LIZNE｜Generic Liguran, a generic product that has evolved

Hello, I am a doctor at Smart Skin Clinic, a cosmetic dermatology clinic.

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LIZNE is the latest skin regeneration treatment that is gaining attention in the world of aesthetic medicine.Riguran without pain."It is also known as "the most popular treatment method" and is gaining popularity among many people. However, many people may want to know more about its effectiveness, safety, and differences from other treatment methods.

Therefore, in order to resolve these questions and concerns, Smart Skin Clinic, a cosmetic dermatology clinic, will explain LIZNE in an easy-to-understand manner from a professional standpoint.

This article describes Lizune in detail from all angles, including its features, effects, treatment methods, and prices. We hope it will be a useful source of information for those considering cosmetic treatments.

*If you would like to know about a specific item, such as fees, you can directly access the appropriate section from the table of contents below.

About LIZNE: Evolved Liguran Generic

LIZNE is the latest skin regeneration skin booster formulation that is gaining attention in the field of aesthetic medicine. This product is,Generic product developed after the patent expiration of the famous Rejuranand is positioned as an evolutionary version of Rejuran, inheriting its excellent effects and improving on its shortcomings.

Origin of the name

The name LIZNE has a deep meaning.

• LIZ: Means Leeds (heyday) and represents the time when the skin was at its most beautiful.
• NE: meaning Rene (rebirth), it symbolizes skin regeneration and rejuvenation.

In other words, "LIZNE" was named with the hope that the skin will be "reborn to its youthful age. This name simply expresses the purpose and effectiveness of the product.

Relationship with Rejuran

Rizne is a generic version of Rejuran, but it is not a mere copy product.While building on the excellent effects of Rejuran, this product was developed as a safer and more effective product by incorporating the latest technology and research results. In particular, we focused on the problems of pain and redness, which had been issues with Rejuran, and have greatly improved them.

Characteristics of Rizne: 5 evolutionary points from Ridjulan

Rizune has evolved significantly in the following five areas, while inheriting the excellent points of Ridjulan.

(1) High purity polynucleotides (PDRN)

Although Lysne is primarily composed of polynucleotides (PN) extracted from salmonid fish DNA,Its purity has been raised to 99%.This high purity simultaneously improves efficacy and reduces the risk of side effects.

(2) Significant reduction of pain

Lizune.Riguran without pain."The pain at the time of injection is reduced to the extent that it is also referred to as This is due to the removal of impurities by high-purity PN extraction and purification technology and pH adjustment of the solution. Clinical trials have also confirmed that the pain is significantly less than that of Rejelan.

(iii) Reduction of post-treatment redness

Lizune.Significantly reduced redness after treatment.The new product is a nice evolution for those who have been receiving Rejuran. This is a nice evolution for those who have received Rejuran because of the reduction in comparison to Rejuran.

Optimal adjustment of pH

The pH of the solution in Lysne is adjusted to the optimum condition for the skin. This reduces irritation during injection, which not only reduces pain, but also reduces the burden on the skin after the procedure.

(5) Possibility of use in a wide range of applications

Lysne can be used on a wide range of areas, including the entire face, neck, and décolleté. A particularly important feature of this product is that it can be safely used on areas that have been difficult to use with conventional products, such as around the eyes and mouth.

These advancements make Lizne more comfortable and effective for the person undergoing the procedure. The reduction in pain and redness has lowered the hurdles to undergoing the procedure, making it easier for more people to receive the treatment.

Main benefits of Lysne: skin elasticity, luster and overall rejuvenation

Lysne has the effect of improving skin texture, especiallyStrong "bounce and shine" effect.It is.

Rizne is also an injectable formulation based on polynucleotides (PN); PN has the following properties

• Cell activation effect
• Promotes tissue repair and regeneration
• anti-inflammatory action
• antioxidant action

Due to these PN properties, Lysne is expected to have a comprehensive skin rejuvenation effect, including improvement of skin elasticity and luster, and overall skin quality.

