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What is VITARAN? Successor to LIZNE
I liked Rizne, but they stopped carrying it."
I would love to continue with skin growth treatments like Rejuran, but I just can't bear the pain."
I'd like to know more about the new polynucleotide formulation being talked about in Korea."
Do you have any of these questions or concerns about Vitaran?
Hello. We are Smart Skin Clinic, a cosmetic dermatology clinic with a track record of over 10,000 injections per year.
This article provides a thorough explanation of Vitaran, from its features and effects to its differences from Rejelan and Rizne, as well as pain and downtime.
*If you would like to know about a specific item, such as fees, you can directly access the appropriate section from the table of contents below.
Chief Director of Smart Skin Clinic Group
stone Kouta
career
Graduated from Juntendo University School of Medicine
Tokyo Women's Medical University Hospital and related facilities
Worked at a major beauty clinic in Tokyo
Affiliation / Qualifications
Japan Surgical Society Specialist
Japanese Society of Anti-Aging Medicine
What is VITARAN?
Vitaran is a skin-regenerating skin booster formulation.
polynucleotide preparationIt is one of the most effective ways to improve the skin's natural regenerative power.Fundamental skin quality improvementThe goal is to achieve the following
The main ingredient is "polynucleotides (PN)" contained in the Riduran system, which also contains "pure vitamins". Purevita-Min" + "Rejurun" = "VitaranIt is thought that the name "the
Also known as generic Rejuran, which will be discussed in more detail below.Successor to "RizneIt is safe to assume that
Features of VITARAN
- Highly concentrated polynucleotides
- Pain Reduction
- Reduction of redness
- pH optimum adjustment
- Wide range of use possibilities
- vitamin component
Vitaran is aContains the same highly concentrated polynucleotides as Rizne as its main ingredient, plus "pure vitaminsThe skin is clear and radiant. In addition to the regenerative ability of polynucleotides, the antioxidant effect of vitamins creates a synergistic effect that supports the improvement of clearer skin texture.
In the medical device manufacturing license issued by the Korean regulatory authority (MFDS/formerly KFDA), "HP VITARAN" and "LIZNE" are listed in parallel within the same license number frame.
This is as a matter of public fact,Rizne and Vitaran are made in the same factory and with the same quality standards.This proves that
Polynucleotides, the main component of Vitaran, are giant molecules (biopolymers) created in the body of living organisms by combining multiple molecules called "nucleotides" that make up DNA.
The higher concentration means that theRich in materials necessary for skin regenerationThis means that you can expect solid results.
Specific effects that can be expected from Vitaran: improvement of skin elasticity, luster, and skin texture.
Three main effects can be expected from injecting Vitaran
- Improved skin elasticity and firmness, improved fine lines and wrinkles
- Fundamental improvement of skin texture (texture, moisture content, dry and rough skin)
- Acne scar and scar repair support
Improved skin elasticity and firmness, improved fine lines and wrinkles
When polynucleotides reach the dermal layer,Activates "fibroblasts" that support skin elasticityI will make them do it.
This strongly promotes the production of collagen and elastin, improving skin firmness and elasticity and reducing the appearance of fine lines and wrinkles. This treatment is especially recommended for those who suffer from fine lines around the eyes and mouth, horizontal wrinkles on the forehead, and wrinkles on the neck.
Fundamental improvement of skin texture (texture, moisture content, dry and rough skin)
In addition to its ability to attract water many times its own weight, polynucleotides have the ability to attract water many times their own weight,Helps normalize the balance of oil and moisture in the skinThere are
Also,Repair skin's lamellar structure (barrier function)This will make the skin more resistant to external stimuli.
As a result, dry and inner-dry skin is improved, pores are less noticeable, and redness and irritation are calmed, leading to a "fundamental improvement" in skin texture.
Acne scar and scar repair support
polynucleotides have.Strong anti-inflammatory actionalso works on inflamed acne.
Further,angiogenesisIn order to ensure that nutrition is distributed by theSmooth tissue repair of scars.
By enhancing the skin's self-repair function, turnover is normalized and the marks gradually become less noticeable.
How polynucleotides work on the skin
- Activation of fibroblasts: Stimulates cells that produce collagen and elastin in the skin
- Angiogenesis: Creation of new blood vessels and smooth supply of oxygen and nutrients to repair wounds and normalize turnover
- Anti-inflammatory: reduces inflammation and soothes skin problems
When polynucleotides are injected into the dermal layer, they repair the skin from the inside out and lead to improved skin texture. Like hyaluronic acidSkin growth treatment that "nurtures from within" instead of "adding from outsideIt is.
Polynucleotides extracted from salmon (salmon and trout) sperm have a similar structure to human DNA, which has the advantage of being less likely to cause allergic reactions.
