Lately, I've grown increasingly concerned about the changes that come with age. I felt I'd reached the limits of self-care when it came to sagging around my mouth, hollow cheeks, nasolabial folds, sunken temples, and the wrinkles and hollows under my eyes. I found Smart Skin Clinic through an online search,and it had extremely high reviews,so I decided to come here. I chose Profhilo because I wanted minimal downtime, safety, and rejuvenation of my whole face. Treatment began right after the consultation, with injections at five points on each side of my face, ten in total. The moment of the needle is just a slight prick, but the discomfort builds as the solution goes in. Still, it's not painful enough to require anesthesia. After the procedure, the injection sites swell a little like mosquito bites, but it's mild enough to hide with a mask and doesn't interfere with heading home. In my case, one spot under my eye bruised, and I'm still covering it with a mask for work. I expect the bruise to fade in about 10 days. On day 1 after the procedure, my cheeks felt fuller. It's now day 5, andthe results far exceed what I imagined,and I couldn't be happier.
Rejuran Generic (Kiarareju) Japan's Lowest Price Level 3,980 yen (per 1cc)|Smart Skin Clinic [Official]

| 1 vial (2.2 cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 22,320 yen | ¥10,150 |
| 2 sessions (20% off) | ¥36,560 (¥18,280 per session) | ¥8,310 |
| 4 sessions (20% off) | 63,360 yen (15,840 yen per session) | 7,200 yen |
| 2 bottles (4.4cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 31,320 yen | ¥7,120 |
| 2 sessions (20% off) | 49,280 yen (24,640 yen per session) | 5,600 yen |
| 4 sessions (20% off) | 91,520 yen (22,880 yen per session) | 5,200 yen |
| 3 bottles (6.6cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 35,820 yen | ¥5,430 |
| 2 sessions (20% off) | 55,440 yen (27,720 yen per session) | 4,200 yen |
| 4 sessions (20% off) | 104,960 yen (26,240 yen per session) | 3,980 yen |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
At our clinic, the free consultation is handled directly by a specialist physician, not by a beauty counselor as at major clinics. For this reason, there is no hard selling whatsoever during the free consultation, which has made it very well received even by patients who are new to aesthetic treatments. Please book with peace of mind.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
Rejuran generic (Kiarareju): what is it?
In short, Rejuran generic (Kiarareju) is a formulation injected with the same main ingredient as Rejuran—polynucleotide (PDRN).
For that reason, you can consider its effect to be the same as Rejuran's.
On the other hand, because it is a later-developed formulation with lower R&D costs, it can be offered at a lower price than Rejuran.
Details of Rejuran generic (Kiarareju)
Rejuran generic (Kiarareju) is a formulation whose main ingredient is salmon-derived polydeoxynucleotide (PDRN). In addition to polydeoxynucleotide, it contains hyaluronic acid and niacinamide, and because it promotes (boosts) the skin's own natural capacity, it is also called a skin booster. Because it uses salmon-derived polydeoxynucleotide, it is also sometimes referred to as a “salmon injection.”
When you hear “salmon-derived polydeoxynucleotide,” you may think of Rejuran, which is known for its cell-regenerating effect.
Rejuran is a preparation whose active ingredient is polydeoxynucleotide (PDRN), extracted from salmon DNA, and it works to enhance the skin's self-regenerating ability.
Polydeoxynucleotide (PDRN) offers a variety of effects, including increased production of growth factors, improved capillary circulation, anti-inflammatory action, and DNA resynthesis.
Rejuran generic (Kiarareju):The effect of
The effect of Rejuran generic (Kiarareju) isessentially the same as those of Rejuran..
- Improvement of skin quality
- Hydration
- Improved skin tone
- Improved skin elasticity
- Improvement of fine lines and crepey wrinkles
- Strengthening of the skin's barrier function
Rejuran generic (Kiarareju):The components of
- Polydeoxynucleotide: skin regeneration
- Hyaluronic acid: high hydration, long-lasting
- Niacinamide: brightening
Rejuran generic (Kiarareju) containsingredients similar to those in Rejuran..
The following study reports improvements in wrinkles and skin texture when polydeoxynucleotide was injected on its own into the nasolabial folds.
The selected right-side nasolabial fold received 4 ml of PN-HPT® (≈polydeoxynucleotide) intradermally during the initial priming phase (the "NLF Rx group"), while the selected left-side nasolabial fold received 4 ml of saline (placebo) (the "NLF Lx group"). Three and six weeks later, all patients received 2 ml of subcutaneous cross-linked HA in both NLF areas (4 ml in total).
(omitted) The Antera 3D® device showed that, in the NLF Rx, wrinkles and skin texture improved significantly compared with baseline at 6 weeks (monotherapy phase) and at 3 and 6 months (PN-HPT® priming + HA phase). HA levels as measured by the quantitative Vectra H2® assessment technique in the right NLF were significantly higher than the contralateral side at both 3 and 6 months.
PN-HPT® monotherapy was confirmed to be a potentially valuable and effective option for rapidly improving the dermal texture and quality of the skin in patients with moderate to severe NLF. Acting as a priming agent within the skin, PN-HPT® prolongs the clinical efficacy of cross-linked HA.
Antonino Araco, Francesco Araco, Mauro Raichi. Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross-linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study. Journal of cosmetic dermatology. 2023 Jan;22(1);146-155. doi: 10.1111/jocd.15064.
Features of Smart Skin Clinic's Water Light Injection
At our clinic (Smart Skin Clinic), Rejuran generic (Kiarareju) is injected using a device called Water Light Injection.
We perform our Water Light Injection with strong dedication to our clients, so please take a look at the post below.
Rejuran generic (Kiarareju):The treatment areas for
- Face (forehead, temples, nose, cheeks, fine lines and crepey wrinkles)
- Neck
- Décolleté
- Back of the hand
Rejuran generic (Kiarareju) can be used over a wide area—from the entire face to the neck and décolletage.
Pain during the Rejuran generic (Kiarareju) treatment
- No more than a slight prickling sensation as the needle enters the skin
*Individual variation applies; anesthesia is available
