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【Starting at ¥18,400】Exosome IV Therapy (Umbilical Cord-Derived) at Affordable Prices in Tokyo and Yokohama at Smart Skin Clinic【Official】
250mg
| First-visit price | 18,400 yen |
| Once | 23,000 yen |
| 3 times | 65,500 yen (21,833 yen per session) |
| 5 sessions | 99,800 yen (19,960 yen per session) |
| 7 times | 132,500 yen (18,930 yen per session) |
| 10 sessions | 179,000 yen (per session 17,900 yen) |
500mg
| First-visit price | 29,440 yen |
| Once | 36,800 yen |
| 3 times | 99,800 yen (33,266 yen per session) |
| 5 sessions | 159,800 yen (31,960 yen per session) |
| 7 times | 213,300 yen (30,470 yen per session) |
| 10 sessions | 289,800 yen (per session 28,980 yen) |
1,000mg
| Initial Price | 58,880 yen |
| Once | 73,600 yen |
| 3 times | 199,600 yen (66,533 yen per session) |
| 5 sessions | 319,600 yen (63,920 yen per session) |
| 7 times | 426,600 yen (60,940 yen per session) |
| 10 sessions | 579,600 yen (per session 57,960 yen) |
2,000 mg
| Initial Price | 99,800 yen |
| Once | 119,800 yen |
| 3 times | 341,400 yen (113,800 yen per session) |
| 5 sessions | 544,000 yen (108,800 yen per session) |
| 7 times | 723,100 yen (103,300 yen per session) |
| 10 sessions | 978,000 yen (per session 97,800 yen) |
"What exactly is an Exosome IV drip?"
"I'm comparing clinics that offer the Exosome IV drip, and I'm concerned about things like the price."
"I'd like to receive umbilical cord–derived exosomes."
Hello, I am a doctor at Smart Skin Clinic, an aesthetic dermatology clinic.
Do you have any of these questions or concerns?
In this article,Ministry of Health, Labour and Welfare – Accredited Facility for Regenerative Medicine Provision Planour cosmetic dermatology clinic explains it in an easy-to-understand way from a professional standpoint.
(*Type II and Type III Regenerative Medicine Provision Plan accreditation number: NA8230001)
*If you'd like to know the prices, you can jump to the relevant section from the table of contents below.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What is Exosome IV drip therapy?
Summary
By administering a component called exosomes into the bloodstream,an anti-aging effect throughout the entire bodyis the kind of outcome this IV drip treatment aims to support.
What is an exosome?
Exosomes are substances that occur naturally within the body. In medical terms, they are tiny cellular vesicles enclosed in a lipid bilayer membrane. They are actively secreted by a wide range of cells and play an important role in cell-to-cell communication.
Through this role in cell-to-cell communication, exosomes are understood to exert a range of effects, including anti-apoptotic, anti-inflammatory, neurogenic, and angiogenic actions. These effects, in turn, are thought to contribute to what is commonly referred to as anti-aging.
Exosomes are granule-like substances 50-150 nm (nanometers: one billionth of a meter) in diameter secreted by cells.
One key function of exosomes that has drawn attention is their role in transferring information between cells. Exosomes are believed to act as a communication tool between cells.
Tokyo Metropolitan Institute of Gerontology and Geriatric Medicine
Types of exosomes (by origin)
Exosomes can be grouped into three main types, according to the three principal sites from which they are sourced.
These three types are as follows:
- Umbilical cord-derived
- Fat-derived
- Bone marrow– and dental pulp–derived
Effect
The effects that may be expected from an Exosome IV drip are wide-ranging, as shown in the image below. This is related to the fact that exosomes are involved in cell-to-cell communication and act to help activate cells, while also working throughout the entire body.
We have selected a few of these varied effects to explain in more detail.
Anti-aging(Rejuvenation) and whole-body effects
Anti-aging is a holistic concept, not limited to any single part of the body, and includes rejuvenation at the invisible, cellular level.
Because the Exosome IV drip acts on cells throughout the body, it may help support anti-aging goals.