The following studies confirm that injection of polynucleotide preparations is a safe and effective treatment that significantly improves skin texture, firmness, tone, and luster in Asian skin.
Reference:Lim, T. S., Liew, S. R., Tee, X. J., Chong, I., Lo, F. J., Ho, M. J., Ong, K. T., & Cavallini, M. (2024). Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation. Clinical, Cosmetic and Investigational Dermatology, 17, 417-431. doi:10.2147/CCID.S437942
Number of Vitaran treatments, recommended intervals, and durability
- Interval between treatments: 3-4 treatments are usually recommended every 2-4 weeks
- Durability: Approximately 3-6 months
The number of treatments is the same as for Riguran Rizne.
Persistence is more improved with Rizne Vitalan compared to RidjulanI did.
Time to realization of effects
- 1st time: 1 to 2 weeks after injection, skin feels firmer, skin looks more radiant and makeup is easier to apply, and moisture content is increased.
- 2nd to 3rd visit: Improvement of texture and reduction of fine lines and wrinkles begin to be visible.
- After the 4th visit: Improvement of firmness and elasticity, change in skin texture
VITALAN is not a treatment like hyaluronic acid, which "bulges immediately after insertion," but a treatment that gradually grows the skin.
It takes time for cells to activate and collagen to increase.
Skin density increases with each session and the duration of the effect is longer.It will be.
Vitaran pain can be alleviated with anesthesia.
Conclusions,Vitaran's pain is "milder than Riguran's."However, it is not "completely painless".
For example, the following pain may be felt
- Needle sticking pain: prick pain
- Pressure of drug entry: feeling of being pushed
- Irritation of the formulation itself: Tingling sensation (individual differences vary widely)
Vitaran has been used by patients due to the pH adjustment of the formulation and other factors.Many customers feel that the irritating sensation of the formulation is less than that of Rejuran.It is.
In addition,Use of anesthesia is recommended when injecting with water light injections.Therefore, the procedure is basically performed under cream or local anesthesia.
Downtime, Side Effects, and Risks
As a rule, downtime for Vitaran is 2-3 days.
- Swelling and redness: several hours to several days (depending on the individual)
- Swelling due to water-light injection: about 48 hours
- Needle scar is about 2 to 3 days
- Internal bleeding: 1-2 weeks
Swelling/redness
Immediately after the procedure, there may be swelling and redness in and around the needle hole.
It usually settles down within a few hours or the next day, and can be covered with makeup after the next day.
Redness temporarily intensifies when blood circulation is increased by bathing, drinking, etc.Please keep calm on the day of the surgery.
Swelling after water light injection (embossing phenomenon)
Immediately after the procedure, the injected area will swell up like an insect bite, a condition called "embossing.
this (something or someone close to the speaker (including the speaker), or ideas expressed by the speaker)A popping bulge is evidence that the drug is lodged in the dermis and is a normal responseIt is.
As early as a few hours, usually the next day or a few days, it is absorbed into the skin and flattens out.
Compared to Rejuran, Vitaran has a faster swelling pull (absorption)Many people say, "I'm not sure I can do this.
internal hemorrhage
If the needle touches a capillary, petechial internal bleeding may occur.
This isPossible risks with all injectable treatments, not just VitaranIt is.
Even if internal bleeding occurs,Can be concealed with concealer or foundation.Most of the time, it is only about 2.5 degrees and disappears in 1-2 weeks.
To learn more about the detailed progress, please see the following article.
infection
Although extremely rare, bacteria can enter through the needle hole and cause infection.
To reduce the risk of infection, please be careful not to touch the treated area after surgery.
allergy
The polynucleotides that are the main component of Vitaran are very similar in structure to human DNA,Very unlikely to cause allergic reactions.Preparation.
However, in very rare cases, allergic reactions (rash, intense itching, unusual heat, etc.) may occur.
In case,If the swelling or itching does not go down or increases after a few days, please contact the clinic immediately.
How to spend time after VITALAN treatment and precautions
- Facial cleansing and skin care: You can start on the day of the procedure, but please do not rub the injection site strongly. Keep the skin clean and refrain from using harsh skin care products.
- Drinking alcohol, strenuous exercise, sauna: Avoid on the same day. Excessive blood circulation may cause severe redness, internal bleeding, and swelling.
- Makeup: Immediately after the procedure, the needle holes are open, so please avoid makeup on the day of the procedure. Makeup can be applied as usual on the following day.
- Moisturizing and UV protection: Fine scratches make the skin dry easily and susceptible to UV damage. Please take more care of your skin than usual.
