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Eclairis fat-dissolving injection｜Partial slimming with less swelling and pain
I can't keep my face line clear even if I lose weight."
Even though I try my best with diet and exercise, I can't lose weight in certain areas, such as my double chin, arms, and thighs."
Liposuction has a long downtime, so it's hard to take the plunge."
I want to look good for an event or wedding, but I'm looking for a slimming treatment that won't rebound easily."
Do you have any of these problems?
Hello. We are Smart Skin Clinic, a cosmetic dermatology clinic that performs over 20,000 injections per year.
In this article, we will explain the effects of the fat melting injection "ecrylisse," the difference from FatX Core, downtime, and side effects in an easy-to-understand manner from an expert's point of view.
*If you already know what you want to know, you can jump to the appropriate section from the table of contents.
Chief Director of Smart Skin Clinic Group
stone Kouta
career
Graduated from Juntendo University School of Medicine
Tokyo Women's Medical University Hospital and related facilities
Worked at a major beauty clinic in Tokyo
Affiliation / Qualifications
Japan Surgical Society Specialist
Japanese Society of Anti-Aging Medicine
What is Eclairis?
ECRILIS is a fat dissolving injection developed by TNS in Korea.
Eclairis was developed by TNS in Korea.Has a fat-dissolving effect1% for "deoxycholic acid."Injectable formulation formulated withIt is.
The same fat dissolving injection, "BNLS neo," has a concentration of deoxycholic acid of about 0.001-0.021 TP3T. On the other hand, Acrylisse contains about 10,000 times more deoxycholic acid than BNLS neo, and is an injection that is expected to have a more powerful fat-dissolving effect.
Main ingredients and composition of ecrylisse
In addition to deoxycholic acid, the main fat-dissolving agent, Ecrylis contains several auxiliary ingredients.
- Deoxycholic acid: the main ingredient that physically breaks down the cell membrane of fat cells and reduces the fat cells themselves
- L-Carnitine: Amino acid derivative that supports fat burning
- Oleic acid: Unsaturated fatty acid that promotes the discharge of decomposed fat
- Ginseng extract: Plant-derived ingredient expected to promote metabolism and have anti-inflammatory effects
- Anti-inflammatory ingredients of the NAIS Complex system: a complex of plant extracts and amino acids that reduce swelling and swelling after treatment
The main ingredient, deoxycholic acid, is a pharmaceutical ingredient approved by the U.S. FDA (Food and Drug Administration) in 2015 under the name Kybella for submental fat reduction.
The combination of these ingredients is,It is designed not only to melt fat, but also to provide total support for the elimination of waste products from the body.
Why is Equiris called "FatX Core OEM"?
When it comes to fat dissolving injections, some may be wondering how they differ from "FatX Core".
In conclusion, ECRILIS is a fat dissolving injection "FatX Core" andA new formulation containing deoxycholic acid at an equally high concentration (1.01 TP3T)It is. Since the core concentration of fat-dissolving ingredients is the same, equally powerful effects can be expected.
However, due to adjustments in the ratio of ancillary ingredients and anti-inflammatory ingredients, the swelling period tends to be slightly shorter with Ecrylis compared to FatX Core.Equiris is "as effective as FatX Core, with less downtime."This is an attractive point.
Mechanism of ecrylis that destroys fat cells themselves
Deoxycholic acid, the main ingredient of ecrylis, has the effect of physically disrupting the cell membrane of adipocytes (focal adipocytolysis).
[Injected deoxycholic acid works].
- Interacts with the cell membrane of adipocytes, destabilizing the membrane structure and melting the cells
- Melted adipocytes are phagocytosed by immune cells (macrophages)
- Fibroblasts are then mobilized to produce collagen
- After a series of tissue reactions, the broken down fat is finally expelled from the body as carbon dioxide through exhalation and as water through the urine, etc.
In other words,Ecrylis does not "temporarily reduce the size of fat," but rather "reduces the fat cells themselves.The point is a key feature.
The details of the mechanism by which deoxycholic acid physically disrupts adipocyte membranes and ultimately reduces fat through tissue responses such as macrophage infiltration and fibroblast mobilization are reviewed in the following paper.
Effects of ecrylisse｜Partial slimming, rebound prevention, and small face effect
The biggest concern for those considering ecrylisse is still, "Does it really work?" and "Does it really work? Here, we will explain the mechanism by which ecrylis is effective and the specific changes that can be expected, along with the scientific evidence.
