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Rejuran Generic (Kiarareju) [Smart Skin Clinic]
"What exactly is Kiarareju, and what does it do?"
"What about pain and downtime?"
"How is Kiarareju different from Rejuran?"
Do you have questions or concerns like these about Kiarareju?
Hello. I am a physician at Smart Skin Clinic, an aesthetic dermatology clinic.
You may not have heard of Kiarareju before, but you are likely familiar with Rejuran.
It may be easiest to think of Kiarareju as"a generic version of Rejuran."Rejuran is an injectable formulation whose main ingredient is polynucleotide (PDRN), a component extracted from salmon, and Kiarareju is likewise an injectable formulation based on this same polynucleotide (PDRN).
This article explains, in clear terms, what Kiarareju is, along with its mechanism, effects, and risks.
*If you would like to check the pricing right away, you can jump ahead using the table of contents below.
Group Chief Director, Smart Skin Clinic Group
Ishii Kota
Career
Graduated from Juntendo University School of Medicine
Worked at Tokyo Women's Medical University Hospital and affiliated facilities
Worked at a major aesthetic clinic in Tokyo
Affiliations / Qualifications
Board-certified specialist, Japan Surgical Society
Board-certified specialist, Japanese Society of Anti-Aging Medicine
What is Kiarareju Water Light Injection?
Kiarareju Water Light Injection is a skin-nurturing treatment in which the Kiarareju formulation is injected using a Water Light Injection device, aiming to beautify the skin from within.
What is Kiarareju?
Kiarareju is a formulation whose main ingredient is salmon-derived polydeoxynucleotide (PDRN). In addition to PDRN, it contains hyaluronic acid and niacinamide, and because it is designed to boost the skin's own natural capabilities, it is also referred to as a skin booster. Since it uses salmon-derived polydeoxynucleotide, it is sometimes described as a "salmon injection."
When you hear “salmon-derived polydeoxynucleotide,” you may think of Rejuran, which is known for its cell-regenerating effect.
Rejuran is a preparation whose active ingredient is polydeoxynucleotide (PDRN), extracted from salmon DNA, and it works to enhance the skin's self-regenerating ability.
Polydeoxynucleotide (PDRN) offers a variety of effects, including increased production of growth factors, improved capillary circulation, anti-inflammatory action, and DNA resynthesis.
Kiarareju holds a position much like a generic version of Rejuran,It is one of the inexpensive formulations manufactured following the now off-patent Rejuran.
For more details on Rejuran and Rejuran Water Light Injection, please see here.
What Is Water Light Injection?
The Water Light Injection is a device that injects the formulation like a stamp, using nine ultra-fine needles per shot.
Suction pressure allows the ultra-fine needles to enter the skin, delivering the formulation evenly at a preset depth.
Thanks to the effect of the formulation and the skin's natural response to heal the tiny needle marks, this may help support collagen production and skin regeneration.
For more about Water Light Injections, please also see this article.
Effects You Can Expect from Kiarareju
The effects you can expect from Kiarareju are:essentially the same as those of Rejuran..
- Improvement of skin quality
- Hydration
- Improved skin tone
- Improved skin elasticity
- Improvement of fine lines and crepey wrinkles
- Strengthening of the skin's barrier function
Ingredients of Kiarareju
- Polydeoxynucleotide: skin regeneration
- Hyaluronic acid: high hydration, long-lasting
- Niacinamide: brightening
Kiarareju containsingredients similar to those in Rejuran..
Hyaluronic acid is a component found in human skin and cartilage that offers a high level of water retention. It naturally decreases with age. Because it is absorbed by the body, it is considered to have a relatively high safety profile.
Niacinamide is an ingredient recognized by Japan's Ministry of Health, Labour and Welfare for its "brightening," "wrinkle-improving," and "rough-skin-improving" effects.
The following study reports improvements in wrinkles and skin texture when polydeoxynucleotide was injected on its own into the nasolabial folds.
The selected right-side nasolabial fold received 4 ml of PN-HPT® (≈polydeoxynucleotide) intradermally during the initial priming phase (the "NLF Rx group"), while the selected left-side nasolabial fold received 4 ml of saline (placebo) (the "NLF Lx group"). Three and six weeks later, all patients received 2 ml of subcutaneous cross-linked HA in both NLF areas (4 ml in total).
(omitted) The Antera 3D® device showed that, in the NLF Rx, wrinkles and skin texture improved significantly compared with baseline at 6 weeks (monotherapy phase) and at 3 and 6 months (PN-HPT® priming + HA phase). HA levels as measured by the quantitative Vectra H2® assessment technique in the right NLF were significantly higher than the contralateral side at both 3 and 6 months.
PN-HPT® monotherapy was confirmed to be a potentially valuable and effective option for rapidly improving the dermal texture and quality of the skin in patients with moderate to severe NLF. Acting as a priming agent within the skin, PN-HPT® prolongs the clinical efficacy of cross-linked HA.