Comparison of the difference between Vitalan, Lizune, and Lijulan
What, in the end, is the difference between Ridjulan, Rizne, and Vitalan?" "Which one is better?" We have compared the three formulations to answer these questions.
| Comparison items | VITARAN | LYZNE (LIZNE) | REJURAN | |
| raw materials | trout | trout | salmon (any fish of the family Salmonidae) | |
| PN Concentration | 20 mg/mL (2%) | 20 mg/mL (2%) | 20 mg/mL (2%) | |
| manufacturer | BR PHARM, Inc. | BR PHARM, Inc. | PharmaResearch, Inc. | |
| Pain level | Relatively mild | Relatively mild | Tends to be strong. | |
| Downtime Symptoms | swelling up | Light to Medium | Light to Medium | during (a certain time when one did or is doing something) |
| blush | Mild | Mild | Light to moderate | |
| Features of the Formulation | Same manufacturer as Rizne Good balance between cosmetics and pain. | Discontinued | Pioneer with No. 1 name recognition Easy to cause pain due to acidity, etc. | |
| Expected Main Benefits | Similar to Rejuran | Similar to Rejuran | Skin regeneration Improvement of wrinkles Improvement of elasticity and resilience | |
VITALAN and RIZNE: Peace of mind from the same manufacturer
We understand that some of you may be anxious about future treatment with the end of Rizne's handling.
Vitaran and Rizne are manufactured by BR PHARM in Korea under the same strict quality control standards.The same manufacturer is a great reassurance in quality. The fact that the manufacturer is the same is a great reassurance of quality.
- Equal quality standards for raw materials
- Same level of control over the manufacturing process (MFDS permit obtained)
- Know-how in formulation technology is shared.
BR PHARM manages its own salmon (trout) farms in clean areas on the south coast.
We manage everything from procurement of raw materials to extraction, purification, and commercialization of DNA using our patented technology in an integrated manner in-house.
By this,Eliminates the risk of viruses and impurities to the extreme, enabling the provision of consistently stable, high-quality polynucleotide products.The first two are the following.
VITALAN Rizne and Ridjulan: Differences in Effectiveness and Pain
- Rejuran: known to be very painful when injected
- Vitalan Rizne: Significantly reduced
Important,Less pain does not mean less effective.This is the point.
The polynucleotide concentration of Vitalan is 20 mg/mL, the same as that of Rejuran Healer (the standard formulation in the Rejuran series).
In other words,Theoretical skin growth effect of Vitaran can be expected to be equivalent to that of Rejuran Lizune.
Rejuran is a pioneer in polynucleotide formulations and is known for its effectiveness in improving the appearance of stubborn fine lines and wrinkles around the eyes and mouth.
However, it was highly viscous and tended to cause pain during injection and swelling during downtime.
On the other hand,VITARAN is designed to be relatively less painful to inject than Riguran by adjusting the pH (degree of acidity/alkalinity) and devising the viscosity and osmotic pressure of the formulation.The company has been
How to choose
- Pain is not an issue, want to keep costs down, or want to treat a large area: VITALAN
- Absolute commitment to the brand, pain is acceptable: Rejran.
To learn more about Rejuran, please see the following article.
To learn more about Lizne, please see the following article.
Smart Skin Clinic Fees
| two (long cylindrical things) (2cc) | limited discount price (~2/28) | per cc Price |
| Once (10%Off) | 33,210 yen | 16,600 yen |
| 3 times (20%Off) | 79,920 yen (1 time 26,640 yen) | ¥13,320 |
| four times (20%Off) | 98,880 yen (1 time 24,720 yen) | ¥12,360 |
| four (long cylindrical things) (4cc) | limited discount price (~2/28) | per cc Price |
| Once (10%Off) | 49,410 yen | 12,350 yen |
| 3 times (20%Off) | 118,560 yen (1 time 39,520 yen) | ¥9,880 |
| four times (20%Off) | 146,880 yen (1 time 36,720 yen) | ¥9,180 |
| six (long cylindrical things) (6cc) | limited discount price (~2/28) | per cc Price |
| Once (10%Off) | 65,610 yen | ¥10,940 |
| 3 times (20%Off) | 157,440 yen (1 time 52,480 yen) | ¥8,750 |
| four times (20%Off) | 191,360 yen (1 time 47,840 yen) | 7,980 yen |
We are a free clinic and not covered by insurance.
Need for anesthesia｜High
Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.
Why Smart Skin Clinic chose Vitalan
At Smart Skin Clinic,The general manager of the company himself has examined the ingredients and manufacturing background of Vitaran, and introduced it with confidence.I did.
When the decision was made to stop supplying Lizné, "Quality that does not betray the patients who trusted Rizne.In order to provide the "Rizne", we thought it was important to have the reliability of the manufacturer. As a result, we decided to introduce Vitaran because the manufacturing license of MFDS in Korea confirmed that Vitaran is made on the same BR PHARM production line as Rizne.
