What Is LIZNE? | A Doctor Explains the Effects of Rijuran Generics and How They Differ from Its Successor, Vitaran

*Patients who have already begun (or are continuing) treatment with Lizne can still book Lizne treatments as long as stock is available. If you would like this, please feel free to contact us.

Hello, I am a doctor at Smart Skin Clinic, an aesthetic dermatology clinic.

Do you have questions or concerns like these?

Lizne is one of the latest skin-regeneration treatments drawing attention in the field of aesthetic medicine."Pain-free Rejuran"As it is also called, it has become popular with many patients. However, many people may want to learn more about its effectiveness, safety, and how it differs from other treatments.

To help answer these questions and concerns, Smart Skin Clinic, a cosmetic dermatology clinic, offers a clear, professional explanation of Lizne.

This article explains Lizne in detail from every angle, including its features, effects, treatment method, and pricing. We hope it will be a helpful resource for anyone considering cosmetic treatments.

*If you would like to know about a specific topic, such as pricing, you can jump directly to the relevant section from the table of contents below.

*Lizne is currently not accepting new reservations. Please consider the successor product, "VITARAN."

Supervisor Information

Group Chief Director, Smart Skin Clinic Group

IshiiIshii KotaKota

Career

Graduated from Juntendo University School of Medicine

Worked at Tokyo Women's Medical University Hospital and affiliated facilities

Worked at a major aesthetic clinic in Tokyo

Affiliations / Qualifications

Board-certified specialist, Japan Surgical Society

Board-certified specialist, Japanese Society of Anti-Aging Medicine

What Is Lizne: An Evolved Rejuran Generic

Lizne is one of the latest skin-regeneration skin booster formulations drawing attention in the field of aesthetic medicine. This product isa generic product developed following the patent expiration of the well-known Rejuranand is positioned as an evolved version of Rejuran—inheriting its excellent effects while improving on its shortcomings.

Origin of the name

The name "Lizne" carries a deeper meaning.

• LIZ: from "Leeds" (peak/prime), representing the time when your skin was at its most beautiful.
• NE: from "Rene" (rebirth), symbolizing skin regeneration and rejuvenation.

In other words, "Lizne" was named with the wish to be "reborn to youthful skin." The name concisely captures the product's purpose and effect.

Relationship with Rejuran

Lizne is a generic version of Rejuran, but it is not simply a copy.Building on Rejuran's excellent effects, it was developed as a safer and more effective product by incorporating the latest technology and research. In particular, it focuses on the pain and redness that had been drawbacks of Rejuran, greatly improving both.

View this post on Instagram

A post shared by Smart Skin Clinic [Aesthetic Dermatology] Jimbocho Juvelook & Profhilo & Sunekos (@smartskin_clinic)

Features of Lizne: 5 Points of Evolution from Rejuran

Lizne inherits Rejuran's strengths while evolving significantly in the following five ways.

(1) High-purity polynucleotides (PDRN)

While Lizne is primarily composed of polynucleotides (PN) extracted from the DNA of salmonid fish,its purity has been raised to as high as 99%.This higher purity simultaneously improves efficacy and reduces the risk of side effects.

(2) Significantly reduced pain

Lizne is"Pain-free Rejuran"so much so that the pain during injection is reduced to the point that it is also called this. This is thanks to the removal of impurities through high-purity PN extraction and refinement technology and the pH adjustment of the solution. Clinical trials have also confirmed significantly less pain compared with Rejuran.

(3) Reduced post-treatment redness

Lizne isRedness after treatment is also significantly reducedas well. Because it is reduced compared with Rejuran, this should be a welcome evolution for those who have been receiving Rejuran.

(4) Optimal pH adjustment

In Lizne, the pH of the solution is adjusted to the ideal level for the skin. This reduces irritation during injection, easing not only pain but also the burden on the skin after treatment.

(5) Suitability for a wide range of areas

Lizne can be used on a wide range of areas, including the entire face, neck, and décolleté. A key feature is that it can be used safely even on areas that were difficult to treat with conventional products, such as around the eyes and mouth.

Thanks to these advances, Lizne offers a more comfortable and effective treatment for patients. Reducing pain and redness lowers the hurdle to receiving treatment, making it easier for more people to receive it.

*In addition, these excellent features of Lizne have been carried over to its successor, "VITARAN" as well. Vitaran is manufactured by BR PHARM—the same company as Lizne—to the same quality standards, and it is an evolved version that also incorporates pure vitamins.

Main Benefits of Lizne: Firmer, More Radiant Skin and Overall Rejuvenation

Lizne improves skin quality, and in particularit has a strong "firmness and radiance" effect.

