![Official] Smart Skin Clinic｜Aesthetic Dermatology Group (Jimbocho, Yokohama)](https://smartskin-clinic.com/wp-content/uploads/2023/05/Smart-skin-clinic-ロゴ500-×-100-px.png)
Lately, I've grown increasingly concerned about the changes that come with age. I felt I'd reached the limits of self-care when it came to sagging around my mouth, hollow cheeks, nasolabial folds, sunken temples, and the wrinkles and hollows under my eyes. I found Smart Skin Clinic through an online search,and it had extremely high reviews,so I decided to come here. I chose Profhilo because I wanted minimal downtime, safety, and rejuvenation of my whole face. Treatment began right after the consultation, with injections at five points on each side of my face, ten in total. The moment of the needle is just a slight prick, but the discomfort builds as the solution goes in. Still, it's not painful enough to require anesthesia. After the procedure, the injection sites swell a little like mosquito bites, but it's mild enough to hide with a mask and doesn't interfere with heading home. In my case, one spot under my eye bruised, and I'm still covering it with a mask for work. I expect the bruise to fade in about 10 days. On day 1 after the procedure, my cheeks felt fuller. It's now day 5, andthe results far exceed what I imagined,and I couldn't be happier.
【Japan's Lowest Price】LIZNE: ¥7,970 per 1cc｜Smart Skin Clinic【Official】
At our clinic, the free consultation is handled directly by a specialist physician, not by a beauty counselor as at major clinics. For this reason, there is no hard selling whatsoever during the free consultation, which has made it very well received even by patients who are new to aesthetic treatments. Please book with peace of mind.
Water Light Injection add-on medication discount campaign now on
Those receiving a Water Light Injection are eligible for the following two options:
1. High-concentration vitamin C or glutathione can be added for +1,000 yen per session (regular standalone price: 21,800 yen)
2. Skin Botox can be added for +2,000 yen per session (regular standalone price: 23,800 yen)
"What is Lizne? What benefits does it offer?"
"What does it mean that it's a generic version of Rejuran?"
"I'm looking for a clinic that offers Lizne, and I'd like to compare prices."
"What's the difference between it and Rejuran?"
Hello, I am a doctor at Smart Skin Clinic, an aesthetic dermatology clinic.
Do you have questions or concerns like these?
Lizne is one of the latest skin-regeneration treatments drawing attention in the field of aesthetic medicine."Pain-free Rejuran"As it is also called, it has become popular with many patients. However, many people may want to learn more about its effectiveness, safety, and how it differs from other treatments.
To help answer these questions and concerns, Smart Skin Clinic, a cosmetic dermatology clinic, offers a clear, professional explanation of Lizne.
This article explains Lizne in detail from every angle, including its features, effects, treatment method, and pricing. We hope it will be a helpful resource for anyone considering cosmetic treatments.
*If you would like to know about a specific topic, such as pricing, you can jump directly to the relevant section from the table of contents below.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What Is Lizne: An Evolved Rejuran Generic
Lizne is one of the latest skin-regeneration skin booster formulations drawing attention in the field of aesthetic medicine. This product isa generic product developed following the patent expiration of the well-known Rejuranand is positioned as an evolved version of Rejuran—inheriting its excellent effects while improving on its shortcomings.
Origin of the name
The name "Lizne" carries a deeper meaning.
- LIZ: from "Leeds" (peak/prime), representing the time when your skin was at its most beautiful.
- NE: from "Rene" (rebirth), symbolizing skin regeneration and rejuvenation.
In other words, "Lizne" was named with the wish to be "reborn to youthful skin." The name concisely captures the product's purpose and effect.
Relationship with Rejuran
Lizne is a generic version of Rejuran, but it is not simply a copy.Building on Rejuran's excellent effects, it was developed as a safer and more effective product by incorporating the latest technology and research. In particular, it focuses on the pain and redness that had been drawbacks of Rejuran, greatly improving both.
Features of Lizne: 5 Points of Evolution from Rejuran
Lizne inherits Rejuran's strengths while evolving significantly in the following five ways.
(1) High-purity polynucleotides (PDRN)
While Lizne is primarily composed of polynucleotides (PN) extracted from the DNA of salmonid fish,its purity has been raised to as high as 99%.This higher purity simultaneously improves efficacy and reduces the risk of side effects.