Antonino Araco, Francesco Araco, Mauro Raichi. Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross-linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study. Journal of cosmetic dermatology. 2023 Jan;22(1);146-155. doi: 10.1111/jocd.15064.
Pricing
Chiara Reju(Rejuran Generic)
*Polynucleotide (PDRN) formulation similar to Rejuran
| 1 vial (2.2 cc) | Price | Per 1 cc Price |
| Once | 22,320 yen | 10,100 yen |
| 2 sessions | 36,520 yen (18,260 yen per session) | 8,300 yen |
| 4 sessions | 63,360 yen (15,840 yen per session) | 7,200 yen |
| 2 bottles (4.4cc) | Price | Per 1 cc Price |
| Once | 31,320 yen | 7,200 yen |
| 2 sessions | 49,280 yen (24,640 yen per session) | 5,600 yen |
| 4 sessions | 91,520 yen (22,880 yen per session) | 5,200 yen |
| 3 bottles (6.6cc) | Price | Per 1 cc Price |
| Once | 35,820 yen | 5,400 yen |
| 2 sessions | 55,440 yen (27,720 yen per session) | 4,200 yen |
| 4 sessions | 104,960 yen (26,240 yen per session) | 3,980 yen |
*We offer self-pay (non-insured) treatments only; insurance does not apply.
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Cocktail Water Light Injection with Juvelook
| Rejuran-heavy cocktail [6cc] | Price |
|---|---|
| Once | 44,800 yen |
| 3 times | 114,700 yen (per session 38,200 yen) |
| Juvelook-heavy cocktail [6cc] | Price |
|---|---|
| Once | 49,300 yen |
| 3 times | 125,700 yen (per session 41,900 yen) |
Need for Anesthesia | High
Prices shown are all-inclusive, covering anesthesia and other fees.
This is because anesthesia is recommended for this treatment, so the standard practice is to perform it after applying anesthetic cream or administering local anesthesia.
Kiarareju treatment areas
- Face (forehead, temples, nose, cheeks, fine lines and crepey wrinkles)
- Neck
- Décolleté
- Back of the hand
Kiarareju can be used over a wide range of areas, from the entire face to the neck and décolleté.
Pain during Kiarareju Water Light Injection
- No more than a slight prickling sensation as the needle enters the skin
*Individual variation applies; anesthesia is available
Kiarareju Water Light Injection reduces pain by applying suction as the needle enters the skin.
Because the needles are ultra-fine and nine can be delivered at once, the number of insertions is kept to a minimum.
Pain can also be reduced by cooling the treatment area beforehand and by using anesthesia. Smart Skin Clinic's pricing includes the cost of anesthesia.
Timing, Duration, and Recommended Maintenance Frequency of the Effects You Can Expect from Kiarareju
【When Effects Can Be Expected】
- Hydration and brightening effects = immediately after treatment
- Skin-regenerating effects = approx. 2 to 4 weeks later
[Recommended number of treatments]
- About 3 to 4 sessions, spaced 2 to 4 weeks apart (= 1 course)
【Expected Duration of Effects】
- More than 1 year
*When a full course of treatment is completed
[Recommended maintenance frequency]
- 1 course every 6 months to 1 year
At first you will notice the hydration and tone-brightening effects of the hyaluronic acid, and after 2 to 4 weeks you can expect the skin-regenerating effects of the polydeoxyribonucleotide.
As with Rejuran, you can see results after just one session, but you can expect greater results by repeating treatments.
Recommended injection volume for Kiarareju
[Pattern 1] Lighter treatment is fine for the forehead and the area below the nose ⇒ 3cc
[Pattern 2] The area below the nose can be a little lighter, but I want thorough treatment above the nose ⇒ 4cc
[Pattern 3] I want thorough treatment across the whole face, including below the nose ⇒ 6cc
For more details, please also refer to this illustration.
If you are unsure which volume best suits your concerns, please feel free to discuss it during your counseling session.
Downtime and risks of Kiarareju Water Light Injection
The concern most people have about Kiarareju Water Light Injection is how it may affect daily life afterward.
Downtime of Kiarareju Water Light Injection
[Period]
- About 2 to 3 days
[Symptoms]
- Redness and small raised bumps at the needle sites: resolve within 24 hours
- Stinging sensation: several days
- Bruising: gradually fades over 10 to 14 days
Pain and swelling can be relieved by cooling. Wrap an ice pack or similar in a clean cloth and apply it intermittently to the treated area.
For details on the downtime of Water Light Injections, please also see here.
How to care for your skin after Kiarareju Water Light Injection
After treatment, please keep the following points in mind.
- Skincare: possible immediately after the treatment
- Shower: possible on the same day
- Makeup: possible after about 24 hours
Kiarareju Water Light Injection has no major impact on daily life. If you work at a desk, you can carry on as usual. Any bruising can be covered with concealer.