The main effects of Lizne are as follows

(1) Improvement of skin elasticity and luster

The highly purified PN contained in Lysne activates fibroblasts in the dermal layer and promotes the production of collagen and elastin. This improves skin firmness and elasticity, and at the same time improves the reflection of light on the skin's surface, leading to a glowing skin.

(2) Improvement of wrinkles

The cell activating effect of PN improves wrinkles such as fine lines and wrinkles. It is particularly effective for fine wrinkles around the eyes and mouth.

(iii) Overall improvement of skin texture

Moisturizing effect: PN has high water retention properties and improves the skin's ability to retain moisture.
Reduction of skin problems: Anti-inflammatory action helps improve acne scars and scars.
Pore tightening: Improved overall skin elasticity reduces the appearance of open pores.
Improved skin tone: Antioxidant action suppresses melanin production, leading to a dull, brighter skin tone.

Durability of Lysne's effect

Overseas clinical studies have shown that more than 90% of patients who used high-purity PN formulations such as Lizune experienced lasting results even after 3 months. This indicates that Lizune promotes regeneration from deep within the skin, rather than merely superficial improvement.

Thus, Lysne is a procedure that has a comprehensive skin rejuvenation effect while improving skin elasticity and luster. In particular, it can achieve a natural improvement in skin texture that cannot be achieved with conventional hyaluronic acid formulations.

Rizne mechanism of action

The effectiveness of Lysne is due to the combined action of its main component, polynucleotides (PN). Specifically, three main mechanisms are at work

(1) Activation of fibroblasts

PN directly stimulates and activates fibroblasts in the dermal layer. Activated fibroblasts promote the production of collagen, elastin, and hyaluronic acid. These components play an important role in supporting the skin's structure and providing firmness and elasticity. As a result, wrinkles are improved and sagging is eliminated.

(2) Angiogenesis

PN has the ability to promote angiogenesis. The formation of new capillaries improves the supply of nutrients and oxygen to the skin. This activates skin metabolism, which promotes the removal of dead skin cells and the production of new cells. As a result, the skin appears more blood-colored, brighter, and healthier.

(iii) Anti-inflammatory action

PN has potent anti-inflammatory properties. Chronic inflammation is one of the factors that accelerate skin aging, but PN inhibits it. It is also effective in improving inflammatory skin problems such as acne and redness. It also protects the skin from inflammation caused by external stimuli such as UV rays.

The combined action of these mechanisms enables Lysne to produce a comprehensive skin texture improvement effect. Particularly noteworthy is that these actions exert their effects over a wide area, from the deeper layers of the skin to the surface.

In addition, the latest research suggests that polynucleotides (PN) may promote DNA repair. This would be a welcome effect, considering that the accumulation of DNA damage caused by UV light and other factors contributes to skin aging.

Thus, Lysne does not merely make superficial improvements, but works comprehensively from the cellular level of the skin to produce lasting, natural skin quality improvement effects.

Recommended for

Those who wish to improve skin elasticity and luster:

• Those who want to achieve more radiant and translucent skin.
• Those who want to have a glowing skin texture that makes you want to touch it.
• Those who want to improve makeup application and have glowing skin from the inside out.

Those who are considering preventive aging care:

• Those who wish to prevent future skin aging
• Those who want to maintain youthful skin in the long term with early care.

Concerned about fine lines and wrinkles:

• Those who have fine wrinkles around the eyes and mouth.
• Those who have deeper lines and look older than their age.

Those who suffer from dry or sensitive skin:

• Those who are concerned about skin dryness in any season.
• Skin sensitivity and incompatibility with various beauty products

Those who are concerned about dull skin and open pores:

• Those with darker skin tone and dull appearance
• Those who have visible pores and want to restore smooth skin texture.