With Rejuran generic (Kiarareju), pain can be reduced by applying suction as the needle is inserted.
Because the needles are ultra-fine and nine can be delivered at once, the number of insertions is kept to a minimum.
Pain can also be reduced by cooling the treatment area beforehand and by using anesthesia. Smart Skin Clinic's pricing includes the cost of anesthesia.
The onset, duration, and recommended maintenance frequency of Rejuran generic (Kiarareju)
[When the effects appear]
- Hydration and brightening effects = immediately after treatment
- Skin-regenerating effects = approx. 2 to 4 weeks later
[Recommended number of treatments]
- About 3 to 4 sessions, spaced 2 to 4 weeks apart (= 1 course)
[Duration of effect]
- More than 1 year
*When a full course of treatment is completed
[Recommended maintenance frequency]
- 1 course every 6 months to 1 year
At first, the hyaluronic acid provides hydration and a brightening effect, and after 2 to 4 weeks the skin-regenerating effect of the polydeoxynucleotide begins to appear.
As with Rejuran, a single session can produce results, but the effects become easier to appreciate with repeated treatments.
Recommended injection amount of Rejuran generic (Kiarareju)
[Pattern 1] Lighter treatment is fine for the forehead and the area below the nose ⇒ 3cc
[Pattern 2] The area below the nose can be a little lighter, but I want thorough treatment above the nose ⇒ 4cc
[Pattern 3] I want thorough treatment across the whole face, including below the nose ⇒ 6cc
If you are unsure which volume best suits your concerns, please feel free to discuss it during your counseling session.
Downtime and risks of Rejuran generic (Kiarareju)
The biggest concern with Rejuran generic (Kiarareju) is likely the impact on daily life after the procedure.
Downtime of Rejuran generic (Kiarareju)
[Period]
- About 2 to 3 days
[Symptoms]
- Redness and small raised bumps at the needle sites: resolve within 24 hours
- Stinging sensation: several days
- Bruising: gradually fades over 10 to 14 days
Pain and swelling can be relieved by cooling. Wrap an ice pack or similar in a clean cloth and apply it intermittently to the treated area.
How to spend your time after Rejuran generic (Kiarareju)
After treatment, please keep the following points in mind.
- Skincare: possible immediately after the treatment
- Shower: possible on the same day
- Makeup: possible after about 24 hours
There is no major impact on daily life after Rejuran generic (Kiarareju). If you have a desk job, you can carry on as usual. If any bruising occurs, it can be covered with concealer.
However, beneath the surface, the skin is working to repair micro-injuries that are not visible to the eye. Please avoid activities that increase circulation and may hinder recovery, such as long baths, strenuous exercise, and massage, as these can intensify downtime symptoms.
Risks of Rejuran generic (Kiarareju)
Beyond downtime symptoms, Rejuran generic (Kiarareju) has the following possible side effects:
- Pigmentation
- Infection
- Allergy
After treatment, avoid touching the treated area more than necessary, as this may lead to pigmentation or infection. In addition, skin that is still regenerating can be prone not only to pigmentation but to various skin concerns, so be diligent with moisturizing and sun protection.
Swelling, pain, and redness resemble downtime symptoms but usually subside over time. Worsening symptoms are an important sign of an allergic reaction. Please consult the clinic as soon as you notice them.
Note that, like Rejuran, Rejuran generic (Kiarareju) is derived from salmon, so it cannot be used by people with a fish allergy.
Rejuran generic(Kiarareju)at one of the lowest price levels in Japan
Water Light Injection add-on medication discount campaign now on
Those receiving a Water Light Injection are eligible for the following two options:
1. High-concentration vitamin C or glutathione can be added for +1,000 yen per session (regular standalone price: 21,800 yen)
2. Skin Botox can be added for +2,000 yen per session (regular standalone price: 23,800 yen)
| 1 vial (2.2 cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 22,320 yen | ¥10,150 |
| 2 sessions (20% off) | ¥36,560 (¥18,280 per session) | ¥8,310 |
| 4 sessions (20% off) | 63,360 yen (15,840 yen per session) | 7,200 yen |
| 2 bottles (4.4cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 31,320 yen | ¥7,120 |
| 2 sessions (20% off) | 49,280 yen (24,640 yen per session) | 5,600 yen |
| 4 sessions (20% off) | 91,520 yen (22,880 yen per session) | 5,200 yen |
| 3 bottles (6.6cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 35,820 yen | ¥5,430 |
| 2 sessions (20% off) | 55,440 yen (27,720 yen per session) | 4,200 yen |
| 4 sessions (20% off) | 104,960 yen (26,240 yen per session) | 3,980 yen |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Cocktail Water Light Injection with Juvelook
A cocktail injection blending the Rejuran-generic products "Kiarareju" and "Juvelook."
We offer two versions—one with more Rejuran and one with more Juvelook—so you can choose the one that best suits your concerns.
・Rejuran-heavy cocktail: 4.4 cc Kiarareju + 1.6 cc Juvelook
・Juvelook-heavy cocktail: 2.2 cc Kiarareju + 3.8 cc Juvelook
| Rejuran-heavy cocktail [6cc] | Limited-time discount price (until July 31) |
|---|---|
| Once (10% off) | 44,800 yen |
| 3 times (20% off) | 119,520 yen (Per session 39,840 yen) |
| Juvelook-heavy cocktail [6cc] | Limited-time discount price (until July 31) |
|---|---|
| Once (10% off) | 49,300 yen |
| 3 times (20% off) | 125,700 yen (Per session 41,900 yen) |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Why we can deliver both "high quality" and "some of the lowest prices in the nation"The reasons we can achieve this
In fact, more than 90% of aesthetic clinics carry too many unnecessary costs to offer their patients the best possible price.
Guided by this awareness of the problem, we created an aesthetic clinic completely unlike the conventional norm.
(1) Areas with low rent
(2) Cutting back on lavish interiors
(3) Cutting back on excess staffing
(4) Cutting back on excessive advertising spend
This is how we deliver something other clinics can't match: the "High-quality Rejuran genericinjections offered at one of the lowest price levels in Japan" we're able to achieve.
Some patients are also concerned about whether a formulation is genuine, given the low price.
To ease such concerns,we open a brand-new formulation on the spot and show it to you,which gives our patients peace of mind.

