drips have been reported.
However, the risks and side effects that can occur with IV drip treatments in general, as described below, may apply.
- In rare cases, an anaphylactic reaction (an acute allergic reaction) may occur
- Pain at the puncture site, bruising, and nerve irritation
- Other symptoms such as headache or nausea
Safety Information
At present, no serious side effects have been reported.
The following information is available.
A research group led by Professor Yutaka Ito, together with a team at the University of Washington in the United States, was the first in the world to show that NMN can be safely administered to healthy humans.
In Japan, a group at Keio University Hospital conducted the following clinical trial and concluded that NMN can be safely administered to humans.
Ten healthy men aged 40 to 60 took 100–500 mg of NMN three times in total, at an average interval of two months. There were no changes in blood pressure or pulse, and tests of liver and kidney function showed no abnormalities.
"World's First: Anti-Aging Candidate NMN Shown to Be Safely Administrable to Humans" (Keio University School of Medicine)
Safety in a human clinical trial of intravenous administration of 300 mg of NMN was confirmed at Hyogo Medical University.
Intravenous administration of NMN did not affect electrocardiogram, pulse rate, or blood pressure, nor did it affect metabolic markers in the liver, heart, pancreas, or kidneys. These results indicate that intravenous administration of NMN is safe and beneficial in humans.
Kimura S, et al. Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals. Cureus. 2022 Sep; 14(9): e28812. doi:10.7759/cureus.28812
Recommended Number & Frequency of Treatments
For anti-aging purposes, it is recommended to continue treatment at intervals of about 2 to 4 weeks.
When do the effects appear?
Effects may be expected from a single session, but since anti-aging involves multiple factors such as skin, muscle, and stamina, how quickly effects are felt inevitably varies from person to person.
Short-term effects include relief from insomnia, reduced fatigue, and a clearer head, which can often be felt on the same day or the following day.
Treatment Flow
You can easily book from your smartphone.
Check-in is smart and simple—just give us your name.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
Please rest assured that the IV drip is administered in the same way as any standard IV.
We explain in detail how to care for the treated area and what to keep in mind in daily life. From a prevention and maintenance standpoint, we also suggest suitable home care, such as oral medications and skincare products that can support improvement of your concerns.
Features of the NMN IV Drip at Smart Skin Clinic
Pricing
150 mg
| First-visit price | 19,800 yen |
| Once | 24,800 yen |
| 3 times | 69,800 yen (23,266 yen per session) |
| 5 sessions | 109,800 yen (21,960 yen per session) |
| 7 times | 144,800 yen (20,685 yen per session) |
| 10 sessions | 189,000 yen (per session 18,900 yen) |
300 mg
| First-visit price | 28,800 yen |
| Once | 34,800 yen |
| 3 times | 99,800 yen (33,266 yen per session) |
| 5 sessions | 148,000 yen (29,600 yen per session) |
| 7 times | 198,800 yen (28,542 yen per session) |
| 10 sessions | 269,800 yen (26,980 yen per session) |
600 mg
| First-visit price | 46,800 yen |
| Once | 52,800 yen |
| 3 times | 152,400 yen (50,800 yen per session) |
| 5 sessions | 244,000 yen (48,800 yen per session) |
| 7 times | 327,600 yen (46,800 yen per session) |
| 10 sessions | 448,000 yen (44,800 yen per session) |
Exosome IV drip + NMN IV drip
Exosome 250mg + NMN 150mg
| First-visit price | 34,800 yen |
| Once | 42,980 yen |
| 3 times | 124,800 yen (41,600 yen per session) |
| 5 sessions | 198,000 yen (39,600 yen per session) |
| 10 sessions | 349,800 yen (34,980 yen per session) |
Exosome 500mg + NMN 300mg
| First-visit price | 49,800 yen |
| Once | 64,980 yen |
| 3 times | 179,700 yen (59,900 yen per session) |
| 5 sessions | 288,800 yen (57,760 yen per session) |
| 10 sessions | 529,800 yen (52,980 yen per session) |
Exosome 1,000mg + NMN 300mg
| First-visit price | 79,800 yen |
| Once | 99,800 yen |
| 3 times | 269,980 yen (89,993 yen per session) |
| 5 sessions | 421,000 yen (84,200 yen per session) |
| 10 sessions | 764,480 yen (76,448 yen per session) |
Exosome 2,000mg + NMN 600mg
| First-visit price | 131,940 yen |
| Once | 155,340 yen |
| 3 times | 444,420 yen (148,140 yen per session) |
| 5 sessions | 709,200 yen (141,840 yen per session) |
| 10 sessions | 1,283,400 yen (128,340 yen per session) |
If you would like to know more about our Exosome IV drip, please also see the following page.
FAQ
- Is a single session effective?
Dr. IshiiResults vary from person to person, but even a single session can be effective. That said, NMN IV drip therapy tends to deliver more noticeable results when continued over time. We suggest a session once every 2 to 4 weeks, continued for about 3 to 6 months.
- Is the NMN IV drip safe?
- Dr. Ishii
NMN is one of the substances the body produces naturally, and to date there have been no reports of major side effects from IV drips.
- I am taking NMN supplements—can I still receive the IV drip?
- Dr. Ishii
Yes, this is generally possible. Let's determine the dosage, frequency, and other details in consultation with your physician.
Details
| Treatment Time | 15–30 min. |
| Recommended Number & Frequency of Treatments | At least 5 sessions at intervals of about 2 to 4 weeks |
| Downtime | Almost none |
| Treatment on the day of counseling | Available |
| Pain | The slight prick of the needle felt during a standard injection or IV |
Legal Notices and Precautions
The NMN used in this treatment is an unapproved drug and is therefore an unapproved treatment under the Pharmaceuticals and Medical Devices Act. However, in Japan, physicians are permitted to use unapproved drugs under their own responsibility.
Related Pages
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last supervision date: June 26, 2025