(2) Significantly reduced pain
Lizne is"Pain-free Rejuran"so much so that the pain during injection is reduced to the point that it is also called this. This is thanks to the removal of impurities through high-purity PN extraction and refinement technology and the pH adjustment of the solution. Clinical trials have also confirmed significantly less pain compared with Rejuran.
(3) Reduced post-treatment redness
Lizne isRedness after treatment is also significantly reducedas well. Because it is reduced compared with Rejuran, this should be a welcome evolution for those who have been receiving Rejuran.
(4) Optimal pH adjustment
In Lizne, the pH of the solution is adjusted to the ideal level for the skin. This reduces irritation during injection, easing not only pain but also the burden on the skin after treatment.
(5) Suitability for a wide range of areas
Lizne can be used on a wide range of areas, including the entire face, neck, and décolleté. A key feature is that it can be used safely even on areas that were difficult to treat with conventional products, such as around the eyes and mouth.
Thanks to these advances, Lizne offers a more comfortable and effective treatment for patients. Reducing pain and redness lowers the hurdle to receiving treatment, making it easier for more people to receive it.
Main Benefits of Lizne: Firmer, More Radiant Skin and Overall Rejuvenation
Lizne improves skin quality, and in particularit has a strong "firmness and radiance" effect.
Lizne is also an injectable formulation based on polynucleotides (PN). PN has the following properties:
- Cell-activating effect
- Promotes tissue repair and regeneration
- anti-inflammatory action
- antioxidant action
Thanks to these properties of PN, Lizne is designed to support comprehensive skin rejuvenation, including improved firmness and radiance and better overall skin quality.
The main benefits of Lizne are as follows:
(1) Improved skin firmness and radiance
The high-purity PN in Lizne activates fibroblasts in the dermal layer and promotes the production of collagen and elastin. This helps improve the skin's firmness and elasticity, while enhancing how light reflects off the skin's surface, leading to more radiant skin.
(2) Improvement of wrinkles
Through PN's cell-activating effect, wrinkles such as fine lines and nasolabial folds may be improved. It is particularly effective for fine wrinkles around the eyes and mouth.
(3) Overall improvement of skin quality
Moisturizing effect: PN has strong water-retention properties and enhances the skin's ability to hold moisture.
Reduced skin problems: Its anti-inflammatory action helps improve acne scars and other scarring.
Pore tightening: As overall skin firmness improves, enlarged pores become less noticeable.
Improved skin tone: Its antioxidant action helps suppress melanin production, supporting brighter, clearer skin without dullness.
Common hyaluronic acid products (cross-linked) work by "filling in" the loss of bone and fat volume that comes with aging, helping to refine facial contours and improve wrinkles and nasolabial folds. The injected hyaluronic acid stays in the treatment area and produces a localized effect.
Lizne, on the other hand, spreads widely after injection and acts on the skin as a whole. In other words, rather than adding volume, it aims to deliver overall rejuvenation by improving the skin quality itself and activating cells.
How Long Lizne's Effects Last
Overseas clinical studies have reported that more than 90% of patients treated with high-purity PN formulations like Lizne felt the effects lasting even three months later. This suggests that Lizne promotes regeneration from deep within the skin, not merely superficial improvement.
In this way, Lizne is a treatment that improves the skin's firmness and radiance while offering comprehensive rejuvenation. In particular, it can aim for the kind of natural improvement in skin quality that conventional hyaluronic acid products could not achieve.
How Lizne Works
Lizne's effects come from the combined action of its main component, polynucleotides (PN). Specifically, three main mechanisms are at work:
(1) Activation of fibroblasts
PN directly stimulates and activates the fibroblasts in the dermal layer. Activated fibroblasts promote the production of collagen, elastin, and hyaluronic acid. These components play an important role in supporting the skin's structure and giving it firmness and elasticity. As a result, wrinkles may improve and sagging may be reduced.
(2) Angiogenesis (new blood vessel formation)
PN helps promote the formation of new blood vessels. New capillaries improve the supply of nutrients and oxygen to the skin. This activates the skin's metabolism, promoting the removal of old dead skin cells and the production of new cells. As a result, the skin gains healthier color and looks brighter and more vital.
(iii) Anti-inflammatory action
PN has a powerful anti-inflammatory action. Chronic inflammation is one of the factors that accelerate skin aging, and PN helps suppress it. It is also effective in improving inflammatory skin problems such as acne and redness. In addition, it helps protect the skin from inflammation caused by external stimuli such as UV rays.