Also,Continuation" is the key to skin growth treatment.It is. No matter how good the medicine is, if it is too painful to continue a second time, it will be difficult to realize the benefits. It is more important for long-term improvement of skin quality to be able to go to the clinic regularly at a reasonable price, rather than to receive an expensive treatment only once.It is.
VITALAN is a formulation that balances effectiveness, pain, and cost, and is easy to follow without difficulty.The company has determined that it is
How to inject VITARAN
Doctor's handshake
If you want to improve your skin texture, or if you are only concerned about the fine lines under your eyes, or if you want to do just the area around your mouth,High-density, concentrated injections can be performed on areas of concern.It is It can also be used on areas with thin skin, such as around the eyes.
Vital Injector
The water light injection is a device that injects drugs like a stamp with nine ultrafine needles per shot. Suction pressure causes the ultrafine needles to penetrate the skin, and the drug is injected evenly at a pre-set depth.
The effects of Vitaran and the skin's attempt to heal needle wounds can be expected to increase collagen and regenerate the skin.
See also this article for more information about water light injections.
Vitaran'sApproximate quantity (number) required
The required volume for the entire face is generally 3 cc or more for any technique, and about 6 cc if a firm injection is desired for the entire face.It is.
For more information, please contact us for a counseling session.
People who cannot receive VITALAN or need attention
- Those with serious allergies to fish.
- Pregnant or nursing mothers.
- Those taking anticoagulants (blood thinners) may have difficulty stopping internal bleeding.
- If there is dermatitis (severe acne or infection) at the injection site, the procedure will be performed after it has healed.
Flow of treatment
You can easily make reservations with your mobile phone.
This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.
Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.
We will carry out the infusion while talking to you.
We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.
Treatment Overview
| (data) item | Contents |
| Treatment Time | 15 to 30 minutes, excluding anesthesia time |
| anesthesia | Surface anesthesia (cream) |
| Down time | Embossing (bumpy): several hours to the next day Redness: hours to days Internal bleeding: 1 to 2 weeks |
| Makeup and Face Wash | Possible from the next day (only washing face with lukewarm water is recommended on the same day) |
| Shower/Bath | Showering starts the same day, bathing the next day. |
| Recommended pace of hospital visits | Once every 2 to 3 weeks for 3 to 4 consecutive sessions is recommended |
[Legal description
Treatment includes the use of drugs or medical devices that are not approved in Japan. The drugs and devices used in the treatment have been imported on a personal import basis at the discretion of our physicians.
Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".
FAQ
- Is it exactly the same as Lizne?
-
The manufacturer (BR PHARM) is the same and the ingredient specifications are almost identical.
It is a formulation that is very close in feel and effect, and can be confidently recommended as a successor to Lysne. - Is there any effect even after just one session?
-
Although many people notice a "glow to the skin" and "good makeup application" even after a single treatment, polynucleotide preparations are a treatment that shows its true value by accumulating.
Wrinkles do not disappear dramatically in a single session, so multiple sessions are recommended. - When can I start wearing makeup after the procedure?
-
It is possible to start the day after the procedure. Since the needle holes are still open, please refrain from wearing makeup on the day of the procedure to prevent infection.
- Can I have it the same day as other injections?
-
Some formulations may be possible. The same day or another day will be offered depending on the physician's decision.
- Will my skin return to normal after I stop? (Is there a rebound?)
-
There is no rapid deterioration (rebound). However, aging is progressive, and if treatment is stopped, the patient will gradually return to the natural aging process. Regular maintenance is recommended to keep them in good condition.
- Is it ever ineffective?
-
Although complete lack of change is rare, the realization of the effect varies from person to person. Vitaran alone may be difficult to use, especially for deep wrinkles and sagging skin. In such cases, we suggest combining VITALAN™ with other treatments such as a thread lift.
Vitalan is a smart skin clinic
For those who are looking for a new option following the discontinuation of Rizne, Vitaran is the most reliable place to switch to, as it is the "same manufacturer" and "same quality".
Vitaran will also be the perfect entry formulation for those who were hesitant to try Rejelan, saying that they are interested in skin growth but afraid of pain.
Please feel free to contact us for a free consultation to see if Vitaran is right for your skin. Counseling will be conducted by a physician.
Reference
Clinic List
Jimbocho Institute
〒101-0054
EX Kanda Nishiki-cho Building 8F (general reception), 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo 7F
Business hours: Monday-Friday 11:00-20:00 / Saturday and Sunday 10:00-19:00
Yokohama Institute of Technology
〒221-0835
TS Plaza Bldg. 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Business hours: 10:00-19:00
About the physician supervision of this site
This site is operated under the supervision of a physician supervised by Smart Skin Clinic.
This page was revised and enacted in June 2018. Medical Advertising Guidelines We produce and provide information based on
- Scope of supervision: treatment description, risks and side effects, price labeling
- Last supervision date: June 26, 2025