Those who are also considering neck and décolleté care:

• Those who wish to improve the skin texture of the face as well as the neck and décolleté

Those seeking a more natural finish:

• Those who feel that hyaluronic acid injections or Botox injections are insufficient or unnatural
• Those seeking long-term, natural rejuvenation effects

Those who are sensitive to pain and resistant to conventional injectable treatments:

• Those who have avoided cosmetic treatments because they are not comfortable with the pain of injections.
• Those who cannot tolerate the pain of conventional skin booster injections such as Rejuran

Especially for those in their 20s,Popular for "improving skin elasticity and lusterIt is.

Detailed Comparison of Rizne and Ridjulan

Although Rizne was developed as a generic version of Riduran, it is not just a copy product, but an advanced formulation. A comparison is shown below.

Component

• Rejuran: polynucleotide (PN) is the main ingredient.
• Lysne: Also composed mainly of PN, but with a purity as high as 99%.

Effect

• Rejuran: Skin regeneration, improvement of wrinkles, and enhancement of firmness and elasticity.
• Rizne: Basically the same effect as Ridjulan.

Pain

• Rejuran: Known to be relatively painful upon injection.
• Lysne: pain is greatly reduced by high purity PN extraction and purification technology and pH adjustment.

Down time

• Rejelan: There is redness and swelling after the treatment.
• Rhythne: Redness and swelling are reduced in comparison to Rejelan, and downtime is slightly shorter.

durability

• Rejuran: The duration of effect varies from person to person, but generally lasts 3-6 months.
• Rizune: Highly purified polynucleotides (PN) improve the persistence of effect over Riduran.

Number of treatments

• Rejuran: 3-4 treatments are usually recommended every 2-4 weeks.
• Rizne: Same as Ridjulan.

Charge

• Rejuran: Relatively expensive because it was the first polynucleotide (PN) product to be introduced to the market (and patented at that time).
• Rizne: Because it is a generic product, it can often be offered at a lower price than Riduran.

Clinical Results

• Rejuran: Has been used for many years and a lot of clinical data has been accumulated.
• Rizne: A relatively new product, but clinical data have been accumulated. To begin with, it is a polynucleotide (PN) product similar to Rejuran, and data on Rejuran are available.

Like this,Rizune is a polynucleotide (PN) formulation that inherits the excellence of Rejuran, but has been improved and evolved in various aspects, including reduced pain, redness, and charges.The result will be the following. In particular, the reduction of "pain," which was considered a problem with Rejelan, would be a great advantage for those who want to undergo Rejelan.

Recommended number and frequency of treatments

Three to four times, spaced about three to four weeks apart. After that, maintenance once every 6 months to a year.

Down time

This section describes the downtime period, symptoms, and progress of water light injections.

Downtime period

Downtime for hydroxyapatite injections is about 2 to 3 days.

Downtime Symptoms

Downtime symptoms include redness, swelling, pain, edema, internal bleeding, and temporary bumps at the injection site.

As for the ridging of the water-light injectable drug, in most cases it will return to normal within 48 hours. If internal bleeding occurs, it will gradually fade over 10-14 days.
After 48 hours, it can be covered with makeup, but please make adjustments if you have important appointments.

Swelling/redness

The needle is inserted while suctioning the skin for water-light injections. Suction pressure and needle puncture may cause redness and swelling at the treatment site.

Symptoms subside in approximately 1-5 days, depending on the depth of the injection.

needle mark

The needle hole may remain red immediately after injection. This can be covered with makeup such as foundation.

Symptoms subside within a few days.

internal hemorrhage

If the needle damages blood vessels that pass through the skin during injection, internal bleeding may occur. Internal bleeding is more likely to occur in areas with thin skin, and care should be taken around the eyes and neck, but it can be covered with concealer or other makeup.

Symptoms subside in a few days to about 10 days.

If you would like to know more about the detailed progress with photos, please see the following article.

After-sales service

The following points should be kept in mind on the day of treatment and for the next few days. Proper aftercare is important to maximize and maintain the long-term effects of LYSNE. Proper daily skin care and a healthy lifestyle also contribute to maintaining the effects of the treatment.