Through the combined action of these mechanisms, Lizne delivers comprehensive improvement in skin quality. Particularly noteworthy is that these effects reach across a wide range, from the deeper layers of the skin to the surface.
Furthermore, the latest research suggests that polynucleotides (PN) may help promote DNA repair. Considering that the accumulation of DNA damage from UV rays and other factors contributes to skin aging, this is a welcome effect.
In this way, rather than making only superficial improvements, Lizne works comprehensively from the cellular level of the skin, delivering lasting, natural improvement in skin quality.
Recommended for
Those who want to improve their skin's firmness and radiance:
- Those who want more radiant, translucent skin
- Those who want supple, touchable skin
- Those who want makeup to sit better and achieve skin that glows from within
Those considering preventive aging care:
- Those who want to help prevent future skin aging
- Those who want to maintain youthful skin over the long term through early care
Those concerned about fine lines and nasolabial folds:
- Those who have started to notice fine wrinkles around the eyes and mouth
- Those whose nasolabial folds have deepened and who are told they look older than their age
Those troubled by dry or sensitive skin:
- Those concerned about skin dryness year-round
- Those with sensitive skin that doesn't get along with various beauty products
Those concerned about dull skin and enlarged pores:
- Those whose skin tone has darkened and looks dull
- Those with noticeable pores who want to restore smooth skin
Those also considering neck and décolleté care:
- Those who want to improve the skin quality of the neck and décolleté, not just the face
Those seeking a more natural result:
- For those who feel that hyaluronic acid injections aren't enough, or find them unnatural.
- Those seeking long-term, natural rejuvenation
Those sensitive to pain who are hesitant about conventional injectable treatments:
- Those who have avoided cosmetic treatments because they don't handle the pain of injections well
- Those who couldn't tolerate the pain of conventional skin booster injections such as Rejuran
Especially among those in their 20s,the benefit of "improving skin firmness and radiance" is popular.
A Detailed Comparison of Lizne and Rejuran
Lizne was developed as a generic version of Rejuran, but it is not simply a copy—it is an evolved formulation. A comparison is shown below.
Component
- Rejuran: primarily composed of polynucleotides (PN).
- Lizne: also primarily composed of PN, but with a high purity of 99%.
Effect
- Rejuran: offers effects such as skin regeneration, wrinkle improvement, and enhanced firmness and elasticity.
- Lizne: essentially offers the same effects as Rejuran.
Pain
- Rejuran: known for relatively strong pain during injection.
- Lizne: pain is greatly reduced thanks to high-purity PN extraction and refinement technology and pH adjustment.
Downtime
- Rejuran: involves redness and swelling after treatment.
- Lizne: redness and swelling are reduced compared with Rejuran, and downtime is slightly shorter.
Duration
- Rejuran: the duration of effect varies from person to person but generally lasts about 3 to 6 months.
- Lizne: with its high-purity polynucleotides (PN), the effects last longer than with Rejuran.
Number of Treatments
- Rejuran: typically, 3 to 4 treatments spaced 2 to 4 weeks apart are recommended.
- Lizne: same as Rejuran.
Pricing
- Rejuran: relatively expensive, as it was the first polynucleotide (PN) product brought to market (and patented at that time).
- Lizne: as a generic product, it can often be offered at a lower price than Rejuran.
Clinical Track Record
- Rejuran: has a long track record of use, with a large body of accumulated clinical data.
- Lizne: a relatively new product, but clinical data have been accumulating. Fundamentally, it is a polynucleotide (PN) formulation similar to Rejuran, so Rejuran's data also apply.
In this way,Lizne is an evolved polynucleotide (PN) formulation that inherits Rejuran's strengths while improving in various ways, including reduced pain, reduced redness, and lower pricingis the result. In particular, the reduced "pain" that had been a problem with Rejuran should be a major benefit for those who want to receive Rejuran.
Recommended Number & Frequency of Treatments
3 to 4 times, spaced about 3 to 4 weeks apart. After that, maintenance once every six months to a year.
Downtime
This section explains the downtime period, symptoms, and recovery process for Water Light Injection.
Downtime Period
Downtime for Water Light Injection is about 2 to 3 days.
Downtime Symptoms
Downtime symptoms include redness, swelling, pain, edema, bruising, and temporary bumps at the injection site.