Relieving fatigue and maintaining wellness
As exosomes act throughout the body, they may help support recovery from fatigue at the cellular level. This is thought to involve the cell-repair and anti-inflammatory actions of exosomes.
Effects on the skin
As shown in the Rohto Pharmaceutical study below, exosomes act on fibroblasts—cells deep within the skin—supporting the synthesis of collagen and elastin, which influence the skin's firmness and radiance. This may help promote healthier, more beautiful skin.
Researchers found that it suppresses fibroblast senescence via exosomes and promotes the synthesis of dermal components such as collagen and elastin.
[Rohto Pharmaceutical] Discovery of an ingredient (glycogen / tetrapeptide-5) that suppresses fibroblast aging via exosomes, drawing attention in regenerative medicine research
Effects on the brain (improved sleep, greater concentration, enhanced cognitive function)
The cell-repair and anti-inflammatory actions of exosomes are thought to have a positive effect on the brain as well, which may help improve sleep and support concentration by soothing the brain.
Exosomes are thought to potentially influence causative agents of Alzheimer's-type dementia, such as amyloid-β and tau proteins, and are hoped to have a beneficial effect on cognitive function.
Reduced downtime
Exosomes are carried throughout the body via the bloodstream and move freely between tissues, exerting anti-inflammatory, antioxidant, and cell-repair actions through processes such as angiogenesis.
Through this mechanism, they may help accelerate wound healing and reduce downtime.
Effects on the hair
Just as they act on the skin, exosomes may act on hair—which is also made up of "cells"—and may help improve elasticity and body, and even support the appearance of gray hair.
Effects on immunity and allergic conditions
As noted in the medical paper below, exosomes may contribute to strengthening immunity.
These results indicate that circulating exosomes containing spike proteins play an important role in effective immunization following mRNA-based vaccination. This is further supported by the induction of humoral and cellular immune responses in mice immunized with exosomes carrying spike proteins.
Sandhya Bansal, et al. Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines. J Immunol (2021) 207 (10): 2405–2410.
In this video, Takafumi Horie (Horiemon) and Dr. Yamakawa discuss exosomes.
Evidence / Data
As for the evidence behind the Exosome IV drip, a wide range of research is underway, as cited in the section on its effects.
Clinical research is still ongoing into the treatment of various conditions, including stroke, liver cirrhosis, cancer, lymphedema, joint disorders, and dementia.
Who cannot receive this treatment
As a general rule, those who fall under any of the following categories are not eligible to receive the Exosome IV drip.
In addition, please rest assured that a physician will examine you before the treatment.
- Those who may wish to donate blood or receive a transfusion in the future (once you have received the Exosome IV drip, you will no longer be able to donate blood or receive a transfusion)
- Those who have had an allergic reaction to an exosome-related treatment in the past
- Those currently affected by an infectious disease or in an immunosuppressed state
- Those who are pregnant or breastfeeding
- Those with a history of cancer or who currently have cancer (due to the possible risk of exosomes promoting cancer growth)
- Those with a blood disorder such as a coagulation abnormality, or who are taking anticoagulants
- Those with an autoimmune disease or a condition related to the immune system
- (Caution required) Those who have not had a recent medical checkup, or whose state of health is unclear
Risks and Side Effects
Common risks and side effects that may occur with the Exosome IV drip include the following:
- Pain at the puncture site, bruising, and nerve irritation
- Other symptoms such as headache or nausea
- In rare cases, an anaphylactic reaction (an acute allergic reaction) may occur
There are also two points particular to exosomes: their potential impact on cancer, and their implications for blood donation.
Potential risk of promoting cancer
It has been suggested that, where cancer cells are present, exosomes may have the potential to promote the growth of those cancer cells.
Faezeh Vakhshiteh, et al. Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy.
Int J Nanomedicine. 2019 Apr 23:14:2847-2859.
On the other hand, there are also opposing research reports suggesting that exosomes may suppress the growth of cancer cells.
For safety reasons, our clinic does not treat patients who have been diagnosed with cancer, or who have not had a medical checkup for many years and whose current state of health is unknown.