- partial weight loss
- Prevention of rebound｜Because the number of fat cells itself is reduced
- Collagen production prevents skin from sagging
(1) Partial slimming
Even with diet and exercise, it is inevitably difficult to lose weight in certain areas, such as under the chin, arms, thighs, and stomach.
For example, a person with a small jaw may be affected by the skeletal structure, such as a person with a small jaw who tends to have a double chin even with a little fat. Or, even if the whole body is equally thin, areas that have a lot of fat to begin with may stand out.
Pinpoint injection of the drug into the area of concern enables "partial slimming" by reducing the fat cells in the area itself.Facial fat reduction. This is an effective approach for localized fat problems such as facial lines, double chins, arms, and inner thighs.
(2) Prevention of rebound｜Because the number of fat cells itself is reduced
Fat loss through normal dieting and exercise only reduces the size of fat cells, but does not change the number of fat cells themselves. Therefore, if lifestyle habits are disrupted, the cells will expand again, and rebounding is likely to occur.
On the other hand, because ecrylis is ejected from the body, the destroyed fat cells are ejected from the body,The number of fat cells in the treated area itself is reduced..Once fat cells are reduced, they are difficult to regenerate in that area.and, as a result, "rebound prevention" can be expected.
Regarding the long-term durability of deoxycholic acid, the following paper reports that in a 3-year follow-up study conducted in the United States, the fat reduction effect of the procedure was maintained in 82.41 TP3T subjects after 3 years.
(3) Skin elasticity and firmness｜Collagen production prevents skin from sagging
Some people are concerned that fat loss will cause the skin to sag. Some people are concerned that the skin will sag as fat is reduced.
However, due to tissue reactions (macrophage mobilization, collagen production by fibroblasts) that occur in the process of deoxycholic acid destroying fat cellsSkin sagging is prevented and a firming and tightening effect can be expected..
With general liposuction, the problem of "fat reduction but excess skin sagging" tends to occur, but because ECrylisse involves tissue reconstruction through collagen production, it is also beneficial from the perspective of preventing sagging.
Estimated time and number of times until the effect is felt
Ecrylisse is not an immediate treatment, but a treatment with gradual effects.
- Effects felt: Changes begin to be felt from about 3 days to 1 week after treatment, and settle down after about 3 to 6 weeks.
- Recommended number of sessions: 3-5 sessions at 2-4 week intervals (individual differences depending on the amount of fat in the area and the goal to be achieved)
A particularly important point to understand is that it is not realistic to expect dramatic changes in a single session.
Since it takes time for fat cells to be destroyed and expelled, you will experience natural changes as fat cells are gradually reduced by continuing with multiple treatmentsis the original process.
We recommend that you plan from a long-term perspective and not for short-term changes.
Recommended areas for ecrylisse and injection volume (cc)
The following is an introduction to the specific areas that Ecrylis can be used for, along with a guideline for the amount of injections.
Facial contouring/small face treatment (double chin, facial lines, cheeks, gills)
Facial fat is a thin and delicate area of the face, so a small amount of fat injected into the face can be expected to make a big impression.
- Cheekbone Area1 to 5 cc
- Cheeks / Nasolabial Folds1 to 5 cc
- Jawline Area1 to 10 cc
- Jawline Contour1 to 5 cc
- Submental Area / Under the Chin3 to 10 cc
*All on one side
*This is only a guideline.
It is especially favored by those who are concerned about "leanness under the chin," "want to make a round face look sharper," and "are concerned about their profile.
Kybella, an FDA-approved drug, was also originally developed with the primary goal of improving submental fat.
Partial body slimming (arms, stomach, thighs, calves)
For the body, a larger injection volume is generally required than for the face.
- Armpit Fat (Front)5 to 10 cc
- Upper Abdomen10–20 cc
- Lower Abdomen10 to 40 cc
- Flanks (Love Handles)20–40 cc
- Inner Thighs10–20 cc
- Outer Thighs10–20 cc
- Above the Knees5 to 10 cc
- Upper Arms10–20 cc
- Bra Bulge (Back)5 to 10 cc
- Upper Back (Shoulder Blade Area）10–20 cc
- Back10–20 cc
- Waist / Lower Back10–20 cc
- Under Buttocks (Banana Roll)10 to 40 cc
- Thighs (Both Sides)10–40 cc (both sides)
- Calves10–20 cc
- Ankles5–10 cc (both sides)
*All on one side
*Note: The maximum injection volume for body treatments is 100cc per area.
