Doctors Explain] Is the Rejuvenation Effect of Exosomes Real? An easy-to-understand explanation of the mechanism of rejuvenation
I want to know how the exosome's rejuvenating effects work."
I've heard that exosomes can rejuvenate you, but is it true?"
I want to rejuvenate with exosomes."
Hello, I am a doctor at Smart Skin Clinic.
Do you have any of these questions?
Exosomes are said to have a "rejuvenating effect". It has recently (as of September 2023) received particular attention as a so-called "anti-aging treatment.
On the other hand, at the same time, we hear people say, "I don't really understand why it is possible to get younger.
This article provides an easy-to-understand explanation of how exosomes work and the evidence for their rejuvenating effects from a medical standpoint.
Smart Skin Clinic also handles exosomes, so please feel free to contact us if you are interested.
What is an exosome?
Exosome is both a substance name and a therapeutic name at the same time.
Exosomes, intercellular signaling molecules
Exosomes are intercellular "information transmitters" secreted by stem cells.
Stem cells transform into a variety of cells and self-renew to repair tissues. Exosomes contained in stem cells are thought to be capable of "tissue repair" and other effects similar to those of stem cells by transmitting RNA, proteins, and other information between cells.
Treatment with exosomes
Treatment using exosomes was originally derived from "regenerative medicine" technology.
Regenerative medicine is a treatment for difficult-to-treat diseases that aims to restore lost functions by administering artificially cultured "stem cells.
Stem cells have a "self-repair capacity". Their number gradually decreases from birth, as does the cell's ability to repair itself. For example, the number of tissue stem cells in the bone marrow is about 1/200th that of newborns in their 80s.
Therefore, this treatment attempts to repair the tissue by culturing and administering stem cells.
The filtered supernatant fluid of "stem cell culture medium" used in regenerative medicine is called "stem cell culture supernatant fluid" and contains various physiologically active substances such as growth factors and exosomes.
Exosomes used for treatment are extracted from stem cells in the order [stem cell culture medium > stem cell culture supernatant > exosomes].
Can exosomes be used to rejuvenate the body?
We cannot irresponsibly assert that the body and skin will actually return to the body and skin of a teenager or 20-something by incorporating exosomes. Also, because it is a new treatment, there are still fewer papers than conventional treatments, and we should expect further research in the future.
However, based on the papers and data that have been published,Rejuvenation effect can be expected.I guess you could say that.
We would like to introduce two papers to show the evidence for the expected rejuvenation effect.
For example, the following paper reports that "Exosomes extracted from adipose-derived stem cells were injected into photoaged rat skin, resulting in decreased epidermal thickness and stratum corneum percentage, increased dermal thickness and collagen, and decreased proteolytic enzymes."
This suggests that exosomes may be effective in restoring the aging epidermis and dermis.
In the rat model of photoaged skin, the injected exosomes markedly decreased the epidermal thickness and increased the dermal thickness of the photoaged Moreover, the proportion of the stratum corneum of the epidermis was decreased. Furthermore, real-time RT-PCR showed that the mRNA expression of type I collagen was increased and that of type III collagen, MMP-1, and MMP-3 was decreased. derived exosome treatment could significantly improve skin photodamage and that ADSC-derived exosomes may be a potential agent for photoaged skin treatment.
(Japanese translation) In a rat model of photoaging skin, injection of exosomes significantly reduced the thickness of the epidermis and increased the thickness of the dermis of photoaged skin after 7 days of treatment. Furthermore, the percentage of stratum corneum in the epidermis decreased. Furthermore, real-time RT-PCR showed increased mRNA expression of type I collagen and decreased mRNA expression of type III collagen, MMP-1, and MMP-3 (proteolytic enzymes). These results indicate that treatment with exosomes extracted from adipose-derived stem cells (ADSCs) may significantly improve photodamage of the skin, and that ADSC-derived exosomes may be a potential agent for photoaging skin therapy.
reference
Jun-Xian Liang, Xuan Liao, Sheng-Hong Li, Xiao Jiang, Ze-Hua Li, Yin-Di Wu, Li-Ling Xiao, Guang-Hui Xie, Jian-Xing Song, Hong-Wei Liu
(2020). Antiaging Properties of Exosomes from Adipose-Derived Mesenchymal Stem Cells in Photaged Rat Skin. BioMed research international. 2020;6406395. doi:10.1155/2020/6406395.
In addition, the following paper also compares the use of a solution containing human adipose tissue stem cell-derived exosomes (HACS) and microneedles (dermapen) in combination in patients with aging skin.
The study compared wrinkles, elasticity, moisture, and pigmentation on one side of the same person's face with those on the opposite side with saline solution, and found that the HACS side showed greater improvement.
Exosomes are effective in treating skin problems caused by aging.