As for the raised bumps from the Water Light Injection solution, they resolve within 48 hours in most cases. If bruising occurs, it gradually fades over 10 to 14 days.
After 48 hours, it can generally be covered with makeup, but if you have important plans, please schedule accordingly.
Swelling and redness
With Water Light Injection, the needle is inserted while the skin is suctioned. The suction pressure and needle punctures may cause redness or swelling at the treatment site.
These symptoms subside in about 1 to 5 days, depending on the depth of injection.
Needle marks
The needle punctures may remain slightly red immediately after injection. This can be covered with makeup such as foundation.
These symptoms subside within a few days.
Bruising
If the needle damages a blood vessel running through the skin during injection, bruising may occur. Bruising is more likely in areas with thin skin, so extra care is needed around the eyes and neck, but it can generally be covered with makeup such as concealer.
These symptoms subside in a few days to about 10 days.
If you would like to see the detailed recovery process in photos, please read the following article.
Aftercare
For the first several days from the day of treatment, please keep the following points in mind. Proper aftercare is important to bring out the full effect of Lizne and maintain it over the long term. Appropriate daily skincare and healthy lifestyle habits also help sustain the results.
Keeping the skin clean:
- On the day of treatment, refrain from bathing and just rinse lightly in the shower. You may gently wash your face from the next day.
- Avoid high-temperature environments such as hot springs and saunas for 3 days after treatment.
UV protection:
- Avoid direct sunlight for one week after treatment, and be diligent about sunscreen when going out.
- Using sunscreen with strong UV protection is recommended.
Skincare:
- Refrain from using harsh cosmetics (retinol-containing products, peeling agents, etc.) for 3 days after treatment.
- Focus on skincare that emphasizes moisturizing.
Makeup:
- Makeup can be applied from the day after treatment, but be sure to apply it gently.
- Using products that are gentle on the skin is recommended.
Lifestyle:
- Avoid alcohol and strenuous exercise on the day of treatment.
- Try to get enough sleep and stay well hydrated.
Safety
Lizne is a formulation with a high level of safety, from the following perspectives.
Biocompatibility:
- Polynucleotides (PN), the main component of Lizne, have a structure similar to human DNA, making them highly biocompatible.
- As a result, the risk of allergic reactions and rejection is extremely low.
High purity:
- Lizne uses PN with a high purity of 99%.
- With fewer impurities, the risk of side effects is reduced.
pH adjustment:
- Because the pH of the solution is adjusted to the ideal level for the skin, there is less irritation.
Non-permanent:
- Because PN is gradually broken down within the body, any problems that may arise are temporary.
Large-scale overseas clinical trials have highly rated the safety of high-purity PN formulations like Lizne. One study reported zero serious side effects across more than 1,000 procedures.
However, the risks vary depending on your individual constitution and health condition. When considering treatment, it is important to always have a detailed consultation beforehand to confirm whether it is suitable for you.
Features of Smart Skin Clinic's Water Light Injection
Lizne Pricing
Water Light Injection add-on medication discount campaign now on
Those receiving a Water Light Injection are eligible for the following two options:
1. High-concentration vitamin C or glutathione can be added for +1,000 yen per session (regular standalone price: 21,800 yen)
2. Skin Botox can be added for +2,000 yen per session (regular standalone price: 23,800 yen)
| 2 bottles (2cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 33,210 yen | 16,600 yen |
| 3 times (20% off) | 79,920 yen (26,640 yen per session) | ¥13,320 |
| 4 sessions (20% off) | 98,880 yen (24,720 yen per session) | ¥12,360 |
| 4 bottles (4cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 49,410 yen | 12,350 yen |
| 3 times (20% off) | 118,560 yen (39,520 yen per session) | ¥9,880 |
| 4 sessions (20% off) | 146,880 yen (36,720 yen per session) | ¥9,180 |
| 6 threads (6cc) | Limited-time discount price (until July 31) | Per 1 cc Price |
| Once (10% off) | 65,610 yen | ¥10,940 |
| 3 times (20% off) | 157,440 yen (52,480 yen per session) | ¥8,750 |
| 4 sessions (20% off) | 191,360 yen (47,840 yen per session) | 7,980 yen |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Very popular! Pricing for the Rejuran × Juvelook cocktail injection
A cocktail injection blending the Rejuran-generic products "Kiarareju" and "Juvelook."
