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Rejuvenation under the eyes with Profibro｜Explanation of effects and injection sites
*Number of cases | During the period from September 1, 2023 to March 31, 2024
I wonder if Profilo can be used around the eyes (under the eyes)?"
I wonder if Profilo will help with sagging under eyes?"
'I can't get rid of the fine lines under my eyes even with eye cream...'
If possible, I would like to avoid injections and lasers, and want to rejuvenate naturally..."
Hello. I am a physician at Smart Skin Clinic, an aesthetic dermatology clinic.
Do you have any of these concerns or questions?
The area under the eyes is prone to age-related changes, but many people find it difficult to care for. The hyaluronic acid preparation "Profibro" has been attracting attention for rejuvenating the area under the eyes.
In this article, we will explain in detail the characteristics and effects of Profibro and how it is injected under the eyes from a cosmetic dermatologist's professional standpoint. Please take a look at how Profibro approaches problems under the eyes.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What is Profhilo?
PROFILO is an injectable formulation of two types of hyaluronic acid, high molecular weight and low molecular weight.
Because we use hyaluronic acid that has been non-cross-linked using our proprietary technology, it is easily absorbed by the body, and natural, long-term effects can be expected.
Conventional hyaluronic acid injections are injected locally, mainly to improve wrinkles and laugh lines.
Profibro, on the other hand, spreads throughout the dermis layer, promoting repair and regeneration of damaged tissue. It improves skin firmness, elasticity, and texture.
Effects of Profhilo
Improvement of skin elasticity and firmness
Improvement of wrinkles and sagging skin
Improvement of skin quality
Hyaluronic acid has water retention properties and stimulates the production of collagen and elastin in the dermis layer. The two types of hyaluronic acid in PROFILO are widely spread from the epidermis to the dermis, pushing up the skin from the inside and improving skin texture.
In addition, the long-lasting effect of Profibro is due to a technology called NAHYCO™ technology.
This technology combines high and low molecular weight hyaluronic acid in a heat treatment to enhance stability and durability.
[(Source) Laurino C, et al. Efficacy, Safety, and Tolerance of a New Injection Technique for High- and Low-Molecular-Weight Hyaluronic Acid Hybrid Complexes. eplasty. 2015; 15: e46.]
Rejuvenation under the eyes with Profilo
With aging, the loss of fat under the eyes causes sagging and the decrease in collagen in the dermis causes fine lines and wrinkles.
In addition, the skin under the eyes is thin and prone to dark circles.
PROFILO approaches collagen and elastin in the dermal layer to increase firmness and elasticity, leading to improvement of these problems.
Two types of hyaluronic acid penetrate the entire dermis under the eyes, providing firm hydration while drawing out the skin's natural strength.
Profibro injection site and effect on under eye
Profibro is injected using a unique technique called the BAP method (bio-esthetic point method).
There are 10 predetermined injection points on the face, which are injected evenly.
The following concerns and questions may arise here.
I wonder if Profilo can be used around the eyes (under the eyes)?"
In answer to the question here,Yes, it works fine.That is the point.
Strictly speaking, we do not inject directly under the eyes, but since the Profibro injected into the three areas of the cheeks will spread to the dermis layer under the eyes, it will naturally have an effect under the eyes as well.
Spreads 2 cm square from injection siteThat being said, hyaluronic acid can also penetrate the area from the top of the lower eyelid to the outer corner of the eye, which is why it is so effective.
[(Source) Laurino C, et al. Efficacy, Safety, and Tolerance of a New Injection Technique for High- and Low-Molecular-Weight Hyaluronic Acid Hybrid Complexes. eplasty. 2015; 15: e46.]
Profilo treatment methods and precautions
The Profilo procedure is performed in the following manner.
Counseling and diagnosis
Injection (0.2 cc per site, 2 cc total)
Aftercare guidance
No anesthesia is required because a fine needle is used for injection. The pain is limited to a slight tingling, but varies from person to person.
After the procedure, redness, swelling, and internal bleeding at the injection site may occur. It is unlikely to be concealed by makeup and will settle down within 1-2 days, but it is recommended to leave 2-3 days just to be safe.
Makeup can be applied immediately afterwards, but the injection site should be avoided.
What to expect when undergoing the Profilo procedure
Profibro is a treatment that is indicated for most people, but not for those who
Those who are pregnant or breastfeeding
Those who are under treatment for diabetes or other diseases.
Keloidal constitution
Although the effects may vary from person to person, most people feel a change in about one month.
The duration is 6 months to 1 year, and it is easier to feel the effects of the treatment if you receive it continuously.
For profilo, go to Smart Skin Clinic.
Profibro is a treatment that approaches sagging, dark circles, and fine lines under the eyes from within the skin.
It spreads from the injection site to the dermis layer under the eyes, stimulating the production of collagen and elastin, leading to firm and elastic skin.
The appeal of this treatment is that it has short downtime and is painless, making it an easy way to achieve a rejuvenated look.
We offer the best treatment plan for each of our clients, including Profilo. We aim to achieve your ideal skin through careful counseling and our advanced technology.
If you have problems under your eyes, please contact us for a consultation.
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last supervision date: June 26, 2025
