Plural BioSculpture (PLURYAL BIOSCULPTURE)

Hello, I’m a doctor at Smart Skin Clinic, a cosmetic dermatology practice.

Do any of you have questions or concerns like these?

In this article, we’ll explain “BioSculpture”—one of the four products in the Plural series—in an easy-to-understand way from a professional cosmetic dermatology clinic perspective.

Supervisor Information

Group Chief Director, Smart Skin Clinic Group

IshiiIshii KotaKota

Career

Graduated from Juntendo University School of Medicine

Worked at Tokyo Women's Medical University Hospital and affiliated facilities

Worked at a major aesthetic clinic in Tokyo

Affiliations / Qualifications

Board-certified specialist, Japan Surgical Society

Board-certified specialist, Japanese Society of Anti-Aging Medicine

What is Pluryal Biosculpture (PLURYAL BIOSCULPTURE)?

Plural BioSculpture (PLURYAL BIOSCULPTURE) is a formulation within the Plural (PLURYAL) series that is specifically designed for three-dimensional rejuvenation.

It is a formulation that can be described as ”3D rejuvenation,” as it refines facial contours, adds volume, and improves skin texture.

It has the following three features:

1. A blend of three types of HA using Matricyal 3D technology: It combines high-molecular-weight HA, medium-molecular-weight HA, and low-molecular-weight non-cross-linked HA using a special technique. This is what makes it remarkable!
2. Three-dimensional volume restoration: Unlike conventional fillers, it is not a mere "filler"—it three-dimensionally rebuilds the internal structure of the skin. It is like "sculpting the face from the inside out."
3. Both immediate effect and long-term improvement of skin quality: You can expect both an effect from right after injection and improvement of skin quality over time. It offers both "immediacy" and "gradual results."

Its position within the Pluryal (PLURYAL) series

Plural BioSculpture (PLURYAL BIOSCULPTURE) is a formulation within the Plural (PLURYAL) series that focuses specifically on ”three-dimensionality” and ”contour”.

While other products are primarily specialized in improving skin texture or caring for specific areas, Biosculpture literally creates a three-dimensional look on the face, just like a ”sculpture.”

About the Main Ingredients

The three main ingredients of Pluryal Biosculpture (PLURYAL BIOSCULPTURE) are:

1. High-molecular-weight cross-linked hyaluronic acid (HA): It provides an immediate volumizing effect. You could call it "building the foundation with immediate effect."
2. Medium-molecular-weight cross-linked hyaluronic acid (HA): It handles the medium-term effect. It is the "gradually working" type.
3. Low-molecular-weight non-cross-linked hyaluronic acid (HA): It penetrates deep into the skin and promotes long-term improvement of skin quality. It handles "rejuvenation from the inside out."

These three types of HA are blended in an optimal ratio through Matricyal 3D technology.

Treatment areas for Pluryal Biosculpture (PLURYAL BIOSCULPTURE)

Pluryal Biosculpture (PLURYAL BIOSCULPTURE) can be applied mainly to the following areas:

• The entire face (especially the cheeks, temples, and jawline)
• Back of the hand
• neck wrinkles
• Areas where dullness is a concern

It is an ideal formulation especially for those who want to refine their facial contours or restore the dimensionality of the face lost with age.

Effective for concerns such as these

Pluryal Biosculpture (PLURYAL BIOSCULPTURE) may be especially helpful for those with the following concerns:

• Those concerned about facial volume loss
• Those who want to improve wrinkles and sagging
• Those who want to improve overall skin quality
• Those who want to sharpen the contours of their face
• Those concerned about dullness
• Those concerned about open pores
• Those who want to improve the skin's water retention and elasticity
• Those concerned about horizontal wrinkles on the neck
• Those concerned about age-related wrinkles on the hands

If you have any of these concerns, Pluryal Biosculpture (PLURYAL BIOSCULPTURE) may be able to help.