Lizne is also an injectable formulation based on polynucleotides (PN). PN has the following properties:

• Cell-activating effect
• Promotes tissue repair and regeneration
• anti-inflammatory action
• antioxidant action

Thanks to these properties of PN, Lizne is designed to support comprehensive skin rejuvenation, including improved firmness and radiance and better overall skin quality.

The main benefits of Lizne are as follows:

(1) Improved skin firmness and radiance

The high-purity PN in Lizne activates fibroblasts in the dermal layer and promotes the production of collagen and elastin. This helps improve the skin's firmness and elasticity, while enhancing how light reflects off the skin's surface, leading to more radiant skin.

(2) Improvement of wrinkles

Through PN's cell-activating effect, wrinkles such as fine lines and nasolabial folds may be improved. It is particularly effective for fine wrinkles around the eyes and mouth.

(3) Overall improvement of skin quality

Moisturizing effect: PN has strong water-retention properties and enhances the skin's ability to hold moisture.
Reduced skin problems: Its anti-inflammatory action helps improve acne scars and other scarring.
Pore tightening: As overall skin firmness improves, enlarged pores become less noticeable.
Improved skin tone: Its antioxidant action helps suppress melanin production, supporting brighter, clearer skin without dullness.

How Long Lizne's Effects Last

Overseas clinical studies have reported that more than 90% of patients treated with high-purity PN formulations like Lizne felt the effects lasting even three months later. This suggests that Lizne promotes regeneration from deep within the skin, not merely superficial improvement.

In this way, Lizne is a treatment that improves the skin's firmness and radiance while offering comprehensive rejuvenation. In particular, it can aim for the kind of natural improvement in skin quality that conventional hyaluronic acid products could not achieve.

How Lizne Works

Lizne's effects come from the combined action of its main component, polynucleotides (PN). Specifically, three main mechanisms are at work:

(1) Activation of fibroblasts

PN directly stimulates and activates the fibroblasts in the dermal layer. Activated fibroblasts promote the production of collagen, elastin, and hyaluronic acid. These components play an important role in supporting the skin's structure and giving it firmness and elasticity. As a result, wrinkles may improve and sagging may be reduced.

(2) Angiogenesis (new blood vessel formation)

PN helps promote the formation of new blood vessels. New capillaries improve the supply of nutrients and oxygen to the skin. This activates the skin's metabolism, promoting the removal of old dead skin cells and the production of new cells. As a result, the skin gains healthier color and looks brighter and more vital.

(iii) Anti-inflammatory action

PN has a powerful anti-inflammatory action. Chronic inflammation is one of the factors that accelerate skin aging, and PN helps suppress it. It is also effective in improving inflammatory skin problems such as acne and redness. In addition, it helps protect the skin from inflammation caused by external stimuli such as UV rays.

Through the combined action of these mechanisms, Lizne delivers comprehensive improvement in skin quality. Particularly noteworthy is that these effects reach across a wide range, from the deeper layers of the skin to the surface.

Furthermore, the latest research suggests that polynucleotides (PN) may help promote DNA repair. Considering that the accumulation of DNA damage from UV rays and other factors contributes to skin aging, this is a welcome effect.

In this way, rather than making only superficial improvements, Lizne works comprehensively from the cellular level of the skin, delivering lasting, natural improvement in skin quality.

Recommended for

Those who want to improve their skin's firmness and radiance:

• Those who want more radiant, translucent skin
• Those who want supple, touchable skin
• Those who want makeup to sit better and achieve skin that glows from within

Those considering preventive aging care:

• Those who want to help prevent future skin aging
• Those who want to maintain youthful skin over the long term through early care

Those concerned about fine lines and nasolabial folds:

• Those who have started to notice fine wrinkles around the eyes and mouth
• Those whose nasolabial folds have deepened and who are told they look older than their age

Those troubled by dry or sensitive skin:

• Those concerned about skin dryness year-round
• Those with sensitive skin that doesn't get along with various beauty products

Those concerned about dull skin and enlarged pores:

• Those whose skin tone has darkened and looks dull
• Those with noticeable pores who want to restore smooth skin

Those also considering neck and décolleté care:

• Those who want to improve the skin quality of the neck and décolleté, not just the face

Those seeking a more natural result:

• Those who find hyaluronic acid injections or botulinum toxin injections unsatisfying or unnatural
• Those seeking long-term, natural rejuvenation

Those sensitive to pain who are hesitant about conventional injectable treatments:

• Those who have avoided cosmetic treatments because they don't handle the pain of injections well
• Those who couldn't tolerate the pain of conventional skin booster injections such as Rejuran

Especially among those in their 20s,the benefit of "improving skin firmness and radiance" is popular.

*If you have any of the concerns above, you can expect similar results with Lizne's successor product, "VITARAN." Please do consider it.

A Detailed Comparison of Lizne and Rejuran

Lizne was developed as a generic version of Rejuran, but it is not simply a copy—it is an evolved formulation. A comparison is shown below.