*This is only a guideline.
The strength of ecrylisse is its ability to pinpoint areas that are difficult to lose weight even with exercise, such as "swinging arms," "inner thighs," and "flabby lower abdomen," in particular.
Regarding the effectiveness of deoxycholic acid on the body, the following paper shows that 86.71 TP3T subjects showed improvement after 12 weeks of follow-up for deoxycholic acid injections into flank fat.
Namakizadeh Esfahani, N., Khorasanizadeh, F., Ehsani, A., Nasimi, M., Mahmoudi, H., Kafi, H., Sabzvari, A., Gholami, H., Saeedi, K., & Balighi, K. (2025 ). Evaluating the Efficacy and Safety of Deoxycholic Acid Injection in the Reduction of Flank Fat. Journal of Cosmetic Dermatology, 24(9), e70436. doi:10. 1111/jocd.70436
However, downtime tends to be longer for the body than for the face because of the larger amount of fat and injections. The amount of injections depends on the thickness of the fat and the goal to be achieved.
Comparison of Fat Melting Injection
Many patients ask, "What's the difference between Ecrylisse and other fat melting injections?" Many patients ask us "What is the difference between Ecrylisse and other fat dissolving injections?
Here is a list of the differences from the major fat dissolving injections.
Fat melting injection Comparison table of major formulations
| Product Name | ecrylis | FatX Core | cabbage | BNLS neo |
| Deoxycholic acid concentration | 1.0% | 1.0% | 0.5% | 0.001 to 0.02% |
| Fat dissolving effect | 'good work' (equiv. of silver star awarded to children at school) | 'good work' (equiv. of silver star awarded to children at school) | symbol used as a placeholder (either because a number of other words could be used in that position or because of censorship) | weak |
| Down time | 3-7 days | 1 to 2 weeks | 2-5 days | 1-3 days |
| Number of injections | 3-5 times | 3-5 times | 3-6 times | 5 to 10 times or more |
| injection site | Face & Whole body | Face & Whole body | Face & Whole body | Mainly face (small area) |
| Supporting Ingredients | L-carnitine, ginseng, anti-inflammatory ingredients | Amino acids, plant extracts | L-carnitine, artichoke extract | Mainly plant-derived extracts |
The biggest difference is stillConcentrations of deoxycholic acid."It is. The higher the concentration of deoxycholic acid, the stronger the fat-dissolving effect, but at the same time the risk of swelling and side effects tends to increase. 1% is considered the upper limit for safety, and Ecrylisse and FatX Core are highly concentrated formulations designed to reach this limit.
3 key factors that make Ecrylis a better choice than FatX Core
There are three advantages to choosing Ecrylisse over FatX Core, which has a comparable concentration.
- Equally high concentration of deoxycholic acid in a more refined formulation balance: Adjustment of anti-inflammatory ingredients tends to make the irritant sensation milder
- Additional metabolism-supporting ingredients such as L-carnitine and ginseng extract: Comprehensively supports not only fat dissolution but also fat removal
- Tends to have a shorter duration of swelling than FatX Core: Although it varies from person to person, in most cases, it settles down in 3 to 7 days.
Those who are concerned about post-treatment swelling and those who wish to reduce downtime due to work commitments tend to choose Acrylisse.
How is it different from BNLS neo/cabelin?
BNLS neo is a fat-dissolving injection mainly composed of herb-derived plant ingredients (licorice extract, carnitine, etc.), and the concentration of deoxycholic acid is only about 0.001-0.021 TP3T. The approach method is centered on "promotion of lymphatic circulation + mild stimulation of fat cells," and is characterized by gentle metabolic acceleration by plant ingredients rather than strong fat cell destruction.While the advantage is that there is almost no swelling, the fat dissolving effect is mild and is suitable for pinpoint contouring and mild fat.
Cabela's formulation contains 0.51 TP3T of deoxycholic acid.The effect is milder than that of the ECLIris FatX Core, but with a shorter downtime of 2 to 5 days,Preparation recommended for those who receive fat dissolving injections for the first timeIt is.