You will no longer be able to donate blood
After the IV drip, you will no longer be able to donate blood or receive a transfusion.
Recommended if you have any of these concerns
- I have trouble sleeping
- I want to relieve fatigue and ease a persistent feeling of sluggishness
- I want to strengthen my immune system
- I want to restore firmness and radiance to my skin
- I want to restore body and resilience to my hair
- I want to pursue anti-aging
- I want to improve my physical condition
- I want to regain a more youthful look
- I want to improve my allergy-prone constitution
- I want to ease pain in my joints and limbs
Disadvantages of the Exosome IV drip
One disadvantage of the Exosome IV drip is that you will no longer be able to donate blood in the future.
There are no other major disadvantages, but we explain them in detail in the article below, so please take a look if you are interested.
Downtime and Post-Treatment Care for Exosome Infusions
Since the exosome IV treatment delivers active ingredients into the body via an IV drip, there is virtually no downtime associated with the procedure itself. There are no incisions or significant swelling, so you can return to your normal daily routine immediately after the treatment. It’s easy to fit into your schedule and maintain over the long term.
Guidelines for Aftercare
| Item | Guideline |
|---|---|
| Wounds or severe swelling caused by the procedure | Almost none |
| Bruising or mild discomfort at the puncture site (where the needle was inserted) | This occurs rarely, but usually becomes less noticeable within a few days. |
| Makeup and Bathing | Available starting the same day |
| Intense exercise, excessive alcohol consumption, and prolonged sauna use | Please take it easy on the day of the event and do what feels best for you. |
| Guidelines for Continuation | Your doctor will recommend the appropriate intervals and frequency after your examination. |
During or immediately after the IV infusion, you may rarely experience symptoms such as a sensation of heat in the body or a mild heaviness in the head. If this occurs, we will adjust the infusion rate accordingly. Since allergic reactions are possible in very rare cases, please inform your doctor if you notice any changes in your physical condition during or after the procedure. If you have any pre-existing medical conditions, are currently taking medication, or are pregnant or breastfeeding, please inform your doctor in advance.
The Exosome IV drip at Smart Skin ClinicFeatures of
Use of umbilical cord–derived exosomes
At Smart Skin Clinic, we use "(1) umbilical cord–derived" exosomes—one of the three main types of exosomes: (1) umbilical cord–derived, (2) fat-derived, and (3) dental pulp– / bone marrow–derived.
Compared with other exosomes, umbilical cord–derived exosomes contain more than 14 times the amount of active components, as shown in the figure below.
We would also like to highlight two of these "active ingredients," including specific data.
(1) Rich in active ingredients for the skin
The first is data on the active ingredients for the "skin."
Exosomes offer a variety of anti-aging effects, one of which is their effect on the "skin." As the figure below shows, umbilical cord–derived exosomes contain a richer concentration of active ingredients for the skin than other exosomes.
(2) Rich in the rejuvenating protein "GDF-11"
The second is data on components involved in "rejuvenation."
There is a component called GDF-11 that is involved in rejuvenation, and umbilical cord–derived exosomes contain it in abundance, as the data below shows.
In accordance with MISEV2018, "Minimal Information for Studies of Extracellular Vesicles (MISEV), 2018 Edition"
Exosomes vary in their extraction method, exosome size, storage method, shape, and so on.
For this reason, the International Society for Extracellular Vesicles (ISEV) has established guidelines for standardizing exosome protocols.
The guidelines proposed by ISEV are the "Minimal Information for Studies of Extracellular Vesicles (MISEV), 2018 Edition."
At our clinic, we carry out extraction and purification in accordance with this MISEV2018 at a cell culture and processing facility, and use the resulting product at our clinic.
The Difference Between Exosome Infusions and Other Treatments
Even with the same exosomes, the purpose varies depending on “where they are delivered.” For whole-body anti-aging care, IV drips are recommended, while for targeted treatment of specific areas of concern, combining them with hydrafacials or Dermapen treatments is ideal. A simple way to decide is to first consider whether you want “whole-body” or “localized skin” treatment.