Cleanliness retention:

• On the day of treatment, refrain from taking a bath and shower only lightly. Gently wash your face from the next day.
• Avoid hot environments such as hot springs and saunas for 3 days after treatment.

UV protection:

• Avoid direct sunlight for one week after the procedure and use sunscreen thoroughly when going outside.
• Use of sunscreen with high UV protection is recommended.

Skin Care:

• Refrain from using harsh cosmetics (products containing retinol, peeling agents, etc.) for 3 days after the procedure.
• Keep skin care emphasizing moisturizing.

Makeup:

• Makeup can be applied the day after the procedure, but be sure to apply it gently.
• Recommend using products that are gentle on the skin.

Lifestyle:

• Avoid drinking alcohol and strenuous exercise on the day of treatment.
• Try to get enough sleep and drink plenty of water.

Safety

Rizne is a safe formulation from the following perspectives

Biocompatibility:

• Polynucleotides (PN), the main component of Lysne, have a structure similar to that of DNA in the human body, making them extremely biocompatible.
• This results in an extremely low risk of allergic reactions and rejection.

High purity:

• Lysne uses PN with a high purity of 99%.
• Fewer impurities reduce the risk of side effects.

pH adjustment:

• The pH of the solution is adjusted to the optimum condition for the skin, resulting in less irritation.

Non-permanent:

• PN is gradually broken down in the body, so if problems do occur, they are temporary.

Large-scale clinical trials overseas have highly evaluated the safety of high-purity PN preparations such as Lizune. One study found that there were zero reports of serious side effects in over 1,000 procedures.

However, the risks vary depending on the individual's constitution and health. When considering a procedure, it is always important to have a detailed consultation beforehand to confirm that it is appropriate for your condition.

Features of Smart Skin Clinic's water light injections

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Charge

2cc (2 bottles)
Once	36,900 yen
3 sets	99,900 yen (33,300 yen per session)
4 sets	123,600 yen (per time)30,900 yen)

4cc (4 pcs)
Once	54,900 yen
3 sets	148,200 yen (49,400 yen per session)
4 sets	183,600 yen (per time)45,900suffix for names of swords, armour, musical instruments, etc.)

6cc (6 pcs)
Once	72,900 yen
3 sets	196,800 yen (65,600 yen per session)
4 sets	239,200 yen (per time)59,800suffix for names of swords, armour, musical instruments, etc.)

Frequently Asked Questions (Q&A)

When can I start to feel the effects of Lizune?

Although there are individual differences, most people feel an improvement in skin firmness and elasticity immediately after the treatment. The overall skin texture improvement effect begins to gradually appear after 2-3 weeks and is often maximal over 2-3 months.

How long do the effects of Lysne last?

The duration of effect varies from person to person, but averages about 4 to 8 months.

What is the difference between Riguran and Riguran?

Rizune is a generic version of Rejuran, but it uses a more highly purified polynucleotide and has an adjusted pH, resulting in less pain and redness. It is also effective for a wider range of symptoms.

How much is the pain?

Rhythne is so painless that it has been called the "painless Rejuran". Many people report feeling only mild irritation. However, the perception of pain varies from person to person.

Is there a risk of side effects?

Although Rizne is a very safe formulation, temporary side effects such as mild redness, swelling, and internal bleeding may occur. Serious side effects are extremely rare.

How many times should I take the course?

We recommend 3~4 treatments every 3~4 weeks.

Can I receive the program if I have a fish allergy?

Because Lysne uses DNA derived from salmon, those who are allergic to fish or fish eggs cannot undergo the procedure.

summary

LIZNE is a generic version of Riguran, which is a polynucleotide (PN)-based formulation similar to Riguran.

Compared to Rejuran, it is an advanced formulation with less pain, less redness, and lower cost.

We would like to contribute to improving the quality of your skin. If you are interested in Lysne treatment, please visit us for a consultation.

[Legal description

Water Light Injection includes procedures using medicines or medical devices that are not approved in Japan. The medicines and devices used in the treatment have been imported on a personal import basis under the judgment of our physicians.

Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".