Smart Skin Clinic's Rejuran generic consistently earns high reviews on Google, Hot Pepper, Kirei Pass, and more
At Smart Skin Clinic, we think carefully about what our patients truly need and thoroughly cut out unnecessary costs, allowing us to deliver affordability, high quality, and high satisfaction all at once.
As a result,we earn high ratings across a variety of review sites, including Google and Hot Pepper Beauty.we have earned.
As a result, about 80% of those who visit us once return for repeat treatment.
Google review rating 4.5/5.0 (97 reviews)

Hot Pepper Beauty rating 4.57/5.00

KireiPass rating4.30/5.00

Kumapon rating4.71/5.00

Gangnam Unni rating9.3/10.0

Details of Rejuran generic (Kiarareju)
| Treatment Time | About 30 to 40 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | We recommend about 3 to 4 sessions at intervals of roughly 2 to 4 weeks. |
| Downtime | About 2 to 3 days |
| Treatment on the day of counseling | Available |
| Makeup | Possible from about 24 hours later |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | A slight pricking sensation when the needle is inserted. |
The treatment method for Rejuran generic (Kiarareju)
The procedure takes about 30 to 40 minutes excluding counseling, and about 60 minutes including anesthesia.
The treatment flow is as follows.
STEP
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
We apply anesthetic cream, administer local anesthesia, and perform the injection while checking in with you.
We explain in detail how to care for the treated area and what to keep in mind in daily life. From a prevention and maintenance standpoint, we also suggest suitable home care, such as oral medications and skincare products that can support improvement of your concerns.
For Rejuran generic (Kiarareju), come to Smart Skin Clinic
Smart Skin Clinic's Rejuran generic (Kiarareju) uses 9 ultra-fine needles, with depth adjustable from 0.6 to 1.2 mm beneath the skin and controllable injection volume.
Our pricing is clear and transparent. To suit your treatment areas and preferences, we offer three volume options per unit—2.2 cc / 4.4 cc / 6.6 cc—along with an easy-to-try single-session price and easy-to-continue 3- and 4-session set prices.
If you have any questions, please feel free to ask during a free consultation. Our doctors will recommend the most suitable treatment for you.
Introducing other injectable treatments at Smart Skin Clinic for those with skin-quality concerns
In addition to Rejuran generic (Kiarareju), Smart Skin Clinic offers other injection treatments effective for improving skin quality.


If you are interested in the Juvelook injection shown in the case photo above, please refer to the link below.
Physician Who Supervised This Page

Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
![Official] Smart Skin Clinic|Aesthetic Dermatology Group (Jimbocho, Yokohama)](https://smartskin-clinic.com/wp-content/uploads/2023/05/Smart-skin-clinic-ロゴ500-×-100-px.png)