It is important to select the optimal formulation in consultation with your physician according to your lifestyle and desires.
About Pain During Treatment
Some people are worried about pain when they hear the word "injection.
The sensation during the procedure depends on the injection site and how the individual feels, but is generally described as follows
- During injection: prickling sensation of the needle and light pressure when the drug is spread.
- Immediately after injection: Heat or tingling sensation at the injection site (calms down in a few minutes to a few dozen minutes)
In particular, because Ecrylisse contains a high concentration of deoxycholic acid, the irritation sensation upon injection may be slightly stronger than milder formulations such as BNLS neo.
We consider Ecrylisse to be basically anesthesia-free. Local anesthesia can be used upon request (at an additional cost).
Downtime, swelling, and pain with ecrylisse
Downtime and side effects of ecrylisse are relatively mild, but may vary from person to person.If you have an important appointment, please allow about 2 weeks.We recommend that you make a schedule.
Approximate progress from the day of treatment to 1 week (explained in chronological order)
Downtime for ecrylisse generally follows the following course of events.
- Day of treatment: Peaks immediately after injection. Mild swelling, redness, heat, and prickling pain are common.
- Next day to 3rd day: Time for swelling to peak out. Internal bleeding may appear. (For the face, it can be covered with a mask or makeup.
- Days 4-7: Swelling and redness gradually subside, and appearance is almost normal.
- After 2 weeks: Almost no interruption in daily life. Time when fat cells are discharged and the effects begin to be felt.
However, these are only guidelines. Downtime may vary depending on the amount of injection, the area, and the individual's constitution.
Approximate downtime by site
The ease of swelling and length of downtime varies depending on the site.
- Face (face line and under the chin): 3-7 days
- Arms and stomach: 5 to 10 days (tends to be longer than face)
- Thighs and calves: 1 to 2 weeks
The downtime tends to be longer for the body than for the face due to the larger amount of fat and injections. Please use this as a reference when considering the timing of your treatment in order to accommodate your work and schedule. It is best to avoid weddings, graduations, and important events, and to have the procedure completed at least two to three weeks prior to the event.
Aftercare to reduce swelling quickly
To shorten the downtime as much as possible, keep the following aftercare tips in mind after the procedure.
- NG: Avoid massage, strenuous exercise, drinking, sauna, and long baths for about a week (may increase swelling due to increased blood circulation).
- Cooling care: Gently apply cooling agent over a clean towel.
- Hydration: Frequent water intake stimulates metabolism and supports the elimination of waste products.
- Bathing: Shower only on the day, bathtubs are allowed from the next day.
- Makeup: Available from the next day
Being aware of how you spend your time after the procedure will help you get through the downtime more smoothly.
Possible Side Effects
Typical side effects of ecrylis include the following
- Transient numbness, itching at the injection site
- Rarely induration (lump), skin tightness, pigmentation
- Extremely rare: nerve damage, infection, allergic reaction
In the unlikely event that symptoms such as severe pain, unusual swelling, or fever appear after the procedure, please contact our office immediately for treatment. With early treatment, most symptoms can be expected to improve.
Regarding the safety of deoxycholic acid, the following paper shows that a systematic review & meta-analysis integrating several randomized controlled trials evaluated that "side effects are acceptable and manageable".
Three disadvantages of ecrylisse
There are three disadvantages to consider when considering Equirilis, which should be understood in advance.
- Difficult to see dramatic changes in a single session.
- It takes time for the effect to appear.
- Self-funded treatment not covered by insurance
EKRYLIS is supposed to be performed multiple times. In addition, since the destruction and expulsion of fat cells takes time, this procedure is not suitable for those who want to lose weight immediately, cannot afford any downtime, or want to complete the procedure in a single session.
We urge you to carefully weigh your wishes against the reality of the situation.
Those who are not eligible for the ECRILIS treatment.
The following persons are not eligible to receive the ECRILIS treatment
- Pregnant or nursing
- Persons with severe cardiac, renal, or hepatic disease
- Those with bleeding tendency (including those taking anticoagulants)
- Allergic to deoxycholic acid or any of the ingredients in the preparation
- Those with infection or inflammation in the area to be injected
- Individuals with infections or skin conditions at the treatment site
If you are concerned about your health condition or if you are currently taking any medications, please be sure to inform your doctor at the time of counseling.
Flow of treatment of ecrylisse
You can easily make reservations with your mobile phone.