We offer two versions—one with more Rejuran and one with more Juvelook—so you can choose the one that best suits your concerns.
・Rejuran-heavy cocktail: 4.4 cc Kiarareju + 1.6 cc Juvelook
・Juvelook-heavy cocktail: 2.2 cc Kiarareju + 3.8 cc Juvelook
| Rejuran-heavy cocktail [6cc] | Limited-time discount price (until July 31) |
|---|---|
| Once (10% off) | 44,800 yen |
| 3 times (20% off) | 119,520 yen (Per session 39,840 yen) |
| Juvelook-heavy cocktail [6cc] | Limited-time discount price (until July 31) |
|---|---|
| Once (10% off) | 49,300 yen |
| 3 times (20% off) | 125,700 yen (Per session 41,900 yen) |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Why we can deliver both "high quality" and "some of the lowest prices in the nation"The reasons we can achieve this
In fact, more than 90% of aesthetic clinics carry too many unnecessary costs to offer their patients the best possible price.
Guided by this awareness of the problem, we created an aesthetic clinic completely unlike the conventional norm.
(1) Areas with low rent
(2) Cutting back on lavish interiors
(3) Cutting back on excess staffing
(4) Cutting back on excessive advertising spend
This is how we deliver something other clinics can't match: the "High-quality Lizneinjections offered at one of the lowest price levels in Japan" we're able to achieve.
Some patients are also concerned about whether a formulation is genuine, given the low price.
To ease such concerns,we open a brand-new formulation on the spot and show it to you,which gives our patients peace of mind.
Smart Skin Clinic's Lizne consistently earns high ratings in reviews on Google, Hot Pepper, Kirei Pass, and more.
At Smart Skin Clinic, we think carefully about what our patients truly need and thoroughly cut out unnecessary costs, allowing us to deliver affordability, high quality, and high satisfaction all at once.
As a result,we earn high ratings across a variety of review sites, including Google and Hot Pepper Beauty.we have earned.
As a result, about 80% of those who visit us once return for repeat treatment.
Google review rating 4.5/5.0 (97 reviews)
Hot Pepper Beauty rating 4.57/5.00
KireiPass rating4.30/5.00
Kumapon rating4.71/5.00
Gangnam Unni rating9.3/10.0
Frequently Asked Questions (Q&A)
- When can I start to feel the effects of Lizne?
-
Results vary from person to person, but many people feel improved firmness and elasticity immediately after treatment. The overall improvement in skin quality tends to appear gradually from about 2 to 3 weeks and often peaks over 2 to 3 months.
- How long do the effects of Lizne last?
-
The duration of effect varies from person to person but averages about 4 to 8 months.
- What is the difference between it and Rejuran?
-
Lizne is a generic version of Rejuran, but it uses more highly purified polynucleotides and has an adjusted pH, so it tends to cause less pain and less redness. It is also effective for a wider range of concerns.
- How much does it hurt?
-
Lizne causes so little pain that it is called "pain-free Rejuran." Many people report feeling only mild irritation. That said, the perception of pain varies from person to person.
- Is there a risk of side effects?
-
Lizne is a very safe formulation, but temporary side effects such as mild redness, swelling, and bruising may occur. Serious side effects are extremely rare.
- How many treatments should I have?
-
We recommend 3 to 4 treatments spaced 3 to 4 weeks apart.
- Can I receive it if I have a fish allergy?
-
Because Lizne uses salmon-derived DNA, those with an allergy to fish or fish roe cannot undergo the treatment.
Summary
Lizne is a generic version of Rejuran, a formulation based on polynucleotides (PN), just like Rejuran.
Compared with Rejuran, it is an evolved formulation with reduced pain, reduced redness, and a lower price.
At our clinic, we want to help improve the quality of your skin. If you are interested in Lizne treatment, please come in for a consultation.
Introducing other injectable treatments at Smart Skin Clinic for those with skin-quality concerns
In addition to Rejuran generic (Lizne), Smart Skin Clinic offers other injection treatments that are effective for improving skin quality.
If you are interested in the Juvelook injection shown in the case photo above, please refer to the link below.
[Legal Notices]
Water Light Injection includes procedures using drugs or medical devices that are not approved in Japan. The drugs and devices used in treatment have been imported through personal importation at the discretion of our physicians.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00