Even with the same exosomes, the intended purpose varies depending on the “administration method”
| Administration Method | Mainly within the coverage area | Suitable Uses | Downtime | Our Services |
|---|---|---|---|---|
| IV Drip (This Page) | Whole (body) | Whole-Body Anti-Aging Care and Wellness | Almost none | Exosome infusion |
| Nasal administration | Continuing Nasal Care at Home | I want to keep it up without too much effort | Almost none | exosome nasal spray |
| HydraFacial (Meso) | Skin on the face and other areas (the superficial layer of the dermis) | Localized Improvement in Skin Texture and Firmness | A few days | HydraFacial × Exosomes |
| Combined Use with Dermapen | The outer layer of the skin, such as on the face | Skin Condition Improvement + Ingredient Delivery | A few days | Dermapen 4 x Exosome |
Differences from “Other IV Treatments” Administered Systemically
| IV drip | Concept (Principal Component) | Primary Purpose | For those who |
|---|---|---|---|
| Exosome infusion | Umbilical cord-derived exosomes (substances that transmit information between cells) | Full-Body Anti-Aging Care | I want to improve my overall health and maintain my youthful vitality |
| NMN IV drip | NMN (a precursor to NAD⁺) | From the Perspective of Energy Metabolism | I want to address this from the perspective of fatigue and energy levels |
| Placenta | Placenta Extract | Overall Condition | For ongoing maintenance |
Exosome Infusions andNMN IV dripSince the purposes differ, our clinic also offers an “Exosome + NMN IV Set” that combines both treatments. For those primarily concerned with localized skin issues, combining these treatments with hydrafacials or Dermapen treatments may be suitable. Our doctors will make recommendations based on your specific goals.
*This comparison is intended to help you organize your thoughts when choosing a treatment. Results may vary from person to person, and a doctor will determine suitability based on a medical examination.
Safety Initiatives | Compliance with the Guidance of the Japanese Society for Regenerative Medicine
Our Exosome IV drip therapy is carried out in accordance with the "Guidance on the Clinical Application of Extracellular Vesicles, etc. (1st Edition)," published by the Japanese Society for Regenerative Medicine on April 30, 2024.
This guidance serves as an important set of principles for ensuring the safety and efficacy of exosome therapy, and at our clinic we carry out rigorous quality control and safety measures based on this guidance.
Our clinic's specific measures to ensure safety
- Conducting risk profiling
- We identify the potential risks associated with treatment and take appropriate measures.
- Rigorous preparation processes and quality control
- Our manufacturing processes and quality checks are based on the latest scientific findings.
- Carrying out appropriate verification of effectiveness
- We continually assess the effectiveness of treatment and strive to provide the most suitable care for each patient.
Placing your safety first, we are committed to providing treatment grounded in the latest scientific findings.
What is the Exosome nasal spray?
Exosomes can also be administered via a "nasal spray." Much like a nasal spray for hay fever, it can be used at home.
We explain this in detail in the article below, so please take a look if you are interested.
Treatment Flow
You can easily book from your smartphone.
Check-in is "smart" and simple—all you need to do is give us your name.
Please feel free to raise any concerns during your counseling session. Rest assured, there is no pushy sales.
Please rest assured that the IV drip is administered in the same way as any standard IV.
We explain in detail how to care for the treated area and what to keep in mind in daily life. From a prevention and maintenance standpoint, we also suggest suitable home care, such as oral medications and skincare products that can support improvement of your concerns.