Expected benefits

Using Pluryal Biosculpture (PLURYAL BIOSCULPTURE), you may expect benefits such as the following:

1. Restoring Volume: Restores the facial contours lost due to aging.
2. Improving Wrinkles and Sagging: It lifts and improves deep wrinkles and sagging from the inside out. You could call it a ”lift from within the skin.”
3. Overall Improvement in Skin Quality: Low-molecular-weight hyaluronic acid moisturizes the skin from within, improving texture and firmness.
4. Contour Redefinition: Sharpens facial contours to restore a youthful appearance.
5. Reducing Dullness: By improving the skin’s internal structure, it reduces dullness and restores a bright complexion. It’s like ”lighting up the skin from within.”
6. Improving Skin Sagging: Improves skin elasticity and reduces sagging.
7. Improved Moisture Retention and Elasticity: Enhances the skin's ability to retain moisture, leading to more elastic skin.

How Pluryal Biosculpture (PLURYAL BIOSCULPTURE) works

Pluryal Biosculpture (PLURYAL BIOSCULPTURE) works through the following mechanisms:

1. Immediate Volume Effect: High-molecular-weight HA provides an immediate volume effect.
2. Medium- to Long-Term Moisturizing Effect: Medium-molecular-weight hyaluronic acid gradually breaks down, providing long-lasting moisturization.
3. Deep Skin Texture Improvement: Low-molecular-weight, non-crosslinked HA penetrates deep into the skin to improve skin texture from within. It is responsible for ”rejuvenation from within.”
4. Promotes Collagen Production: HA stimulates fibroblasts and promotes collagen production. It’s all about ”building the foundation of the skin.”

Downtime and Post-Treatment Care for Plural BioSculpture

Plural BioSculpture is a formulation that restores volume in a three-dimensional manner using three types of hyaluronic acid (Matricyal 3D technology). Depending on the injection volume and treatment site, mild swelling or bruising may occasionally occur for a few days.

Guidelines for Aftercare

Item	Guideline
Swelling or Severe Scarring Caused by the Procedure	Depending on the amount injected, mild swelling may occur for a few days.
Bruising and redness at the injection site	This occurs rarely and usually becomes less noticeable within a few days.
Makeup and face washing	It's often possible to start on the same day or the next day.
Bathing, Exercise, and Alcohol Consumption	On the day of the event, please avoid activities that increase blood flow.
Guidelines for Continuation	Our doctors will make recommendations based on your concerns and the specific area of treatment.

The extent of swelling and bruising varies from person to person. Immediately after the injection, it may take some time for the results to stabilize. If you have any pre-existing medical conditions or are taking medication, or if you are pregnant or breastfeeding, please be sure to consult your doctor before undergoing the procedure.

Treatment Method

The Pluryal Biosculpture (PLURYAL BIOSCULPTURE) procedure follows the flow below:

1. Consultation: We listen to your concerns and wishes and conduct a detailed assessment of your facial condition. We will then propose the most appropriate treatment plan for you.
2. Preparation Before Treatment: We’ll thoroughly clean and disinfect the treatment area. If necessary, we’ll apply a topical anesthetic cream.
3. Injection: Using a specialized fine needle or cannula, small amounts are injected into the desired areas of the face.
4. Post-Treatment Care Instructions: We will provide detailed instructions on precautions and proper skincare methods, and confirm the schedule for your next treatment.

The procedure usually takes about 30 to 45 minutes. Including counseling and preparation time before and after, please allow around one hour for your visit to the clinic.

Recommended number/frequency of treatments

The standard treatment plan for Pluryal Biosculpture (PLURYAL BIOSCULPTURE) is as follows:

• Initial course: 3 sessions at 1-month intervals
• Maintenance: 1 session every 6 to 12 months depending on the effect

However, since there are individual differences depending on skin condition and the desired effect, this is only a guide.