Component

• Rejuran: primarily composed of polynucleotides (PN).
• Lizne: also primarily composed of PN, but with a high purity of 99%.

Effect

• Rejuran: offers effects such as skin regeneration, wrinkle improvement, and enhanced firmness and elasticity.
• Lizne: essentially offers the same effects as Rejuran.

Pain

• Rejuran: known for relatively strong pain during injection.
• Lizne: pain is greatly reduced thanks to high-purity PN extraction and refinement technology and pH adjustment.

Downtime

• Rejuran: involves redness and swelling after treatment.
• Lizne: redness and swelling are reduced compared with Rejuran, and downtime is slightly shorter.

Duration

• Rejuran: the duration of effect varies from person to person but generally lasts about 3 to 6 months.
• Lizne: with its high-purity polynucleotides (PN), the effects last longer than with Rejuran.

Number of Treatments

• Rejuran: typically, 3 to 4 treatments spaced 2 to 4 weeks apart are recommended.
• Lizne: same as Rejuran.

Pricing

• Rejuran: relatively expensive, as it was the first polynucleotide (PN) product brought to market (and patented at that time).
• Lizne: as a generic product, it can often be offered at a lower price than Rejuran.

Clinical Track Record

• Rejuran: has a long track record of use, with a large body of accumulated clinical data.
• Lizne: a relatively new product, but clinical data have been accumulating. Fundamentally, it is a polynucleotide (PN) formulation similar to Rejuran, so Rejuran's data also apply.

In this way,Lizne is an evolved polynucleotide (PN) formulation that inherits Rejuran's strengths while improving in various ways, including reduced pain, reduced redness, and lower pricingis the result. In particular, the reduced "pain" that had been a problem with Rejuran should be a major benefit for those who want to receive Rejuran.

Which layer is it injected into?

Injectable preparations differ in both their ingredients and their purpose.
For this reason, the layer suited to each preparation"layer"and"amount"is very important for drawing out the effect correctly.

In the case of Lizne, the primary injection layer is the "superficial dermis."

The skin has a layered structure—from the surface: the epidermis, the dermis (superficial, middle, and deep layers), the subcutaneous fat layer, and the muscle layer—each playing a different role. The superficial dermis lies just beneath the epidermis and is the layer responsible for the skin's "visible texture," such as smoothness, firmness, and moisture.

The superficial dermis is the layer where Lizne's ingredients and intended effects are most effectively delivered, and this is the medical rationale behind our clinic's practice of injecting this formulation into that layer.

Recommended Number & Frequency of Treatments

3 to 4 times, spaced about 3 to 4 weeks apart. After that, maintenance once every six months to a year.

Downtime

This section explains the downtime period, symptoms, and recovery process for Water Light Injection.

Downtime Period

Downtime for Water Light Injection is about 2 to 3 days.

Downtime Symptoms

Downtime symptoms include redness, swelling, pain, edema, bruising, and temporary bumps at the injection site.

As for the raised bumps from the Water Light Injection solution, they resolve within 48 hours in most cases. If bruising occurs, it gradually fades over 10 to 14 days.
After 48 hours, it can generally be covered with makeup, but if you have important plans, please schedule accordingly.

Swelling and redness

With Water Light Injection, the needle is inserted while the skin is suctioned. The suction pressure and needle punctures may cause redness or swelling at the treatment site.

These symptoms subside in about 1 to 5 days, depending on the depth of injection.

Needle marks

The needle punctures may remain slightly red immediately after injection. This can be covered with makeup such as foundation.

These symptoms subside within a few days.

Bruising

If the needle damages a blood vessel running through the skin during injection, bruising may occur. Bruising is more likely in areas with thin skin, so extra care is needed around the eyes and neck, but it can generally be covered with makeup such as concealer.

These symptoms subside in a few days to about 10 days.

If you would like to see the detailed recovery process in photos, please read the following article.

Aftercare

For the first several days from the day of treatment, please keep the following points in mind. Proper aftercare is important to bring out the full effect of Lizne and maintain it over the long term. Appropriate daily skincare and healthy lifestyle habits also help sustain the results.

Keeping the skin clean:

• On the day of treatment, refrain from bathing and just rinse lightly in the shower. You may gently wash your face from the next day.
• Avoid high-temperature environments such as hot springs and saunas for 3 days after treatment.

UV protection:

• Avoid direct sunlight for one week after treatment, and be diligent about sunscreen when going out.
• Using sunscreen with strong UV protection is recommended.

Skincare:

• Refrain from using harsh cosmetics (retinol-containing products, peeling agents, etc.) for 3 days after treatment.
• Focus on skincare that emphasizes moisturizing.

Makeup:

• Makeup can be applied from the day after treatment, but be sure to apply it gently.
• Using products that are gentle on the skin is recommended.