You can reserve a convenient date and time through our online reservation system or by phone. Both initial and follow-up appointments are available 24 hours a day, 7 days a week.
When you come to the clinic, simply tell us your name at the reception desk. First-time visitors will be asked to fill out a brief medical questionnaire.
During counseling, feel free to discuss any concerns you may have. Rest assured, there is no high-pressure sales tactics. Next, we evaluate the thickness of your fat and the condition of your skin through palpation and ultrasound examinations to determine the appropriate injection volume and injection sites.
After disinfection and marking, cooling is performed as needed. We will administer the injection while communicating with you throughout the process.
We will explain in detail about the care of the treated area and precautions for daily life.
We also offer appropriate home care from the perspective of prevention and maintenance, including oral medications and skin care cosmetics that can be expected to improve your problems.
Immediately after the procedure, you may experience some swelling or puffiness, but you can return to your daily routine right away. Makeup can be applied starting the next morning.
If you have any concerns, please feel free to contact us at any time.
Frequently asked questions about ecrylis
- Is one dose of ecrylis effective?
-
Although fat cells can be reduced even after one session, we recommend 3 to 5 sessions in order to get the full effect of a refreshed appearance.
- How long does it take to feel the effects?
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Changes can be felt as early as one week, but the final effect will not be established until three to six weeks after the destroyed fat has been expelled from the body.
- How much is the pain?
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There is a stinging pain at the time of injection and a heavy dull pain after the surgery. Basically, anesthesia is not necessary, but if you wish to use local anesthesia, a separate fee of 5,500 yen (tax included) per injection will be charged.
- Can I use makeup, take a bath, or exercise on the day of treatment?
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It is possible to start the next day. Please refrain from taking long baths, saunas, and strenuous exercise for about a week, as they may cause prolonged swelling.
- Does ecrylis rebound?
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Because the treatment reduces the number of fat cells themselves, rebound is basically unlikely. However, if there is an extreme weight gain, the remaining fat cells may become enlarged.
- Can it be used with diet pills?
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Depending on the type of diet drug, always consult your doctor regarding concomitant use with oral or injectable drugs such as GLP-1 receptor agonists, as drug-drug interactions and systemic conditions must be checked.
- How long do the effects last?
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Once destroyed and expelled, fat cells do not regenerate, so the effect is semi-permanent.
- Can I receive treatment while pregnant or breastfeeding?
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Pregnant and lactating women may not receive this treatment because its safety has not been established.
- Can I have my surgery performed on the same day as other cosmetic treatments?
-
Depending on the treatment and area, some cases can be performed on the same day, while others cannot be recommended. For specific combinations, please consult with us at the time of consultation.
Ecrylis is a smart skin clinic.
Ecrylisse is one of the leading options for those who desire "partial body slimming without cutting".
Our clinic offers a wide range of formulations that have been carefully selected by the director himself. In addition, we have a track record of over 20,000 injections per year. In addition, counseling is conducted by the doctor himself to reduce unnecessary costs.
The design of the amount, area, and frequency of injections will vary greatly depending on each patient's individual fat volume and lifestyle. If you are not sure if Ecrylisse is right for you, or if you are not sure about other procedures, please contact our office for a free consultation.
More Information
| Treatment Time | Approximately 10 to 15 minutes (excluding counseling) |
| Recommended number and frequency of treatments | Basically 3-5 times at 2-4 week intervals Consult with your doctor for intervals, as they vary depending on the site. |
| Down time | Redness and swelling, rare internal bleeding Several days to a week (depending on the site) |
| Treatment on the day of counseling | Possible |
| Make | Recommended after the next morning to prevent infection. |
| Skin care | Possible immediately after the treatment |
| Shower | Possible from the same day |
*There are individual differences.
Reference
Clinic List
Jimbocho Institute
〒101-0054
EX Kanda Nishiki-cho Building 8F (general reception), 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo 7F
Business hours: Monday-Friday 11:00-20:00 / Saturday and Sunday 10:00-19:00
Yokohama Institute of Technology
〒221-0835
TS Plaza Bldg. 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Business hours: 10:00-19:00
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This site is operated under the supervision of a physician supervised by Smart Skin Clinic.
This page was revised and enacted in June 2018. Medical Advertising Guidelines We produce and provide information based on
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- Last supervision date: June 26, 2025