Smart Skin Clinic Pricing
Exosome infusion
250mg
| First-visit price | 18,400 yen |
| Once | 23,000 yen |
| 3 times | 65,500 yen (21,833 yen per session) |
| 5 sessions | 99,800 yen (19,960 yen per session) |
| 7 times | 132,500 yen (18,930 yen per session) |
| 10 sessions | 179,000 yen (per session 17,900 yen) |
500mg
| First-visit price | 29,440 yen |
| Once | 36,800 yen |
| 3 times | 99,800 yen (33,266 yen per session) |
| 5 sessions | 159,800 yen (31,960 yen per session) |
| 7 times | 213,300 yen (30,470 yen per session) |
| 10 sessions | 289,800 yen (per session 28,980 yen) |
1,000mg
| Initial Price | 58,880 yen |
| Once | 73,600 yen |
| 3 times | 199,600 yen (66,533 yen per session) |
| 5 sessions | 319,600 yen (63,920 yen per session) |
| 7 times | 426,600 yen (60,940 yen per session) |
| 10 sessions | 579,600 yen (per session 57,960 yen) |
2,000 mg
| Initial Price | 99,800 yen |
| Once | 119,800 yen |
| 3 times | 341,400 yen (113,800 yen per session) |
| 5 sessions | 544,000 yen (108,800 yen per session) |
| 7 times | 723,100 yen (103,300 yen per session) |
| 10 sessions | 978,000 yen (per session 97,800 yen) |
exosome nasal spray
| 1 bottle of 5cc [one-week supply] | |
|---|---|
| First-visit price | 29,440 yen |
| 1 bottle | 36,800 yen |
| 2 bottles (two-week supply) | 71,600 yen (35,800 yen per bottle) |
| 4 bottles (one-month supply) | 131,200 yen (per bottle 32,800 yen) |
| 12 bottles (three-month supply) | 345,600 yen (per bottle 28,800 yen) |
Exosome + NMN IV drip set
Exosome 250mg + NMN 150mg
| First-visit price | 34,800 yen |
| Once | 42,980 yen |
| 3 times | 124,800 yen (41,600 yen per session) |
| 5 sessions | 198,000 yen (39,600 yen per session) |
| 10 sessions | 349,800 yen (34,980 yen per session) |
Exosome 500mg + NMN 300mg
| First-visit price | 49,800 yen |
| Once | 64,980 yen |
| 3 times | 179,700 yen (59,900 yen per session) |
| 5 sessions | 288,800 yen (57,760 yen per session) |
| 10 sessions | 529,800 yen (52,980 yen per session) |
Exosome 1,000mg + NMN 300mg
| First-visit price | 79,800 yen |
| Once | 99,800 yen |
| 3 times | 269,980 yen (89,993 yen per session) |
| 5 sessions | 421,000 yen (84,200 yen per session) |
| 10 sessions | 764,480 yen (76,448 yen per session) |
Exosome 2,000mg + NMN 600mg
| First-visit price | 131,940 yen |
| Once | 155,340 yen |
| 3 times | 444,420 yen (148,140 yen per session) |
| 5 sessions | 709,200 yen (141,840 yen per session) |
| 10 sessions | 1,283,400 yen (128,340 yen per session) |
About insurance coverage for the Exosome IV drip
The Exosome IV drip is not covered by public medical insurance.
As an elective (self-pay) treatment, it is handled in the same way as any standard cosmetic procedure.
If you would like to know more, please see the article below for a detailed explanation.
FAQ(FAQ)
- Is a single session effective?
Dr. IshiiA single session can be effective. That said, the Exosome IV drip is a treatment designed to deliver more noticeable results when repeated. For this reason, we generally recommend a course of about 8 to 12 sessions, spaced roughly 1 to 2 weeks apart.
- Could it affect one's genes or similar?
- Dr. Ishii
To date, no research has produced data showing that genetic information is altered.
- Could exosomes cause cancer?
- Dr. Ishii
As a rule, no. Exosomes themselves are not thought to induce cancer. That said, if cancer is already present in the body, they may potentially activate it.
- Are allergic reactions a concern?
- Dr. Ishii
When allergies are checked in advance, the risk is generally comparable to that of a standard IV drip. Should an allergic reaction occur, please rest assured that a physician is on hand to respond.
Details
| Treatment Time | 15–30 min. |
| Recommended Number & Frequency of Treatments | About 5 sessions, roughly one month apart |
| Downtime | Almost none |
| Treatment on the day of counseling | Available |
| Pain | The slight prick of the needle felt during a standard injection or IV |
References / Literature
・Tokyo Metropolitan Institute of Gerontology and Geriatric Medicine
Related Pages
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last supervision date: June 26, 2025