However, beneath the surface, the skin is working to repair micro-injuries that are not visible to the eye. Please avoid activities that increase circulation and may hinder recovery, such as long baths, strenuous exercise, and massage, as these can intensify downtime symptoms.
Risks of Kiarareju Water Light Injection
Beyond downtime symptoms, Kiarareju × Water Light Injection treatment may involve the following side effects.
- Pigmentation
- Infection
- Allergy
After treatment, avoid touching the treated area more than necessary, as this may lead to pigmentation or infection. In addition, skin that is still regenerating can be prone not only to pigmentation but to various skin concerns, so be diligent with moisturizing and sun protection.
Swelling, pain, and redness resemble downtime symptoms but usually subside over time. Worsening symptoms are an important sign of an allergic reaction. Please consult the clinic as soon as you notice them.
Please note that, like Rejuran, Kiarareju is derived from salmon, so it cannot be used by those with a fish allergy.
Kiarareju treatment procedure
The procedure takes about 30 to 40 minutes excluding counseling, and about 60 minutes including anesthesia.
You can easily book from your smartphone.
A smart, effortless check-in: just give your name and our clinic IT system completes reception right away.
During counseling, please feel free to share any concerns. Rest assured, there is no pushy sales.
We apply anesthetic cream, administer local anesthesia, and perform the injection while checking in with you.
We explain in detail how to care for the treated area and what to keep in mind in daily life. From a prevention and maintenance standpoint, we also suggest suitable home care, such as oral medications and skincare products that can support improvement of your concerns.
How to avoid a disappointing outcome with Kiarareju Water Light Injection
- Choose a trustworthy clinic based on its case results and reviews.
- Make sure the pricing is something you can sustain over time.
- During counseling, share your concerns and goals with the doctor, confirm suitability, treatment details, and downtime, and proceed only once you feel fully informed and comfortable.
- Follow the aftercare instructions.
- Receive treatment at the recommended frequency and maintenance intervals.
Even for the same treatment, the level of skill and the fee structure vary from clinic to clinic.
Be sure to also confirm how the clinic thinks about the expected results and downtime. In Japan in particular, many people prefer treatments that minimize the impact on daily life, whereas at overseas clinics downtime is sometimes of less concern than it is for Japanese patients. The needle depth and suction pressure can be adjusted, so take the time to discuss your preferences carefully.
Details
| Treatment Time | About 30 to 40 minutes (not including counseling) |
| Recommended Number & Frequency of Treatments | We recommend about 3 to 4 sessions at intervals of roughly 2 to 4 weeks. |
| Downtime | About 2 to 3 days |
| Treatment on the day of counseling | Available |
| Makeup | Possible from about 24 hours later |
| Skincare | Possible right after the treatment |
| Shower | Possible from the same day |
| Pain | A slight pricking sensation when the needle is inserted. |
For Kiarareju Water Light Injection, choose Smart Skin Clinic.
At Smart Skin Clinic, Kiarareju Water Light Injection uses nine ultra-fine needles, with the depth adjustable from 0.6 to 1.2 mm beneath the skin and the injection volume fully controllable.
Our pricing is clear and transparent. To suit your treatment areas and preferences, we offer three volume options per unit—2.2 cc / 4.4 cc / 6.6 cc—along with an easy-to-try single-session price and easy-to-continue 3- and 4-session set prices.
If you have any questions, please feel free to ask during a free consultation. Our doctors will recommend the most suitable treatment for you.
Reference
Legal Notices
Kiarareju Water Light Injection therapy includes procedures using drugs or medical devices not approved in Japan. The drugs and devices used in treatment are imported personally under the judgment of our clinic's physicians.
Disclosure of whether an approved equivalent drug exists in Japan: Kiarareju is an unapproved drug in Japan.
Please refer to this page for information on medications and similar items that require caution in personal importation.
Ministry of Health, Labour and Welfare, "Medications and Similar Items That Require Caution in Personal Importation."
Physician Who Supervised This Page
Smart Skin Clinic, Chief Medical Director / Physician
Kota Ishii
We oversee treatment policies across the entire group, tailored to the skin condition of each individual patient. The content on this page has been reviewed and approved in line with our clinic's treatment policies.
Interview with Director Kota Ishii
Kota Ishii, our Chief Medical Director, shares our clinic's approach to patient care.
Clinic List
Jimbocho Clinic
〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F
Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00
Yokohama Clinic
〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa
Hours: 10:00–19:00
About the physician supervision of this site
This site is operated under the supervision of a Smart Skin Clinic supervising physician.
This page was produced in accordance with the Medical Advertising Guidelines Medical Advertising Guidelines revised and enforced in June 2018, under which we produce and provide this information.
- Scope of supervision: treatment descriptions, risks and side effects, price display
- Last supervision date: June 26, 2025