Lifestyle:

• Avoid alcohol and strenuous exercise on the day of treatment.
• Try to get enough sleep and stay well hydrated.

Safety

Lizne is a formulation with a high level of safety, from the following perspectives.

Biocompatibility:

• Polynucleotides (PN), the main component of Lizne, have a structure similar to human DNA, making them highly biocompatible.
• As a result, the risk of allergic reactions and rejection is extremely low.

High purity:

• Lizne uses PN with a high purity of 99%.
• With fewer impurities, the risk of side effects is reduced.

pH adjustment:

• Because the pH of the solution is adjusted to the ideal level for the skin, there is less irritation.

Non-permanent:

• Because PN is gradually broken down within the body, any problems that may arise are temporary.

Large-scale overseas clinical trials have highly rated the safety of high-purity PN formulations like Lizne. One study reported zero serious side effects across more than 1,000 procedures.

However, the risks vary depending on your individual constitution and health condition. When considering treatment, it is important to always have a detailed consultation beforehand to confirm whether it is suitable for you.

Features of Smart Skin Clinic's Water Light Injection

View this post on Instagram

A post shared by Smart Skin Clinic [Aesthetic Dermatology] Jimbocho Juvelook & Profhilo & Sunekos (@smartskin_clinic)

Pricing

*Lizne is currently not accepting new reservations. Successor product "VITARAN." For pricing, please see the Vitaran details page.

Very popular! Pricing for the Rejuran × Juvelook cocktail injection

Frequently Asked Questions (Q&A)

Can I make a new reservation for Lizne?

Lizne is currently not accepting new reservations due to the discontinuation of the formulation's supply. We now offer the successor product produced by the same manufacturer (BR PHARM), "VITARAN." Please note that patients who have already begun (or are continuing) treatment with Lizne can still book Lizne treatments as long as stock is available.

Is it okay to switch from Lizne to Vitaran?

Yes, there is no problem. Vitaran is manufactured by BR PHARM—the same company as Lizne—to the same quality standards, and it is listed under the same license-number designation on the Korean MFDS manufacturing license. The ingredient specifications are also nearly identical, with the addition of pure vitamins. Patients currently undergoing treatment with Lizne can transition smoothly.

When can I start to feel the effects of Lizne?

Results vary from person to person, but many people feel improved firmness and elasticity immediately after treatment. The overall improvement in skin quality tends to appear gradually from about 2 to 3 weeks and often peaks over 2 to 3 months.

How long do the effects of Lizne last?

The duration of effect varies from person to person but averages about 4 to 8 months.

What is the difference between it and Rejuran?

Lizne is a generic version of Rejuran, but it uses more highly purified polynucleotides and has an adjusted pH, so it tends to cause less pain and less redness. It is also effective for a wider range of concerns.

How much does it hurt?

Lizne causes so little pain that it is called "pain-free Rejuran." Many people report feeling only mild irritation. That said, the perception of pain varies from person to person.

Is there a risk of side effects?

Lizne is a very safe formulation, but temporary side effects such as mild redness, swelling, and bruising may occur. Serious side effects are extremely rare.

How many treatments should I have?

We recommend 3 to 4 treatments spaced 3 to 4 weeks apart.

Can I receive it if I have a fish allergy?

Because Lizne uses salmon-derived DNA, those with an allergy to fish or fish roe cannot undergo the treatment.

Summary

Lizne is a generic version of Rejuran, a formulation based on polynucleotides (PN), just like Rejuran.

Compared with Rejuran, it is an evolved formulation with reduced pain, reduced redness, and a lower price.

Lizne is currently not accepting new reservations due to the suspension of the formulation's supply.At our clinic, we are switching to the successor product manufactured by BR PHARM, the same company as Lizne,"VITARAN"we are switching to it. Vitaran inherits Lizne's excellent features while further incorporating pure vitamins in an evolved version.

Please note that patients who have already begun (or are continuing) treatment with Lizne can still book Lizne treatments as long as stock is available.

At our clinic, we want to help improve the quality of your skin. If you are interested in skin-conditioning treatment with polynucleotide formulations, please come in for a consultation.

CLINIC LIST

Clinic List

Jimbocho Clinic

〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F

Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00

Yokohama Clinic

〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa

Hours: 10:00–19:00

About the physician supervision of this site

This site is operated under the supervision of a Smart Skin Clinic supervising physician.

This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.

• Scope of supervision: treatment descriptions, risks and side effects, price display
• Last supervision date: June 26, 2025

*Treatment effects vary from person to person. Please be sure to consult a physician regarding side effects and risks.

[Legal Notices]

Water Light Injection includes procedures using drugs or medical devices that are not approved in Japan. The drugs and devices used in treatment have been imported through personal importation at the discretion of our physicians.

Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."