The Difference Between Plural BioSculpture and Other Treatments

Even within the same Plural series, the active ingredients and intended purposes vary by product. It’s easier to choose if you base your decision on whether you want to “enhance your facial contours and definition” or “improve your skin’s overall condition.”

Preparation	Ingredients and Features	Suitable Areas and Purposes	Downtime	For those who
BioSculpture (this product)	3 Types of Hyaluronic Acid (Matricyal 3D)	Facial Contours, Dimension, and Volume + Skin Texture	Mild swelling and bruising are rare and last a few days	Patients concerned about sagging skin and a loss of facial contour
Pluryal Densify	Polynucleotide (PN) + Non-crosslinked hyaluronic acid + Mannitol	Skin texture, firmness, and hydration across the entire face	Rare and mild bruising	Patients who want to improve the overall skin quality of their face
Pluryal Silk	High-Purity Polynucleotides (PN)	Fine lines around the eyes and mouth; firmness	If you develop a bruise, it will fade in about 1 to 2 weeks.	Patients who want specialized care for the eye area
Pluryal Hair Density	High-concentration polynucleotides (PN)	Hair Growth for the Scalp, Hair, Eyebrows, and Beard	Rarely, redness at the injection site may last for a few days	Patients Concerned About Thinning Hair or Lack of Volume
Common Hyaluronic Acid Fillers	Cross-linked hyaluronic acid	Precise Shaping and Volumizing	Prone to bruising and swelling	Patients seeking noticeable changes in their appearance

*Results may vary from person to person, and a doctor will determine suitability following an examination.

Pricing

Frequently Asked Questions (FAQ)

Q1: When can I start to see results?

A: The point at which results are felt varies from person to person, but the general timeline is as follows:

• Immediately after treatment: You can feel the volumizing effect.
• After 1 to 2 weeks: The skin begins to look firmer and more radiant.
• After 1 to 2 months: The improvement in skin quality becomes noticeable.
• After 3 to 6 months: This is when the greatest effect appears.

Pluryal Biosculpture (PLURYAL BIOSCULPTURE) can offer both immediate and long-term effects. You can enjoy both "immediacy" and "gradual results."

Q2: Can it be combined with other cosmetic treatments?

A: Yes, it can be combined with many cosmetic treatments. It is considered to pair particularly well with botulinum toxin and laser treatments. That said, in some cases appropriate spacing between treatments is required when combining them.

Notes

Pluryal Biosculpture (PLURYAL BIOSCULPTURE) is a very safe formulation, but the following individuals may not be able to undergo the procedure:

• Those who are pregnant or breastfeeding
• Those with active inflammation or infection at the treatment site
• Those with an autoimmune disease
• Those with a bleeding disorder
• Those with a keloid-prone constitution

In addition, the following points require attention after the procedure:

• Avoid strenuous exercise and alcohol on the day of treatment
• Avoid hot environments (such as saunas) for about a week
• Do not rub or massage the treated area vigorously
• Follow the aftercare directed by your physician

By following these precautions, you can achieve safer and more effective results.

Summary: Why Pluryal Biosculpture (PLURYAL BIOSCULPTURE) is chosen

Pluryal Biosculpture (PLURYAL BIOSCULPTURE) is chosen by many people for the following reasons:

1. Three-Dimensional Rejuvenation Effect: It refines facial contours and restores a three-dimensional appearance.
2. Comprehensive Effects: You can expect a variety of benefits, including increased volume, wrinkle reduction, and improved skin texture.
3. Natural-Looking Results: The combination of three types of HA delivers a rejuvenating effect that looks completely natural.
4. Long-Term Effects: You can expect both immediate results and long-term improvements in skin texture.
5. Low Irritation, Low Risk: Because it contains non-crosslinked HA, it is safer than conventional fillers.
6. Wide Range of Applications: It can be used not only on the entire face, but also on the hands and neck.

Thanks to these features, Pluryal Biosculpture (PLURYAL BIOSCULPTURE) is drawing attention as a three-dimensional rejuvenation treatment.