The Global Aesthetic Improvement Scale score was significantly higher on the HACS-treated side than on the control side at the final follow-up visit (p = 0 .005). Objective measurements obtained by different devices including PRIMOS Premium, Cutometer MPA 580, Corneometer CM 825, and Mark-Vu confirmed greater Objective measurements obtained by different devices including PRIMOS Premium, Cutometer MPA 580, Corneometer CM 825, and Mark-Vu confirmed greater clinical improvements in skin wrinkles, elasticity, hydration, and pigmentation on the HACS-treated side than on the control side. The results of the histopathological evaluation were consistent with the clinical findings.
（Global Aesthetic Improvement Scale scores were significantly higher on the treated side of the solution containing human adipose tissue stem cell-derived exosomes than on the control side (p = 0.005). CM 825, and Mark-Vu confirmed a clinically significant improvement in skin wrinkling, elasticity, moisture, and pigmentation on the HACS treated side over the control side. Results of histopathological evaluation were consistent with clinical findings. No serious adverse events were observed.
reference
Gyeong-Hun Park, Hyuck Hoon Kwon, Joon Seok, Steven Hoseong Yang, Joon Lee, Byung Chul Park, Eun Shin, Kui Young Park." Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging": A 12-week Journal of cosmetic dermatology. 2023 Jun 28; doi: 10.1111/jocd.15872.
The experiment here is that we used exosomes as an introductory solution for dermapen (microneedles). In other words, I think it is safe to say that the dermapen x exosome introduction solution is "effective".
What is the rejuvenating effect of exosomes?
The rejuvenating effects of exosomes are limited to the skin when introduced after a dermapen, but when administered intravenously, they act on the entire body, so multiple effects may be expected. The effects are wide-ranging, but some examples are described below.
Regulates skin turnover
Exosome infusion is considered to "regulate skin turnover".
Turnover is the renewal of the epidermis, the top layer of the skin. Old cells on the surface of the skin are expelled as plaque, and at the same time new cells are born from the bottom of the epidermis.
The ideal cycle of turnover is approximately 28 days, neither too fast nor too slow. The cycle slows down as skin cells lose function due to aging and speeds up as they try to recover from damage. The reduced function of skin cells is restored and the turnover cycle is more easily regulated.
The turnover process will maintain healthy skin conditions and reduce the risk of skin problems such as dryness, fine lines, dullness, and blotches.
Increase collagen and elastin production
According to Rohto's research, exosomes can be expected to "increase collagen and elastin," which are the source of firmness and elasticity deep within the skin.
Fibroblasts" produce collagen and elastin, but their ability to do so declines with age. However, there is data showing that the production of aging fibroblasts is improved by incorporating exosomes. This is a great benefit for those who suffer from wrinkles and sagging.
Reference:Rohto Pharmaceuticals
Anti-inflammatory action, reduces skin irritation
Exosomes can also be expected to "reduce inflammation.
As blood vessels gather in an attempt to heal a wound, an inflammatory response occurs, such as swelling and heat in the wound. Temporary inflammation is a normal response, but chronic inflammation is a burden to the body and skin.
Redness of the cheeks and inflamed acne are skin problems caused by inflammation. The anti-inflammatory properties of exosomes are expected.
Therefore, if you use the Exosome Introductory Solution after the DermapenIt's going to shorten our downtime."It is said.
Treatment with exosomes
Treatment with exosomes can have a variety of effects on the entire body or on desired areas, depending on the treatment method.
Different clinics handle different treatments, such as
- Exosome x infusion:
Exosomes are injected through an intravenous drip. Exosomes enter through blood vessels and spread throughout the body. This is suitable for those who want a whole-body treatment and no downtime. - Exosome x injection:
Injects exosomes with pinpoint accuracy using an ultra-fine injection needle. Suitable for those who want partial treatment. - Exosome x Dermapen:
The skin is punctured with 16 ultrafine needles and exosomes are applied. This treatment is expected to have natural healing and pharmacological effects. - Exosomes x ultrasound:
Ultrasound is a form of electrical energy. It allows the applied exosomes to penetrate deep into the skin. It requires little pain or downtime and draws out the skin's natural strength. - Exosome x fractional laser:
Laser irradiation is used to make small holes in the skin and apply exosomes. This treatment is expected to have natural healing and pharmacological effects.
Smart Skin Clinic for Exosome
Have your questions been answered about the rejuvenating effects of exosomes?
Smart Skin Clinic's Exosome is featured on binanbijyo with over 400,000 PV per month.
Exosome is a treatment that uses the repair power of cells. It is expected to have a rejuvenating effect on the skin as well as the entire body. Because it is a new treatment method, the effectiveness of 100% has not yet been established, but its effectiveness is being verified in various papers.
At Smart Skin Clinic,
Exosome infusion
Exosome x Dermapen
The company handles the following
We use a Japanese exosome infusion of 991 TP3T purity derived from umbilical cord. We also use the official Dermapen exosome induction solution.
If you are interested, please feel free to contact us.
Reference
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